Author results

4U7U
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CRYSTAL STRUCTURE OF RNA-GUIDED IMMUNE CASCADE COMPLEX FROM E.COLI
分子名称:CRISPR system Cascade subunit CasA, CRISPR system Cascade subunit CasB, CRISPR system Cascade subunit CasE, ...
著者Zhao, H., Sheng, G., Wang, J., Wang, M., Bunkoczi, G., Gong, W., Wei, Z., Wang, Y.
登録日2014-07-31
公開日2014-08-27
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (3.003 Å)
主引用文献Crystal structure of the RNA-guided immune surveillance Cascade complex in Escherichia coli
Nature, 515, 2014
5C4W
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CRYSTAL STRUCTURE OF COXSACKIEVIRUS A16
分子名称:VP1, VP2, VP3, ...
著者Ren, J., Wang, X., Zhu, L., Hu, Z., Gao, Q., Yang, P., Li, X., Wang, J., Shen, X., Fry, E.E., Rao, Z., Stuart, D.I.
登録日2015-06-18
公開日2015-08-26
最終更新日2015-09-30
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity.
J.Virol., 89, 2015
5C8C
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CRYSTAL STRUCTURE OF RECOMBINANT COXSACKIEVIRUS A16 CAPSID
分子名称:VP1, VP0, VP3, ...
著者Ren, J., Wang, X., Zhu, L., Hu, Z., Gao, Q., Yang, P., Li, X., Wang, J., Shen, X., Fry, E.E., Rao, Z., Stuart, D.I.
登録日2015-06-25
公開日2015-09-30
最終更新日2019-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity.
J.Virol., 89, 2015
5C9A
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CRYSTAL STRUCTURE OF EMPTY COXSACKIEVIRUS A16 PARTICLE
分子名称:VP1, VP0, VP3, ...
著者Ren, J., Wang, X., Zhu, L., Hu, Z., Gao, Q., Yang, P., Li, X., Wang, J., Shen, X., Fry, E.E., Rao, Z., Stuart, D.I.
登録日2015-06-26
公開日2015-08-26
最終更新日2015-09-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of Coxsackievirus A16 Capsids with Native Antigenicity: Implications for Particle Expansion, Receptor Binding, and Immunogenicity.
J.Virol., 89, 2015
5IAY
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NMR STRUCTURE OF UHRF1 TANDEM TUDOR DOMAINS IN A COMPLEX WITH SPACER PEPTIDE
分子名称:E3 ubiquitin-protein ligase UHRF1, Spacer
著者Fang, J., Cheng, J., Wang, J., Zhang, Q., Liu, M., Gong, R., Wang, P., Zhang, X., Feng, Y., Lan, W., Gong, Z., Tang, C., Wong, J., Yang, H., Cao, C., Xu, Y.
登録日2016-02-22
公開日2016-04-20
実験手法SOLUTION NMR
主引用文献Hemi-methylated DNA opens a closed conformation of UHRF1 to facilitate its histone recognition
Nat Commun, 7, 2016
5KZN
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METABOTROPIC GLUTAMATE RECEPTOR
分子名称:Metabotropic glutamate receptor 2, N-ACETYL-D-GLUCOSAMINE, MAGNESIUM ION
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5KZQ
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METABOTROPIC GLUTAMATE RECEPTOR IN COMPLEX WITH ANTAGONIST (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-AZANYL-3-[[3,4-BIS(FLUORANYL)PHENYL]SULFANYLMETHYL]-4-OXIDANYL-BICYCLO[3.1.0]HEXANE-2,6-DICARBOXYLIC ACID
分子名称:Metabotropic glutamate receptor 2, (1~{S},2~{R},3~{S},4~{S},5~{R},6~{R})-2-azanyl-3-[[3,4-bis(fluoranyl)phenyl]sulfanylmethyl]-4-oxidanyl-bicyclo[3.1.0]hexane-2,6-dicarboxylic acid, N-ACETYL-D-GLUCOSAMINE
著者Chappell, M.D., Li, R., Smith, S.C., Dressman, B.A., Tromiczak, E.G., Tripp, A.E., Blanco, M.-J., Vetman, T., Quimby, S.J., Matt, J., Britton, T., Fivush, A.M., Schkeryantz, J.M., Mayhugh, D., Erickson, J.A., Bures, M., Jaramillo, C., Carpintero, M., de Diego, J.E., Barberis, M., Garcia-Cerrada, S., Soriano, J.F., Antonysamy, S., Atwell, S., MacEwan, I., Condon, B., Bradley, C., Wang, J., Zhang, A., Conners, K., Groshong, C., Wasserman, S.R., Koss, J.W., Witkin, J.M., Li, X., Overshiner, C., Wafford, K.A., Seidel, W., Wang, X.-S., Heinz, B.A., Swanson, S., Catlow, J., Bedwell, D., Monn, J.A., Mitch, C.H., Ornstein, P.
