Author results

2XRU
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AURORA-A T288E COMPLEXED WITH PHA-828300
Descriptor:SERINE/THREONINE-PROTEIN KINASE 6, 3-({[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]CARBONYL}AMINO)-N-[(1R)-1-PHENYLPROPYL]-1H-THIENO[3,2-C]PYRAZOLE-5-CARBOXAMIDE
Authors:Bindi, S., Fancelli, D., Alli, C., Berta, D., Bertrand, J.A., Cameron, A.D., Cappella, P., Carpinelli, P., Cervi, G., Croci, W., D'Anello, M., Forte, B., LauraGiorgini, M., Marsiglio, A., Moll, J., Pesenti, E., Pittala, V., Pulici, M., Riccardi-Sirtori, F., Roletto, F., Soncini, C., Storici, P., Varasi, M., Volpi, D., Zugnoni, P., Vianello, P.
Deposit date:2010-09-22
Release date:2010-09-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Thieno[3,2-C]Pyrazoles: A Novel Class of Aurora Inhibitors with Favorable Antitumor Activity.
Bioorg.Med.Chem., 18, 2010
2XUT
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CRYSTAL STRUCTURE OF A PROTON DEPENDENT OLIGOPEPTIDE (POT) FAMILY TRANSPORTER.
Descriptor:PROTON/PEPTIDE SYMPORTER FAMILY PROTEIN
Authors:Newstead, S., Drew, D., Cameron, A.D., Postis, V.L., Xia, X., Fowler, P.W., Ingram, J.C., Carpenter, E.P., Sansom, M.S.P., McPherson, M.J., Baldwin, S.A., Iwata, S.
Deposit date:2010-10-21
Release date:2010-12-15
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (3.62 Å)
Cite:Crystal Structure of a Prokaryotic Homologue of the Mammalian Oligopeptide-Proton Symporters, Pept1 and Pept2.
Embo J., 30, 2011
2XVA
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CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SINEFUNGIN
Descriptor:TELLURITE RESISTANCE PROTEIN TEHB, SINEFUNGIN, ZINC ION
Authors:Choudhury, H.G., Cameron, A.D., Iwata, S., Beis, K.
Deposit date:2010-10-25
Release date:2011-02-16
Last modified:2012-09-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli.
Biochem.J., 435, 2011
2XVM
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CRYSTAL STRUCTURE OF THE TELLURITE DETOXIFICATION PROTEIN TEHB FROM E. COLI IN COMPLEX WITH SAH
Descriptor:TELLURITE RESISTANCE PROTEIN TEHB, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Choudhury, H.G., Cameron, A.D., Iwata, S., Beis, K.
Deposit date:2010-10-26
Release date:2011-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.48 Å)
Cite:Structure and Mechanism of the Chalcogen Detoxifying Protein Tehb from Escherichia Coli.
Biochem.J., 435, 2011
3VG9
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 2.7 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ...
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
3VGA
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CRYSTAL STRUCTURE OF HUMAN ADENOSINE A2A RECEPTOR WITH AN ALLOSTERIC INVERSE-AGONIST ANTIBODY AT 3.1 A RESOLUTION
Descriptor:Adenosine receptor A2a, antibody fab fragment light chain, antibody fab fragment heavy chain, ...
Authors:Hino, T., Arakawa, T., Iwanari, H., Yurugi-Kobayashi, T., Ikeda-Suno, C., Nakada-Nakura, Y., Kusano-Arai, O., Weyand, S., Shimamura, T., Nomura, N., Cameron, A.D., Kobayashi, T., Hamakubo, T., Iwata, S., Murata, T.
Deposit date:2011-08-04
Release date:2012-02-01
Last modified:2012-02-15
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:G-protein-coupled receptor inactivation by an allosteric inverse-agonist antibody
Nature, 482, 2012
3ZUX
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CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.
Descriptor:TRANSPORTER, SODIUM ION, MERCURY (II) ION, ...
Authors:Hu, N.-J., Iwata, S., Cameron, A.D., Drew, D.
Deposit date:2011-07-21
Release date:2011-10-12
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt.
Nature, 478, 2011
3ZUY
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CRYSTAL STRUCTURE OF A BACTERIAL HOMOLOGUE OF THE BILE ACID SODIUM SYMPORTER ASBT.
Descriptor:TRANSPORTER, SODIUM ION, TAUROCHOLIC ACID, ...
Authors:Hu, N.-J., Iwata, S., Cameron, A.D., Drew, D.
Deposit date:2011-07-21
Release date:2011-10-12
Last modified:2011-10-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Bacterial Homologue of the Bile Acid Sodium Symporter Asbt.
Nature, 478, 2011
4APS
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CRYSTAL STRUCTURE OF A POT FAMILY PEPTIDE TRANSPORTER IN AN INWARD OPEN CONFORMATION.
