Author results

1N8R
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STRUCTURE OF LARGE RIBOSOMAL SUBUNIT IN COMPLEX WITH VIRGINIAMYCIN M
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2P, ...
Authors:Hansen, J.L., Moore, P.B., Steitz, T.A.
Deposit date:2002-11-21
Release date:2003-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit
J.Mol.Biol., 330, 2003
1NJI
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STRUCTURE OF CHLORAMPHENICOL BOUND TO THE 50S RIBOSOMAL SUBUNIT
Descriptor:23S ribosomal RNA, 5S ribosomal RNA, 50S ribosomal protein L2P, ...
Authors:Hansen, J.L., Moore, P.B., Steitz, T.A.
Deposit date:2002-12-31
Release date:2003-07-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Structures of Five Antibiotics Bound at the Peptidyl Transferase Center of the Large Ribosomal Subunit
J.Mol.Biol., 330, 2003
1QSL
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KLENOW FRAGMENT COMPLEXED WITH SINGLE-STRANDED SUBSTRATE AND EUROPIUM (III) ION
Descriptor:5'-D(*GP*CP*TP*TP*AP*CP*GP*C)-3', DNA POLYMERASE I, EUROPIUM ION
Authors:Brautigam, C.A., Aschheim, K., Steitz, T.A.
Deposit date:1999-06-22
Release date:1999-06-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural elucidation of the binding and inhibitory properties of lanthanide (III) ions at the 3'-5' exonucleolytic active site of the Klenow fragment
Chem.Biol., 6, 1999
1REA
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STRUCTURE OF THE RECA PROTEIN-ADP COMPLEX
Descriptor:REC A, ADENOSINE-5'-DIPHOSPHATE
Authors:Story, R.M., Steitz, T.A.
Deposit date:1991-12-19
Release date:1993-10-31
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure of the recA protein-ADP complex.
Nature, 355, 1992
1TV6
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HIV-1 REVERSE TRANSCRIPTASE COMPLEXED WITH CP-94,707
Descriptor:reverse transcriptase p66 subunit, reverse transcriptase p51 subunit, 3-[4-(2-METHYL-IMIDAZO[4,5-C]PYRIDIN-1-YL)BENZYL]-3H-BENZOTHIAZOL-2-ONE
Authors:Pata, J.D., Stirtan, W.G., Goldstein, S.W., Steitz, T.A.
Deposit date:2004-06-28
Release date:2004-07-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant RTs resistant to other non-nucleoside inhibitors
Proc.Natl.Acad.Sci.USA, 101, 2004
2REB
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THE STRUCTURE OF THE E. COLI RECA PROTEIN MONOMER AND POLYMER
Descriptor:REC A
Authors:Story, R.M., Steitz, T.A.
Deposit date:1992-03-06
Release date:1993-10-31
Last modified:2012-05-09
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The structure of the E. coli recA protein monomer and polymer.
Nature, 355, 1992
3CFO
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TRIPLE MUTANT APO STRUCTURE
Descriptor:DNA polymerase, SULFATE ION, GUANOSINE
Authors:Wang, J., Klimenko, D., Wang, M., Steitz, T.A., Konigsberg, W.H.
Deposit date:2008-03-04
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant
To be Published
3CFP
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STRUCTURE OF THE REPLICATING COMPLEX OF A POL ALPHA FAMILY DNA POLYMERASE, TERNARY COMPLEX 1
Descriptor:DNA (5'-D(*DAP*DCP*DAP*DGP*DGP*DTP*DAP*DAP*DGP*DCP*DAP*DGP*DTP*DCP*DCP*DGP*DCP*DG)-3'), DNA (5'-D(*DGP*DCP*DGP*DGP*DAP*DCP*DTP*DGP*DCP*DTP*DTP*DAP*DCP*(DOC))-3'), DNA polymerase, ...
Authors:Wang, J., Klimenko, D., Wang, M., Steitz, T.A., Konigsberg, W.H.
