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316D
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BU of 316d by Molmil
Selectivity of F8-actinomycin D for RNA:DNA hybrids and its anti-leukemia activity
Descriptor: 8-FLUORO-ACTINOMYCIN D, DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3')
Authors:Takusagawa, F, Takusagawa, K.T, Carlson, R.G, Weaver, R.F.
Deposit date:1997-03-05
Release date:1997-11-05
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Selectivity of F8-Actinomycin D for RNA:DNA Hybrids and its Anti-Leukemia Activity.
Bioorg.Med.Chem., 5, 1997
5ANA
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BU of 5ana by Molmil
THE CRYSTAL STRUCTURE OF D(GTACGTAC) AT 2.25 ANGSTROMS RESOLUTION. ARE THE A-DNA'S ALWAYS UNWOUND APPROXIMATELY 10 DEGREES AT THE C-G STEPS
Descriptor: DNA (5'-D(*GP*TP*AP*CP*GP*TP*AP*C)-3'), MAGNESIUM ION
Authors:Takusagawa, F.
Deposit date:1989-10-31
Release date:1990-04-15
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:The crystal structure of d(GTACGTAC) at 2.25 A resolution: are the A-DNA's always unwound approximately 10 degrees at the C-G steps
J.Biomol.Struct.Dyn., 7, 1990
1KIA
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BU of 1kia by Molmil
Crystal structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate
Descriptor: ACETATE ION, Glycine N-methyltransferase, S-ADENOSYLMETHIONINE
Authors:Takusagawa, F, Huang, Y.
Deposit date:2001-12-02
Release date:2003-06-10
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of glycine N-methyltransferase complexed with S-adenosylmethionine and acetate
To be Published
1MXA
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BU of 1mxa by Molmil
S-ADENOSYLMETHIONINE SYNTHETASE WITH PPI
Descriptor: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1MXC
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BU of 1mxc by Molmil
S-ADENOSYLMETHIONINE SYNTHETASE WITH 8-BR-ADP
Descriptor: 8-BROMOADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Takusagawa, F, Kamitori, S, Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1MXB
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BU of 1mxb by Molmil
S-ADENOSYLMETHIONINE SYNTHETASE WITH ADP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Takusagawa, F, Kamitori, S, Markham, G.D.
Deposit date:1996-01-10
Release date:1996-07-11
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure and function of S-adenosylmethionine synthetase: crystal structures of S-adenosylmethionine synthetase with ADP, BrADP, and PPi at 28 angstroms resolution.
Biochemistry, 35, 1996
1XRB
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BU of 1xrb by Molmil
S-adenosylmethionine synthetase (MAT, ATP: L-methionine S-adenosyltransferase, E.C.2.5.1.6) in which MET residues are replaced with selenomethionine residues (MSE)
Descriptor: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRC
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BU of 1xrc by Molmil
CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor: COBALT (II) ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
1XRA
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BU of 1xra by Molmil
CRYSTAL STRUCTURE OF S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor: MAGNESIUM ION, PHOSPHATE ION, POTASSIUM ION, ...
Authors:Takusagawa, F, Kamitori, S, Misaki, S, Markham, G.D.
Deposit date:1995-10-26
Release date:1996-03-08
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of S-adenosylmethionine synthetase.
J.Biol.Chem., 271, 1996
2PBJ
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BU of 2pbj by Molmil
GSH-heme bound microsomal prostaglandin E synthase
Descriptor: CHLORIDE ION, GLUTATHIONE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Takusagawa, F, Yamada, T.
Deposit date:2007-03-28
Release date:2008-02-12
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:PGH2 degradation pathway catalyzed by GSH-heme complex bound microsomal prostaglandin E2 synthase type 2: the first example of a dual-function enzyme.
