Author results

2JNU
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SOLUTION STRUCTURE OF THE RGS DOMAIN OF HUMAN RGS14
Descriptor:Regulator of G-protein signaling 14
Authors:Dowler, E.F., Diehl, A., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G.A., Yang, X., Brockmann, C., Leidert, M., Rehbein, K., Schmieder, P., Kuhne, R., Higman, V.A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-02
Release date:2007-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2OWI
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SOLUTION STRUCTURE OF THE RGS DOMAIN FROM HUMAN RGS18
Descriptor:Regulator of G-protein signaling 18
Authors:Higman, V.A., Leidert, M., Bray, J., Elkins, J., Soundararajan, M., Doyle, D.A., Gileadi, C., Phillips, C., Schoch, G., Yang, X., Brockmann, C., Schmieder, P., Diehl, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., Oschkinat, H., Ball, L.J., Structural Genomics Consortium (SGC)
Deposit date:2007-02-16
Release date:2007-02-27
Last modified:2012-08-15
Method:SOLUTION NMR
Cite:Structural diversity in the RGS domain and its interaction with heterotrimeric G protein alpha-subunits.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2W2I
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CRYSTAL STRUCTURE OF THE HUMAN 2-OXOGLUTARATE OXYGENASE LOC390245
Descriptor:2-OXOGLUTARATE OXYGENASE, NICKEL (II) ION, PYRIDINE-2,4-DICARBOXYLIC ACID, ...
Authors:Yue, W.W., Ng, S., Shafqat, N., Ugochukwu, E., McDonough, M., Pike, A.C.W., Filippakopoulos, P., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Schofield, C., Oppermann, U.
Deposit date:2008-10-31
Release date:2009-01-20
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human Kdm4 Histone Demethylase Family.
J.Biol.Chem., 286, 2011
2WWU
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF PHD FINGER PROTEIN 8
Descriptor:PHD FINGER PROTEIN 8, SULFATE ION, ACETATE ION, ...
Authors:Yue, W.W., Hozjan, V., Cooper, C., Tumber, A., Krojer, T., Muniz, J., Allerston, C., Salah, E., McDonough, M.A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Schofield, C.J., Kavanagh, K.L., Oppermann, U.
Deposit date:2009-10-29
Release date:2009-11-17
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Crystal structure of the PHF8 Jumonji domain, an Nepsilon-methyl lysine demethylase.
FEBS Lett., 584, 2010
2XML
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CRYSTAL STRUCTURE OF HUMAN JMJD2C CATALYTIC DOMAIN
Descriptor:LYSINE-SPECIFIC DEMETHYLASE 4C, N-OXALYLGLYCINE, NICKEL (II) ION, ...
Authors:Yue, W.W., Gileadi, C., Krojer, T., Pike, A.C.W., von Delft, F., Ng, S., Carpenter, L., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-07-28
Release date:2010-09-29
Last modified:2015-05-13
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structural and Evolutionary Basis for the Dual Substrate Selectivity of Human Kdm4 Histone Demethylase Family.
J.Biol.Chem., 286, 2011
5O2D
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PARP14 MACRODOMAIN 2 WITH INHIBITOR
Descriptor:Poly [ADP-ribose] polymerase 14, ~{N}-[2-(9~{H}-carbazol-1-yl)phenyl]methanesulfonamide
Authors:Uth, K., Schuller, M., Sieg, C., Wang, J., Krojer, T., Knapp, S., Riedels, K., Bracher, F., Edwards, A.M., Arrowsmith, C., Bountra, C., Elkins, J.M., Structural Genomics Consortium (SGC)
Deposit date:2017-05-20
Release date:2017-11-08
Last modified:2018-09-19
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Discovery of a Selective Allosteric Inhibitor Targeting Macrodomain 2 of Polyadenosine-Diphosphate-Ribose Polymerase 14.
ACS Chem. Biol., 12, 2017
2BYD
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STRUCTURE OF AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE- PHOSPHOPANTETHEINYL TRANSFERASE
Descriptor:HSPC223, BROMIDE ION
Authors:Bunkoczi, G., Wu, X., Dubinina, E., Johansson, C., Smee, C., Turnbull, A., Oppermann, U., von Delft, F., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J.