Deposit date:2008-03-04
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant
To be Published
3CFR
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STRUCTURE OF THE REPLICATING COMPLEX OF A POL ALPHA FAMILY DNA POLYMERASE, TERNARY COMPLEX 2
Descriptor:DNA (5'-D(*DTP*DCP*DAP*DAP*DGP*DTP*DAP*DAP*DGP*DCP*DAP*DGP*DTP*DCP*DCP*DGP*DCP*DG)-3'), DNA (5'-D(*DGP*DCP*DGP*DGP*DAP*DCP*DTP*DGP*DCP*DTP*DTP*DAP*(DOC))-3'), DNA polymerase, ...
Authors:Wang, J., Klimenko, D., Wang, M., Steitz, T.A., Konigsberg, W.H.
Deposit date:2008-03-04
Release date:2009-03-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Insights into base selectivity from the structures of an RB69 DNA Polymerase triple mutant
To be Published
3P22
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CRYSTAL STRUCTURE OF THE ENE, A VIRAL RNA STABILITY ELEMENT, IN COMPLEX WITH A9 RNA
Descriptor:Core ENE hairpin from KSHV PAN RNA, oligo(A)9 RNA
Authors:Mitton-Fry, R.M., DeGregorio, S.J., Wang, J., Steitz, T.A., Steitz, J.A.
Deposit date:2010-10-01
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Poly(A) tail recognition by a viral RNA element through assembly of a triple helix.
Science, 330, 2010
1WAF
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DNA POLYMERASE FROM BACTERIOPHAGE RB69
Descriptor:DNA POLYMERASE, GUANOSINE
Authors:Wang, J., Satter, A.K.M.A., Wang, C.C., Karam, J.D., Konigsberg, W.H., Steitz, T.A.
Deposit date:1997-04-13
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
Cell(Cambridge,Mass.), 89, 1997
1WAJ
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DNA POLYMERASE FROM BACTERIOPHAGE RB69
Descriptor:DNA POLYMERASE, GUANOSINE-5'-MONOPHOSPHATE
Authors:Wang, J., Satter, A.K.M.A., Wang, C.C., Karam, J.D., Konigsberg, W.H., Steitz, T.A.
Deposit date:1997-04-13
Release date:1998-01-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of a pol alpha family replication DNA polymerase from bacteriophage RB69.
Cell(Cambridge,Mass.), 89, 1997
4W2F
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH AMICOUMACIN, MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2G
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (SOAKED), MRNA AND THREE DEACYLATED TRNAS IN THE A, P AND E SITES
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
4W2H
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CRYSTAL STRUCTURE OF THE THERMUS THERMOPHILUS 70S RIBOSOME IN COMPLEX WITH PACTAMYCIN (CO-CRYSTALLIZED), MRNA AND DEACYLATED TRNA IN THE P SITE
Descriptor:16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ...
Authors:Polikanov, Y.S., Osterman, I.A., Szal, T., Tashlitsky, V.N., Serebryakova, M.V., Kusochek, P., Bulkley, D., Malanicheva, I.A., Efimenko, T.A., Efremenkova, O.V., Konevega, A.L., Shaw, K.J., Bogdanov, A.A., Rodnina, M.V., Dontsova, O.A., Mankin, A.S., Steitz, T.A., Sergiev, P.V.
Deposit date:2014-09-12
Release date:2014-10-15
Last modified:2015-01-14
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Amicoumacin a inhibits translation by stabilizing mRNA interaction with the ribosome.
Mol.Cell, 56, 2014
1C04
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IDENTIFICATION OF KNOWN PROTEIN AND RNA STRUCTURES IN A 5 A MAP OF THE LARGE RIBOSOMAL SUBUNIT FROM HALOARCULA MARISMORTUI
Descriptor:23S RRNA FRAGMENT, RIBOSOMAL PROTEIN L2, RIBOSOMAL PROTEIN L6, ...
Authors:Ban, N., Nissen, P., Capel, M., Moore, P.B., Steitz, T.A.
Deposit date:1999-07-14
Release date:1999-08-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (5 Å)
Cite:Placement of protein and RNA structures into a 5 A-resolution map of the 50S ribosomal subunit.
