Author results

2XIQ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN AND MALONYL-COA
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, COBALAMIN, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Ugochukwu, E., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010
4CRS
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HUMAN PROTEIN KINASE N2 (PKN2, PRKCL2) IN COMPLEX WITH ATPGAMMAS
Descriptor:SERINE/THREONINE-PROTEIN KINASE N2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, MAGNESIUM ION, ...
Authors:Mathea, S., Elkins, J.M., Shrestha, L., Szklarz, M., Tallant, C., Newman, J.A., Cooper, C.D., Shrestha, B., Tumber, A., Cocking, R., Salah, E., von Delft, F., Arrowsmith, C., Edwards, A.M., Bountra, C., Knapp, S.
Deposit date:2014-02-28
Release date:2014-03-12
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:Structure of Pkn2
To be Published
4CVH
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CRYSTAL STRUCTURE OF HUMAN ISOPRENOID SYNTHASE DOMAIN-CONTAINING PROTEIN
Descriptor:ISOPRENOID SYNTHASE DOMAIN-CONTAINING PROTEIN, MAGNESIUM ION, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Froese, D.S., Krojer, T., Newman, J., Kiyani, W., Goubin, S., Strain-Damerell, C., Vollmar, M., von Delft, F., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Lefeber, D.J., Yue, W.W.
Deposit date:2014-03-27
Release date:2015-02-04
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Human Ispd is a Cytidyltransferase Required for Dystroglycan O-Mannosylation.
Chem.Biol., 22, 2015
4CXA
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CRYSTAL STRUCTURE OF THE HUMAN CDK12-CYCLIN K COMPLEX BOUND TO AMPPNP
Descriptor:CYCLIN-DEPENDENT KINASE 12, CYCLIN-K, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Dixon Clarke, S.E., Elkins, J.M., Pike, A.C.W., Nowak, R., Goubin, S., Mahajan, R.P., Kopec, J., Froese, S., Tallant, C., Carpenter, E.P., Mackenzie, A., Faust, B., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A.M., Bountra, C., Bullock, A.
Deposit date:2014-04-04
Release date:2014-05-21
Last modified:2015-12-09
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Structures of the Cdk12/Cyck Complex with AMP-Pnp Reveal a Flexible C-Terminal Kinase Extension Important for ATP Binding.
Sci.Rep., 5, 2015
4D0N
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AKAP13 (AKAP-LBC) RHOGEF DOMAIN IN COMPLEX WITH RHOA
Descriptor:TRANSFORMING PROTEIN RHOA, A-KINASE ANCHOR PROTEIN 13, GUANOSINE-5'-DIPHOSPHATE, ...
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
4D0O
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AKAP13 (AKAP-LBC) DH DOMAIN
Descriptor:A-KINASE ANCHOR PROTEIN 13
Authors:Abdul Azeez, K.R., Shrestha, L., Krojer, T., Allerston, C., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Klussmann, E., Elkins, J.M.
Deposit date:2014-04-29
Release date:2014-05-21
Last modified:2014-11-26
Method:X-RAY DIFFRACTION (2.75 Å)
Cite:The Crystal Structure of the Rhoa : Akap-Lbc Dh-Ph Domain Complex.
Biochem.J., 464, 2014
5AIL
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HUMAN PARP9 2ND MACRODOMAIN
Descriptor:POLY [ADP-RIBOSE] POLYMERASE 9, 1,2-ETHANEDIOL, POLYETHYLENE GLYCOL (N=34), ...
Authors:Sieg, C., Shrestha, L., Talon, R., Sorrell, F., Williams, E., von Delft, F., Bountra, C., Arrowsmith, C., Edwards, A.M., Knapp, S., Elkins, J.M.
Deposit date:2015-02-15
Release date:2015-02-25
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structure of Parp9 2Nd Macrodomain
To be Published
5IN3
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CRYSTAL STRUCTURE OF GLUCOSE-1-PHOSPHATE BOUND NUCLEOTIDYLATED HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
Descriptor:Galactose-1-phosphate uridylyltransferase, ZINC ION, 5,6-DIHYDROURIDINE-5'-MONOPHOSPHATE, ...