Deposit date:2005-07-29
Release date:2005-08-05
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanism and substrate recognition of human holo ACP synthase.
Chem. Biol., 14, 2007
2C43
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STRUCTURE OF AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE- PHOSPHOPANTETHEINYL TRANSFERASE IN COMPLEX WITH COENZYME A
Descriptor:AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE-PHOSPHOPANTETHEINYL TRANSFERASE, COENZYME A, MAGNESIUM ION, ...
Authors:Bunkoczi, G., Wu, X., Dubinina, E., Johansson, C., Smee, C., Turnbull, A., von Delft, F., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., Oppermann, U.
Deposit date:2005-10-14
Release date:2005-10-24
Last modified:2018-02-28
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mechanism and substrate recognition of human holo ACP synthase.
Chem. Biol., 14, 2007
2FVV
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HUMAN DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE 1
Descriptor:Diphosphoinositol polyphosphate phosphohydrolase 1, CHLORIDE ION, SULFATE ION, ...
Authors:Hallberg, B.M., Kursula, P., Ogg, D., Arrowsmith, C., Berglund, H., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Sagemark, J., Stenmark, P., Sundstrom, M., Thorsell, A.G., van den Berg, S., Weigelt, J., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2006-01-31
Release date:2006-03-11
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Crystal structure of human diphosphoinositol phosphatase 1
Proteins, 77, 2009
2FVZ
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HUMAN INOSITOL MONOPHOSPHOSPHATASE 2
Descriptor:Inositol monophosphatase 2
Authors:Ogg, D., Hallberg, B.M., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Kotenyova, T., Kursula, P., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Persson, C., Sagemark, J., Stenmark, P., Sundstrom, M., Van Den Berg, S., Weigelt, J., Thorsell, A.G., Structural Genomics Consortium (SGC)
Deposit date:2006-01-31
Release date:2006-02-21
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of Human Inositol Monophosphatase 2
To be published
2FZP
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CRYSTAL STRUCTURE OF THE USP8 INTERACTION DOMAIN OF HUMAN NRDP1
Descriptor:ring finger protein 41 isoform 1
Authors:Walker, J.R., Avvakumov, G.V., Xue, S., Newman, E.M., Butler-Cole, C., Finerty Jr., P.J., Weigelt, J., Sundstrom, M., Arrowsmith, C., Edwards, A., Bochkarev, A., Dhe-Paganon, S., Structural Genomics Consortium (SGC)
Deposit date:2006-02-10
Release date:2006-03-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Amino-terminal Dimerization, NRDP1-Rhodanese Interaction, and Inhibited Catalytic Domain Conformation of the Ubiquitin-specific Protease 8 (USP8).
J.Biol.Chem., 281, 2006
2G3Y
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CRYSTAL STRUCTURE OF THE HUMAN SMALL GTPASE GEM
Descriptor:GTP-binding protein GEM, GUANOSINE-5'-DIPHOSPHATE
Authors:Ugochukwu, E., Soundararajan, M., Elkins, J., Gileadi, C., Schoch, G., Sobott, F., Fedorov, O., Bray, J., Pantic, N., Berridge, G., Burgess, N., Lee, W.H., Turnbull, A., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Doyle, D., Structural Genomics Consortium (SGC)
Deposit date:2006-02-21
Release date:2006-04-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the human small GTPase GEM
To be Published
2H63
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CRYSTAL STRUCTURE OF HUMAN BILIVERDIN REDUCTASE A
Descriptor:Biliverdin reductase A, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Kavanagh, K., Elkins, J., Ugochukwu, E., Guo, K., Pilka, E., Lukacik, P., Smee, C., Papagrigoriou, E., Bunkoczi, G., Sundstrom, M., Arrowsmith, C., Weigelt, J., Edwards, A., von Delft, F., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-05-30
Release date:2006-07-04
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of Human Biliverdin Reductase A
To be Published
2HE7
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FERM DOMAIN OF EPB41L3 (DAL-1)
Descriptor:Band 4.1-like protein 3
Authors:Hallberg, B.M., Busam, R.D., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Schiavone, L.H., Johansson, I., Hogbom, M., Karlberg, T., Kotenyova, T., Nilvebrandt, J., Norberg, P., Stenmark, P., Nordlund, P., Nilsson-ehle, P., Nyman, T., Ogg, D., Sagemark, J., Sundstrom, M., Uppenberg, J., Van den berg, S., Weigelt, J., Persson, C., Thorsell, A.G., Structural Genomics Consortium (SGC)
Deposit date:2006-06-21
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis of tumor suppressor in lung cancer 1 (TSLC1) binding to differentially expressed in adenocarcinoma of the lung (DAL-1/4.1B).
