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6VW2
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BU of 6vw2 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils
Descriptor: Islet amyloid polypeptide (SUMO-tagged)
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2020-02-18
Release date:2020-06-10
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.
Nat.Struct.Mol.Biol., 27, 2020
7M64
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BU of 7m64 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 3
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M61
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BU of 7m61 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 1
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M65
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BU of 7m65 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 4
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
7M62
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BU of 7m62 by Molmil
Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils seeded by patient extracted fibrils, polymorph 2
Descriptor: Islet amyloid polypeptide
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-03-25
Release date:2021-09-22
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Cryo-EM structures of hIAPP fibrils seeded by patient-extracted fibrils reveal new polymorphs and conserved fibril cores
Nat.Struct.Mol.Biol., 28, 2021
3V6L
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BU of 3v6l by Molmil
Crystal Structure of caspase-6 inactivation mutation
Descriptor: Caspase-6
Authors:Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D.
Deposit date:2011-12-20
Release date:2012-03-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays
J.Biol.Chem., 287, 2012
3V6M
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BU of 3v6m by Molmil
Inhibition of caspase-6 activity by single mutation outside the active site
Descriptor: Caspase-6
Authors:Cao, Q, Wang, X.J, Liu, D.F, Li, L.F, Su, X.D.
Deposit date:2011-12-20
Release date:2012-03-28
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.692 Å)
Cite:Inhibitory mechanism of caspase-6 phosphorylation revealed by crystal structures, molecular dynamics simulations, and biochemical assays
J.Biol.Chem., 287, 2012
4IYR
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BU of 4iyr by Molmil
Crystal structure of full-length caspase-6 zymogen
Descriptor: Caspase-6
Authors:Cao, Q, Wang, X.-J, Li, L.-F, Su, X.-D.
Deposit date:2013-01-29
Release date:2014-01-15
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.697 Å)
Cite:The regulatory mechanism of the caspase 6 pro-domain revealed by crystal structure and biochemical assays.
Acta Crystallogr.,Sect.D, 70, 2014
6N3A
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BU of 6n3a by Molmil
SegA-long, conformation of TDP-43 low complexity domain segment A long
Descriptor: TAR DNA-binding protein 43, segA long small
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-11-14
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
6N37
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BU of 6n37 by Molmil
SegA-sym, conformation of TDP-43 low complexity domain segment A sym
Descriptor: TAR DNA-binding protein 43
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-11-14
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
6N3C
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BU of 6n3c by Molmil
SegB, conformation of TDP-43 low complexity domain segment A
Descriptor: TAR DNA-binding protein 43
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-11-14
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
6N3B
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BU of 6n3b by Molmil
SegA-asym, conformation of TDP-43 low complexity domain segment A asym
Descriptor: TAR DNA-binding protein 43
Authors:Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-11-14
Release date:2019-06-26
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Cryo-EM structures of four polymorphic TDP-43 amyloid cores.
Nat.Struct.Mol.Biol., 26, 2019
6BCS
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BU of 6bcs by Molmil
LilrB2 D1D2 domains complexed with benzamidine
Descriptor: BENZAMIDINE, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Cao, Q, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2017-10-20
Release date:2018-09-05
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Inhibiting amyloid-beta cytotoxicity through its interaction with the cell surface receptor LilrB2 by structure-based design.
Nat Chem, 10, 2018
7SAR
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BU of 7sar by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAQ
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BU of 7saq by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 1
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
7SAS
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BU of 7sas by Molmil
Cryo-EM structure of TMEM106B fibrils extracted from a FTLD-TDP patient, polymorph 3
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 106B
Authors:Cao, Q, Jiang, Y, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2021-09-23
Release date:2022-03-09
Last modified:2022-05-25
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Amyloid fibrils in FTLD-TDP are composed of TMEM106B and not TDP-43.
Nature, 605, 2022
8JMV
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BU of 8jmv by Molmil
Flagellar fibrils from Bacillus amyloliquefaciens
Descriptor: Flagella
Authors:Cao, Q, Cheng, Y.
Deposit date:2023-06-05
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM.
Nat Commun, 14, 2023
8JMW
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BU of 8jmw by Molmil
Fibril form of serine peptidase Vpr
Descriptor: S8 family serine peptidase
Authors:Cao, Q, Cheng, Y.
Deposit date:2023-06-05
Release date:2023-12-06
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Serine peptidase Vpr forms enzymatically active fibrils outside Bacillus bacteria revealed by cryo-EM.
Nat Commun, 14, 2023
6WQK
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BU of 6wqk by Molmil
hnRNPA2 Low complexity domain (LCD) determined by cryoEM
Descriptor: MCherry fluorescent protein,Heterogeneous nuclear ribonucleoproteins A2/B1 chimera
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-29
Release date:2020-08-26
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
6WPQ
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BU of 6wpq by Molmil
GNYNVF from hnRNPA2-low complexity domain segment, residues 286-291, D290V variant
Descriptor: Heterogeneous nuclear ribonucleoprotein A2
Authors:Lu, J, Cao, Q, Hughes, M.P, Sawaya, M.R, Boyer, D.R, Cascio, D, Eisenberg, D.S.
Deposit date:2020-04-27
Release date:2020-08-19
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid.
Nat Commun, 11, 2020
6CB9
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BU of 6cb9 by Molmil
Segment AALQSS from the low complexity domain of TDP-43, residues 328-333
Descriptor: AALQSS
Authors:Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-02-02
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CEW
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BU of 6cew by Molmil
Segment AMMAAA from the low complexity domain of TDP-43, residues 321-326
Descriptor: AMMAAA
Authors:Guenther, E.L, Cao, Q, Lu, J, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-02-12
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
6CF4
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BU of 6cf4 by Molmil
Segment NFGTFS, with familial mutation A315T and phosphorylated threonine, from the low complexity domain of TDP-43, residues 312-317
Descriptor: NFGTFS
Authors:Guenther, E.L, Cao, Q, Boyer, D.R, Sawaya, M.R, Eisenberg, D.S.
Deposit date:2018-02-13
Release date:2018-05-23
Last modified:2021-06-30
Method:ELECTRON CRYSTALLOGRAPHY (0.75 Å)
Cite:Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation.
Nat. Struct. Mol. Biol., 25, 2018
3L87
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BU of 3l87 by Molmil
The Crystal Structure of smu.143c from Streptococcus mutans UA159
Descriptor: FE (III) ION, Peptide deformylase
Authors:Su, X.-D, Cao, Q, Liu, X.
Deposit date:2009-12-30
Release date:2011-01-05
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:The Crystal Structure of smu.143c from Streptococcus mutans UA159
TO BE PUBLISHED
3L9T
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BU of 3l9t by Molmil
The Crystal Structure of smu.31 from Streptococcus mutans UA159
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Putative uncharacterized protein smu.31
Authors:Su, X.-D, Cao, Q, Liu, X.
Deposit date:2010-01-05
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.206 Å)
Cite:The Crystal Structure of smu.31 from Streptococcus mutans UA159
TO BE PUBLISHED

 

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