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1FMX
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BU of 1fmx by Molmil
STRUCTURE OF NATIVE PROTEINASE A IN THE SPACE GROUP P21
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SACCHAROPEPSIN, ...
Authors:Gustchina, A, Li, M, Phylip, L.H, Lees, W.E, Kay, J, Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1FMU
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BU of 1fmu by Molmil
STRUCTURE OF NATIVE PROTEINASE A IN P3221 SPACE GROUP.
Descriptor: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, SACCHAROPEPSIN, ...
Authors:Gustchina, A, Li, M, Phylip, L.H, Lees, W.E, Kay, J, Wlodawer, A.
Deposit date:2000-08-18
Release date:2002-07-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:An unusual orientation for Tyr75 in the active site of the aspartic proteinase from Saccharomyces cerevisiae.
Biochem.Biophys.Res.Commun., 295, 2002
1B11
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BU of 1b11 by Molmil
STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH TL-3-093
Descriptor: PROTEIN (Feline Immunodeficiency Virus PROTEASE), SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Gustchina, A, Li, M, Wlodawer, A.
Deposit date:1998-11-25
Release date:1998-12-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
8DVH
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BU of 8dvh by Molmil
Crystal structure of ATP-dependent Lon protease from Bacillus subtillis (BsLonBA)
Descriptor: Lon protease 2, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, SODIUM ION
Authors:Sekula, B, Li, M, Gustchina, A, Wlodawer, A.
Deposit date:2022-07-29
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Unique Structural Fold of LonBA Protease from Bacillus subtilis, a Member of a Newly Identified Subfamily of Lon Proteases.
Int J Mol Sci, 23, 2022
1YG9
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BU of 1yg9 by Molmil
The structure of mutant (N93Q) of bla g 2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aspartic protease Bla g 2, ...
Authors:Li, M, Gustchina, A, Wuenschmann, S, Pomes, A, Wlodawer, A.
Deposit date:2005-01-04
Release date:2005-03-22
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of cockroach allergen Bla g 2, an unusual zinc binding aspartic protease with a novel mode of self-inhibition.
J.Mol.Biol., 348, 2005
1FMB
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BU of 1fmb by Molmil
EIAV PROTEASE COMPLEXED WITH THE INHIBITOR HBY-793
Descriptor: EIAV PROTEASE, [2-(2-METHYL-PROPANE-2-SULFONYLMETHYL)-3-NAPHTHALEN-1-YL-PROPIONYL-VALINYL]-PHENYLALANINOL
Authors:Wlodawer, A, Gustchina, A, Zdanov, A, Kervinen, J.
Deposit date:1996-02-27
Release date:1996-10-14
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of equine infectious anemia virus proteinase complexed with an inhibitor.
Protein Sci., 5, 1996
4KHX
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BU of 4khx by Molmil
Crystal structure of gp41 helix complexed with antibody 8062
Descriptor: 8062 heavy chain, 8062 light chain, gp41 helix
Authors:Li, M, Gustchina, A, Wlodawer, A.
Deposit date:2013-05-01
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.921 Å)
Cite:Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.
Plos One, 8, 2013
4RLD
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BU of 4rld by Molmil
Crystal structure of kkf mutant of bla G 2 protein
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aspartic protease Bla g 2, ZINC ION
Authors:Li, M, Gustchina, A, Pomes, A, Wlodawer, A.
Deposit date:2014-10-16
Release date:2015-10-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:to be determined
To be Published
2FIV
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BU of 2fiv by Molmil
Crystal structure of feline immunodeficiency virus protease complexed with a substrate
Descriptor: ACE-ALN-VAL-STA-GLU-ALN-NH2, FELINE IMMUNODEFICIENCY VIRUS PROTEASE, SULFATE ION
Authors:Schalk-Hihi, C, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A.