Authors:Kopec, J., McCorvie, T., Tallant, C., Velupillai, S., Shrestha, L., Fitzpatrick, F., Patel, D., Chalk, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, A., Bountra, C., Yue, W.W.
Deposit date:2016-03-07
Release date:2016-03-30
Last modified:2017-08-30
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis of classic galactosemia from the structure of human galactose 1-phosphate uridylyltransferase.
Hum.Mol.Genet., 25, 2016
5L78
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CRYSTAL STRUCTURE OF HUMAN AMINOADIPATE SEMIALDEHYDE SYNTHASE, SACCHAROPINE DEHYDROGENASE DOMAIN (IN NAD+ BOUND FORM)
Descriptor:Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Pena, I.A., Rembeza, E., Strain-Damerell, C., Chalk, R., Borkowska, O., Goubin, S., Velupillai, S., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Arruda, P., Yue, W.W.
Deposit date:2016-06-02
Release date:2017-05-10
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain (in NAD+ bound form)
To Be Published
5NFJ
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CRYSTAL STRUCTURE OF THE METHYLTRANSFERASE SUBUNIT OF HUMAN MITOCHONDRIAL RIBONUCLEASE P (MRPP1) BOUND TO S-ADENOSYL-METHIONINE (SAM)
Descriptor:Mitochondrial ribonuclease P protein 1, S-ADENOSYLMETHIONINE, GLYCEROL, ...
Authors:Oerum, S., Kopec, J., Fitzpatrick, F., Newman, J.A., Chalk, R., Shrestha, L., Fairhead, M., Talon, R., Burgess-Brown, N., von Delft, F., Arrowsmith, C., Edwards, C., Bountra, C., Oppermann, U., Yue, W.W., Structural Genomics Consortium (SGC)
Deposit date:2017-03-14
Release date:2018-05-16
Method:X-RAY DIFFRACTION (1.96 Å)
Cite:Crystal structure of the methyltransferase subunit of human mitochondrial Ribonuclease P (MRPP1) bound to S-adenosyl-methionine (SAM)
To Be Published
5O1N
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CRYSTAL STRUCTURE OF HUMAN AMINOADIPATE SEMIALDEHYDE SYNTHASE, SACCHAROPINE DEHYDROGENASE DOMAIN WITH N-[(2S)-2-PYRROLIDINYLMETHYL]-TRIFLUOROMETHANESULFONAMIDE BOUND
Descriptor:Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1,1,1-tris(fluoranyl)-~{N}-[[(2~{S})-pyrrolidin-2-yl]methyl]methanesulfonamide, ...
Authors:Kopec, J., Rembeza, E., Pena, I.A., Strain-Damerell, C., Goubin, S., Sethi, R., Velupillai, S., Talon, R., Collins, P., Krojer, T., McLaughlin, M., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., Brennan, P., von Delft, F., Arruda, P., Yue, W.W.
Deposit date:2017-05-18
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with N-[(2S)-2-Pyrrolidinylmethyl]-trifluoromethanesulfonamide bound
To Be Published
5O1O
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CRYSTAL STRUCTURE OF HUMAN AMINOADIPATE SEMIALDEHYDE SYNTHASE, SACCHAROPINE DEHYDROGENASE DOMAIN WITH PROLINE BOUND.
Descriptor:Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Rembeza, E., Pena, I.A., Mathea, S., Velupillai, S., Strain-Damerell, C., Goubin, S., Kupinska, K., Talon, R., Collins, P., Krojer, T., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., von Delft, F., Arruda, P., Yue, W.W.
Deposit date:2017-05-18
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.48 Å)
Cite:Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase domain with proline bound.
