Author results

5IXK
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RORGAMMA IN COMPLEX WITH INVERSE AGONIST BIO399.
分子名称:Nuclear receptor ROR-gamma, N-(5-ethyl-3,3-dimethyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-8-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide
著者Marcotte, D.J.
登録日2016-03-23
公開日2016-06-15
最終更新日2017-11-01
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
Bmc Struct.Biol., 16, 2016
5IZ0
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RORGAMMA IN COMPLEX WITH AGONIST BIO592 AND COACTIVATOR EBI96
分子名称:Nuclear receptor ROR-gamma, GLU-PHE-PRO-TYR-LEU-LEU-SER-LEU-LEU-GLY-GLU-VAL-SER-PRO-GLN, N-(4-ethyl-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-7-yl)-3,4-dimethyl-N-(2,2,2-trifluoroethyl)benzene-1-sulfonamide, ...
著者Marcotte, D.J.
登録日2016-03-24
公開日2016-06-15
実験手法X-RAY DIFFRACTION (2.635 Å)
主引用文献Structural determinant for inducing RORgamma specific inverse agonism triggered by a synthetic benzoxazinone ligand.
Bmc Struct.Biol., 16, 2016
5HZQ
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CRYSTAL STRUCTURE OF CELLULAR RETINOIC ACID BINDING PROTEIN 2 (CRABP2)-ARYL FLUOROSULFATE COVALENT CONJUGATE
分子名称:Cellular retinoic acid-binding protein 2, 4'-[(3,6,9,12-tetraoxapentadec-14-yn-1-yl)oxy][1,1'-biphenyl]-4-yl sulfurofluoridate, GLYCEROL
著者Chen, W., Mortenson, D.E., Wilson, I.A., Kelly, J.W.
登録日2016-02-02
公開日2016-06-01
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue.
J.Am.Chem.Soc., 138, 2016
5CEH
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STRUCTURE OF HISTONE LYSINE DEMETHYLASE KDM5A IN COMPLEX WITH SELECTIVE INHIBITOR
分子名称:Lysine-specific demethylase 5A, Unknown Peptide, NICKEL (II) ION, ...
著者Kiefer, J.R., Vinogradova, M.
登録日2015-07-06
公開日2016-05-18
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.14 Å)
主引用文献An inhibitor of KDM5 demethylases reduces survival of drug-tolerant cancer cells.
Nat.Chem.Biol., 12, 2016
5H94
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CRYSTAL STRUCTURE OF SWINE MHC CLASSI FOR 1.48 ANGSTROMS
分子名称:MHC class I antigen, Beta-2-microglobulin, Nonapeptide from Influenza A virus HA protein
著者Fan, S., Zhang, N., Wang, S., Wu, Y., Xia, C.
登録日2015-12-25
公開日2016-05-18
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Structural and Biochemical Analyses of Swine Major Histocompatibility Complex Class I Complexes and Prediction of the Epitope Map of Important Influenza A Virus Strains
J.Virol., 90, 2016
4ZOU
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CRYSTAL STRUCTURE OF THE BTB DOMAIN OF SLX4
分子名称:Structure-specific endonuclease subunit SLX4
著者Wan, B., Chen, Y., Wu, J., Liu, Y., Lei, M.
登録日2015-05-07
公開日2016-05-04
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The BTB domain is both a structural and functional pivot of the SLX4-nuclease complex
to be published
5I9D
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CRYSTAL STRUCTURE OF DESIGNED PENTATRICOPEPTIDE REPEAT PROTEIN DPPR-U8A2 IN COMPLEX WITH ITS TARGET RNA U8A2
分子名称:pentatricopeptide repeat protein dPPR-U8A2, RNA (5'-R(*GP*GP*GP*G*UP*UP*UP*UP*AP*AP*UP*UP*UP*UP*CP*CP*CP*C)-3')
著者Shen, C., Zhang, D., Guan, Z., Zou, T., Yin, P.
