Author results

5WQ8
  • Download 5wq8
  • View 5wq8
Molmil generated image of 5wq8
CRYOEM STRUCTURE OF TYPE II SECRETION SYSTEM SECRETIN GSPD IN VIBRIO CHOLERAE
分子名称:Type II secretion system protein D
著者Yan, Z., Yin, M., Li, X.
登録日2016-11-23
公開日2016-12-28
最終更新日2017-02-22
実験手法ELECTRON MICROSCOPY (3.26 Å)
主引用文献Structural insights into the secretin translocation channel in the type II secretion system
Nat. Struct. Mol. Biol., 24, 2017
5WQ9
  • Download 5wq9
  • View 5wq9
Molmil generated image of 5wq9
CRYOEM STRUCTURE OF TYPE II SECRETION SYSTEM SECRETIN GSPD G453A MUTANT IN VIBRIO CHOLERAE
分子名称:Type II secretion system protein D
著者Yan, Z., Yin, M., Li, X.
登録日2016-11-23
公開日2016-12-28
最終更新日2017-02-22
実験手法ELECTRON MICROSCOPY (4.22 Å)
主引用文献Structural insights into the secretin translocation channel in the type II secretion system
Nat. Struct. Mol. Biol., 24, 2017
5XR8
  • Download 5xr8
  • View 5xr8
Molmil generated image of 5xr8
CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM841
分子名称:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,9R,10aR)-3-(8-azanyl-2-methyl-octan-2-yl)-9-(hydroxymethyl)-6,6-dimethyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol, ...
著者Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
登録日2017-06-07
公開日2017-07-12
最終更新日2017-11-08
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
5XRA
  • Download 5xra
  • View 5xra
Molmil generated image of 5xra
CRYSTAL STRUCTURE OF THE HUMAN CB1 IN COMPLEX WITH AGONIST AM11542
分子名称:Cannabinoid receptor 1,Flavodoxin,Cannabinoid receptor 1, FLAVIN MONONUCLEOTIDE, (6aR,10aR)-3-(8-bromanyl-2-methyl-octan-2-yl)-6,6,9-trimethyl-6a,7,10,10a-tetrahydrobenzo[c]chromen-1-ol, ...
著者Hua, T., Vemuri, K., Nikas, P.S., Laprairie, R.B., Wu, Y., Qu, L., Pu, M., Korde, A., Shan, J., Ho, J.H., Han, G.W., Ding, K., Li, X., Liu, H., Hanson, M.A., Zhao, S., Bohn, L.M., Makriyannis, A., Stevens, R.C., Liu, Z.J.
登録日2017-06-08
公開日2017-07-12
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structures of agonist-bound human cannabinoid receptor CB1
Nature, 547, 2017
5YEF
  • Download 5yef
  • View 5yef
Molmil generated image of 5yef
CRYSTAL STRUCTURE OF CTCF ZFS2-8-HS5-1AE
分子名称:Transcriptional repressor CTCF, DNA (27-MER), ZINC ION
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-17
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2.807 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEG
  • Download 5yeg
  • View 5yeg
Molmil generated image of 5yeg
CRYSTAL STRUCTURE OF CTCF ZFS4-8-HS5-1A COMPLEX
分子名称:Transcriptional repressor CTCF, DNA (5'-D(*TP*CP*GP*CP*CP*CP*TP*CP*TP*GP*CP*TP*GP*GP*TP*TP*AP*AP*AP*G)-3'), DNA (5'-D(*AP*CP*TP*TP*TP*AP*AP*CP*CP*AP*GP*CP*AP*GP*AP*GP*GP*GP*CP*G)-3'), ...
著者Yin, M., Wang, J., Wang, M., Li, X.
登録日2017-09-17
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEH
  • Download 5yeh
  • View 5yeh
Molmil generated image of 5yeh
CRYSTAL STRUCTURE OF CTCF ZFS4-8-ECBS
分子名称:Transcriptional repressor CTCF, DNA (5'-D(*AP*CP*GP*GP*TP*TP*TP*CP*CP*GP*CP*TP*AP*GP*AP*GP*GP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*CP*CP*TP*CP*TP*AP*GP*CP*GP*GP*AP*AP*AP*CP*CP*G)-3'), ...