To Be Published
5O1P
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CRYSTAL STRUCTURE OF HUMAN AMINOADIPATE SEMIALDEHYDE SYNTHASE, SACCHAROPINE DEHYDROGENASE.
Descriptor:Alpha-aminoadipic semialdehyde synthase, mitochondrial, 1,2-ETHANEDIOL, ...
Authors:Kopec, J., Rembeza, E., Pena, I.A., Williams, E., Velupillai, S., Kupinska, K., Strain-Damerell, C., Goubin, S., Talon, R., Collins, P., Krojer, T., Burgess-Brown, N., Arrowsmith, C., Edwards, A., Bountra, C., von Delft, F., Arruda, P., Yue, W.W.
Deposit date:2017-05-18
Release date:2017-06-28
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure of human aminoadipate semialdehyde synthase, saccharopine dehydrogenase.
To Be Published
1ZV4
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 17 (RGSZ2)
Descriptor:Regulator of G-protein signaling 17
Authors:Schoch, G.A., Jansson, A., Elkins, J.M., Haroniti, A., Niesen, F.H., Bunkoczi, G., Lee, W.H., Turnbull, A.P., Yang, X., Sundstrom, M., Arrowsmith, C., Edwards, A., Marsden, B., Gileadi, O., Ball, L., von Delft, F., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-01
Release date:2005-06-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2A2N
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CRYSTAL STRUCTURE OF THE PEPTIDYLPROLYL ISOMERASE DOMAIN OF HUMAN PPWD1
Descriptor:peptidylprolyl isomerase domain and WD repeat containing 1, GLYCEROL
Authors:Walker, J.R., Davis, T.L., Newman, E.M., Mackenzie, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2005-06-22
Release date:2005-07-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:The crystal structure of human WD40 repeat-containing peptidylprolyl isomerase (PPWD1).
Febs J., 275, 2008
2A3K
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE, PTPN7 (HEPTP, HEMATOPOIETIC PROTEIN TYROSINE PHOSPHATASE)
Descriptor:protein tyrosine phosphatase, non-receptor type 7, isoform 1, ...
Authors:Barr, A., Turnbull, A.P., Das, S., Eswaran, J., Debreczeni, J.E., Longmann, E., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., von Delft, F., Knapp, S., Structural Genomics Consortium (SGC)
Deposit date:2005-06-24
Release date:2005-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:The crystal structure of human receptor protein tyrosine phosphatase kappa phosphatase domain 1.
Protein Sci., 15, 2006
2BIJ
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 (STEP, STRIATUM ENRICHED ENRICHED PHOSPHATASE)
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION
Authors:Barr, A.J., Debreczeni, J.E., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S., von Delft, F.
Deposit date:2005-01-21
Release date:2005-03-17
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2BT2
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STRUCTURE OF THE REGULATOR OF G-PROTEIN SIGNALING 16
Descriptor:REGULATOR OF G-PROTEIN SIGNALING 16
Authors:Bunkoczi, G., Haroniti, A., Longman, E., Niesen, F., Soundararajan, M., Ball, L.J., von Delft, F., Doyle, D.A., Arrowsmith, C., Edwards, A., Sundstrom, M.
Deposit date:2005-05-25
Release date:2005-06-03
Last modified:2011-08-24
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Diversity in the Rgs Domain and its Interaction with Heterotrimeric G Protein Alpha- Subunits.
Proc.Natl.Acad.Sci.USA, 105, 2008
2BTP
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14-3-3 PROTEIN THETA (HUMAN) COMPLEXED TO PEPTIDE
Descriptor:14-3-3 PROTEIN TAU, CONSENSUS PEPTIDE FOR 14-3-3 PROTEINS
Authors:Elkins, J.M., Johansson, A.C.E., Smee, C., Yang, X., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A., Structural Genomics Consortium (SGC)
Deposit date:2005-06-05
Release date:2005-06-28
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for Protein-Protein Interactions in the 14-3-3 Protein Family.