登録日2016-02-20
公開日2016-04-27
実験手法X-RAY DIFFRACTION (2.596 Å)
主引用文献Structure of RNA binding protein with target RNA
Nat Commun, 2016
5I9F
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CRYSTAL STRUCTURE OF DESIGNED PENTATRICOPEPTIDE REPEAT PROTEIN DPPR-U10 IN COMPLEX WITH ITS TARGET RNA U10
分子名称:pentatricopeptide repeat protein dPPR-U10, RNA (5'-R(*GP*GP*GP*GP*UP*UP*UP*UP*UP*UP*UP*UP*UP*UP*CP*CP*CP*C)-3')
著者Shen, C., Zhang, D., Guan, Z., Zou, T., Yin, Y.
登録日2016-02-20
公開日2016-04-27
実験手法X-RAY DIFFRACTION (2.194 Å)
主引用文献Structure of RNA binding protein with target RNA
Nat Commun, 2016
5I9G
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CRYSTAL STRUCTURE OF DESIGNED PENTATRICOPEPTIDE REPEAT PROTEIN DPPR-U8C2 IN COMPLEX WITH ITS TARGET RNA U8C2
分子名称:pentatricopeptide repeat protein dPPR-U8C2, RNA (5'-R(*GP*GP*G*GP*UP*UP*UP*UP*CP*CP*UP*UP*UP*UP*CP*CP*CP*C)-3')
著者Shen, C., Zhang, D., Guan, Z., Zou, T., Yin, P.
登録日2016-02-20
公開日2016-04-27
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.288 Å)
主引用文献Structure of RNA binding protein with target RNA
Nat Commun, 2016
5I9H
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CRYSTAL STRUCTURE OF DESIGNED PENTATRICOPEPTIDE REPEAT PROTEIN DPPR-U8G2 IN COMPLEX WITH ITS TARGET RNA U8G2
分子名称:pentatricopeptide repeat protein dPPR-U8G2, RNA (5'-R(*GP*GP*GP*GP*UP*UP*UP*UP*GP*GP*UP*UP*UP*UP*CP*CP*CP*C)-3')
著者Shen, C., Zhang, D., Guan, Z., Zou, T., Yin, P.
登録日2016-02-20
公開日2016-04-27
最終更新日2017-10-04
実験手法X-RAY DIFFRACTION (2.504 Å)
主引用文献Structure of RNA binding protein with target RNA
Nat Commun, 2016
4ZUS
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE REV-QW11
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLN-ALA-GLU-VAL-LEU-GLN-GLU-ARG-LEU-GLU-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUT
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-GW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUU
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-CF9
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, CYS-THR-SER-GLU-GLU-MET-ASN-ALA-PHE
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUV
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00602) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE ENV-RW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, ARG-VAL-GLU-ASP-VAL-THR-ASN-THR-ALA-GLU-TYR-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
4ZUW
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CRYSTAL STRUCTURE OF EQUINE MHC I(EQCA-N*00601) IN COMPLEXED WITH EQUINE INFECTIOUS ANAEMIA VIRUS (EIAV) DERIVED PEPTIDE GAG-GW12
分子名称:Classical MHC class I antigen, Beta-2-microglobulin, GLY-SER-GLN-LYS-LEU-THR-THR-GLY-ASN-CYS-ASN-TRP
著者Yao, S., Liu, J., Qi, J., Chen, R., Zhang, N., Liu, Y., Xia, C.
登録日2015-05-17
公開日2016-04-06
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Illumination of Equine MHC Class I Molecules Highlights Unconventional Epitope Presentation Manner That Is Evolved in Equine Leukocyte Antigen Alleles
J Immunol., 196, 2016
5EJO
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CRYSTAL STRUCTURE OF THE WINGED HELIX DOMAIN IN CHROMATIN ASSEMBLY FACTOR 1 SUBUNIT P90
分子名称:Chromatin assembly factor 1 subunit p90
著者Zhang, K., Gao, Y., Li, J., Burgess, R., Han, J., Liang, H., Zhang, Z., Liu, Y.
