Author results

5OAC
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FLIP MAJOR CAPSID PROTEIN
Descriptor:Major capsid protein
Authors:De Colibus, L., Stuart, D.I., Huiskonen, J.T.
Deposit date:2017-06-21
Release date:2017-07-26
Last modified:2017-08-09
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Virus found in a boreal lake links ssDNA and dsDNA viruses.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5OSN
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CRYSTAL STRUCTURE OF BOVINE ENTEROVIRUS 2 DETERMINED WITH SERIAL FEMTOSECOND X-RAY CRYSTALLOGRAPHY
Descriptor:Capsid protein, SPHINGOSINE, POTASSIUM ION, ...
Authors:Roedig, P., Ginn, H.M., Pakendorf, T., Sutton, G., Harlos, K., Walter, T.S., Meyer, J., Fischer, P., Duman, R., Vartiainen, I., Reime, B., Warmer, M., Brewster, A.S., Young, I.D., Michels-Clark, T., Sauter, N.K., Kotecha, A., Kelly, J., Rowlands, D.J., Sikorsky, M., Nelson, S., Damiani, D.S., Alonso-Mori, R., Ren, J., Fry, E.E., David, C., Stuart, D.I., Wagner, A., Meents, A.
Deposit date:2017-08-17
Release date:2017-08-30
Last modified:2018-11-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:High-speed fixed-target serial virus crystallography.
Nat. Methods, 14, 2017
5OW6
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CRYOEM STRUCTURE OF RECOMBINANT CMV PARTICLES WITH TETANUS-EPITOPE
Descriptor:VP1, Capsid protein, VP2, ...
Authors:Kotecha, A., Stuart, D.I., Backmann, M.
Deposit date:2017-08-30
Release date:2017-09-13
Last modified:2018-01-03
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Incorporation of tetanus-epitope into virus-like particles achieves vaccine responses even in older recipients in models of psoriasis, Alzheimer's and cat allergy.
NPJ Vaccines, 2, 2017
5OWX
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INSIDE-OUT FMDV A10 CAPSID
Descriptor:Genome polyprotein
Authors:Kotecha, A., Malik, N., Fry, E.E., Stuart, D.I.
Deposit date:2017-09-04
Release date:2017-09-20
Last modified:2017-10-04
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.
PLoS Pathog., 13, 2017
5OYI
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FMDV A10 DISSOCIATED PENTAMER
Descriptor:Genome polyprotein
Authors:Kotecha, A., Malik, N., Stuart, D.I.
Deposit date:2017-09-09
Release date:2017-09-20
Last modified:2018-10-03
Method:ELECTRON MICROSCOPY (8.2 Å)
Cite:Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.
PLoS Pathog., 13, 2017
5WTE
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS FULL PARTICLE
Descriptor:VP1, VP2, VP3
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTF
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS EMPTY PARTICLE
Descriptor:VP1, VP0, VP3
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTG
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HAV ANTIBODY R10
Descriptor:FAB Light chain, FAB Heavy chain
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-11
Release date:2017-01-25
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (2.907 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTH
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS COMPLEXED WITH FAB
Descriptor:Polyprotein, VP2, VP3, ...
Authors:Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
Deposit date:2016-12-12
Release date:2017-01-25
Last modified:2017-02-08
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
6F5U
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH BEPRIDIL
Descriptor:Envelope glycoprotein,Envelope glycoprotein,GP1, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ren, J., Zhao, Y., Fry, E.E., Stuart, D.I.
Deposit date:2017-12-03
Release date:2018-01-03
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Target Identification and Mode of Action of Four Chemically Divergent Drugs against Ebolavirus Infection.
J. Med. Chem., 61, 2018
6G95
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH THIORIDAZINE
Descriptor:Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Zhao, Y., Ren, J., Fry, E.E., Xiao, J., Townsend, A.R., Stuart, D.I.
Deposit date:2018-04-10
Release date:2018-05-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.
J. Med. Chem., 61, 2018
6G9B
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH IMIPRAMINE
Descriptor:Envelope glycoprotein,Envelope glycoprotein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Zhao, Y., Ren, J., Fry, E.E., Xiao, J., Townsend, A.R., Stuart, D.I.
Deposit date:2018-04-10
Release date:2018-05-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.
J. Med. Chem., 61, 2018
6G9I
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH CLOMIPRAMINE
Descriptor:Envelope glycoprotein,Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, GLYCEROL, ...
Authors:Zhao, Y., Ren, J., Fry, E.E., Xiao, J., Townsend, A.R., Stuart, D.I.
Deposit date:2018-04-10
Release date:2018-05-23
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structures of Ebola Virus Glycoprotein Complexes with Tricyclic Antidepressant and Antipsychotic Drugs.
