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1XD6
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CRYSTAL STRUCTURES OF NOVEL MONOMERIC MONOCOT MANNOSE-BINDING LECTINS FROM GASTRODIA ELATA
Descriptor:gastrodianin-4, SULFATE ION
Authors:Liu, W., Yang, N., Wang, M., Huang, R.H., Hu, Z., Wang, D.C.
Deposit date:2004-09-04
Release date:2005-01-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Mechanism Governing the Quaternary Organization of Monocot Mannose-binding Lectin Revealed by the Novel Monomeric Structure of an Orchid Lectin
J.Biol.Chem., 280, 2005
2OSH
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CRYSTAL STRUCTURE OF NATRATOXIN, A SNAKE SPLA2 THAT BLOCKS A-TYPE K+ CHANNEL
Descriptor:Phospholipase A2 1
Authors:Teng, M.K., Sun, L.
Deposit date:2007-02-06
Release date:2007-03-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of Natratoxin, a novel snake secreted phospholipaseA2 neurotoxin from Naja atra venom inhibiting A-type K+ currents.
Proteins, 72, 2008
2QDY
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CRYSTAL STRUCTURE OF FE-TYPE NHASE FROM RHODOCOCCUS ERYTHROPOLIS AJ270
Descriptor:Nitrile hydratase subunit alpha, Nitrile hydratase subunit beta, FE (III) ION, ...
Authors:Song, L., Shi, J., Xue, Z., Wang, M.-X., Qian, S.
Deposit date:2007-06-22
Release date:2008-05-13
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High resolution X-ray molecular structure of the nitrile hydratase from Rhodococcus erythropolis AJ270 reveals posttranslational oxidation of two cysteines into sulfinic acids and a novel biocatalytic nitrile hydration mechanism
Biochem.Biophys.Res.Commun., 362, 2007
2R6W
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ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN COMPLEXED TO A SERM
Descriptor:Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[2-(4-methylpiperidin-1-yl)ethoxy]phenyl}methanone
Authors:Wang, Y.
Deposit date:2007-09-06
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2R6Y
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ESTROGEN RECEPTOR ALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH A SERM
Descriptor:Estrogen receptor, [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl][4-(2-pyrrolidin-1-ylethoxy)phenyl]methanone
Authors:Wang, Y.
Deposit date:2007-09-06
Release date:2008-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3QNN
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RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DGT OPPOSITE 3TCO
Descriptor:DNA polymerase, DNA Template, DNA Primer, ...
Authors:Xia, S., Wang, M., Wang, J., Konigsberg, W.H.
Deposit date:2011-02-08
Release date:2012-02-08
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Using a Fluorescent Cytosine Analogue tC(o) To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase.
Biochemistry, 51, 2012
3QNO
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RB69 DNA POLYMERASE (Y567A) TERNARY COMPLEX WITH DATP OPPOSITE 3TCO
Descriptor:DNA Polymerase, DNA Tempalte, DNA Primer, ...
Authors:Xia, S., Wang, M., Wang, J., Konigsberg, W.H.
Deposit date:2011-02-08
Release date:2012-03-14
Last modified:2012-10-03
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Using a Fluorescent Cytosine Analogue tC(o) To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase.
Biochemistry, 51, 2012
3SPY
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RB69 DNA POLYMERASE(L415A/L561A/S565G/Y567A) TERNARY COMPLEX WITH DUPCPP OPPOSITE DA
Descriptor:DNA polymerase, 5'-D(*TP*CP*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3', ...
Authors:Xia, S., Konigsberg, W.H., Wang, J.
Deposit date:2011-07-04
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
3SPZ
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DNA POLYMERASE(L415A/L561A/S565G/Y567A) TERNARY COMPLEX WITH DUPCPP OPPOSITE DA (CA2+)
Descriptor:DNA polymerase, 5'-D(P*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*C)-3', ...
Authors:Xia, S., Konigsberg, W.H., Wang, J.
Deposit date:2011-07-04
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
3SQ0
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DNA POLYMERASE(L561A/S565G/Y567A) TERNARY COMPLEX WITH DUPNPP OPPOSITE DA (MN2+)
Descriptor:DNA polymerase, 5'-D(*TP*CP*AP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', ...
Authors:Xia, S., Konigsberg, W.H., Wang, J.
Deposit date:2011-07-04
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
3SQ1
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RB69 DNA POLYMERASE TERNARY COMPLEX WITH DUPCPP OPPOSITE DA
Descriptor:DNA polymerase, 5'-D(*TP*CP*GP*AP*GP*TP*AP*AP*GP*CP*AP*GP*TP*CP*CP*GP*CP*G)-3', 5'-D(*GP*CP*GP*GP*AP*CP*TP*GP*CP*TP*TP*AP*(DOC))-3', ...
Authors:Xia, S., Konigsberg, W.H., Wang, J.
Deposit date:2011-07-04
Release date:2011-10-12
Last modified:2011-11-02
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase.