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-17
公開日2017-11-29
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (2.328 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEL
  • Download 5yel
  • View 5yel
Molmil generated image of 5yel
CRYSTAL STRUCTURE OF CTCF ZFS6-11-GB7CSE
分子名称:DNA (26-MER), Transcriptional repressor CTCF, ZINC ION
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-18
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5Z10
  • Download 5z10
  • View 5z10
Molmil generated image of 5z10
STRUCTURE OF THE MECHANOSENSITIVE PIEZO1 CHANNEL
分子名称:Piezo-type mechanosensitive ion channel component 1
著者Zhao, Q., Zhou, H., Chi, S., Wang, Y., Wang, J., Geng, J., Wu, K., Liu, W., Zhang, T., Dong, M.-Q., Wang, J., Li, X., Xiao, B.
登録日2017-12-22
公開日2018-01-31
最終更新日2018-03-07
実験手法ELECTRON MICROSCOPY (3.97 Å)
主引用文献Structure and mechanogating mechanism of the Piezo1 channel.
Nature, 554, 2018
5ZDH
  • Download 5zdh
  • View 5zdh
Molmil generated image of 5zdh
CRYOEM STRUCTURE OF ETEC PILOTIN-SECRETIN ASPS-GSPD COMPLEX
分子名称:Type II secretion system protein D, Type II secretion system lipoprotein
著者Yin, M., Yan, Z., Li, X.
登録日2018-02-23
公開日2018-04-18
最終更新日2018-06-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural insight into the assembly of the type II secretion system pilotin-secretin complex from enterotoxigenic Escherichia coli.
Nat Microbiol, 3, 2018
5ZKS
  • Download 5zks
  • View 5zks
Molmil generated image of 5zks
CRYSTAL STRUCTURE OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6
分子名称:DFA-IIIase
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZKU
  • Download 5zku
  • View 5zku
Molmil generated image of 5zku
CRYSTAL STRUCTURE OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6 IN COMPLEX WITH DFA-III
分子名称:DFA-IIIase, (2R,3'S,4'S,4aR,5'R,6R,7R,7aS)-4a,5',6-tris(hydroxymethyl)spiro[3,6,7,7a-tetrahydrofuro[2,3-b][1,4]dioxine-2,2'-oxolane]-3',4',7-triol
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (2.32 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZKW
  • Download 5zkw
  • View 5zkw
Molmil generated image of 5zkw
CRYSTAL STRUCTURE OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6 IN COMPLEX WITH GF2
分子名称:DFA-IIIase, FRUCTOSE, ALPHA-D-GLUCOSE
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZKY
  • Download 5zky
  • View 5zky
Molmil generated image of 5zky
CRYSTAL STRUCTURE OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6 WITHOUT ITS LID
分子名称:DFA-IIIase
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZL4
  • Download 5zl4
  • View 5zl4
Molmil generated image of 5zl4
CRYSTAL STRUCTURE OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6 WIHOUT ITS LID IN COMPLEX WITH GF2
分子名称:DFA-IIIase, beta-D-fructofuranosyl-(2->1)-beta-D-fructofuranosyl alpha-D-glucopyranoside
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZL5
  • Download 5zl5
  • View 5zl5
Molmil generated image of 5zl5
CRYSTAL STRUCTURE OF DFA-IIIASE MUTANT C387A FROM ARTHROBACTER CHLOROPHENOLICUS A6
分子名称:DFA-IIIase C387A mutant, GLYCEROL
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-26
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
5ZLA
  • Download 5zla
  • View 5zla
Molmil generated image of 5zla
CRYSTAL STRUCTURE OF MUTANT C387A OF DFA-IIIASE FROM ARTHROBACTER CHLOROPHENOLICUS A6 IN COMPLEX WITH DFA-III
分子名称:DFA-IIIase C387A mutant, (2R,3'S,4'S,4aR,5'R,6R,7R,7aS)-4a,5',6-tris(hydroxymethyl)spiro[3,6,7,7a-tetrahydrofuro[2,3-b][1,4]dioxine-2,2'-oxolane]-3',4',7-triol
著者Yu, S.H., Shen, H., Li, X., Mu, W.M.