J. Med. Chem., 61, 2018
6H3B
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LYSOZYME: MACHINING PROTEIN MICROCRYSTALS FOR STRUCTURE DETERMINATION BY ELECTRON DIFFRACTION
Descriptor:Lysozyme C, CHLORIDE ION
Authors:Duyvesteyn, H.M.E., Ginn, H.M., Stuart, D.I.
Deposit date:2018-07-18
Release date:2018-09-12
Last modified:2018-09-26
Method:ELECTRON CRYSTALLOGRAPHY (1.9 Å)
Cite:Machining protein microcrystals for structure determination by electron diffraction.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
6HRO
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH INHIBITOR 118A
Descriptor:Envelope glycoprotein,Envelope glycoprotein,Envelope glycoprotein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ren, J., Zhao, Y., Stuart, D.I.
Deposit date:2018-09-27
Release date:2019-02-27
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.
J. Med. Chem., 2019
6HS4
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CRYSTAL STRUCTURE OF EBOLAVIRUS GLYCOPROTEIN IN COMPLEX WITH INHIBITOR 118
Descriptor:Envelope glycoprotein,GP1,Envelope glycoprotein, Envelope glycoprotein, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Ren, J., Zhao, Y., Stuart, D.I.
Deposit date:2018-09-28
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-based In Silico Screening Identifies a Potent Ebolavirus Inhibitor from a Traditional Chinese Medicine Library.
J. Med. Chem., 2019
6I2K
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STRUCTURE OF EV71 COMPLEXED WITH ITS RECEPTOR SCARB2
Descriptor:Polyprotein, Lysosome membrane protein 2, 1-(2-aminopyridin-4-yl)-3-[(3S)-5-{4-[(E)-(ethoxyimino)methyl]phenoxy}-3-methylpentyl]imidazolidin-2-one, ...
Authors:Zhou, D., Zhao, Y., Kotecha, A., Fry, E.E., Kelly, J., Wang, X., Rao, Z., Rowlands, D.J., Ren, J., Stuart, D.I.
Deposit date:2018-11-01
Release date:2018-11-28
Last modified:2019-03-06
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Unexpected mode of engagement between enterovirus 71 and its receptor SCARB2.
Nat Microbiol, 4, 2019
6J7V
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STRUCTURE OF HRPV6 VP5 FITTED IN THE CRYOEM DENSITY OF THE SPIKE
Descriptor:VP5
Authors:El Omari, K., Li, S., Huiskonen, J.T., Stuart, D.I.
Deposit date:2019-01-18
Release date:2019-03-06
Method:ELECTRON MICROSCOPY (16 Å)
Cite:The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.
Nat Commun, 10, 2019
6QGI
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CRYSTAL STRUCTURE OF VP5 FROM HALOARCHAEAL PLEOMORPHIC VIRUS 2
Descriptor:VP5, N-ACETYL-D-GLUCOSAMINE, CHLORIDE ION
Authors:El Omari, K., Walter, T.S., Harlos, K., Grimes, J.M., Stuart, D.I., Roine, E.
Deposit date:2019-01-11
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.46 Å)
Cite:The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.
Nat Commun, 10, 2019
6QGL
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CRYSTAL STRUCTURE OF VP5 FROM HALOARCHAEAL PLEOMORPHIC VIRUS 6
Descriptor:VP5, BROMIDE ION
Authors:El Omari, K., Walter, T.S., Harlos, K., Grimes, J.M., Stuart, D.I., Roine, E.
Deposit date:2019-01-11
Release date:2019-02-27
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:The structure of a prokaryotic viral envelope protein expands the landscape of membrane fusion proteins.
Nat Commun, 10, 2019
1S1T
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, PHOSPHATE ION, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1U
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1V
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CRYSTAL STRUCTURE OF L100I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH TNK-651
Descriptor:Reverse transcriptase, 6-BENZYL-1-BENZYLOXYMETHYL-5-ISOPROPYL URACIL
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1W
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CRYSTAL STRUCTURE OF V106A MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH UC-781
Descriptor:Reverse transcriptase, 2-METHYL-FURAN-3-CARBOTHIOIC ACID [4-CHLORO-3-(3-METHYL-BUT-2-ENYLOXY)-PHENYL]-AMIDE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004
1S1X
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CRYSTAL STRUCTURE OF V108I MUTANT HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH NEVIRAPINE
Descriptor:Reverse transcriptase, 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE
Authors:Ren, J., Nichols, C.E., Chamberlain, P.P., Stammers, D.K.
Deposit date:2004-01-07
Release date:2004-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of HIV-1 reverse transcriptases mutated at codons 100, 106 and 108 and mechanisms of resistance to non-nucleoside inhibitors
J.Mol.Biol., 336, 2004