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2ZCY
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BU of 2zcy by Molmil
yeast 20S proteasome:syringolin A-complex
Descriptor: (2S)-2-[[(2S)-1-[[(5S,8S,9E)-2,7-dioxo-5-propan-2-yl-1,6-diazacyclododeca-3,9-dien-8-yl]amino]-3-methyl-1-oxo-butan-2-yl]carbamoylamino]-3-methyl-butanoic acid, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Dudler, R, Kaiser, M.
Deposit date:2007-11-15
Release date:2008-04-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
1G0U
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BU of 1g0u by Molmil
A GATED CHANNEL INTO THE PROTEASOME CORE PARTICLE
Descriptor: MAGNESIUM ION, PROTEASOME COMPONENT C1, PROTEASOME COMPONENT C11, ...
Authors:Groll, M, Bajorek, M, Kohler, A, Moroder, L, Rubin, D.M, Huber, R, Glickman, M.H, Finley, D.
Deposit date:2000-10-09
Release date:2000-11-06
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A gated channel into the proteasome core particle.
Nat.Struct.Biol., 7, 2000
2GPL
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BU of 2gpl by Molmil
TMC-95 based biphenyl-ether macrocycles: specific proteasome inhibitors
Descriptor: BENZYL [12-(2-AMINO-2-OXOETHYL)-4-NITRO-10,13-DIOXO-15-[(PROPYLAMINO)CARBONYL]-2-OXA-11,14-DIAZATRICYCLO[15 .2.2.1~3,7~]DOCOSA-1(19),3(22),4,6,17,20-HEXAEN-9-YL]CARBAMATE, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Goetz, M, Kaiser, M, Weyher, E, Moroder, M.
Deposit date:2006-04-18
Release date:2006-07-11
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:TMC-95-Based Inhibitor Design Provides Evidence for the Catalytic Versatility of the Proteasome.
Chem.Biol., 13, 2006
3NZW
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BU of 3nzw by Molmil
Crystal structure of the yeast 20S proteasome in complex with 2b
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZJ
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BU of 3nzj by Molmil
Crystal structure of yeast 20S proteasome in complex with ligand 2a
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-16
Release date:2011-02-16
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3NZX
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BU of 3nzx by Molmil
Crystal structure of the yeast 20S proteasome in complex with ligand 2c
Descriptor: Proteasome component C1, Proteasome component C11, Proteasome component C5, ...
Authors:Groll, M, Gallastegui, N, Marechal, X, Le Ravalec, V, Basse, N, Richy, N, Genin, E, Huber, R, Moroder, M, Vidal, V, Reboud-Ravaux, M.
Deposit date:2010-07-17
Release date:2011-02-16
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:20S proteasome inhibition: designing noncovalent linear peptide mimics of the natural product TMC-95A.
Chemmedchem, 5, 2010
3BDM
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BU of 3bdm by Molmil
yeast 20S proteasome:glidobactin A-complex
Descriptor: (2E,4E)-N-[(2S,3R)-3-hydroxy-1-[[(3Z,5S,8S,10S)-10-hydroxy-5-methyl-2,7-dioxo-1,6-diazacyclododec-3-en-8-yl]amino]-1-ox obutan-2-yl]dodeca-2,4-dienamide, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Dudler, R, Kaiser, M.
Deposit date:2007-11-15
Release date:2008-04-08
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A plant pathogen virulence factor inhibits the eukaryotic proteasome by a novel mechanism
Nature, 452, 2008
1J2Q
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BU of 1j2q by Molmil
20S proteasome in complex with calpain-Inhibitor I from archaeoglobus fulgidus
Descriptor: 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID [1-(1-FORMYL-PENTYLCARBAMOYL)-3-METHYL-BUTYL]-AMIDE, Proteasome alpha subunit, Proteasome beta subunit
Authors:Groll, M, Brandstetter, H, Bartunik, H, Bourenkow, G, Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1J2P
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BU of 1j2p by Molmil
alpha-ring from the proteasome from archaeoglobus fulgidus
Descriptor: Proteasome alpha subunit
Authors:Groll, M, Brandstetter, H, Bartunik, H, Bourenkow, G, Huber, R.
