Author results

5KUY
  • Download 5kuy
  • View 5kuy
Molmil generated image of 5kuy
INFLUENZA HEMAGGLUTININ H3 A/HONG KONG/1/1968 IN COMPLEX WITH DESIGNED INHIBITOR PROTEIN HSB.2A
Descriptor:Hemagglutinin HA1, Hemagglutinin HA2, Designed influenza inhibitor HSB.2A, ...
Authors:Bernard, S.M., Wilson, I.A.
Deposit date:2016-07-13
Release date:2017-06-14
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.598 Å)
Cite:Computational design of trimeric influenza-neutralizing proteins targeting the hemagglutinin receptor binding site.
Nat. Biotechnol., 35, 2017
5UN5
  • Download 5un5
  • View 5un5
Molmil generated image of 5un5
FRIZZLED-8 COMPLEX WITH DESIGNED SURROGATE WNT AGONIST, CRYSTAL FORM 1
Descriptor:Frizzled-8, Designed Wnt agonist B12
Authors:Janda, C.Y., Garcia, K.C.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (2.994 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
5UN6
  • Download 5un6
  • View 5un6
Molmil generated image of 5un6
FRIZZLED-8 COMPLEX WITH DESIGNED SURROGATE WNT AGONIST, A1 DATASET
Descriptor:Frizzled-8, Designed Wnt agonist B12
Authors:Janda, C.Y., Garcia, K.C., Jude, K.M.
Deposit date:2017-01-30
Release date:2017-05-03
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Surrogate Wnt agonists that phenocopy canonical Wnt and beta-catenin signalling.
Nature, 545, 2017
6P6F
  • Download 6p6f
  • View 6p6f
Molmil generated image of 6p6f
BG505 SOSIP-I53-50NP
Descriptor:I53-50A.1NT1, I53-50B.4PT1
Authors:Berndsen, Z.T., Ward, A.B.
Deposit date:2019-06-03
Release date:2019-06-19
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers by presentation on a two-component protein nanoparticle
To be Published
1TVG
  • Download 1tvg
  • View 1tvg
Molmil generated image of 1tvg
X-RAY STRUCTURE OF HUMAN PP25 GENE PRODUCT, HSPC034. NORTHEAST STRUCTURAL GENOMICS TARGET HR1958.
Descriptor:LOC51668 protein, CALCIUM ION, SAMARIUM (III) ION
Authors:Kuzin, A.P., Vorobiev, S.M., Lee, I., Acton, T.B., Montelione, G.T., Tong, L., Hunt, J.F., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-06-29
Release date:2004-11-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study.
Proteins, 75, 2009
1XPW
  • Download 1xpw
  • View 1xpw
Molmil generated image of 1xpw
SOLUTION NMR STRUCTURE OF HUMAN PROTEIN HSPCO34. NORTHEAST STRUCTURAL GENOMICS TARGET HR1958
Descriptor:LOC51668 protein
Authors:Ramelot, T.A., Xiao, R., Ma, L.C., Acton, T.B., Montelione, G.T., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-10-09
Release date:2004-11-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Improving NMR protein structure quality by Rosetta refinement: a molecular replacement study.
Proteins, 75, 2009
2GJF
  • Download 2gjf
  • View 2gjf
Molmil generated image of 2gjf
NMR STRUCTURE OF THE COMPUTATIONALLY DESIGNED PROCARBOXYPEPTIDASE-A (1AYE) DOMAIN
Descriptor:DESIGNED PROTEIN
Authors:Reichow, S.
Deposit date:2006-03-30
Release date:2007-01-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:High-resolution structural and thermodynamic analysis of extreme stabilization of human procarboxypeptidase by computational protein design.
J.Mol.Biol., 366, 2007
2GJH
  • Download 2gjh
  • View 2gjh
Molmil generated image of 2gjh
NMR STRUCTURE OF CFR (C-TERMINAL FRAGMENT OF COMPUTATIONALLY DESIGNED NOVEL-TOPOLOGY PROTEIN TOP7)
Descriptor:DESIGNED PROTEIN
Authors:Dantas, G.
Deposit date:2006-03-30
Release date:2006-10-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Mis-translation of a Computationally Designed Protein Yields an Exceptionally Stable Homodimer: Implications for Protein Engineering and Evolution.