Biochemistry, 46, 2007
1K0U
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BU of 1k0u by Molmil
Inhibition of S-adenosylhomocysteine Hydrolase by "acyclic sugar" Adenosine Analogue D-eritadenine
Descriptor: D-ERITADENINE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-ADENOSYL-L-HOMOCYSTEINE HYDROLASE
Authors:Takusagawa, F, Huang, Y, Komoto, J, Takata, Y, Gomi, T, Ogawa, H, Fujioka, M, Powell, D.
Deposit date:2001-09-20
Release date:2001-10-17
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibition of S-adenosylhomocysteine hydrolase by acyclic sugar adenosine analogue D-eritadenine. Crystal structure of S-adenosylhomocysteine hydrolase complexed with D-eritadenine.
J.Biol.Chem., 277, 2002
1KHH
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BU of 1khh by Molmil
Crystal Structure of Guanidinoacetate Methyltransferase from Rat Liver: A Template Structure of Protein Arginine Methyltransferase
Descriptor: Guanidinoacetate methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Takusagawa, F, Komoto, J.
Deposit date:2001-11-30
Release date:2001-12-12
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of guanidinoacetate methyltransferase from rat liver: a model structure of protein arginine methyltransferase.
J.Mol.Biol., 320, 2002
1P7L
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BU of 1p7l by Molmil
S-Adenosylmethionine synthetase complexed with AMPPNP and Met.
Descriptor: (DIPHOSPHONO)AMINOPHOSPHONIC ACID, MAGNESIUM ION, METHIONINE, ...
Authors:Takusagawa, F, Komoto, J.
Deposit date:2003-05-02
Release date:2004-03-02
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the s-adenosylmethionine synthetase ternary complex: a novel catalytic mechanism of s-adenosylmethionine synthesis from ATP and MET.
Biochemistry, 43, 2004
1B3R
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BU of 1b3r by Molmil
RAT LIVER S-ADENOSYLHOMOCYSTEIN HYDROLASE
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PROTEIN (S-ADENOSYLHOMOCYSTEINE HYDROLASE)
Authors:Hu, Y, Komoto, J, Huang, Y, Takusagawa, F, Gomi, T, Ogawa, H, Takata, Y, Fujioka, M.
Deposit date:1998-12-14
Release date:1998-12-23
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of S-adenosylhomocysteine hydrolase from rat liver.
Biochemistry, 38, 1999
172D
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BU of 172d by Molmil
MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Descriptor: DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3')
Authors:Kamitori, S, Takusagawa, F.
Deposit date:1994-04-18
Release date:1994-10-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of d(GAAGCTTC)2-Actinomycin D Complexes and Its Host DNA
J.Am.Chem.Soc., 116, 1994
173D
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BU of 173d by Molmil
MULTIPLE BINDING MODES OF ANTICANCER DRUG ACTINOMYCIN D: X-RAY, MOLECULAR MODELING, AND SPECTROSCOPIC STUDIES OF D(GAAGCTTC)2-ACTINOMYCIN D COMPLEXES AND ITS HOST DNA
Descriptor: ACTINOMYCIN D, DNA (5'-D(*GP*AP*AP*GP*CP*TP*TP*C)-3')
Authors:Kamitori, S, Takusagawa, F.
Deposit date:1994-04-18
Release date:1994-10-15
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Multiple Binding Modes of Anticancer Drug Actinomycin D: X-Ray, Molecular Modeling, and Spectroscopic Studies of D(Gaagcttc)2-Actinomycin D Complexes and its Host DNA
J.Am.Chem.Soc., 116, 1994
1KY4
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BU of 1ky4 by Molmil
S-Adenosylhomocysteine hydrolase refined with noncrystallographic restraints
Descriptor: NICOTINAMIDE-ADENINE-DINUCLEOTIDE, S-adenosylhomocysteine hydrolase
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine Hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
1KY5
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BU of 1ky5 by Molmil
D244E mutant S-Adenosylhomocysteine hydrolase refined with noncrystallographic restraints
Descriptor: 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 3'-OXO-ADENOSINE, S-adenosylhomocysteine hydrolase
Authors:Takata, Y, Takusagawa, F.
