Author results

3NR6
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CRYSTAL STRUCTURE OF XENOTROPIC MURINE LEUKEMIA VIRUS-RELATED VIRUS (XMRV) PROTEASE
Descriptor:Protease p14, POTASSIUM ION, PHOSPHATE ION
Authors:Lubkowski, J., Li, M., Gustchina, A., Zhou, D., Dauter, Z., Wlodawer, A.
Deposit date:2010-06-30
Release date:2011-02-02
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Crystal structure of XMRV protease differs from the structures of other retropepsins.
Nat.Struct.Mol.Biol., 18, 2011
3PPD
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GGVLVN SEGMENT FROM HUMAN PROSTATIC ACID PHOSPHATASE RESIDUES 260-265, INVOLVED IN SEMEN-DERIVED ENHANCER OF VIRAL INFECTION
Descriptor:GGVLVN peptide, amyloid forming segment, ZINC ION, ...
Authors:Zhao, A., Sawaya, M.R., Eisenberg, D.
Deposit date:2010-11-24
Release date:2011-06-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation.
Nature, 475, 2011
3Q6O
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OXIDOREDUCTASE FRAGMENT OF HUMAN QSOX1
Descriptor:Sulfhydryl oxidase 1, SULFATE ION
Authors:Fass, D., Alon, A.
Deposit date:2011-01-03
Release date:2012-05-30
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature, 488, 2012
3QCP
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QSOX FROM TRYPANOSOMA BRUCEI
Descriptor:QSOX from Trypanosoma brucei (TbQSOX), FLAVIN-ADENINE DINUCLEOTIDE
Authors:Alon, A., Fass, D.
Deposit date:2011-01-17
Release date:2012-05-30
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature, 488, 2012
3QD9
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C72S/C353S MUTANT OF TRYPANOSOMA BRUCEI QSOX CONTAINING AN INTERDOMAIN DISULFIDE
Descriptor:QSOX from Trypanosoma brucei (TbQSOX), FLAVIN-ADENINE DINUCLEOTIDE
Authors:Alon, A., Fass, D.
Deposit date:2011-01-18
Release date:2012-05-30
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature, 488, 2012
3T58
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C76A/C455S MUTANT OF MOUSE QSOX1 CONTAINING AN INTERDOMAIN DISULFIDE
Descriptor:Sulfhydryl oxidase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fass, D., Alon, A., Gat, Y.
Deposit date:2011-07-27
Release date:2012-05-30
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature, 488, 2012
3T59
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C76A/C455S MUTANT OF MOUSE QSOX1 CONTAINING AN INTERDOMAIN DISULFIDE
Descriptor:Sulfhydryl oxidase 1, FLAVIN-ADENINE DINUCLEOTIDE
Authors:Fass, D., Alon, A., Gat, Y.
Deposit date:2011-07-27
Release date:2012-05-30
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The dynamic disulphide relay of quiescin sulphydryl oxidase.
Nature, 488, 2012
4JPI
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CRYSTAL STRUCTURE OF A PUTATIVE VRC01 GERMLINE PRECURSOR FAB
Descriptor:Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain, GLYCEROL
Authors:Julien, J.-P., Diwanji, D.C., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4JPJ
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN, EOD-GT6
Descriptor:Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, N-ACETYL-D-GLUCOSAMINE
Authors:Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4JPK
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CRYSTAL STRUCTURE OF THE GERMLINE-TARGETING HIV-1 GP120 ENGINEERED OUTER DOMAIN EOD-GT6 IN COMPLEX WITH A PUTATIVE VRC01 GERMLINE PRECURSOR FAB
Descriptor:Putative VRC01 germline precursor Fab heavy chain, Putative VRC01 germline precursor Fab light chain, Germline-targeting HIV-1 gp120 engineered outer domain, ...
Authors:Julien, J.-P., Jardine, J., Schief, W.R., Wilson, I.A.
Deposit date:2013-03-19
Release date:2013-04-10
Last modified:2014-01-15
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Rational HIV immunogen design to target specific germline B cell receptors.
Science, 340, 2013
4O5S
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CRYSTAL STRUCTURE OF DIELS-ALDERASE CE11
Descriptor:Diisopropyl-fluorophosphatase
Authors:Beck, T., Preiswerk, N., Mayer, C., Hilvert, D.
Deposit date:2013-12-20
Release date:2014-06-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
Proc.Natl.Acad.Sci.USA, 2014
4O5T
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CRYSTAL STRUCTURE OF DIELS-ALDERASE CE20 IN COMPLEX WITH A PRODUCT ANALOG
Descriptor:Diisopropyl-fluorophosphatase, 4-{[2-(phosphonooxy)ethyl]carbamoyl}benzyl [(1R,6S)-6-(dimethylcarbamoyl)cyclohex-2-en-1-yl]carbamate
Authors:Beck, T., Preiswerk, N., Mayer, C., Hilvert, D.
Deposit date:2013-12-20
Release date:2014-06-04
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Impact of scaffold rigidity on the design and evolution of an artificial Diels-Alderase
Proc.Natl.Acad.Sci.USA, 2014
4RZS
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LAC REPRESSOR ENGINEERED TO BIND SUCRALOSE, UNLIGANDED TETRAMER
Descriptor:Lac repressor, GLYCEROL
Authors:Arbing, M.A., Cascio, D., Kosuri, S., Church, G.M.