Deposit date:2003-01-08
Release date:2003-03-18
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Investigations on the Maturation and Regulation of Archaebacterial Proteasomes
J.MOL.BIOL., 327, 2003
1JD2
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BU of 1jd2 by Molmil
Crystal Structure of the yeast 20S Proteasome:TMC-95A complex: A non-covalent Proteasome Inhibitor
Descriptor: MAGNESIUM ION, PROTEASOME COMPONENT C1, PROTEASOME COMPONENT C11, ...
Authors:Groll, M, Koguchi, Y, Huber, R, Kohno, J.
Deposit date:2001-06-12
Release date:2002-02-13
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of the 20 S proteasome:TMC-95A complex: a non-covalent proteasome inhibitor.
J.Mol.Biol., 311, 2001
1G65
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BU of 1g65 by Molmil
Crystal structure of epoxomicin:20s proteasome reveals a molecular basis for selectivity of alpha,beta-epoxyketone proteasome inhibitors
Descriptor: EPOXOMICIN (peptide inhibitor), MAGNESIUM ION, Proteasome component C1, ...
Authors:Groll, M, Kim, K.B, Kairies, N, Huber, R, Crews, C.
Deposit date:2000-11-03
Release date:2000-11-27
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Epoxomicin:20S Proteasome reveals a molecular basis for selectivity of alpha,beta-Epoxyketone Proteasome Inhibitors
J.Am.Chem.Soc., 122, 2000
3DY4
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BU of 3dy4 by Molmil
Crystal structure of yeast 20S proteasome in complex with spirolactacystin
Descriptor: Omuralide, open form, Proteasome component C1, ...
Authors:Groll, M, Balskus, E, Jacobsen, E.
Deposit date:2008-07-25
Release date:2008-11-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3DY3
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BU of 3dy3 by Molmil
Crystal structure of yeast 20S proteasome in complex with the epimer form of spirolactacystin
Descriptor: (3R,4R)-3-hydroxy-2-[(1S)-1-hydroxy-2-methylpropyl]-4-methyl-5-oxo-D-proline, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Balskus, E, Jacobsen, E.
Deposit date:2008-07-25
Release date:2008-11-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.81 Å)
Cite:Structural analysis of spiro beta-lactone proteasome inhibitors.
J.Am.Chem.Soc., 130, 2008
3E47
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BU of 3e47 by Molmil
Crystal Structure of the Yeast 20S Proteasome in Complex with Homobelactosin C
Descriptor: Proteasome component C1, Proteasome component C11, Proteasome component C5, ...
Authors:Groll, M, Larionov, O.V, de Meijere, A.
Deposit date:2008-08-10
Release date:2008-09-02
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (3 Å)
Cite:Inhibitor-binding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation
Proc.Natl.Acad.Sci.Usa, 103, 2006
2F16
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BU of 2f16 by Molmil
Crystal structure of the yeast 20S proteasome in complex with bortezomib
Descriptor: N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M.
Deposit date:2005-11-14
Release date:2006-03-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structure of the Boronic Acid-Based Proteasome Inhibitor Bortezomib in Complex with the Yeast 20S Proteasome.
Structure, 14, 2006
2FAK
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BU of 2fak by Molmil
Crystal structure of Salinosporamide A in complex with the yeast 20S proteasome
Descriptor: (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Potts, B.C.
Deposit date:2005-12-07
Release date:2006-04-18
Last modified:2023-05-31
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal Structures of Salinosporamide A (NPI-0052) and B (NPI-0047) in Complex with the 20S Proteasome Reveal Important Consequences of beta-Lactone Ring Opening and a Mechanism for Irreversible Binding.
J.Am.Chem.Soc., 128, 2006
3GPW
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BU of 3gpw by Molmil
Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: irreversible inhibitor ligand
Descriptor: (3AR,6R,6AS)-6-((S)-((S)-CYCLOHEX-2-ENYL)(HYDROXY)METHYL)-6A-METHYL-4-OXO-HEXAHYDRO-2H-FURO[3,2-C]PYRROLE-6-CARBALDEHYDE, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Macherla, V.R, Manam, R.R, Arthur, K.A.M, Potts, C.B.