登録日2015-11-02
公開日2016-03-16
最終更新日2016-07-06
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks
Nucleic Acids Res., 44, 2016
5I2K
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH 7-{[ETHYL(4-FLUOROPHENYL)AMINO]METHYL}-N,2-DIMETHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 19)
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-02-09
公開日2016-03-16
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (2.86 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5I2N
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STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH N-ETHYL-7-{[2-FLUORO-3-(TRIFLUOROMETHYL)PHENYL]METHYL}-2-METHYL-5-OXO-5H-[1,3]THIAZOLO[3,2-A]PYRIMIDINE-3-CARBOXAMIDE (COMPOUND 29)
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-02-09
公開日2016-03-16
最終更新日2016-04-06
実験手法X-RAY DIFFRACTION (2.12 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J.Med.Chem., 59, 2016
5F3W
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STRUCTURE OF THE ATPRS-MRE11/RAD50-DNA COMPLEX
分子名称:DNA double-strand break repair protein Mre11, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, 27-MER DNA, ...
著者Liu, Y.
登録日2015-12-03
公開日2016-03-02
最終更新日2016-04-13
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex
Embo J., 35, 2016
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
分子名称:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
著者Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
登録日2014-08-22
公開日2016-02-24
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
5AYW
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STRUCTURE OF A MEMBRANE COMPLEX
分子名称:Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, Outer membrane protein assembly factor BamC, ...
著者Huang, Y., Han, L., Zheng, J.
登録日2015-09-14
公開日2016-02-24
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (3.555 Å)
主引用文献Structure of the BAM complex and its implications for biogenesis of outer-membrane proteins
Nat.Struct.Mol.Biol., 23, 2016
5D0N
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CRYSTAL STRUCTURE OF MAIZE PDRP BOUND WITH AMP
分子名称:Pyruvate, phosphate dikinase regulatory protein, chloroplastic, ...
著者Jiang, L., Chen, Z.
登録日2015-08-03
公開日2016-02-24
最終更新日2016-03-09
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structural Basis of Reversible Phosphorylation by Maize Pyruvate Orthophosphate Dikinase Regulatory Protein
Plant Physiol., 170, 2016
5D1F
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CRYSTAL STRUCTURE OF MAIZE PDRP BOUND WITH AMP AND HG2+
分子名称:Pyruvate, phosphate dikinase regulatory protein, chloroplastic, ...
著者Jiang, L., Chen, Z.
登録日2015-08-04
公開日2016-02-24
実験手法X-RAY DIFFRACTION (3.4 Å)
主引用文献Structural Basis of Reversible Phosphorylation by Maize Pyruvate Orthophosphate Dikinase Regulatory Protein
Plant Physiol., 170, 2016
5DNY
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STRUCTURE OF THE ATPRS-MRE11/RAD50-DNA COMPLEX
分子名称:DNA double-strand break repair protein Mre11, DNA double-strand break repair Rad50 ATPase,DNA double-strand break repair Rad50 ATPase, DNA (27-MER), ...
著者Liu, Y.
登録日2015-09-10
公開日2016-02-24
最終更新日2016-04-20
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献ATP-dependent DNA binding, unwinding, and resection by the Mre11/Rad50 complex.
Embo J., 35, 2016
5FA5
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CRYSTAL STRUCTURE OF PRMT5:MEP50 IN COMPLEX WITH MTA AND H4 PEPTIDE
分子名称:Protein arginine N-methyltransferase 5, Methylosome protein 50, Histone H4, ...
著者Sprague, E.R., McNamara, J.T.
登録日2015-12-10
公開日2016-02-24
最終更新日2016-03-23
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5.
Science, 351, 2016