登録日2016-07-25
公開日2016-12-28
最終更新日2017-01-04
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of (1S,2R,3S,4S,5R,6R)-2-Amino-3-[(3,4-difluorophenyl)sulfanylmethyl]-4-hydroxy-bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid Hydrochloride (LY3020371HCl): A Potent, Metabotropic Glutamate 2/3 Receptor Antagonist with Antidepressant-Like Activity.
J. Med. Chem., 59, 2016
5WTE
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS FULL PARTICLE
分子名称:VP1, VP2, VP3
著者Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
登録日2016-12-11
公開日2017-01-25
最終更新日2017-02-08
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTF
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS EMPTY PARTICLE
分子名称:VP1, VP0, VP3
著者Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
登録日2016-12-11
公開日2017-01-25
最終更新日2017-02-08
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTG
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CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF ANTI-HAV ANTIBODY R10
分子名称:FAB Light chain, FAB Heavy chain
著者Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
登録日2016-12-11
公開日2017-01-25
最終更新日2017-08-30
実験手法X-RAY DIFFRACTION (2.907 Å)
主引用文献Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5WTH
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CRYO-EM STRUCTURE FOR HEPATITIS A VIRUS COMPLEXED WITH FAB
分子名称:Polyprotein, VP2, VP3, ...
著者Wang, X., Zhu, L., Dang, M., Hu, Z., Gao, Q., Yuan, S., Sun, Y., Zhang, B., Ren, J., Walter, T.S., Wang, J., Fry, E.E., Stuart, D.I., Rao, Z.
登録日2016-12-12
公開日2017-01-25
最終更新日2017-02-08
実験手法ELECTRON MICROSCOPY (4.2 Å)
主引用文献Potent neutralization of hepatitis A virus reveals a receptor mimic mechanism and the receptor recognition site
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5YEF
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CRYSTAL STRUCTURE OF CTCF ZFS2-8-HS5-1AE
分子名称:Transcriptional repressor CTCF, DNA (27-MER), ZINC ION
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-17
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2.807 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEG
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CRYSTAL STRUCTURE OF CTCF ZFS4-8-HS5-1A COMPLEX
分子名称:Transcriptional repressor CTCF, DNA (5'-D(*TP*CP*GP*CP*CP*CP*TP*CP*TP*GP*CP*TP*GP*GP*TP*TP*AP*AP*AP*G)-3'), DNA (5'-D(*AP*CP*TP*TP*TP*AP*AP*CP*CP*AP*GP*CP*AP*GP*AP*GP*GP*GP*CP*G)-3'), ...
著者Yin, M., Wang, J., Wang, M., Li, X.
登録日2017-09-17
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEH
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CRYSTAL STRUCTURE OF CTCF ZFS4-8-ECBS
分子名称:Transcriptional repressor CTCF, DNA (5'-D(*AP*CP*GP*GP*TP*TP*TP*CP*CP*GP*CP*TP*AP*GP*AP*GP*GP*GP*CP*G)-3'), DNA (5'-D(*TP*CP*GP*CP*CP*CP*TP*CP*TP*AP*GP*CP*GP*GP*AP*AP*AP*CP*CP*G)-3'), ...
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-17
公開日2017-11-29
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (2.328 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YEL
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CRYSTAL STRUCTURE OF CTCF ZFS6-11-GB7CSE
分子名称:DNA (26-MER), Transcriptional repressor CTCF, ZINC ION
著者Yin, M., Wang, J., Wang, M., Li, X., Wang, Y.
登録日2017-09-18
公開日2017-11-29
実験手法X-RAY DIFFRACTION (2.96 Å)
主引用文献Molecular mechanism of directional CTCF recognition of a diverse range of genomic sites
Cell Res., 27, 2017
5YKS
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CRYSTAL STRUCTURE OF SUCROSE NONFERMENTING-RELATED KINASE (SNRK)
分子名称:SNF-related serine/threonine-protein kinase
著者Wang, Y.L., Wang, J., Wu, J.W.
