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Crystal structure of bis-phosphorylated insulin receptor kinase domain
Descriptor:	Insulin receptor subunit beta
Authors:	Hubbard, S.R.
Deposit date:	2022-08-01
Release date:	2023-08-16
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Crystal structure of bis-phosphorylated insulin receptor kinase domain To Be Published

3RGK

Crystal Structure of Human Myoglobin Mutant K45R
Descriptor:	Myoglobin, PROTOPORPHYRIN IX CONTAINING FE, SULFATE ION
Authors:	Hubbard, S.R.
Deposit date:	2011-04-08
Release date:	2011-04-27
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	X-ray crystal structure of a recombinant human myoglobin mutant at 2.8 A resolution J.Mol.Biol., 20, 1990

1IR3

PHOSPHORYLATED INSULIN RECEPTOR TYROSINE KINASE IN COMPLEX WITH PEPTIDE SUBSTRATE AND ATP ANALOG
Descriptor:	INSULIN RECEPTOR, MAGNESIUM ION, PEPTIDE SUBSTRATE, ...
Authors:	Hubbard, S.R.
Deposit date:	1997-09-22
Release date:	1998-01-07
Last modified:	2023-08-09
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog. EMBO J., 16, 1997

1IRK

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF THE HUMAN INSULIN RECEPTOR
Descriptor:	ETHYL MERCURY ION, INSULIN RECEPTOR TYROSINE KINASE DOMAIN
Authors:	Hubbard, S.R, Wei, L, Ellis, L, Hendrickson, W.A.
Deposit date:	1995-01-02
Release date:	1995-02-27
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature, 372, 1994

7TEU

Crystal structure of JAK2 JH1 with type II inhibitor YLIU-04-105-1
Descriptor:	3-{(4S)-2-[(cyclopropanecarbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}-N-{3-[(4-ethylpiperazin-1-yl)methyl]-5-(trifluoromethyl)phenyl}-4-methylbenzamide, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:	Hubbard, S.R.
Deposit date:	2022-01-05
Release date:	2023-06-21
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.45 Å)
Cite:	New scaffolds for type II JAK2 inhibitors overcome the acquired G993A resistance mutation. Cell Chem Biol, 30, 2023

6D42

Crystal structure of the KCa3.1 C-terminal four-helix bundle (with copper)
Descriptor:	COPPER (II) ION, Intermediate conductance calcium-activated potassium channel protein 4
Authors:	Hubbard, S.R, Ji, T.
Deposit date:	2018-04-17
Release date:	2018-07-11
Last modified:	2019-12-18
Method:	X-RAY DIFFRACTION (1.75013649 Å)
Cite:	Crystal structure of the C-terminal four-helix bundle of the potassium channel KCa3.1. PLoS ONE, 13, 2018

3HK0

Crystal Structure of the RA and PH Domains of Grb10
Descriptor:	Growth factor receptor-bound protein 10, THIOCYANATE ION
Authors:	Hubbard, S.R, Depetris, R.S, Wu, J.
Deposit date:	2009-05-22
Release date:	2009-08-04
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	Structural and functional studies of the Ras-associating and pleckstrin-homology domains of Grb10 and Grb14. Nat.Struct.Mol.Biol., 16, 2009

4XLV

Crystal structure of the activated insulin receptor tyrosine kinase dimer
Descriptor:	Insulin receptor, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER
Authors:	Hubbard, S.R, Li, S.
Deposit date:	2015-01-13
Release date:	2015-03-25
Last modified:	2019-12-25
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	The insulin and IGF1 receptor kinase domains are functional dimers in the activated state. Nat Commun, 6, 2015

8EX1

Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with Reversine
Descriptor:	GLYCEROL, N~6~-cyclohexyl-N~2~-(4-morpholin-4-ylphenyl)-9H-purine-2,6-diamine, Tyrosine-protein kinase JAK2
Authors:	Sampathkumar, P, Hubbard, S.R.
Deposit date:	2022-10-24
Release date:	2023-02-01
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023