J.Biol.Chem., 286, 2011
2HW4
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOHISTIDINE PHOSPHATASE
Descriptor:14 kDa phosphohistidine phosphatase, FORMIC ACID
Authors:Busam, R.D., Thorsell, A.G., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Holmberg Schiavone, L., Hogbom, M., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Ogg, D., Stenmark, P., Sundstrom, M., Uppenberg, J., Van Den Berg, S., Weigelt, J., Persson, C., Hallberg, B.M., Structural Genomics Consortium (SGC)
Deposit date:2006-07-31
Release date:2006-08-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:First structure of a eukaryotic phosphohistidine phosphatase
J.Biol.Chem., 281, 2006
2I3Y
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CRYSTAL STRUCTURE OF HUMAN GLUTATHIONE PEROXIDASE 5
Descriptor:Epididymal secretory glutathione peroxidase, 1,2-ETHANEDIOL
Authors:Kavanagh, K.L., Johansson, C., Rojkova, A., Umeano, C., Bunkoczi, G., Gileadi, O., von Delft, F., Weigelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2006-08-21
Release date:2006-09-12
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of human glutathione peroxidase 5
To be published
2IBN
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CRYSTAL STRUCTURE OF HUMAN MYO-INOSITOL OXYGENASE (MIOX)
Descriptor:Inositol oxygenase, FE (III) ION, SULFATE ION, ...
Authors:Hallberg, B.M., Busam, R.D., Arrowsmith, C., Berglund, H., Collins, R., Edwards, A., Ehn, M., Flodin, S., Flores, A., Graslund, S., Hammarstrom, M., Hogbom, M., Holmberg-Schiavone, L., Johansson, I., Karlberg, T., Kotenyova, T., Nilsson-Ehle, P., Nordlund, P., Nyman, T., Ogg, D., Sagemark, J., Stenmark, P., Sundstrom, M., Uppenberg, J., Van Den Berg, S., Weigelt, J., Thorsell, A.G., Persson, C., Structural Genomics Consortium (SGC)
Deposit date:2006-09-11
Release date:2006-10-17
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Biophysical Characterization of Human myo-Inositol Oxygenase
J.Biol.Chem., 283, 2008
2IWQ
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7TH PDZ DOMAIN OF MULTIPLE PDZ DOMAIN PROTEIN MPDZ
Descriptor:MULTIPLE PDZ DOMAIN PROTEIN
Authors:Elkins, J.M., Berridge, G., Savitsky, P., Smee, C.E.A., Turnbull, A., Ugochukwu, E., Papagrigoriou, E., Sundstrom, M., Edwards, A., Arrowsmith, C., Weigelt, J., Doyle, D.A.
Deposit date:2006-07-03
Release date:2006-07-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure of Pick1 and Other Pdz Domains Obtained with the Help of Self-Binding C-Terminal Extensions.
Protein Sci., 16, 2007
2J6L
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STRUCTURE OF AMINOADIPATE-SEMIALDEHYDE DEHYDROGENASE
Descriptor:ALDEHYDE DEHYDROGENASE FAMILY 7 MEMBER A1, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, BROMIDE ION, ...
Authors:Bunkoczi, G., Guo, K., Debreczeni, J.E., Smee, C., Arrowsmith, C., Edwards, A., Sundstrom, M., Weigelt, J., von Delft, F., Oppermann, U.
Deposit date:2006-09-29
Release date:2006-10-12
Last modified:2015-05-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Aldehyde Dehydrogenase 7A1 (Aldh7A1) is a Novel Enzyme Involved in Cellular Defense Against Hyperosmotic Stress.