登録日2017-10-16
公開日2017-11-08
最終更新日2018-01-03
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structure of the kinase and UBA domains of SNRK reveals a distinct UBA binding mode in the AMPK family.
Biochem. Biophys. Res. Commun., 495, 2018
5ZM8
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CRYSTAL STRUCTURE OF ORP2-ORD IN COMPLEX WITH PI(4,5)P2
分子名称:Oxysterol-binding protein-related protein 2, [(2~{S})-1-octadecanoyloxy-3-[oxidanyl-[(1~{R},2~{R},3~{S},4~{S},5~{S},6~{S})-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propan-2-yl] icosa-5,8,11,14-tetraenoate
著者Wang, H., Dong, J.Q., Wang, J., Wu, J.W.
登録日2018-04-01
公開日2019-01-02
最終更新日2019-02-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献ORP2 Delivers Cholesterol to the Plasma Membrane in Exchange for Phosphatidylinositol 4, 5-Bisphosphate (PI(4,5)P2).
Mol. Cell, 73, 2019
6DCG
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DISCOVERY OF MK-8353: AN ORALLY BIOAVAILABLE DUAL MECHANISM ERK INHIBITOR FOR ONCOLOGY
分子名称:Mitogen-activated protein kinase 1, SULFATE ION, (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide
著者Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A., Shipps Jr., G.W., Doll, R., Shih, N., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
登録日2018-05-06
公開日2018-08-08
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
6IFN
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CRYSTAL STRUCTURE OF TYPE III-A CRISPR CSM COMPLEX
分子名称:Type III-A CRISPR-associated protein Csm1, Type III-A CRISPR-associated RAMP protein Csm3, Type III-A CRISPR-associated RAMP protein Csm4, ...
著者You, L., Wang, J., Wang, Y.
登録日2018-09-20
公開日2018-12-12
最終更新日2019-01-23
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
1I5U
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SOLUTION STRUCTURE OF CYTOCHROME B5 TRIPLE MUTANT (E48A/E56A/D60A)
分子名称:CYTOCHROME B5, PROTOPORPHYRIN IX CONTAINING FE
著者Qian, C., Yao, Y., Tang, W., Wang, J., Zhongxian, H.
登録日2001-02-28
公開日2001-03-21
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献Effects of charged amino-acid mutation on the solution structure of cytochrome b(5) and binding between cytochrome b(5) and cytochrome c.
Protein Sci., 10, 2001
1QU2
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
分子名称:ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, POTASSIUM ION, ...
著者Silvian, L.F., Wang, J., Steitz, T.A.
登録日1999-07-06
公開日1999-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
1QU3
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INSIGHTS INTO EDITING FROM AN ILE-TRNA SYNTHETASE STRUCTURE WITH TRNA(ILE) AND MUPIROCIN
分子名称:ISOLEUCYL-TRNA, ISOLEUCYL-TRNA SYNTHETASE, ZINC ION, ...
著者Silvian, L.F., Wang, J., Steitz, T.A.
登録日1999-07-06
公開日1999-08-31
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Insights into editing from an ile-tRNA synthetase structure with tRNAile and mupirocin.
Science, 285, 1999
4F2L
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STRUCTURE OF A REGULATORY DOMAIN OF AMPK
分子名称:5'-AMP-activated protein kinase catalytic subunit alpha-1, MAGNESIUM ION
著者Xin, F.J., Zhang, Y.Y., Wang, J., Wang, Z.X., Wu, J.W.
登録日2012-05-08
公開日2013-06-26
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Conserved regulatory elements in AMPK
Nature, 498, 2013
4KPY
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DNA BINDING PROTEIN AND DNA COMPLEX STRUCTURE
分子名称:Uncharacterized protein, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), DNA (5'-D(P*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-05-14
公開日2014-01-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.406 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014
4N41
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STRUCTURE OF THERMUS THERMOPHILUS ARGONAUTE BOUND TO GUIDE DNA AND 15-MER TARGET DNA
分子名称:Argonaute, 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*T*GP*TP*AP*TP*AP*GP*T)-3', 5'-D(P*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3', ...
著者Sheng, G., Zhao, H., Wang, J., Rao, Y., Wang, Y.
登録日2013-10-08
公開日2014-01-15
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.248 Å)
主引用文献Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage.
Proc.Natl.Acad.Sci.USA, 111, 2014