Author results

4KJS
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STRUCTURE OF NATIVE YFKE
Descriptor:cation exchanger YfkE
Authors:Wu, M., Tong, S., Zheng, L.
Deposit date:2013-05-03
Release date:2013-06-26
Last modified:2013-08-07
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Crystal structure of Ca2+/H+ antiporter protein YfkE reveals the mechanisms of Ca2+ efflux and its pH regulation.
Proc.Natl.Acad.Sci.USA, 110, 2013
4LY9
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HUMAN GKRP COMPLEXED TO AMG-1694 [(2R)-1,1,1-TRIFLUORO-2-{4-[(2S)-2-{[(3S)-3-METHYLMORPHOLIN-4-YL]METHYL}-4-(THIOPHEN-2-YLSULFONYL)PIPERAZIN-1-YL]PHENYL}PROPAN-2-OL] AND SORBITOL-6-PHOSPHATE
Descriptor:Glucokinase regulatory protein, IODIDE ION, D-SORBITOL-6-PHOSPHATE, ...
Authors:Jordan, S.R.
Deposit date:2013-07-30
Release date:2013-11-20
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Antidiabetic effects of glucokinase regulatory protein small-molecule disruptors.
Nature, 504, 2013
4U68
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CRYSTAL STRUCTURE OF RHINO CHROMODOMAIN IN COMPLEX WITH H3K9ME3
Descriptor:Rhino, peptide from Histone H3.1
Authors:Yu, B.W., Huang, Y.
Deposit date:2014-07-28
Release date:2015-08-05
Last modified:2016-05-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural insights into Rhino-mediated germline piRNA cluster formation
Cell Res., 25, 2015
5FID
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CRYSTAL STRUCTURE OF THE PROTEIN ELICITOR MOHRIP2 FROM MAGNAPORTHE ORYZAE
Descriptor:Elicitor protein Hrip2
Authors:Liu, M., Duan, L., Qiu, D., Liu, X.
Deposit date:2015-12-23
Release date:2016-12-07
Method:X-RAY DIFFRACTION (1.809 Å)
Cite:Crystal Structure Analysis and the Identification of Distinctive Functional Regions of the Protein Elicitor Mohrip2
Front Plant Sci, 7, 2016
5NGE
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE NON-COVALENT INHIBITOR, FT671
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, 5-[[1-[(3~{S})-4,4-bis(fluoranyl)-3-(3-fluoranylpyrazol-1-yl)butanoyl]-4-oxidanyl-piperidin-4-yl]methyl]-1-(4-fluorophenyl)pyrazolo[3,4-d]pyrimidin-4-one
Authors:Turnbull, A.P., Krajewski, W.W., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
5NGF
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CRYSTAL STRUCTURE OF USP7 IN COMPLEX WITH THE COVALENT INHIBITOR, FT827
Descriptor:Ubiquitin carboxyl-terminal hydrolase 7, ~{N}-[2-[4-[4-[(1-methyl-4-oxidanylidene-pyrazolo[3,4-d]pyrimidin-5-yl)methyl]-4-oxidanyl-piperidin-1-yl]carbonylphenyl]phenyl]ethanesulfonamide, 1,2-ETHANEDIOL
Authors:Krajewski, W.W., Turnbull, A.P., Ioannidis, S., Kessler, B.M., Komander, D.
Deposit date:2017-03-17
Release date:2017-10-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.33 Å)
Cite:Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature, 550, 2017
2GDZ
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CRYSTAL STRUCTURE OF 15-HYDROXYPROSTAGLANDIN DEHYDROGENASE TYPE1, COMPLEXED WITH NAD+
Descriptor:NAD+-dependent 15-hydroxyprostaglandin dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Pilka, E.S., Guo, K., Kavanagh, K., Von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Sundstrom, M., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-03-17
Release date:2006-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:High-Affinity Inhibitors of Human NAD-Dependent 15-Hydroxyprostaglandin Dehydrogenase: Mechanisms of Inhibition and Structure-Activity Relationships.
Plos One, 5, 2010
2HKI
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CRYSTAL STRUCTURE OF PHOTOSYNTHETIC GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A4 ISOFORM
Descriptor:Glyceraldehyde-3-phosphate dehydrogenase A, chloroplast, SULFATE ION
Authors:Camara-Artigas, A.