Biochemistry, 50, 2011
4TZ4
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CRYSTAL STRUCTURE OF HUMAN CEREBLON IN COMPLEX WITH DDB1 AND LENALIDOMIDE
Descriptor:DNA damage-binding protein 1, Protein cereblon, ZINC ION, ...
Authors:Chamberlain, P.P., Pagarigan, B., Delker, S., Leon, B., Riley, M.
Deposit date:2014-07-09
Release date:2014-08-06
Method:X-RAY DIFFRACTION (3.01 Å)
Cite:Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex
To Be Published
5VZ3
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GROWTH FACTOR CRYSTAL STRUCTURE AT 1.97 ANGSTROM RESOLUTION
Descriptor:Growth/differentiation factor 15
Authors:Lakshminarasimhan, D., White, A., Suto, R.K.
Deposit date:2017-05-26
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
5VZ4
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RECEPTOR-GROWTH FACTOR CRYSTAL STRUCTURE AT 2.20 ANGSTROM RESOLUTION
Descriptor:Growth/differentiation factor 15, GDNF family receptor alpha-like, BROMIDE ION, ...
Authors:Lakshminarasimhan, D., White, A., Suto, R.K.
Deposit date:2017-05-26
Release date:2017-09-27
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Non-homeostatic body weight regulation through a brainstem-restricted receptor for GDF15.
Nature, 550, 2017
3S5J
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2.0A CRYSTAL STRUCTURE OF HUMAN PHOSPHORIBOSYL PYROPHOSPHATE SYNTHETASE 1
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2011-05-23
Release date:2012-05-23
Last modified:2015-04-22
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LYG
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CRYSTAL STRUCTURE OF HUMAN PRS1 E43T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZN
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CRYSTAL STRUCTURE OF HUMAN PRS1 D65N MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4LZO
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CRYSTAL STRUCTURE OF HUMAN PRS1 A87T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-07-31
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0P
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CRYSTAL STRUCTURE OF HUMAN PRS1 M115T MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-08-01
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
4M0U
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CRYSTAL STRUCTURE OF HUMAN PRS1 Q133P MUTANT
Descriptor:Ribose-phosphate pyrophosphokinase 1, SULFATE ION
Authors:Chen, P., Teng, M., Li, X.
Deposit date:2013-08-02
Release date:2015-02-04
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Crystal and EM Structures of Human Phosphoribosyl Pyrophosphate Synthase I (PRS1) Provide Novel Insights into the Disease-Associated Mutations
Plos One, 10, 2015
1DJT
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ATOMIC RESOLUTION STRUCTURE OF SCORPION ALPHA-LIKE TOXIN BMK M1 IN A NEW CRYSTAL FORM
Descriptor:ALPHA-LIKE NEUROTOXIN BMK M1
Authors:Wang, D.-C., He, X.-L.
Deposit date:1999-12-05
Release date:2000-12-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Atomic Resolution Structure of Scorpion Alpha-Like Toxin BmK M1 in a New Crystal Form
To be Published
5PGU
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CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-[2-(4-FLUOROPHENYL)-2-ADAMANTYL]-1-(3-METHOXYAZETIDIN-1-YL)ETHANONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[2-(4-fluorophenyl)-2-adamantyl]-1-(3-methoxyazetidin-1-yl)ethanone
Authors:Sheriff, S.
Deposit date:2017-02-06
Release date:2017-11-01
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J. Med. Chem., 60, 2017
5PGV
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CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 1-(3-HYDROXYAZETIDIN-1-YL)-2-[(2S,5R)-2-(4-FLUOROPHENYL)-5-METHOXYADAMANTAN-2-YL]ETHAN-1-ONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 1-(3-HYDROXYAZETIDIN-1-YL)-2-[(2S,5R)-2-(4-FLUOROPHENYL)-5-METHOXYADAMANTAN-2-YL]ETHAN-1-ONE
Authors:Sheriff, S.
Deposit date:2017-02-06
Release date:2017-11-01
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J. Med. Chem., 60, 2017
5PGW
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CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-[(1R,3S,5R,7S)-2-[4-(4-FLUOROPHENYL)PHENYL]-6-HYDROXYADAMANTAN-2-YL]-1-(3- HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(1R,3S,5R,7S)-2-[4-(4-FLUOROPHENYL)PHENYL]-6-HYDROXYADAMANTAN-2-YL]-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
Authors:Sheriff, S.
Deposit date:2017-02-06
Release date:2017-11-01
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.37 Å)
Cite:Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J. Med. Chem., 60, 2017
5PGX
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CRYSTAL STRUCTURE OF 11BETA-HSD1 DOUBLE MUTANT (L262R, F278E) COMPLEXED WITH 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
Descriptor:Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-(2-BENZYL-6-HYDROXYADAMANTAN-2-YL)-1-(3-HYDROXYAZETIDIN-1-YL)ETHAN-1-ONE
Authors:Sheriff, S.
Deposit date:2017-02-06
Release date:2017-11-01
Last modified:2018-02-21
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11 beta-Hydroxysteroid Dehydrogenase Type 1 Inhibitor.
J. Med. Chem., 60, 2017