Proc.Natl.Acad.Sci.USA, 103, 2006
2BV1
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REGULATOR OF G-PROTEIN SIGNALLING 1 (HUMAN)
Descriptor:REGULATOR OF G-PROTEIN SIGNALLING 1
Authors:Elkins, J.M., Yang, X., Soundararajan, M., Schoch, G.A., Haroniti, A., Sundstrom, M., Edwards, A., Arrowsmith, C., Doyle, D.A.
Deposit date:2005-06-20
Release date:2005-06-27
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc. Natl. Acad. Sci. U.S.A., 105, 2008
2BV5
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CRYSTAL STRUCTURE OF THE HUMAN PROTEIN TYROSINE PHOSPHATASE PTPN5 AT 1.8A RESOLUTION
Descriptor:TYROSINE-PROTEIN PHOSPHATASE, NON-RECEPTOR TYPE 5, SULFATE ION, ...
Authors:Debreczeni, J.E., Barr, A.J., Eswaran, J., Smee, C., Burgess, N., Gileadi, O., von Delft, F., Sundstrom, M., Arrowsmith, C., Edwards, A., Knapp, S.
Deposit date:2005-06-22
Release date:2005-07-14
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structures and inhibitor identification for PTPN5, PTPRR and PTPN7: a family of human MAPK-specific protein tyrosine phosphatases.
Biochem. J., 395, 2006
2BW0
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CRYSTAL STRUCTURE OF THE HYDROLASE DOMAIN OF HUMAN 10-FORMYLTETRAHYDROFOLATE 2 DEHYDROGENASE
Descriptor:10-FORMYLTETRAHYDROFOLATE DEHYDROGENASE, SULFATE ION
Authors:Ogg, D.J., Stenmark, P., Arrowsmith, C., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Dobritzsch, D., Weigelt, J.
Deposit date:2005-07-07
Release date:2005-07-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structures of the Hydrolase Domain of Human 10-Formyltetrahydrofolate Dehydrogenase and its Complex with a Substrate Analogue.
Acta Crystallogr.,Sect.D, 62, 2006
2BZN
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CRYSTAL STRUCTURE OF HUMAN GUANOSINE MONOPHOSPHATE REDUCTASE 2 GMPR2 IN COMPLEX WITH IMP
Descriptor:GMP REDUCTASE 2, INOSINIC ACID
Authors:Stenmark, P., Kursula, P., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Graslund, S., Hammarstrom, M., Hallberg, B.M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Ogg, D., Persson, C., Sagemark, J., Schuler, H., Sundstrom, M., Thorsell, A., Weigelt, J.
Deposit date:2005-08-19
Release date:2005-09-02
Last modified:2011-11-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Cofactor Mobility Determines Reaction Outcome in the Impdh and Gmpr (Beta-Alpha)(8) Barrel Enzymes.
Nat.Chem.Biol., 7, 2011
2C2N
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STRUCTURE OF HUMAN MITOCHONDRIAL MALONYLTRANSFERASE
Descriptor:MALONYL COA-ACYL CARRIER PROTEIN TRANSACYLASE, SULFATE ION, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ...
Authors:Wu, X., Bunkoczi, G., Smee, C., Arrowsmith, C., Sundstrom, M., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U.
Deposit date:2005-09-29
Release date:2006-01-18
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases.
Chem.Biol., 16, 2009
2C30
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CRYSTAL STRUCTURE OF THE HUMAN P21-ACTIVATED KINASE 6
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK 6, PHOSPHATE ION, CHLORIDE ION
Authors:Filippakopoulos, P., Berridge, G., Bray, J., Burgess, N., Colebrook, S., Das, S., Eswaran, J., Gileadi, O., Papagrigoriou, E., Savitsky, P., Smee, C., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Knapp, S.
Deposit date:2005-10-02
Release date:2006-02-08
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal Structures of the P21-Activated Kinases Pak4, Pak5, and Pak6 Reveal Catalytic Domain Plasticity of Active Group II Paks.
Structure, 15, 2007