Descriptor:DI-OR TRIPEPTIDE H+ SYMPORTER, CADMIUM ION
Authors:Solcan, N., Kwok, J., Fowler, P.W., Cameron, A.D., Drew, D., Iwata, S., Newstead, S.
Deposit date:2012-04-05
Release date:2012-06-13
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Alternating Access Mechanism in the Pot Family of Oligopeptide Transporters.
Embo J., 31, 2012
4ATV
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STRUCTURE OF A TRIPLE MUTANT OF THE NHAA DIMER, CRYSTALLISED AT LOW PH
Descriptor:NA(+)/H(+) ANTIPORTER NHAA, SULFATE ION, DODECYL-ALPHA-D-MALTOSIDE
Authors:Drew, D., Lee, C., Iwata, S., Cameron, A.D.
Deposit date:2012-05-10
Release date:2013-07-10
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights.
J. Gen. Physiol., 144, 2014
4AU5
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STRUCTURE OF THE NHAA DIMER, CRYSTALLISED AT LOW PH
Descriptor:NA(+)/H(+) ANTIPORTER NHAA, DODECYL-ALPHA-D-MALTOSIDE, SULFATE ION
Authors:Drew, D., Lee, C., Iwata, S., Cameron, A.D.
Deposit date:2012-05-14
Release date:2013-07-10
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (3.696 Å)
Cite:Crystal structure of the sodium-proton antiporter NhaA dimer and new mechanistic insights.
J. Gen. Physiol., 144, 2014
4BWZ
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CRYSTAL STRUCTURE OF THE SODIUM PROTON ANTIPORTER, NAPA
Descriptor:NA(+)/H(+) ANTIPORTER, ZINC ION
Authors:Lee, C., Drew, D., Cameron, A.D.
Deposit date:2013-07-05
Release date:2013-08-28
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.984 Å)
Cite:A two-domain elevator mechanism for sodium/proton antiport.
Nature, 501, 2013
4D1A
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH INDOLYLMETHYL-HYDANTOIN
Descriptor:HYDANTOIN TRANSPORT PROTEIN, (5S)-5-(1H-indol-3-ylmethyl)imidazolidine-2,4-dione, SODIUM ION
Authors:Weyand, S., Brueckner, F., Geng, T., Drew, D., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1B
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH BENZYL-HYDANTOIN
Descriptor:HYDANTOIN TRANSPORT PROTEIN, (5S)-5-benzylimidazolidine-2,4-dione, SODIUM ION
Authors:Brueckner, F., Geng, T., Weyand, S., Drew, D., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1C
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER, IN A CLOSED CONFORMATION WITH BROMOVINYLHYDANTOIN BOUND.
Descriptor:HYDANTOIN TRANSPORT PROTEIN, (5Z)-5-[(3-bromophenyl)methylidene]imidazolidine-2,4-dione, SODIUM ION
Authors:Weyand, S., Brueckner, F., Geng, T., Drew, D., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4D1D
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STRUCTURE OF MHP1, A NUCLEOBASE-CATION-SYMPORT-1 FAMILY TRANSPORTER WITH THE INHIBITOR 5-(2-NAPHTHYLMETHYL)-L-HYDANTOIN.
Descriptor:HYDANTOIN TRANSPORT PROTEIN, 5-(2-NAPHTHYLMETHYL)-L-HYDANTOIN, 5-(2-NAPHTHYLMETHYL)-D-HYDANTOIN, ...
Authors:Weyand, S., Brueckner, F., Geng, T., Drew, D., Iwata, S., Henderson, P.J.F., Cameron, A.D.
Deposit date:2014-05-01
Release date:2014-07-02
Last modified:2014-08-20
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Molecular Mechanism of Ligand Recognition by Membrane Transport Protein, Mhp1.
Embo J., 33, 2014
4G9K
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STRUCTURE OF THE NDI1 PROTEIN FROM SACCHAROMYCES CEREVISIAE
Descriptor:Rotenone-insensitive NADH-ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., Maher, M.J.
Deposit date:2012-07-24
Release date:2012-09-05
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GAP
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STRUCTURE OF THE NDI1 PROTEIN FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH NAD+
Descriptor:Rotenone-insensitive NADH-ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., Maher, M.J.
Deposit date:2012-07-25
Release date:2012-09-05
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4GAV
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STRUCTURE OF THE NDI1 PROTEIN FROM SACCHAROMYCES CEREVISIAE IN COMPLEX WITH QUINONE
Descriptor:Rotenone-insensitive NADH-ubiquinone oxidoreductase, FLAVIN-ADENINE DINUCLEOTIDE, UBIQUINONE-2
Authors:Iwata, M., Lee, Y., Yamashita, T., Yagi, T., Iwata, S., Cameron, A.D., Maher, M.J.
Deposit date:2012-07-25
Release date:2012-09-05
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure of the yeast NADH dehydrogenase (Ndi1) reveals overlapping binding sites for water- and lipid-soluble substrates.