Deposit date:2014-12-24
Release date:2015-12-23
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.71 Å)
Cite:Engineering an allosteric transcription factor to respond to new ligands.
Nat.Methods, 13, 2016
4RZT
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LAC REPRESSOR ENGINEERED TO BIND SUCRALOSE, SUCRALOSE-BOUND TETRAMER
Descriptor:Lac repressor, 1,6-dichloro-1,6-dideoxy-beta-D-fructofuranosyl 4-chloro-4-deoxy-alpha-D-galactopyranoside
Authors:Arbing, M.A., Cascio, D., Sawaya, M.R., Kosuri, S., Church, G.M.
Deposit date:2014-12-24
Release date:2015-12-23
Last modified:2019-07-17
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Engineering an allosteric transcription factor to respond to new ligands.
Nat.Methods, 13, 2016
5AN7
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STRUCTURE OF THE ENGINEERED RETRO-ALDOLASE RA95.5-8F WITH A BOUND 1,3-DIKETONE INHIBITOR
Descriptor:RA95.5-8F, PHOSPHATE ION, (2E)-1-(6-methoxynaphthalen-2-yl)but-2-en-1-one
Authors:Obexer, R., Mittl, P.R.E., Hilvert, D.
Deposit date:2015-09-04
Release date:2016-08-17
Last modified:2019-10-23
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Nat Chem, 9, 2017
5AOU
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STRUCTURE OF THE ENGINEERED RETRO-ALDOLASE RA95.5-8F APO
Descriptor:INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, 1,2-ETHANEDIOL, PHOSPHATE ION
Authors:Obexer, R., Mittl, P., Hilvert, D.
Deposit date:2015-09-11
Release date:2016-08-17
Last modified:2019-05-08
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Emergence of a catalytic tetrad during evolution of a highly active artificial aldolase.
Nat Chem, 9, 2017
2AR1
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STRUCTURE OF HYPOTHETICAL PROTEIN FROM LEISHMANIA MAJOR
Descriptor:hypothetical protein, GLYCEROL
Authors:Arakaki, T.L., Merritt, E.A., Structural Genomics of Pathogenic Protozoa Consortium (SGPP)
Deposit date:2005-08-18
Release date:2005-08-30
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.602 Å)
Cite:Structure of Lmaj006129AAA, a hypothetical protein from Leishmania major.
Acta Crystallogr.,Sect.F, 62, 2006
3I1C
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CRYSTAL STRUCTURE OF A NOVEL ENGINEERED DIELS-ALDERASE: DA_20_00_A74I
Descriptor:Diisopropyl-fluorophosphatase, GLYCEROL
Authors:Lambert, A.R., Stoddard, B.L.
Deposit date:2009-06-26
Release date:2009-08-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Computational design of an enzyme catalyst for a stereoselective bimolecular Diels-Alder reaction.
Science, 329, 2010
3IIO
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE07
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
3IIP
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE7 R6 3/7F, POLYETHYLENE GLYCOL (N=34)
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
3IIV
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EVOLUTIONARY OPTIMIZATION OF COMPUTATIONALLY DESIGNED ENZYMES: KEMP ELIMINASES OF THE KE07 SERIES
Descriptor:KE7 KE7_R7_1/3H, MAGNESIUM ION
Authors:Khersonsky, O., Dym, O., Tawfik, D.S.
Deposit date:2009-08-03
Release date:2010-03-02
Last modified:2014-12-02
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Evolutionary Optimization of Computationally Designed Enzymes: Kemp Eliminases of the KE07 Series.
J.Mol.Biol., 396, 2010
4TVW
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RESORUFIN LIGASE WITH BOUND RESORUFIN-AMP ANALOG
Descriptor:Lipoate-protein ligase A, 5'-O-{[5-(7-hydroxy-3-oxo-3H-phenoxazin-2-yl)pentanoyl]sulfamoyl}adenosine
Authors:Goldman, P.J., Drennan, C.L.
Deposit date:2014-06-28
Release date:2014-10-22
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.505 Å)
Cite:Computational design of a red fluorophore ligase for site-specific protein labeling in living cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
4TVY
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APO RESORUFIN LIGASE
Descriptor:Lipoate-protein ligase A, 5-(3,7-dihydroxy-10H-phenoxazin-2-yl)pentanamide
Authors:Goldman, P.J., Drennan, C.L.
Deposit date:2014-06-28
Release date:2014-10-22
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.151 Å)
Cite:Computational design of a red fluorophore ligase for site-specific protein labeling in living cells.
Proc.Natl.Acad.Sci.USA, 111, 2014
5JSB
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CRYSTAL STRUCTURE OF MCL1-INHIBITOR COMPLEX
Descriptor:Induced myeloid leukemia cell differentiation protein Mcl-1, Mcl-1 inhibitor
Authors:Shen, B.W., Stoddard, B.L.
Deposit date:2016-05-07
Release date:2016-11-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Elife, 5, 2016
5JSN
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BCL2-INHIBITOR COMPLEX
Descriptor:Apoptosis regulator Bcl-2, Bcl2 inhibitor
Authors:Shen, B.W., Stoddard, B.L.
Deposit date:2016-05-09
Release date:2016-11-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.
Elife, 5, 2016