J.Biol.Chem., 285, 2010
2PZ9
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CRYSTAL STRUCTURE OF PUTATIVE TRANSCRIPTIONAL REGULATOR SCO4942 FROM STREPTOMYCES COELICOLOR
Descriptor:Putative regulatory protein, SULFATE ION
Authors:Filippova, E.V., Chruszcz, M., Xu, X., Zheng, H., Cymborowski, M., Savchenko, A., Edwards, A., Joachimiak, A., Minor, W., Midwest Center for Structural Genomics (MCSG)
Deposit date:2007-05-17
Release date:2007-06-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:In situ proteolysis for protein crystallization and structure determination.
Nat.Methods, 4, 2007
2Q3E
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STRUCTURE OF HUMAN UDP-GLUCOSE DEHYDROGENASE COMPLEXED WITH NADH AND UDP-GLUCOSE
Descriptor:UDP-glucose 6-dehydrogenase, CHLORIDE ION, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, ...
Authors:Kavanagh, K.L., Guo, K., Bunkoczi, G., Savitsky, P., Pilka, E., Bhatia, C., Smee, C., Berridge, G., von Delft, F., Wiegelt, J., Arrowsmith, C., Sundstrom, M., Edwards, A., Oppermann, U., Structural Genomics Consortium (SGC)
Deposit date:2007-05-30
Release date:2007-07-03
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure and mechanism of human UDP-glucose 6-dehydrogenase.
J.Biol.Chem., 286, 2011
2WEK
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CRYSTAL STRUCTURE OF THE HUMAN MGC45594 GENE PRODUCT IN COMPLEX WITH DICLOFENAC
Descriptor:ZINC-BINDING ALCOHOL DEHYDROGENASE DOMAIN-CONTAINING PROTEIN 2, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[2,6-DICHLOROPHENYL)AMINO]BENZENEACETIC ACID, ...
Authors:Shafqat, N., Yue, W.W., Ugochukwu, E., Niesen, F., Smee, C., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-03-31
Release date:2009-12-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure of the Human Mgc45594 Gene Product in Complex with Diclofenac
To be Published
2WH5
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CRYSTAL STRUCTURE OF HUMAN ACYL-COA BINDING DOMAIN 4 COMPLEXED WITH STEAROYL-COA
Descriptor:ACYL-COA-BINDING DOMAIN-CONTAINING PROTEIN 4, STEARIC ACID, STEAROYL-COENZYME A, ...
Authors:Yue, W.W., Shafqat, N., Ugochukwu, E., Savitsky, P., Johansson, C., Salah, E., Roos, A.K., Chaikuad, A., von Delft, F., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-04-30
Release date:2009-07-28
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystal Structure of Human Acyl-Coa Binding Domain 4
To be Published
2WYA
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CRYSTAL STRUCTURE OF HUMAN MITOCHONDRIAL 3-HYDROXY-3-METHYLGLUTARYL- COENZYME A SYNTHASE 2 (HMGCS2)
Descriptor:HYDROXYMETHYLGLUTARYL-COA SYNTHASE, MITOCHONDRIAL, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Yue, W.W., Shafqat, N., Savitsky, P., Roos, A.K., Cooper, C., Murray, J.W., von Delft, F., Arrowsmith, C., Wikstrom, M., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2009-11-13
Release date:2009-11-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal Structures of Human Hmg-Coa Synthase Isoforms Provide Insights Into Inherited Ketogenesis Disorders and Inhibitor Design.
J.Mol.Biol., 398, 2010
2XIJ
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CRYSTAL STRUCTURE OF HUMAN METHYLMALONYL-COA MUTASE IN COMPLEX WITH ADENOSYLCOBALAMIN
Descriptor:METHYLMALONYL-COA MUTASE, MITOCHONDRIAL, 5'-DEOXYADENOSINE, ...
Authors:Yue, W.W., Froese, D.S., Kochan, G., Chaikuad, A., Krojer, T., Muniz, J., Vollmar, M., Arrowsmith, C., Weigelt, J., Edwards, A., Bountra, C., Oppermann, U.
Deposit date:2010-06-30
Release date:2010-09-29
Last modified:2012-10-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structures of the Human Gtpase Mmaa and Vitamin B12-Dependent Methylmalonyl-Coa Mutase and Insight Into Their Complex Formation.
J.Biol.Chem., 285, 2010