Proc.Natl.Acad.Sci.USA, 109, 2012
4YZF
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CRYSTAL STRUCTURE OF THE ANION EXCHANGER DOMAIN OF HUMAN ERYTHROCYTE BAND 3
Descriptor:Band 3 anion transport protein, FAB fragment of Immunoglobulin (IgG) molecule, 2,2'-ethane-1,2-diylbis{5-[(sulfanylmethyl)amino]benzenesulfonic acid}
Authors:Alguel, Y., Arakawa, T., Yugiri, T.K., Iwanari, H., Hatae, H., Iwata, M., Abe, Y., Hino, T., Suno, C.I., Kuma, H., Kang, D., Murata, T., Hamakubo, T., Cameron, A.D., Kobayashi, T., Hamasaki, N., Iwata, S.
Deposit date:2015-03-25
Release date:2015-11-04
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Crystal structure of the anion exchanger domain of human erythrocyte band 3.
Science, 350, 2015
5I6C
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THE STRUCTURE OF THE EUKARYOTIC PURINE/H+ SYMPORTER, UAPA, IN COMPLEX WITH XANTHINE
Descriptor:Uric acid-xanthine permease, XANTHINE, DODECYL-BETA-D-MALTOSIDE
Authors:Alguel, Y., Amillis, S., Leung, J., Lambrinidis, G., Capaldi, S., Scull, N.J., Craven, G., Iwata, S., Armstrong, A., Mikros, E., Diallinas, G., Cameron, A.D., Byrne, B.
Deposit date:2016-02-16
Release date:2016-04-27
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Structure of eukaryotic purine/H(+) symporter UapA suggests a role for homodimerization in transport activity.
Nat Commun, 7, 2016
6FV3
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CRYSTAL STRUCTURE OF N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE DEACETYLASE FROM MYCOBACTERIUM SMEGMATIS.
Descriptor:N-acetylglucosamine-6-phosphate deacetylase, ZINC ION
Authors:Ahangar, M.S., Furze, C.M., Guy, C.S., Cooper, C., Maskew, K.S., Graham, B., Cameron, A.D., Fullam, E.
Deposit date:2018-02-28
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
J. Biol. Chem., 293, 2018
6FV4
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THE STRUCTURE OF N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE DEACETYLASE D267A MUTANT FROM MYCOBACTERIUM SMEGMATIS IN COMPLEX WITH N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE
Descriptor:N-acetylglucosamine-6-phosphate deacetylase, ZINC ION, N-ACETYL-D-GLUCOSAMINE-6-PHOSPHATE, ...
Authors:Ahangar, M.S., Furze, C.M., Guy, C.S., Cooper, C., Maskew, K.S., Graham, B., Cameron, A.D., Fullam, E.
Deposit date:2018-03-01
Release date:2018-05-16
Last modified:2018-07-04
Method:X-RAY DIFFRACTION (1.974 Å)
Cite:Structural and functional determination of homologs of theMycobacterium tuberculosis N-acetylglucosamine-6-phosphate deacetylase (NagA).
J. Biol. Chem., 293, 2018
2BMC
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AURORA-2 T287D T288D COMPLEXED WITH PHA-680632
Descriptor:SERINE THREONINE-PROTEIN KINASE 6, (3E)-N-(2,6-DIETHYLPHENYL)-3-{[4-(4-METHYLPIPERAZIN-1-YL)BENZOYL]IMINO}PYRROLO[3,4-C]PYRAZOLE-5(3H)-CARBOXAMIDE
Authors:Cameron, A.D., Izzo, G., Sagliano, A., Rusconi, L., Storici, P., Fancelli, D., Berta, D., Bindi, S., Catana, C., Forte, B., Giordano, P., Mantegani, S., Meroni, M., Moll, J., Pittala, V., Severino, D., Tonani, R., Varasi, M., Vulpetti, A., Vianello, P.
Deposit date:2005-03-11
Release date:2005-03-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Potent and Selective Aurora Inhibitors Identified by the Expansion of a Novel Scaffold for Protein Kinase Inhibition.
J.Med.Chem., 48, 2005
2J4Z
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STRUCTURE OF AURORA-2 IN COMPLEX WITH PHA-680626
Descriptor:SERINE THREONINE-PROTEIN KINASE 6, 4-(4-METHYLPIPERAZIN-1-YL)-N-[5-(2-THIENYLACETYL)-1,5-DIHYDROPYRROLO[3,4-C]PYRAZOL-3-YL]BENZAMIDE, ARSENIC
Authors:Cameron, A.D., Izzo, G., Storici, P., Rusconi, L., Fancelli, D., Varasi, M., Berta, D., Bindi, S., Forte, B., Severino, D., Tonani, R., Vianello, P.
Deposit date:2006-09-08
Release date:2006-11-06
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazoles: identification of a potent Aurora kinase inhibitor with a favorable antitumor kinase inhibition profile.
J. Med. Chem., 49, 2006