Deposit date:1997-07-21
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
6FIV
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BU of 6fiv by Molmil
STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor: RETROPEPSIN, SULFATE ION, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M, Lee, T, Morris, G, Laco, G, Wong, C, Olson, A, Elder, J, Wlodawer, A, Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
1ILK
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BU of 1ilk by Molmil
INTERLEUKIN-10 CRYSTAL STRUCTURE REVEALS THE FUNCTIONAL DIMER WITH AN UNEXPECTED TOPOLOGICAL SIMILARITY TO INTERFERON GAMMA
Descriptor: INTERLEUKIN-10
Authors:Zdanov, A, Schalk-Hihi, C, Gustchina, A, Wlodawer, A.
Deposit date:1995-04-21
Release date:1995-07-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of interleukin-10 reveals the functional dimer with an unexpected topological similarity to interferon gamma.
Structure, 3, 1995
5FIV
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BU of 5fiv by Molmil
STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITH AN EFFICIENT INHIBITOR OF FIV PR
Descriptor: RETROPEPSIN, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M, Lee, T, Morris, G, Laco, G, Wong, C, Olson, A, Elder, J, Wlodawer, A, Gustchina, A.
Deposit date:1998-12-02
Release date:1998-12-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
3TLH
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BU of 3tlh by Molmil
STRUCTURAL STUDIES OF HIV AND FIV PROTEASES COMPLEXED WITHAN EFFICIENT INHIBITOR OF FIV PR
Descriptor: PROTEIN (PROTEASE), benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate
Authors:Li, M, Lee, T, Morris, G, Laco, G, Wong, C, Olson, A, Elder, J, Wlodawer, A, Gustchina, A.
Deposit date:1998-12-03
Release date:1998-12-09
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural studies of FIV and HIV-1 proteases complexed with an efficient inhibitor of FIV protease
Proteins, 38, 2000
4KHT
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BU of 4kht by Molmil
Triple helix bundle of GP41 complexed with fab 8066
Descriptor: 8066 heavy chain, 8066 light chain, Gp41 helix
Authors:Li, M, Gustchina, A, Wlodawer, A.
Deposit date:2013-05-01
Release date:2014-03-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.817 Å)
Cite:Complexes of neutralizing and non-neutralizing affinity matured Fabs with a mimetic of the internal trimeric coiled-coil of HIV-1 gp41.
Plos One, 8, 2013
3FIV
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BU of 3fiv by Molmil
CRYSTAL STRUCTURE OF FELINE IMMUNODEFICIENCY VIRUS PROTEASE COMPLEXED WITH A SUBSTRATE
Descriptor: ACE-ALN-VAL-LEU-ALA-GLU-ALN-NH2, FELINE IMMUNODEFICIENCY VIRUS PROTEASE, SULFATE ION
Authors:Schalk-Hihi, C, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A.
Deposit date:1997-07-09
Release date:1997-11-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structures of the inactive D30N mutant of feline immunodeficiency virus protease complexed with a substrate and an inhibitor.
Biochemistry, 36, 1997
2FMB
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BU of 2fmb by Molmil
EIAV PROTEASE COMPLEXED WITH AN INHIBITOR LP-130
Descriptor: 4-[2-(2-ACETYLAMINO-3-NAPHTALEN-1-YL-PROPIONYLAMINO)-4-METHYL-PENTANOYLAMINO]-3-HYDROXY-6-METHYL-HEPTANOIC ACID [1-(1-CARBAMOYL-2-NAPHTHALEN-1-YL-ETHYLCARBAMOYL)-PROPYL]-AMIDE, EQUINE INFECTIOUS ANEMIA VIRUS PROTEASE
Authors:Kervinen, J, Lubkowski, J, Zdanov, A, Wlodawer, A, Gustchina, A.
Deposit date:1998-07-13
Release date:1999-01-13
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toward a universal inhibitor of retroviral proteases: comparative analysis of the interactions of LP-130 complexed with proteases from HIV-1, FIV, and EIAV.
Protein Sci., 7, 1998
3MAC
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BU of 3mac by Molmil
crystal structure of GP41-derived protein complexed with fab 8062
Descriptor: Fab8062, Transmembrane glycoprotein
Authors:Li, M, Gustchina, E, Louis, J, Gustchina, A, Wlodawer, A, Clore, M.