8EX0

Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with CDK2-IV
Descriptor:	4-{[6-(cyclohexylmethoxy)-7H-purin-2-yl]amino}-N,N-diethylbenzamide, Tyrosine-protein kinase JAK2
Authors:	Sampathkumar, P, Hubbard, S.R.
Deposit date:	2022-10-24
Release date:	2023-02-01
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023

8EX2

Crystal structure of JAK2 JH2 (pseudokinase domain) in complex with HTSA3
Descriptor:	3,5-diphenyl-2-(trifluoromethyl)-6~{H}-pyrazolo[1,5-a]pyrimidin-7-one, GLYCEROL, Tyrosine-protein kinase JAK2
Authors:	Sampathkumar, P, Hubbard, S.R.
Deposit date:	2022-10-24
Release date:	2023-02-01
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Identification of Novel Small Molecule Ligands for JAK2 Pseudokinase Domain. Pharmaceuticals, 16, 2023

1AGW

CRYSTAL STRUCTURE OF THE TYROSINE KINASE DOMAIN OF FIBROBLAST GROWTH FACTOR RECEPTOR 1 IN COMPLEX WITH SU4984 INHIBITOR
Descriptor:	3-[4-(1-FORMYLPIPERAZIN-4-YL)-BENZYLIDENYL]-2-INDOLINONE, FGF RECEPTOR 1
Authors:	Mohammadi, M, Schlessinger, J, Hubbard, S.R.
Deposit date:	1997-03-25
Release date:	1998-03-25
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science, 276, 1997

4K81

Crystal structure of the Grb14 RA and PH domains in complex with GTP-loaded H-Ras
Descriptor:	GLYCEROL, GTPase HRas, GUANOSINE-5'-TRIPHOSPHATE, ...
Authors:	Qamra, R, Hubbard, S.R.
Deposit date:	2013-04-17
Release date:	2013-09-04
Last modified:	2023-09-20
Method:	X-RAY DIFFRACTION (2.4 Å)
Cite:	Structural basis for the interaction of the adaptor protein grb14 with activated ras. Plos One, 8, 2013

3ML4

Crystal structure of a complex between Dok7 PH-PTB and the MuSK juxtamembrane region
Descriptor:	Muscle, skeletal receptor tyrosine-protein kinase, Protein Dok-7
Authors:	Bergamin, E, Hubbard, S.R.
Deposit date:	2010-04-16
Release date:	2010-07-14
Last modified:	2011-07-13
Method:	X-RAY DIFFRACTION (2.6 Å)
Cite:	The Cytoplasmic Adaptor Protein Dok7 Activates the Receptor Tyrosine Kinase MuSK via Dimerization. Mol.Cell, 39, 2010

3HKL

Crystal Structure of the Frizzled-like Cysteine-rich Domain of MuSK
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Muscle, skeletal receptor tyrosine protein kinase
Authors:	Stiegler, A.L, Hubbard, S.R.
Deposit date:	2009-05-24
Release date:	2009-08-25
Last modified:	2020-07-29
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Crystal structure of the frizzled-like cysteine-rich domain of the receptor tyrosine kinase MuSK. J.Mol.Biol., 393, 2009

3TCA

Crystal structure of the Ras-associating and pleckstrin-homology domains of RIAM
Descriptor:	Amyloid beta A4 precursor protein-binding family B member 1-interacting protein
Authors:	Wu, J, Hubbard, S.R.
Deposit date:	2011-08-08
Release date:	2012-09-26
Last modified:	2023-09-13
Method:	X-RAY DIFFRACTION (2.35 Å)
Cite:	Rap1-interacting adapter molecule (RIAM) associates with the plasma membrane via a proximity detector. J.Cell Biol., 199, 2012