J.Mol.Biol., 362, 2006
2KZN
  • Download 2kzn
  • View 2kzn
Molmil generated image of 2kzn
SOLUTION NMR STRUCTURE OF PEPTIDE METHIONINE SULFOXIDE REDUCTASE MSRB FROM BACILLUS SUBTILIS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET SR10
Descriptor:Peptide methionine sulfoxide reductase msrB
Authors:Ertekin, A., Maglaqui, M., Janjua, H., Cooper, B., Ciccosanti, C., Rost, B., Acton, T.B., Xiao, R., Everett, J.K., Prestegard, J., Lee, H., Aramini, J.M., Rossi, P., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2010-06-18
Release date:2010-07-07
Last modified:2012-07-18
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LMD
  • Download 2lmd
  • View 2lmd
Molmil generated image of 2lmd
MINIMAL CONSTRAINTS SOLUTION NMR STRUCTURE OF PROSPERO HOMEOBOX PROTEIN 1 FROM HOMO SAPIENS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HR4660B
Descriptor:Prospero homeobox protein 1
Authors:Rossi, P., Lange, O.A., Lee, H., Maglaqui, M., Janjua, H., Ciccosanti, C., Zhao, L., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2011-11-29
Release date:2011-12-21
Last modified:2012-07-18
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LNU
  • Download 2lnu
  • View 2lnu
Molmil generated image of 2lnu
SOLUTION NMR STRUCTURE OF THE UNCHARACTERIZED PROTEIN FROM GENE LOCUS RRNAC0354 OF HALOARCULA MARISMORTUI, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HMR11
Descriptor:Uncharacterized protein
Authors:Rossi, P., Liu, G., Lange, O.F., Lee, H., Janjua, H., Ciccosanti, C., Wang, H., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-01-05
Release date:2012-01-18
Last modified:2012-07-18
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LOK
  • Download 2lok
  • View 2lok
Molmil generated image of 2lok
SOLUTION NMR STRUCTURE OF THE UNCHARACTERIZED PROTEIN FROM GENE LOCUS VNG_0733H OF HALOBACTERIUM SALINARIUM, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET HSR50
Descriptor:Uncharacterized protein
Authors:Rossi, P., Lange, O.F., Lee, H., Hamilton, K., Ciccosanti, C., Buchwald, W.A., Wang, H., Acton, T.B., Xiao, R., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-01-24
Release date:2012-02-01
Last modified:2012-07-18
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
2LOY
  • Download 2loy
  • View 2loy
Molmil generated image of 2loy
REFINED MIMINAL CONSTRAINT SOLUTION NMR STRUCTURE OF TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN (TCTP) FROM CAENORHABDITIS ELEGANS, NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET WR73
Descriptor:Translationally-controlled tumor protein homolog
Authors:Aramini, J.M., Rossi, P., Cort, J.R., Lee, H., Janjua, H., Maglaqui, M., Cooper, B., Xiao, R., Acton, T.B., Everett, J.K., Montelione, G.T., Northeast Structural Genomics Consortium (NESG)
Deposit date:2012-01-27
Release date:2012-02-15
Last modified:2012-07-25
Method:SOLUTION NMR
Cite:Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples.
Proc.Natl.Acad.Sci.USA, 109, 2012
2MKY
  • Download 2mky
  • View 2mky
Molmil generated image of 2mky
STRUCTURE OF THE PRGK FIRST PERIPLASMIC DOMAIN
Descriptor:Pathogenicity 1 island effector protein
Authors:Bergeron, J., Mcintosh, L., Strynadka, N.
Deposit date:2014-02-14
Release date:2014-10-29
Last modified:2015-02-11
Method:SOLUTION NMR
Cite:The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body.
Structure, 23, 2015
2MT6
  • Download 2mt6
  • View 2mt6
Molmil generated image of 2mt6
SOLUTION STRUCTURE OF THE HUMAN UBIQUITIN CONJUGATING ENZYME UBE2W
Descriptor:Ubiquitin-conjugating enzyme E2 W
Authors:Vittal, V., Shi, L., Wenzel, D.M., Brzovic, P.S., Klevit, R.E.
Deposit date:2014-08-14
Release date:2014-11-26
Last modified:2015-01-14
Method:SOLUTION NMR
Cite:Intrinsic disorder drives N-terminal ubiquitination by Ube2w.
Nat.Chem.Biol., 11, 2015
2N0K
  • Download 2n0k
  • View 2n0k
Molmil generated image of 2n0k
CHEMICAL SHIFT ASSIGNMENTS AND STRUCTURE OF THE ALPHA-CRYSTALLIN DOMAIN FROM HUMAN, HSPB5
Descriptor:Alpha-crystallin B chain
Authors:Rajagopal, P., Klevit, R.E., Shi, L., Baker, D.
Deposit date:2015-03-09
Release date:2015-06-03
Last modified:2017-02-15
Method:SOLUTION NMR
Cite:A conserved histidine modulates HSPB5 structure to trigger chaperone activity in response to stress-related acidosis.
Elife, 4, 2015
2P1Y
  • Download 2p1y
  • View 2p1y
Molmil generated image of 2p1y
1.B2.D9, A BISPECIFIC ALPHA/BETA TCR
Descriptor:bispecific alpha/beta TCR
Authors:McBeth, C., Pizarro, J.C., Strong, R.K.