Deposit date:2009-03-23
Release date:2009-09-15
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3GPT
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BU of 3gpt by Molmil
Crystal structure of the yeast 20S proteasome in complex with Salinosporamide derivatives: slow substrate ligand
Descriptor: (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-4-(2-fluoroethyl)-3-hydroxy-3-methyl-5-oxopyrrolidine-2-carbaldehyde, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Macherla, V.R, Manam, R.R, Arthur, K.A.M, Potts, C.B.
Deposit date:2009-03-23
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
3HYE
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BU of 3hye by Molmil
Crystal structure of 20S proteasome in complex with hydroxylated salinosporamide
Descriptor: (2R,3S,4R)-2-[(S)-(1S)-cyclohex-2-en-1-yl(hydroxy)methyl]-3-hydroxy-4-(2-hydroxyethyl)-3-methyl-5-oxopyrrolidine-2-carbaldehyde, Proteasome component C1, Proteasome component C11, ...
Authors:Groll, M, Arthur, K.A.M, Macherla, V.R, Manam, R.R, Potts, B.C.
Deposit date:2009-06-22
Release date:2009-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Snapshots of the fluorosalinosporamide/20S complex offer mechanistic insights for fine tuning proteasome inhibition
J.Med.Chem., 52, 2009
1RYP
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BU of 1ryp by Molmil
CRYSTAL STRUCTURE OF THE 20S PROTEASOME FROM YEAST AT 2.4 ANGSTROMS RESOLUTION
Descriptor: 20S PROTEASOME, MAGNESIUM ION
Authors:Groll, M, Ditzel, L, Loewe, J, Stock, D, Bochtler, M, Bartunik, H.D, Huber, R.
Deposit date:1997-02-26
Release date:1998-04-15
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of 20S proteasome from yeast at 2.4 A resolution.
Nature, 386, 1997
6GOP
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BU of 6gop by Molmil
Yeast 20S Proteasome in complex with Homosalinosporamide A
Descriptor: CHLORIDE ION, Homosalinosporamide A - bound form, MAGNESIUM ION, ...
Authors:Groll, M, Romo, D.
Deposit date:2018-06-01
Release date:2018-08-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:(-)-Homosalinosporamide A and Its Mode of Proteasome Inhibition: An X-ray Crystallographic Study.
Mar Drugs, 16, 2018
2BHO
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BU of 2bho by Molmil
Crystal structure of the Yersinia enterocolitica type III secretion chaperone SycT
Descriptor: CHAPERONE PROTEIN SYCT, PLATINUM (II) ION
Authors:Groll, M, Wilharm, G.
Deposit date:2005-01-15
Release date:2005-07-06
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of the Yersinia Enterocolitica Type III Secretion Chaperone Syct
J.Biol.Chem., 280, 2005
6Y36
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BU of 6y36 by Molmil
CCAAT-binding complex from Aspergillus fumigatus with cccA DNA
Descriptor: CCAAT-binding factor complex subunit HapC, CCAAT-binding factor complex subunit HapE, CCAAT-binding transcription factor subunit HAPB, ...
Authors:Groll, M, Huber, E.M.
Deposit date:2020-02-17
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus .
Life Sci Alliance, 3, 2020
6Y37
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BU of 6y37 by Molmil
CCAAT-binding complex from Aspergillus nidulans with cccA DNA
Descriptor: CBFD_NFYB_HMF domain-containing protein, DNA (25-MER), GLYCEROL, ...
Authors:Groll, M, Huber, E.M.
Deposit date:2020-02-17
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus .
Life Sci Alliance, 3, 2020
6Y35
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BU of 6y35 by Molmil
CCAAT-binding complex from Aspergillus fumigatus with cycA DNA
Descriptor: CCAAT-binding factor complex subunit HapC, CCAAT-binding factor complex subunit HapE, CCAAT-binding transcription factor subunit HAPB, ...
Authors:Groll, M, Huber, E.M.
Deposit date:2020-02-17
Release date:2020-05-27
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis of HapE P88L -linked antifungal triazole resistance in Aspergillus fumigatus .
Life Sci Alliance, 3, 2020

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