Deposit date:2002-02-03
Release date:2002-09-25
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Catalytic Mechanism of S-adenosylhomocysteine hydrolase. Site-directed mutagenesis of Asp-130, Lys-185, Asp-189, and Asn-190.
J.Biol.Chem., 277, 2002
2RKB
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BU of 2rkb by Molmil
Serine dehydratase like-1 from human cancer cells
Descriptor: POTASSIUM ION, PYRIDOXAL-5'-PHOSPHATE, Serine dehydratase-like
Authors:Yamada, T, Komoto, J, Kasuya, T, Mori, H, Ogawa, H, Takusagawa, F.
Deposit date:2007-10-16
Release date:2008-04-01
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A catalytic mechanism that explains a low catalytic activity of serine dehydratase like-1 from human cancer cells: Crystal structure and site-directed mutagenesis studies.
Biochim.Biophys.Acta, 1780, 2008
1FUG
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BU of 1fug by Molmil
S-ADENOSYLMETHIONINE SYNTHETASE
Descriptor: S-ADENOSYLMETHIONINE SYNTHETASE
Authors:Fu, Z, Markham, G.D, Takusagawa, F.
Deposit date:1996-02-25
Release date:1996-08-01
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Flexible loop in the structure of S-adenosylmethionine synthetase crystallized in the tetragonal modification.
J.Biomol.Struct.Dyn., 13, 1996
1D2G
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BU of 1d2g by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE FROM RAT LIVER
Descriptor: GLYCINE N-METHYLTRANSFERASE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-08
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
2F2F
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BU of 2f2f by Molmil
Crystal structure of cytolethal distending toxin (CDT) from Actinobacillus actinomycetemcomitans
Descriptor: Cytolethal distending toxin A, Cytolethal distending toxin B, cytolethal distending toxin C
Authors:Yamada, T, Komoto, J, Saiki, K, Konishi, K, Takusagawa, F.
Deposit date:2005-11-16
Release date:2006-03-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Variation of loop sequence alters stability of cytolethal distending toxin (CDT): crystal structure of CDT from Actinobacillus actinomycetemcomitans
Protein Sci., 15, 2006
1D2C
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BU of 1d2c by Molmil
METHYLTRANSFERASE
Descriptor: PROTEIN (GLYCINE N-METHYLTRANSFERASE)
Authors:Huang, Y, Takusagawa, F.
Deposit date:1999-09-23
Release date:1999-10-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000
2F38
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Crystal structure of prostaglandin F synathase containing bimatoprost
Descriptor: (5Z)-7-{(1R,2R,3R,5S)-3,5-DIHYDROXY-2-[(1E,3S)-3-HYDROXY-5-PHENYLPENT-1-ENYL]CYCLOPENTYL}-N-ETHYLHEPT-5-ENAMIDE, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Komoto, J, Yamada, T, Watanabe, K, Woodward, D.F, Takusagawa, F.
Deposit date:2005-11-18
Release date:2006-10-31
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Prostaglandin F2alpha formation from prostaglandin H2 by prostaglandin F synthase (PGFS): crystal structure of PGFS containing bimatoprost.
Biochemistry, 45, 2006
1D2H
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BU of 1d2h by Molmil
CRYSTAL STRUCTURE OF R175K MUTANT GLYCINE N-METHYLTRANSFERASE COMPLEXED WITH S-ADENOSYLHOMOCYSTEINE
Descriptor: GLYCINE N-METHYLTRANSFERASE, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Huang, Y, Komoto, J, Takusagawa, F, Konishi, K, Takata, Y.
Deposit date:1999-10-11
Release date:1999-10-25
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3 Å)
Cite:Mechanisms for auto-inhibition and forced product release in glycine N-methyltransferase: crystal structures of wild-type, mutant R175K and S-adenosylhomocysteine-bound R175K enzymes.
J.Mol.Biol., 298, 2000

 

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