Deposit date:2007-03-06
Release date:2008-02-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.42 Å)
Cite:A new twist in TCR diversity revealed by a forbidden alphabeta TCR.
J.Mol.Biol., 375, 2008
2P24
  • Download 2p24
  • View 2p24
Molmil generated image of 2p24
I-AU/MBP125-135
Descriptor:H-2 class II histocompatibility antigen, A-U alpha chain, A-U beta chain
Authors:McBeth, C., Strong, R.K.
Deposit date:2007-03-06
Release date:2008-01-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A new twist in TCR diversity revealed by a forbidden alphabeta TCR.
J.Mol.Biol., 375, 2008
2Y92
  • Download 2y92
  • View 2y92
Molmil generated image of 2y92
CRYSTAL STRUCTURE OF MAL ADAPTOR PROTEIN
Descriptor:TOLL/INTERLEUKIN-1 RECEPTOR DOMAIN-CONTAINING ADAPTER PROTEIN,, 2,3-DIHYDROXY-1,4-DITHIOBUTANE
Authors:Valkov, E., Stamp, A., Martin, J.L., Kobe, B.
Deposit date:2011-02-11
Release date:2011-09-14
Last modified:2011-10-19
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Crystal Structure of Toll-Like Receptor Adaptor Mal/Tirap Reveals the Molecular Basis for Signal Transduction and Disease Protection.
Proc.Natl.Acad.Sci.USA, 108, 2011
3CQU
  • Download 3cqu
  • View 3cqu
Molmil generated image of 3cqu
CRYSTAL STRUCTURE OF AKT-1 COMPLEXED WITH SUBSTRATE PEPTIDE AND INHIBITOR
Descriptor:RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, N-[2-(5-methyl-4H-1,2,4-triazol-3-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Authors:Pandit, J.
Deposit date:2008-04-03
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3CQW
  • Download 3cqw
  • View 3cqw
Molmil generated image of 3cqw
CRYSTAL STRUCTURE OF AKT-1 COMPLEXED WITH SUBSTRATE PEPTIDE AND INHIBITOR
Descriptor:RAC-alpha serine/threonine-protein kinase, Glycogen synthase kinase-3 beta, MANGANESE (II) ION, ...
Authors:Pandit, J.
Deposit date:2008-04-03
Release date:2008-05-27
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Synthesis and structure based optimization of novel Akt inhibitors
Bioorg.Med.Chem.Lett., 18, 2008
3GR0
  • Download 3gr0
  • View 3gr0
Molmil generated image of 3gr0
PERIPLASMIC DOMAIN OF THE T3SS INNER MEMBRANE PROTEIN PRGH FROM S.TYPHIMURIUM (FRAGMENT 170-362)
Descriptor:Protein prgH
Authors:Yip, C.K., Vockovic, M., Yu, A.C., Strynadka, N.C.J.
Deposit date:2009-03-24
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Nat.Struct.Mol.Biol., 16, 2009
3GR1
  • Download 3gr1
  • View 3gr1
Molmil generated image of 3gr1
PERIPLASMIC DOMAIN OF THE T3SS INNER MEMBRANE PROTEIN PRGH FROM S.TYPHIMURIUM (FRAGMENT 170-392)
Descriptor:Protein prgH
Authors:Yip, C.K., Vockovic, M., Yu, A.C., Strynadka, N.C.J.
Deposit date:2009-03-24
Release date:2009-05-19
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Nat.Struct.Mol.Biol., 16, 2009
3GR5
  • Download 3gr5
  • View 3gr5
Molmil generated image of 3gr5
PERIPLASMIC DOMAIN OF THE OUTER MEMBRANE SECRETIN ESCC FROM ENTEROPATHOGENIC E.COLI (EPEC)
Descriptor:EscC, SULFATE ION
Authors:Yip, C.K., Vockovic, M., Strynadka, N.C.J.
Deposit date:2009-03-24
Release date:2009-05-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:A conserved structural motif mediates formation of the periplasmic rings in the type III secretion system.
Nat.Struct.Mol.Biol., 16, 2009
3J6D
  • Download 3j6d
  • View 3j6d
Molmil generated image of 3j6d
MODEL OF THE PRGH-PRGK PERIPLASMIC RINGS
Descriptor:Protein PrgH, Pathogenicity 1 island effector protein
Authors:Bergeron, J.R.C., Strynadka, N.C.J.
Deposit date:2014-02-14
Release date:2015-01-14
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (11.7 Å)
Cite:The Modular Structure of the Inner-Membrane Ring Component PrgK Facilitates Assembly of the Type III Secretion System Basal Body.
Structure, 23, 2015