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1ZB7
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BU of 1zb7 by Molmil
Crystal Structure of Botulinum Neurotoxin Type G Light Chain
Descriptor: CITRATE ANION, ZINC ION, neurotoxin
Authors:Arndt, J.W, Yu, W, Bi, F, Stevens, R.C.
Deposit date:2005-04-07
Release date:2005-07-05
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal structure of botulinum neurotoxin type g light chain: serotype divergence in substrate recognition
Biochemistry, 44, 2005
1YBI
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BU of 1ybi by Molmil
Crystal structure of HA33A, a neurotoxin-associated protein from Clostridium botulinum type A
Descriptor: non-toxin haemagglutinin HA34
Authors:Arndt, J.W, Gu, J, Jaroszewski, L, Schwarzenbacher, R, Hanson, M, Lebeda, F.J, Stevens, R.C.
Deposit date:2004-12-20
Release date:2005-02-22
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Structure of the Neurotoxin-associated Protein HA33/A from Clostridium botulinum Suggests a Reoccurring beta-Trefoil Fold in the Progenitor Toxin Complex.
J.Mol.Biol., 346, 2005
6CO3
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BU of 6co3 by Molmil
aducanumab abeta complex
Descriptor: ALA-GLU-PHE-ARG-HIS-ASP, Fab heavy chain, Fab light chain, ...
Authors:Arndt, J.W.
Deposit date:2018-03-10
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.384 Å)
Cite:Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
6CNR
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BU of 6cnr by Molmil
aducanumab apo Fab
Descriptor: Aducanumab heavy chain, Aducanumab light chain, SULFATE ION
Authors:Arndt, J.W.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-beta.
Sci Rep, 8, 2018
2FPQ
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BU of 2fpq by Molmil
Crystal Structure of Botulinum Neurotoxin Type D Light Chain
Descriptor: BOTULINUM NEUROTOXIN D LIGHT CHAIN, POTASSIUM ION, ZINC ION
Authors:Arndt, J.W, Chai, Q, Christian, T, Stevens, R.C.
Deposit date:2006-01-16
Release date:2006-03-21
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structure of Botulinum Neurotoxin Type D Light Chain at 1.65 A Resolution: Repercussions for VAMP-2 Substrate Specificity(,).
Biochemistry, 45, 2006
1HUO
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BU of 1huo by Molmil
CRYSTAL STRUCTURE OF DNA POLYMERASE BETA COMPLEXED WITH DNA AND CR-TMPPCP
Descriptor: 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*C)-3', CHROMIUM ION, ...
Authors:Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K.
Deposit date:2001-01-04
Release date:2001-04-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
1HUZ
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BU of 1huz by Molmil
CRYSTAL STRUCTURE OF DNA POLYMERASE COMPLEXED WITH DNA AND CR-PCP
Descriptor: 5'-D(*AP*AP*TP*AP*GP*GP*CP*GP*TP*CP*G)-3', 5'-D(P*CP*GP*AP*CP*GP*CP*CP*T)-3', CHROMIUM ION, ...
Authors:Arndt, J.W, Gong, W, Zhong, X, Showalter, A.K, Liu, J, Lin, Z, Paxson, C, Tsai, M.-D, Chan, M.K.
Deposit date:2001-01-04
Release date:2001-04-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insight into the catalytic mechanism of DNA polymerase beta: structures of intermediate complexes.
Biochemistry, 40, 2001
1KA4
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BU of 1ka4 by Molmil
Structure of Pyrococcus furiosus carboxypeptidase Nat-Pb
Descriptor: LEAD (II) ION, M32 carboxypeptidase
Authors:Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K.
Deposit date:2001-10-31
Release date:2002-11-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
1K9X
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Structure of Pyrococcus furiosus carboxypeptidase Apo-Yb
Descriptor: M32 carboxypeptidase
Authors:Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K.
Deposit date:2001-10-31
Release date:2002-11-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
1KA2
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BU of 1ka2 by Molmil
Structure of Pyrococcus furiosus Carboxypeptidase Apo-Mg
Descriptor: M32 carboxypeptidase, MAGNESIUM ION
Authors:Arndt, J.W, Hao, B, Ramakrishnan, V, Cheng, T, Chan, S.I, Chan, M.K.
Deposit date:2001-10-31
Release date:2002-11-06
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of a Novel Carboxypeptidase from the Hyperthermophilic Archaeon Pyrococcus furiosus
Structure, 10, 2002
6CT7
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BU of 6ct7 by Molmil
Fab of anti-a-synuclein antibody BIIB054 in complex with acetylated a-synuclein peptide (1-10)
Descriptor: ACE-MET-ASP-VAL-PHE-MET-LYS-GLY-LEU-SER-LYS, BIIB054 Fab heavy chain, BIIB054 Fab light chain, ...
Authors:Arndt, J.W.
Deposit date:2018-03-22
Release date:2018-12-19
Last modified:2018-12-26
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Development of an aggregate-selective, human-derived alpha-synuclein antibody BIIB054 that ameliorates disease phenotypes in Parkinson's disease models.
Neurobiol. Dis., 124, 2018
4KY1
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BU of 4ky1 by Molmil
humanized HP1/2 Fab
Descriptor: IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, LIGHT CHAIN
Authors:Arndt, J.W, Hanf, K.J.M, Lugovskoy, A, Chen, L.L, Jarpe, M, Boriack-Sjodin, A, Li, Y, van Vlijmen, H, Pepinsky, B, Taylor, F, Silvian, L, Taveras, A.
Deposit date:2013-05-28
Release date:2013-07-24
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.97 Å)
Cite:Antibody humanization by redesign of complementarity-determining region residues proximate to the acceptor framework.