Deposit date:2006-07-04
Release date:2006-11-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallization and structural analysis of GADPH from Spinacia oleracea in a new form.
Acta Crystallogr.,Sect.F, 62, 2006
3HYF
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CRYSTAL STRUCTURE OF HIV-1 RNASE H P15 WITH ENGINEERED E. COLI LOOP AND ACTIVE SITE INHIBITOR
Descriptor:Reverse transcriptase/RNaseH, MANGANESE (II) ION, ACETATE ION, ...
Authors:Lansdon, E.B., Kirschberg, T.A.
Deposit date:2009-06-22
Release date:2009-10-20
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information.
J.Med.Chem., 52, 2009
3NJY
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CRYSTAL STRUCTURE OF JMJD2A COMPLEXED WITH 5-CARBOXY-8-HYDROXYQUINOLINE
Descriptor:Lysine-specific demethylase 4A, NICKEL (II) ION, ZINC ION, ...
Authors:King, O.N.F., Clifton, I.J., Wang, M., Maloney, D.J., Jadhav, A., Oppermann, U., Heightman, T.D., Simeonov, A., McDonough, M.A., Schofield, C.J.
Deposit date:2010-06-18
Release date:2010-12-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Quantitative high-throughput screening identifies 8-hydroxyquinolines as cell-active histone demethylase inhibitors
Plos One, 5, 2010
3WX1
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MOUSE CEREBLON THALIDOMIDE BINDING DOMAIN, SELENOMETHIONINE DERIVATIVE
Descriptor:Protein cereblon, ZINC ION, SULFATE ION
Authors:Mori, T., Ito, T., Hirano, Y., Yamaguchi, Y., Handa, H., Hakoshima, T.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Nat.Struct.Mol.Biol., 21, 2014
3WX2
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MOUSE CEREBLON THALIDOMIDE BINDING DOMAIN, NATIVE
Descriptor:Protein cereblon, ZINC ION, SULFATE ION
Authors:Mori, T., Ito, T., Hirano, Y., Yamaguchi, Y., Handa, H., Hakoshima, T.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2014-09-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs
Nat.Struct.Mol.Biol., 21, 2014
4TZC
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CRYSTAL STRUCTURE OF MURINE CEREBLON IN COMPLEX WITH THALIDOMIDE
Descriptor:Protein cereblon, ZINC ION, S-Thalidomide, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4TZU
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CRYSTAL STRUCTURE OF MURINE CEREBLON IN COMPLEX WITH POMALIDOMIDE
Descriptor:Protein cereblon, SULFATE ION, ZINC ION, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B.
Deposit date:2014-07-10
Release date:2014-08-06
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
to be published
4U93
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-DOMAIN BOUND TO THE INHIBITOR NVP-HSP990
Descriptor:Heat shock protein HSP 90-alpha, (7R)-2-amino-7-[4-fluoro-2-(6-methoxypyridin-2-yl)phenyl]-4-methyl-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one
Authors:Bellamacina, C.R., Shafer, C.M., Bussiere, D.
Deposit date:2014-08-05
Release date:2014-11-19
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
4W7T
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CRYSTAL STRUCTURE OF HSP90-ALPHA N-DOMAIN BOUND TO THE INHIBITOR NVP-HSP990
Descriptor:Heat shock protein HSP 90-alpha, (7S)-2-amino-4-methyl-7-phenyl-7,8-dihydroquinazolin-5(6H)-one
Authors:Bellamacina, C.R., Shafer, C.M., Bussiere, D.
Deposit date:2014-08-22
Release date:2014-11-26
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Design, Structure-Activity Relationship, and in Vivo Characterization of the Development Candidate NVP-HSP990.
J.Med.Chem., 57, 2014
5MKV
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CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINEASE-LIKE 2 (DPYSL2A)/COLLAPSIN RESPONSE MEDIATOR PROTEIN (CRMP2) RESIDUES 13-516
Descriptor:Dihydropyrimidinase-related protein 2, 1,2-ETHANEDIOL
Authors:Sethi, R., Zheng, Y., Krojer, T., Velupillai, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Ahmed, A.A., von Delft, F.
Deposit date:2016-12-05
Release date:2017-02-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.
