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6BS9
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BU of 6bs9 by Molmil
Stage III sporulation protein AB (SpoIIIAB)
Descriptor: SULFATE ION, Stage III sporulation protein AB
Authors:Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A.
Deposit date:2017-12-01
Release date:2018-01-17
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structural characterization of SpoIIIAB sporulation-essential protein in Bacillus subtilis.
J. Struct. Biol., 202, 2018
6DCS
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BU of 6dcs by Molmil
Stage III sporulation protein AF (SpoIIIAF)
Descriptor: SULFATE ION, Stage III sporulation protein AF
Authors:Strynadka, N.C.J, Zeytuni, N, Camp, A.H, Flanagan, K.A.
Deposit date:2018-05-08
Release date:2018-07-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and biochemical characterization of SpoIIIAF, a component of a sporulation-essential channel in Bacillus subtilis.
J. Struct. Biol., 204, 2018
8SXR
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BU of 8sxr by Molmil
Crystal structure of SARS-CoV-2 Mpro with C5a
Descriptor: 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide
Authors:Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J.
Deposit date:2023-05-23
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2.114 Å)
Cite:A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
6ZTG
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BU of 6ztg by Molmil
Spor protein DedD
Descriptor: Cell division protein DedD
Authors:Pazos, M, Peters, K, Boes, A, Safaei, Y, Kenward, C, Caveney, N.A, Laguri, C, Breukink, E, Strynadka, N.C.J, Simorre, J.P, Terrak, M, Vollmer, W.
Deposit date:2020-07-20
Release date:2020-11-11
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:SPOR Proteins Are Required for Functionality of Class A Penicillin-Binding Proteins in Escherichia coli.
Mbio, 11, 2020
7UZ2
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BU of 7uz2 by Molmil
Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-fluoro-valienide.
Descriptor: (1R,2S,3R,4R)-5-fluoro-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol, Beta-galactosidase
Authors:Danby, P.M, Jeong, A, Sim, L, Sweeney, R.P, Wardman, J.F, Geissner, A, Worrall, L.J, Strynadka, N.C.J, Withers, S.G.
Deposit date:2022-05-08
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.83 Å)
Cite:Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Angew.Chem.Int.Ed.Engl., 62, 2023
7UZ1
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BU of 7uz1 by Molmil
Structure of beta-glycosidase from Sulfolobus solfataricus in complex with C5a-bromo-valienide.
Descriptor: (1R,2S,3R,4R)-5-bromo-6-(hydroxymethyl)cyclohex-5-ene-1,2,3,4-tetrol, 1,2-ETHANEDIOL, Beta-galactosidase
Authors:Danby, P.M, Jeong, A, Sim, L, Sweeney, R.P, Wardman, J.F, Karimi, R, Geissner, A, Worrall, L.J, Strynadka, N.C.J, Withers, S.G.
Deposit date:2022-05-08
Release date:2023-04-05
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Vinyl Halide-Modified Unsaturated Cyclitols are Mechanism-Based Glycosidase Inhibitors.
Angew.Chem.Int.Ed.Engl., 62, 2023
7TC5
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BU of 7tc5 by Molmil
All Phe-Azurin variant - F15Y
Descriptor: Azurin, COPPER (II) ION, NITRATE ION, ...
Authors:Fedoretz-Maxwell, B.P, Worrall, L.J, Strynadka, N.C.J, Warren, J.J.
Deposit date:2021-12-22
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins.
Inorg.Chem., 61, 2022
7TC6
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BU of 7tc6 by Molmil
All Phe-Azurin variant - F15W
Descriptor: Azurin, COPPER (II) ION, NITRATE ION
Authors:Fedoretz-Maxwell, B.P, Worrall, L.J, Strynadka, N.C.J, Warren, J.J.
Deposit date:2021-12-22
Release date:2022-06-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:The Impact of Second Coordination Sphere Methionine-Aromatic Interactions in Copper Proteins.
Inorg.Chem., 61, 2022
2DRJ
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BU of 2drj by Molmil
Xray structure of alpha-2,3/8-sialyltransferase CstII F91Y mutant
Descriptor: Alpha-2,3/8-sialyltransferase, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, ISOPROPYL ALCOHOL
Authors:Chiu, C.P.C, Strynadka, N.C.J.
Deposit date:2006-06-09
Release date:2007-04-24
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:High-throughput screening methodology for the directed evolution of glycosyltransferases
Nat.Methods, 3, 2006
5WC6
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BU of 5wc6 by Molmil
Structure of a bacterial polysialyltransferase at 2.2 Angstrom resolution
Descriptor: SULFATE ION, SiaD
Authors:Worrall, L.J, Lizak, C, Strynadka, N.C.J.
Deposit date:2017-06-29
Release date:2017-08-02
Last modified:2019-11-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.
Sci Rep, 7, 2017
5WD7
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BU of 5wd7 by Molmil
Structure of a bacterial polysialyltransferase in complex with fondaparinux
Descriptor: 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, SULFATE ION, SiaD
Authors:Worrall, L.J, Lizak, C, Strynadka, N.C.J.
