Author results

3ANN
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CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH QUINOLIN-2-YLMETHYLPHOSPHONIC ACID
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (quinolin-2-ylmethyl)phosphonic acid
Authors:Endo, K., Kato, M., Deng, L., Song, Y., Yajima, S.
Deposit date:2010-09-03
Release date:2011-02-23
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase/Lipophilic Phosphonate Complexes
ACS Med Chem Lett, 2, 2011
3J9B
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ELECTRON CRYO-MICROSCOPY OF AN RNA POLYMERASE
Descriptor:Polymerase, RNA-directed RNA polymerase catalytic subunit, Polymerase basic protein 2, ...
Authors:Chang, S.H., Sun, D.P., Liang, H.H., Wang, J., Li, J., Guo, L., Wang, X.L., Guan, C.C., Boruah, B.M., Yuan, L.M., Feng, F., Yang, M.R., Wojdyla, J., Wang, J.W., Wang, M.T., Wang, H.W., Liu, Y.F.
Deposit date:2014-12-16
Release date:2015-02-18
Last modified:2019-10-09
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Cryo-EM Structure of Influenza Virus RNA Polymerase Complex at 4.3 angstrom Resolution.
Mol.Cell, 2015
3M06
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CRYSTAL STRUCTURE OF TRAF2
Descriptor:TNF receptor-associated factor 2
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2010-03-02
Release date:2010-04-28
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
3M0A
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CRYSTAL STRUCTURE OF TRAF2:CIAP2 COMPLEX
Descriptor:TNF receptor-associated factor 2, Baculoviral IAP repeat-containing protein 3, ZINC ION
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2010-03-02
Release date:2010-04-28
Last modified:2015-07-29
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
3M0D
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CRYSTAL STRUCTURE OF THE TRAF1:TRAF2:CIAP2 COMPLEX
Descriptor:TNF receptor-associated factor 2, TNF receptor-associated factor 1, Baculoviral IAP repeat-containing protein 3, ...
Authors:Kabaleeswaran, V., Wu, H.
Deposit date:2010-03-02
Release date:2010-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of the TRAF2: cIAP2 and the TRAF1: TRAF2: cIAP2 complexes: affinity, specificity, and regulation.
Mol.Cell, 38, 2010
3RAS
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CRYSTAL STRUCTURE OF 1-DEOXY-D-XYLULOSE 5-PHOSPHATE REDUCTOISOMERASE (DXR) COMPLEXED WITH A LIPOPHILIC PHOSPHONATE INHIBITOR
Descriptor:1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 3-(N-HYDROXYACETAMIDO)-1-(3,4-DICHLOROPHENYL)PROPYLPHOSPHONIC ACID, ...
Authors:Diao, J., Deng, L., Prasad, B.V.V., Song, Y.
Deposit date:2011-03-28
Release date:2011-05-25
Last modified:2012-07-25
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Inhibition of 1-deoxy-D-xylulose-5-phosphate reductoisomerase by lipophilic phosphonates: SAR, QSAR, and crystallographic studies.
J.Med.Chem., 54, 2011
3SR4
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CRYSTAL STRUCTURE OF HUMAN DOT1L IN COMPLEX WITH A SELECTIVE INHIBITOR
Descriptor:Histone-lysine N-methyltransferase, H3 lysine-79 specific, (2S)-2-azanyl-4-[[(2S,3S,4R,5R)-5-[6-(methylamino)purin-9-yl]-3,4-bis(oxidanyl)oxolan-2-yl]methylsulfanyl]butanoic acid, ...
Authors:Diao, J., Chen, P., Yao, Y., Prasad, B.V.V., Song, Y.
Deposit date:2011-07-06
Release date:2011-10-05
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Selective Inhibitors of Histone Methyltransferase DOT1L: Design, Synthesis, and Crystallographic Studies.
J.Am.Chem.Soc., 133, 2011
4EF4
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CRYSTAL STRUCTURE OF STING CTD COMPLEX WITH C-DI-GMP
Descriptor:Transmembrane protein 173, 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), CALCIUM ION
Authors:Ouyang, S., Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Li, Y., Liu, Z.-J.
Deposit date:2012-03-29
Release date:2012-05-16
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.147 Å)
Cite:Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
4EF5
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CRYSTAL STRUCTURE OF STING CTD
Descriptor:Transmembrane protein 173
Authors:Ouyang, S., Ru, H., Shaw, N., Jiang, Y., Niu, F., Zhu, Y., Qiu, W., Li, Y., Liu, Z.-J.