Nat Commun, 9, 2018
5MLE
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CRYSTAL STRUCTURE OF HUMAN DIHYDROPYRIMIDINEASE-LIKE 2 (DPYSL2A)/COLLAPSIN RESPONSE MEDIATOR PROTEIN (CRMP2 13-516) MUTANT Y479E/Y499E
Descriptor:Dihydropyrimidinase-related protein 2, DI(HYDROXYETHYL)ETHER, 1,2-ETHANEDIOL, ...
Authors:Sethi, R., Zheng, Y., Talon, R., Velupillai, S., Arrowsmith, C.H., Edwards, A.M., Bountra, C., Ahmed, A.A., von Delft, F.
Deposit date:2016-12-06
Release date:2017-02-22
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Tuning microtubule dynamics to enhance cancer therapy by modulating FER-mediated CRMP2 phosphorylation.
Nat Commun, 9, 2018
5YAG
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CRYSTAL STRUCTURE OF MOSQUITO ARYLALKYLAMINE N-ACETYLTRANSFERASE LIKE 5B/SPERMINE N-ACETYLTRANSFERASE
Descriptor:AAEL004827-PA, GLYCEROL
Authors:Han, Q., Guan, H., Robinson, H., Li, J.
Deposit date:2017-08-31
Release date:2018-02-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Identification of aaNAT5b as a spermine N-acetyltransferase in the mosquito, Aedes aegypti.
PLoS ONE, 13, 2018
1NIY
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THREE DIMENSIONAL SOLUTION STRUCTURE OF HAINANTOXIN-IV BY 2D 1H-NMR
Descriptor:HAINANTOXIN-IV
Authors:Li, D., Lu, S., Gu, X., Liang, S.
Deposit date:2002-12-30
Release date:2003-01-14
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Structure-Activity Relationships of Hainantoxin-IV and Structure Determination of Active and Inactive Sodium Channel Blockers.
J.Biol.Chem., 279, 2004
1RYG
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THREE DIMENSIONAL SOLUTION STRUCTURE OF THE R29A MUTANT OF SODIUM CHANNELS INHIBITOR HAINANTOXIN-IV BY 2D 1H-NMR
Descriptor:Hainantoxin-IV
Authors:Li, D., Lu, S., Gu, X., Liang, S.
Deposit date:2003-12-22
Release date:2004-01-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers
J.Biol.Chem., 279, 2004
1RYV
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THREE DIMENSIONAL SOLUTION STRUCTURE OF THE K27A MUTANT OF SODIUM CHANNELS INHIBITOR HAINANTOXIN-IV BY 2D 1H-NMR
Descriptor:Hainantoxin-IV
Authors:Li, D., Lu, S., Gu, X., Liang, S.
Deposit date:2003-12-22
Release date:2004-01-13
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure--activity relationships of hainantoxin-IV and structure determination of active and inactive sodium channel blockers
J.Biol.Chem., 279, 2004
2FHH
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEASOME IN COMPLEX WITH A PEPTIDYL BORONATE INHIBITOR MLN-273
Descriptor:20S proteasome, alpha and beta subunits, proteasome, ...
Authors:Li, H.
Deposit date:2005-12-23
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Mol.Microbiol., 59, 2006
2H0D
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STRUCTURE OF A BMI-1-RING1B POLYCOMB GROUP UBIQUITIN LIGASE COMPLEX
Descriptor:B lymphoma Mo-MLV insertion region, Ubiquitin ligase protein RING2, ZINC ION
Authors:Xu, R.M.
Deposit date:2006-05-14
Release date:2006-05-23
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of a Bmi-1-Ring1B Polycomb Group Ubiquitin Ligase Complex.
J.Biol.Chem., 281, 2006
2Q57
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X-RAY STRUCTURE OF CERULEAN GFP: A TRYPTOPHAN-BASED CHROMOPHORE USEFUL FOR FLUORESCENCE LIFETIME IMAGING
Descriptor:Cerulean Green fluorescent protein
Authors:Malo, G.D.
Deposit date:2007-05-31
Release date:2007-11-27
Last modified:2011-09-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:X-ray structure of Cerulean GFP: a tryptophan-based chromophore useful for fluorescence lifetime imaging.
Biochemistry, 46, 2007