1YVH

Crystal Structure of the c-Cbl TKB Domain in Complex with the APS pTyr-618 Phosphopeptide
Descriptor:	13-mer fragment of SH2 and PH domain-containing adapter protein APS, CBL E3 ubiquitin protein ligase, MAGNESIUM ION
Authors:	Hu, J, Hubbard, S.R.
Deposit date:	2005-02-15
Release date:	2005-03-08
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.05 Å)
Cite:	Structural Characterization of a Novel Cbl Phosphotyrosine Recognition Motif in the APS Family of Adapter Proteins J.Biol.Chem., 280, 2005

3BCH

Crystal Structure of the Human Laminin Receptor Precursor
Descriptor:	40S ribosomal protein SA
Authors:	Jamieson, K.V, Wu, J, Hubbard, S.R, Meruelo, D.
Deposit date:	2007-11-12
Release date:	2007-12-04
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (2.15 Å)
Cite:	Crystal structure of the human laminin receptor precursor. J.Biol.Chem., 283, 2008

3BU3

Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide
Descriptor:	Insulin receptor substrate 2, insulin receptor subunit beta
Authors:	Wu, J, Hubbard, S.R.
Deposit date:	2007-12-31
Release date:	2008-02-19
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat.Struct.Mol.Biol., 15, 2008

3BU5

Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB peptide and ATP
Descriptor:	ADENOSINE-5'-TRIPHOSPHATE, Insulin receptor substrate 2, MAGNESIUM ION, ...
Authors:	Wu, J, Hubbard, S.R.
Deposit date:	2007-12-31
Release date:	2008-02-19
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat.Struct.Mol.Biol., 15, 2008

2B4S

Crystal structure of a complex between PTP1B and the insulin receptor tyrosine kinase
Descriptor:	Insulin receptor, SULFATE ION, Tyrosine-protein phosphatase, ...
Authors:	Li, S, Depetris, R.S, Barford, D, Chernoff, J, Hubbard, S.R.
Deposit date:	2005-09-26
Release date:	2005-11-15
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal Structure of a Complex between Protein Tyrosine Phosphatase 1B and the Insulin Receptor Tyrosine Kinase. Structure, 13, 2005

2AUG

Crystal structure of the Grb14 SH2 domain
Descriptor:	Growth factor receptor-bound protein 14
Authors:	Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R.
Deposit date:	2005-08-27
Release date:	2005-11-01
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005

3BU6

Crystal structure of the insulin receptor kinase in complex with IRS2 KRLB phosphopeptide
Descriptor:	Insulin receptor substrate 2, insulin receptor subunit beta
Authors:	Wu, J, Hubbard, S.R.
Deposit date:	2007-12-31
Release date:	2008-02-19
Last modified:	2021-10-20
Method:	X-RAY DIFFRACTION (1.95 Å)
Cite:	Structural and biochemical characterization of the KRLB region in insulin receptor substrate-2. Nat.Struct.Mol.Biol., 15, 2008

2AUH

Crystal structure of the Grb14 BPS region in complex with the insulin receptor tyrosine kinase
Descriptor:	CALCIUM ION, Growth factor receptor-bound protein 14, Insulin receptor
Authors:	Depetris, R.S, Hu, J, Gimpelevich, I, Holt, L.J, Daly, R.J, Hubbard, S.R.
Deposit date:	2005-08-27
Release date:	2005-11-01
Last modified:	2023-11-15
Method:	X-RAY DIFFRACTION (3.2 Å)
Cite:	Structural basis for inhibition of the insulin receptor by the adaptor protein grb14. Mol.Cell, 20, 2005

3D94

Crystal structure of the insulin-like growth factor-1 receptor kinase in complex with PQIP
Descriptor:	3-[cis-3-(4-methylpiperazin-1-yl)cyclobutyl]-1-(2-phenylquinolin-7-yl)imidazo[1,5-a]pyrazin-8-amine, CALCIUM ION, Insulin-like growth factor 1 receptor beta chain
Authors:	Wu, J, Li, W, Miller, W.T, Hubbard, S.R.
Deposit date:	2008-05-26
Release date:	2008-07-29
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Small-molecule inhibition and activation-loop trans-phosphorylation of the IGF1 receptor Embo J., 27, 2008

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