登録日2018-03-27
公開日2018-12-19
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Structural and functional basis of difructose anhydride III hydrolase, which sequentially converts inulin using the same catalytic residue
Acs Catalysis, 8, 2018
6BK8
  • Download 6bk8
  • View 6bk8
Molmil generated image of 6bk8
S. CEREVISIAE SPLICEOSOMAL POST-CATALYTIC P COMPLEX
分子名称:U2 snRNA, U5 snRNA, U6 snRNA, ...
著者Liu, S., Li, X., Zhou, Z.H., Zhao, R.
登録日2017-11-07
公開日2018-02-21
最終更新日2018-02-28
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structure of the yeast spliceosomal postcatalytic P complex.
Science, 358, 2017
6E7P
  • Download 6e7p
  • View 6e7p
Molmil generated image of 6e7p
CRYO-EM STRUCTURE OF HUMAN TRPML1 WITH PI35P2
分子名称:Mucolipin-1, (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)]
著者Schmiege, P., Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6E7Y
  • Download 6e7y
  • View 6e7y
Molmil generated image of 6e7y
CRYO-EM STRUCTURE OF HUMAN TRPML1 WITH PI45P2
分子名称:Mucolipin-1, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Schmiege, P., Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.57 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6E7Z
  • Download 6e7z
  • View 6e7z
Molmil generated image of 6e7z
CRYO-EM STRUCTURE OF HUMAN TRPML1 WITH ML-SA1 AND PI35P2
分子名称:Mucolipin-1, (1R,2S,3S,4R,5S,6R)-5-{[(R)-[(2R)-2,3-bis{[(1S)-1-hydroxyoctyl]oxy}propoxy](hydroxy)phosphoryl]oxy}-2,4,6-trihydroxycyclohexane-1,3-diyl bis[dihydrogen (phosphate)], 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione
著者Schmiege, P., Li, X.
登録日2018-07-27
公開日2018-11-28
実験手法ELECTRON MICROSCOPY (3.73 Å)
主引用文献Structural basis for PtdInsP2-mediated human TRPML1 regulation.
Nat Commun, 9, 2018
6GQJ
  • Download 6gqj
  • View 6gqj
Molmil generated image of 6gqj
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 18)
分子名称:Mast/stem cell growth factor receptor Kit, 2-[4-(6,7-dimethoxyquinazolin-4-yl)oxy-2-methoxy-phenyl]-~{N}-(1-propan-2-ylpyrazol-4-yl)ethanamide
著者Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (2.33 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQK
  • Download 6gqk
  • View 6gqk
Molmil generated image of 6gqk
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 23)
分子名称:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(1-ethylpyrazol-4-yl)ethanamide
著者Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQL
  • Download 6gql
  • View 6gql
Molmil generated image of 6gql
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH AZD3229-ANALOGUE (COMPOUND 35)
分子名称:Mast/stem cell growth factor receptor Kit, ~{N}-[4-(6,7-dimethoxyquinazolin-4-yl)oxyphenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide
著者Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018
6GQM
  • Download 6gqm
  • View 6gqm
Molmil generated image of 6gqm
CRYSTAL STRUCTURE OF HUMAN C-KIT KINASE DOMAIN IN COMPLEX WITH A SMALL MOLECULE INHIBITOR, AZD3229
分子名称:Mast/stem cell growth factor receptor Kit, ~{N}-[4-[[5-fluoranyl-7-(2-methoxyethoxy)quinazolin-4-yl]amino]phenyl]-2-(4-propan-2-yl-1,2,3-triazol-1-yl)ethanamide, CHLORIDE ION
著者Schimpl, M., Hardy, C.J., Ogg, D.J., Overman, R.C., Packer, M.J., Kettle, J.G., Anjum, R., Barry, E., Bhavsar, D., Brown, C., Campbell, A., Goldberg, K., Grondine, M., Guichard, S., Hunt, T., Jones, O., Li, X., Moleva, O., Pearson, S., Shao, W., Smith, A., Smith, J., Stead, D., Stokes, S., Tucker, M., Ye, Y.
登録日2018-06-07
公開日2018-09-19
最終更新日2018-10-31
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Discovery of N-(4-{[5-Fluoro-7-(2-methoxyethoxy)quinazolin-4-yl]amino}phenyl)-2-[4-(propan-2-yl)-1 H-1,2,3-triazol-1-yl]acetamide (AZD3229), a Potent Pan-KIT Mutant Inhibitor for the Treatment of Gastrointestinal Stromal Tumors.
J. Med. Chem., 61, 2018