Deposit date:2017-07-04
Release date:2017-08-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.
Sci Rep, 7, 2017
2F2H
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BU of 2f2h by Molmil
Structure of the YicI thiosugar Michaelis complex
Descriptor: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 4-NITROPHENYL 6-THIO-6-S-ALPHA-D-XYLOPYRANOSYL-BETA-D-GLUCOPYRANOSIDE, GLYCEROL, ...
Authors:Kim, Y.-W, Lovering, A.L, Strynadka, N.C.J, Withers, S.G.
Deposit date:2005-11-16
Release date:2006-02-28
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Expanding the Thioglycoligase Strategy to the Synthesis of alpha-linked Thioglycosides Allows Structural Investigation of the Parent Enzyme/Substrate Complex
J.Am.Chem.Soc., 128, 2006
5WCN
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BU of 5wcn by Molmil
Structure of a bacterial polysialyltransferase in complex with CDP
Descriptor: CYTIDINE-5'-DIPHOSPHATE, SULFATE ION, SiaD
Authors:Worrall, L.J, Lizak, C, Strynadka, N.C.J.
Deposit date:2017-06-30
Release date:2017-08-02
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.
Sci Rep, 7, 2017
6C39
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BU of 6c39 by Molmil
Apo crystal structure of wild-type S. aureus penicillin binding protein 4 (PBP4)
Descriptor: SODIUM ION, SULFATE ION, Serine-type D-Ala-D-Ala carboxypeptidase, ...
Authors:Alexander, J.A.N, Strynadka, N.C.J.
Deposit date:2018-01-09
Release date:2018-11-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural and kinetic analyses of penicillin-binding protein 4 (PBP4)-mediated antibiotic resistance inStaphylococcus aureus.
J. Biol. Chem., 293, 2018
8EXQ
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BU of 8exq by Molmil
Cryo-EM structure of S. aureus BlaR1 with C1 symmetry
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXR
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BU of 8exr by Molmil
Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain
Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ...
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXS
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BU of 8exs by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXP
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BU of 8exp by Molmil
Cryo-EM structure of S. aureus BlaR1 with C2 symmetry
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXT
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BU of 8ext by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2023-01-25
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8FFJ
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BU of 8ffj by Molmil
Structure of Zanidatamab bound to HER2
Descriptor: Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Heavy Chain B, ...
Authors:Worrall, L.J, Atkinson, C.E, Sanches, M, Dixit, S, Strynadka, N.C.J.
Deposit date:2022-12-08
Release date:2023-02-22
Method:ELECTRON MICROSCOPY (7.5 Å)
Cite:Zanidatamab, an Anti-HER2 Biparatopic that Induces Unique Surface HER2 Clusters and Complement-Dependent Cytotoxicity
To be Published
1KN9
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BU of 1kn9 by Molmil
CRYSTAL STRUCTURE OF A BACTERIAL SIGNAL PEPTIDASE APO-ENZYME, IMPLICATIONS FOR SIGNAL PEPTIDE BINDING AND THE SER-LYS DYAD MECHANISM.
Descriptor: Signal peptidase I
Authors:Paetzel, M, Dalbey, R.E, Strynadka, N.C.J.
Deposit date:2001-12-18
Release date:2002-01-30
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of a bacterial signal peptidase apoenzyme: implications for signal peptide binding and the Ser-Lys dyad mechanism
J.Biol.Chem., 277, 2002
6UEX
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BU of 6uex by Molmil
Crystal structure of S. aureus LcpA in complex with octaprenyl-pyrophosphate-GlcNAc
Descriptor: 2-(acetylamino)-2-deoxy-1-O-[(S)-hydroxy{[(S)-hydroxy{[(2Z,6Z,10Z,14Z,18Z,22Z,26Z)-3,7,11,15,19,23,27,31-octamethyldotriaconta-2,6,10,14,18,22,26,30-octaen-1-yl]oxy}phosphoryl]oxy}phosphoryl]-alpha-D-glucopyranose, GLYCEROL, Regulatory protein MsrR, ...
Authors:Li, F.K.K, Strynadka, N.C.J.
Deposit date:2019-09-23
Release date:2020-01-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
6UF6
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BU of 6uf6 by Molmil
Crystal structure of B. subtilis TagU
Descriptor: GLYCEROL, Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagU, SULFATE ION
Authors:Li, F.K.K, Strynadka, N.C.J.
Deposit date:2019-09-23
Release date:2020-01-29
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
6UF3
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BU of 6uf3 by Molmil
Crystal structure of B. subtilis TagV
Descriptor: Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagV
Authors:Li, F.K.K, Strynadka, N.C.J.
Deposit date:2019-09-23
Release date:2020-01-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020
6UF5
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BU of 6uf5 by Molmil
Crystal structure of B. subtilis TagT
Descriptor: Polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase TagT
Authors:Li, F.K.K, Strynadka, N.C.J.
Deposit date:2019-09-23
Release date:2020-01-29
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystallographic analysis ofStaphylococcus aureusLcpA, the primary wall teichoic acid ligase.
J.Biol.Chem., 295, 2020

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