Deposit date:2012-03-29
Release date:2012-05-16
Last modified:2013-07-03
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural analysis of the STING adaptor protein reveals a hydrophobic dimer interface and mode of cyclic di-GMP binding
Immunity, 36, 2012
4NOJ
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CRYSTAL STRUCTURE OF THE MATURE FORM OF ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN ACTIVATED AT PH 3.5
Descriptor:Legumain
Authors:Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
Deposit date:2013-11-19
Release date:2014-02-19
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
4NOK
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CRYSTAL STRUCTURE OF PROENZYME ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN AT PH 7.5
Descriptor:Legumain
Authors:Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
Deposit date:2013-11-19
Release date:2014-02-19
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
4NOL
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CRYSTAL STRUCTURE OF PROENZYME ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN MUTANT D233A AT PH 7.5
Descriptor:Legumain
Authors:Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
Deposit date:2013-11-19
Release date:2014-02-19
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
4NOM
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CRYSTAL STRUCTURE OF ASPARAGINYL ENDOPEPTIDASE (AEP)/LEGUMAIN ACTIVATED AT PH 4.5
Descriptor:Legumain
Authors:Zhao, L., Hua, T., Ru, H., Ni, X., Shaw, N., Jiao, L., Ding, W., Qu, L., Ouyang, S., Liu, Z.J.
Deposit date:2013-11-19
Release date:2014-02-19
Last modified:2014-03-19
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:Structural analysis of asparaginyl endopeptidase reveals the activation mechanism and a reversible intermediate maturation stage.
Cell Res., 24, 2014
4QGU
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PROTEIN DOMAIN COMPLEX WITH SSDNA
Descriptor:Gamma-interferon-inducible protein 16, DNA (5'-D(P*AP*GP*GP*CP*CP*GP*GP*CP*GP*TP*GP*A)-3')
Authors:Ni, X., Ru, H., Zhao, L., Shaw, N., Ding, W., Songying, O., Liu, Z.-J.
Deposit date:2014-05-25
Release date:2015-06-17
Last modified:2016-07-20
Method:X-RAY DIFFRACTION (2.545 Å)
Cite:New insights into the structural basis of DNA recognition by HINa and HINb domains of IFI16.
J Mol Cell Biol, 8, 2016
4Y5U
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TRANSCRIPTION FACTOR
Descriptor:Signal transducer and activator of transcription 6, NICKEL (II) ION
Authors:Li, J., Niu, F., Ouyang, S., Liu, Z.
Deposit date:2015-02-12
Release date:2016-02-17
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (2.708 Å)
Cite:Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
4Y5W
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TRANSCRIPTION FACTOR-DNA COMPLEX
Descriptor:Signal transducer and activator of transcription 6, DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*GP*AP*CP*AP*A)-3'), DNA (5'-D(P*TP*TP*GP*TP*CP*TP*TP*CP*CP*TP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3')
Authors:Li, J., Niu, F., Ouyang, S., Liu, Z.
Deposit date:2015-02-12
Release date:2016-02-17
Last modified:2016-11-30
Method:X-RAY DIFFRACTION (3.104 Å)
Cite:Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
5D39
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TRANSCRIPTION FACTOR-DNA COMPLEX
Descriptor:Signal transducer and activator of transcription 6, DNA (5'-D(P*TP*CP*TP*GP*TP*CP*TP*TP*CP*CP*AP*GP*GP*AP*AP*AP*TP*CP*CP*AP*T)-3'), DNA (5'-D(P*AP*TP*GP*GP*AP*TP*TP*TP*CP*CP*TP*GP*GP*AP*AP*GP*AP*CP*AP*GP*A)-3')
Authors:Li, J., Niu, F., Ouyang, S., Liu, Z.
Deposit date:2015-08-06
Release date:2016-08-10
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural basis for DNA recognition by STAT6
Proc.Natl.Acad.Sci.USA, 113, 2016
5H1Y
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CRYSTAL STRUCTURE OF THE DDX41 DEAD DOMAIN IN COMPLEX WITH SO42- AND MG2+
Descriptor:Probable ATP-dependent RNA helicase DDX41, SULFATE ION, MAGNESIUM ION
Authors:Jiang, Y., Ouyang, S., Liu, Z.J.
Deposit date:2016-10-13
Release date:2017-01-18
Last modified:2017-01-25
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structural and functional analyses of human DDX41 DEAD domain
Protein Cell, 8, 2017
6NZT
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CRYSTAL STRUCTURE OF HCV NS3/4A PROTEASE IN COMPLEX WITH VOXILAPREVIR
Descriptor:HCV NS3/4A protease, Voxilaprevir, ZINC ION, ...
Authors:Appleby, T.C., Taylor, J.G.
Deposit date:2019-02-14
Release date:2019-07-10
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Discovery of the pan-genotypic hepatitis C virus NS3/4A protease inhibitor voxilaprevir (GS-9857): A component of Vosevi®.
Bioorg.Med.Chem.Lett., 29, 2019
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