Deposit date:2010-03-23
Release date:2010-12-08
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41.
Plos Pathog., 6, 2010
3MA9
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BU of 3ma9 by Molmil
Crystal structure of gp41 derived protein complexed with fab 8066
Descriptor: Fab8066 FAB ANTIBODY FRAGMENT, Heavy Chain, Light Chain, ...
Authors:Li, M, Gustchina, E, Louis, J, Gustchina, A, Wlodawer, A, Clore, M.
Deposit date:2010-03-23
Release date:2010-12-01
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structural Basis of HIV-1 Neutralization by Affinity Matured Fabs Directed against the Internal Trimeric Coiled-Coil of gp41.
Plos Pathog., 6, 2010
1SIU
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BU of 1siu by Molmil
KUMAMOLISIN-AS E78H MUTANT
Descriptor: CALCIUM ION, SULFATE ION, kumamolisin-As
Authors:Li, M, Wlodawer, A, Gustchina, A, Tsuruoka, N, Ashida, M, Minakata, H, Oyama, H, Oda, K, Nishino, T, Nakayama, T.
Deposit date:2004-03-01
Release date:2004-03-30
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Crystallographic and biochemical investigations of kumamolisin-As, a serine-carboxyl peptidase with collagenase activity
J.Biol.Chem., 279, 2004
6DWU
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BU of 6dwu by Molmil
Crystal structure of complex of BBKI and Bovine Trypsin
Descriptor: Cationic trypsin, Kunitz-type inihibitor
Authors:Li, M, Wlodawer, A, Gustchina, A.
Deposit date:2018-06-28
Release date:2019-01-30
Method:X-RAY DIFFRACTION (3.96 Å)
Cite:Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Acta Crystallogr D Struct Biol, 75, 2019
6DWF
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BU of 6dwf by Molmil
Crystal structure of complex of BBKI mutant, L55R with Bovine Trypsin
Descriptor: Cationic trypsin, Kunitz-type inihibitor
Authors:Li, M, Wlodawer, A, Gustchina, A.
Deposit date:2018-06-26
Release date:2019-01-30
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Crystal structures of the complex of a kallikrein inhibitor from Bauhinia bauhinioides with trypsin and modeling of kallikrein complexes.
Acta Crystallogr D Struct Biol, 75, 2019
5C9B
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BU of 5c9b by Molmil
Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii
Descriptor: ApRick protease
Authors:Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2019-03-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
5C9D
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Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii
Descriptor: ApRick protease, SODIUM ION
Authors:Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease
Acta Crystallogr.,Sect.D, 71, 2015
5C9F
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Crystal structure of a retropepsin-like aspartic protease from Rickettsia conorii
Descriptor: ApRick protease, CHLORIDE ION, SODIUM ION
Authors:Li, M, Gustchina, A, Cruz, R, Simoes, M, Curto, P, Martinez, J, Faro, C, Simoes, I, Wlodawer, A.
Deposit date:2015-06-26
Release date:2015-10-14
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of RC1339/APRc from Rickettsia conorii, a retropepsin-like aspartic protease.
Acta Crystallogr. D Biol. Crystallogr., 71, 2015
1G0V
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BU of 1g0v by Molmil
THE STRUCTURE OF PROTEINASE A COMPLEXED WITH A IA3 MUTANT, MVV
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEASE A INHIBITOR 3, PROTEINASE A, ...
Authors:Phylip, L.H, Lees, W, Brownsey, B.G, Bur, D, Dunn, B.M, Winther, J, Gustchina, A, Li, M, Copeland, T, Wlodawer, A, Kay, J.
Deposit date:2000-10-09
Release date:2001-04-21
Last modified:2021-11-03
Method:X-RAY DIFFRACTION (2 Å)
Cite:The potency and specificity of the interaction between the IA3 inhibitor and its target aspartic proteinase from Saccharomyces cerevisiae.
J.Biol.Chem., 276, 2001

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