METHODS (SAN DIEGO), 65, 2014
3NMQ
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BU of 3nmq by Molmil
Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor
Descriptor: 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol, Heat shock protein HSP 90-beta
Authors:Arndt, J.W, Yun, T.J, Harning, E.K, Giza, K, Rabah, D, Li, P, Luchetti, D, Shi, J, Manning, A, Kehry, M.R.
Deposit date:2010-06-22
Release date:2010-12-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:EC144, a Synthetic Inhibitor of Heat Shock Protein 90, Blocks Innate and Adaptive Immune Responses in Models of Inflammation and Autoimmunity.
J.Immunol., 186, 2011
3QC4
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BU of 3qc4 by Molmil
PDK1 in complex with DFG-OUT inhibitor xxx
Descriptor: 1-(3,4-difluorobenzyl)-2-oxo-N-{(1R)-2-[(2-oxo-2,3-dihydro-1H-benzimidazol-5-yl)oxy]-1-phenylethyl}-1,2-dihydropyridine-3-carboxamide, 3-phosphoinositide-dependent protein kinase 1
Authors:Arndt, J.W.
Deposit date:2011-01-15
Release date:2011-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery.
Bioorg.Med.Chem.Lett., 21, 2011
3HC3
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BU of 3hc3 by Molmil
BHA10 IgG1 Fab double mutant variant - antibody directed at human LTBR
Descriptor: ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ...
Authors:Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D.
Deposit date:2009-05-05
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
3HC4
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BU of 3hc4 by Molmil
BHA10 IgG1 Fab quadruple mutant variant - antibody directed at human LTBR
Descriptor: ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ...
Authors:Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D.
Deposit date:2009-05-05
Release date:2009-08-04
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
3HC0
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BU of 3hc0 by Molmil
BHA10 IgG1 wild-type Fab - antibody directed at human LTBR
Descriptor: ACETATE ION, IMMUNOGLOBULIN IGG1 FAB, HEAVY CHAIN, ...
Authors:Arndt, J.W, Jordan, J.L, Lugovskoy, A, Wang, D.
Deposit date:2009-05-05
Release date:2009-08-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules
Proteins, 77, 2009
6N29
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BU of 6n29 by Molmil
Crystal structure of monomeric von Willebrand Factor D`D3 assembly
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
Authors:Dong, X, Arndt, J.W, Springer, T.A.
Deposit date:2018-11-12
Release date:2019-01-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The von Willebrand factor D'D3 assembly and structural principles for factor VIII binding and concatemer biogenesis.
Blood, 133, 2019
7TLW
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BU of 7tlw by Molmil
Murine Meteorin-like C-terminal NTR domain
Descriptor: IODIDE ION, Meteorin-like protein
Authors:Quan, C, Arndt, J.W.
Deposit date:2022-01-19
Release date:2023-01-25
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Identification and structure determination of stable domains of meteorin and meteorin-like
To Be Published
7TL6
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BU of 7tl6 by Molmil
Murine meteorin N-terminal CUB domain
Descriptor: Meteorin, SULFATE ION
Authors:Quan, C, Arndt, J.W, Pepinsky, B, Gong, B.J, Dolnikova, J.
Deposit date:2022-01-18
Release date:2023-01-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Identification and structure determination of stable domains of meteorin and meteorin-like
To Be Published
7TLH
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BU of 7tlh by Molmil
Murine meteorin C-terminal NTR domain
Descriptor: Meteorin, SULFATE ION
Authors:Quan, C, Arndt, J.W.
Deposit date:2022-01-18
Release date:2023-01-25
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:Identification and structure determination of stable domains of meteorin and meteorin-like
To Be Published
4OQT
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BU of 4oqt by Molmil
LINGO-1/Li81 Fab complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy Chain of Li81 Fab, ...
Authors:Pepinsky, R.B, Arndt, J.W, Quan, C, Gao, Y, Quintero-Monzon, O, Lee, X, Mi, S.
Deposit date:2014-02-10
Release date:2014-05-14
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.23 Å)
Cite:Structure of the LINGO-1-Anti-LINGO-1 Li81 Antibody Complex Provides Insights into the Biology of LINGO-1 and the Mechanism of Action of the Antibody Therapy.
J.Pharmacol.Exp.Ther., 350, 2014
2NP0
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BU of 2np0 by Molmil
Crystal structure of the Botulinum neurotoxin type B complexed with synaptotagamin-II ectodomain
Descriptor: Botulinum neurotoxin type B, CALCIUM ION, CHLORIDE ION, ...
Authors:Chai, Q, Arndt, J.W, Stevens, R.C.
Deposit date:2006-10-26
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:Structural basis of cell surface receptor recognition by botulinum neurotoxin B.
Nature, 444, 2006
2NZ9
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BU of 2nz9 by Molmil
Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody AR2
Descriptor: AR2 monoclonal antibody, Botulinum neurotoxin type A, CALCIUM ION, ...
Authors:Stevens, R.C, Arndt, J.W.
Deposit date:2006-11-22
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.79 Å)
Cite:Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007
2NYY
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BU of 2nyy by Molmil
Crystal structure of botulinum neurotoxin type A complexed with monoclonal antibody CR1
Descriptor: Botulinum neurotoxin type A, CALCIUM ION, CR1 monoclonal antibody, ...
Authors:Stevens, R.C, Arndt, J.W.
Deposit date:2006-11-21
Release date:2006-12-26
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Molecular evolution of antibody cross-reactivity for two subtypes of type A botulinum neurotoxin.
Nat.Biotechnol., 25, 2007

 

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