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4D3B
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH N1-(2-(1H-IMIDAZOL-1-YL)PYRIMIDIN-4-YL)-N2-(3- FLUOROPHENETHYL)ETHANE-1,2-DIAMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-10-20
Release date:2014-12-24
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (1.798 Å)
Cite:Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase.
J.Med.Chem., 58, 2015
4D7O
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(4-(((3-FLUOROPHENETHYL)AMINO)METHYL)PHENYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2014-11-25
Release date:2015-07-01
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Nitric Oxide Synthase as a Target for Methicillin-Resistant Staphylococcus Aureus
Chem.Biol., 22, 2015
4FVW
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STRUCTURE OF RAT NNOS HEME DOMAIN IN COMPLEX WITH N(OMEGA)-METHOXY-L-ARGININE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4FVX
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STRUCTURE OF RAT NNOS HEME DOMAIN IN COMPLEX WITH N(OMEGA)-ETHOXY-L-ARGININE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4FVY
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STRUCTURE OF RAT NNOS HEME DOMAIN IN COMPLEX WITH N(OMEGA)-HYDROXY- N(OMEGA)-METHYL-L-ARGININE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2013-07-10
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4FVZ
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STRUCTURE OF RAT NNOS HEME DOMAIN IN COMPLEX WITH N(OMEGA)-METHYL- N(OMEGA)-METHOXY-L-ARGININE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4FW0
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STRUCTURE OF RAT NNOS HEME DOMAIN IN COMPLEX WITH N(DELTA)-METHYL- N(OMEGA)-HYDROXY-L-ARGININE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-06-29
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4GQE
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (5E)-5-[(N-TERT-BUTOXYCARBAMIMIDOYL)IMINO]-L-NORVALINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2012-08-22
Release date:2013-05-15
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Methylated N(omega)-Hydroxy-l-arginine Analogues as Mechanistic Probes for the Second Step of the Nitric Oxide Synthase-Catalyzed Reaction
Biochemistry, 52, 2013
4JSE
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(PENTANE-1,5-DIYL)BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSF
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(HEPTANE-1,7-DIYL)BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSG
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-((3-(3-AMINOPROPOXY)PHENOXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSH
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-((3-(PIPERIDIN-4-YLMETHOXY)PHENOXY)METHYL)PYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSI
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-((3-(((3-FLUOROPHENETHYL)AMINO)METHYL)PHENOXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSJ
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((5-(((3-FLUOROPHENETHYL)AMINO)METHYL)PYRIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSK
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(PENTANE-1,5-DIYL)BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSL
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6,6'-(HEPTANE-1,7-DIYL)BIS(4-METHYLPYRIDIN-2-AMINE)
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4JSM
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(((5-(((3-FLUOROPHENETHYL)AMINO)METHYL)PYRIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-03-22
Release date:2013-08-07
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:In search of potent and selective inhibitors of neuronal nitric oxide synthase with more simple structures.
Bioorg.Med.Chem., 21, 2013
4K5D
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-1,2-BIS((2-AMINO-4-METHYLPYRIDIN-6-YL)-METHOXY)-PROPAN-3-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.096 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5E
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (R)-1,2-BIS((2-AMINO-4-METHYLPYRIDIN-6-YL)-METHOXY)-PROPAN-3-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.892 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5F
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-1,3-BIS((2-AMINO-4-METHYLPYRIDIN-6-YL)-METHOXY)-BUTAN-4-AMINE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5G
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STRUCTURE OF NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH ((2S, 3S)-1,3-BIS((6-(2,5-DIMETHYL-1H-PYRROL-1-YL)-4-METHYLPYRIDIN-2-YL)METHOXY)-2-AMINOBUTANE
Descriptor:Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5I
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (R)-1,2-BIS((2-AMINO-4-METHYLPYRIDIN-6-YL)-METHOXY)-PROPAN-3-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.08 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5J
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH (S)-1,3-BIS((2-AMINO-4-METHYLPYRIDIN-6-YL)-METHOXY)-BUTAN-4-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4K5K
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH ((2S, 3S)-1,3-BIS((6-(2,5-DIMETHYL-1H-PYRROL-1-YL)-4-METHYLPYRIDIN-2-YL)METHOXY)-2-AMINOBUTANE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-04-14
Release date:2013-09-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:Chiral linkers to improve selectivity of double-headed neuronal nitric oxide synthase inhibitors.
Bioorg.Med.Chem.Lett., 23, 2013
4LUW
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-((((3R,5S)-5-(((6-AMINO-4-METHYLPYRIDIN-2-YL)METHOXY)METHYL)PYRROLIDIN-3-YL)OXY)METHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2013-07-25
Release date:2013-10-23
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and biological studies on bacterial nitric oxide synthase inhibitors.
Proc.Natl.Acad.Sci.USA, 110, 2013