Nature, 400, 1999
1D89
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A DNA DODECAMER CONTAINING AN ADENINE TRACT CRYSTALLIZES IN A UNIQUE LATTICE AND EXHIBITS A NEW BEND
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*AP*AP*AP*AP*CP*G)-3'), DNA (5'-D(*CP*GP*TP*TP*TP*TP*TP*TP*CP*GP*CP*G)-3')
Authors:DiGabriele, A.D., Steitz, T.A.
Deposit date:1992-07-17
Release date:1993-07-15
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A DNA dodecamer containing an adenine tract crystallizes in a unique lattice and exhibits a new bend.
J.Mol.Biol., 231, 1993
1G6N
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2.1 ANGSTROM STRUCTURE OF CAP-CAMP
Descriptor:CATABOLITE GENE ACTIVATOR PROTEIN, ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE
Authors:Passner, J.M., Schultz, S.C., Steitz, T.A.
Deposit date:2000-11-07
Release date:2000-12-15
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Modeling the cAMP-induced allosteric transition using the crystal structure of CAP-cAMP at 2.1 A resolution.
J.Mol.Biol., 304, 2000
1GTS
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STRUCTURAL BASIS FOR TRANSFER RNA AMINOACEYLATION BY ESCHERICHIA COLI GLUTAMINYL-TRNA SYNTHETASE
Descriptor:TRNAGLN, PROTEIN (GLUTAMINYL-TRNA SYNTHETASE (E.C.6.1.1.18)), ADENOSINE MONOPHOSPHATE
Authors:Perona, J.J., Steitz, T.A., Rould, M.A.
Deposit date:1993-09-15
Release date:1995-02-07
Last modified:2017-02-15
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for transfer RNA aminoacylation by Escherichia coli glutaminyl-tRNA synthetase.
Biochemistry, 32, 1993
1HVU
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HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 REVERSE TRANSCRIPTASE COMPLEXED WITH A 33-BASE NUCLEOTIDE RNA PSEUDOKNOT
Descriptor:RNA (33 NUCLEOTIDE RNA PSEUDOKNOT), PROTEIN (HIV-1 REVERSE TRANSCRIPTASE)
Authors:Jaeger, J., Restle, T., Steitz, T.A.
Deposit date:1998-06-30
Release date:1999-01-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (4.75 Å)
Cite:The structure of HIV-1 reverse transcriptase complexed with an RNA pseudoknot inhibitor.
EMBO J., 17, 1998
1JJ2
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FULLY REFINED CRYSTAL STRUCTURE OF THE HALOARCULA MARISMORTUI LARGE RIBOSOMAL SUBUNIT AT 2.4 ANGSTROM RESOLUTION
Descriptor:23S RRNA, 5S RRNA, RIBOSOMAL PROTEIN L2, ...
Authors:Klein, D.J., Schmeing, T.M., Moore, P.B., Steitz, T.A.
Deposit date:2001-07-03
Release date:2001-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The kink-turn: a new RNA secondary structure motif.
EMBO J., 20, 2001
1KFS
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(*GP*CP*TP*TP*AP*CP*G)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), MAGNESIUM ION, ...
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-18
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1KRP
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(P*TP*TP*PST)-3'), PROTEIN (DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7)), ZINC ION
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-19
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1KSP
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DNA POLYMERASE I KLENOW FRAGMENT (E.C.2.7.7.7) MUTANT/DNA COMPLEX
Descriptor:DNA (5'-D(P*TP*TP*PST)-3'), PROTEIN (DNA POLYMERASE I-KLENOW FRAGMENT (E.C.2.7.7.7)), ZINC ION
Authors:Brautigam, C.A., Steitz, T.A.
Deposit date:1997-08-19
Release date:1998-02-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural principles for the inhibition of the 3'-5' exonuclease activity of Escherichia coli DNA polymerase I by phosphorothioates.
J.Mol.Biol., 277, 1998
1TAQ
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STRUCTURE OF TAQ DNA POLYMERASE
Descriptor:TAQ DNA POLYMERASE, B-2-OCTYLGLUCOSIDE, ZINC ION
Authors:Kim, Y., Eom, S.H., Wang, J., Lee, D.-S., Suh, S.W., Steitz, T.A.
Deposit date:1996-06-04
Release date:1996-12-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of Thermus aquaticus DNA polymerase.
Nature, 376, 1995