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5FVS
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.948 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVT
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4- METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.828 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVU
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.224 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVV
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(1-METHYLPIPERIDIN-4-YL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVW
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(3-(METHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL) PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVX
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STRUCTURE OF HUMAN NNOS R354A G357D MUTANT HEME DOMAIN IN COMPLEX WITH WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL) PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVY
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 4-METHYL-6-(2-(5-(4-METHYLPIPERAZIN-1-YL)PYRIDIN-3-YL) ETHYL)PYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, ENDOTHELIAL, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.098 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FVZ
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STRUCTURE OF BOVINE ENDOTHELIAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-(3-(DIMETHYLAMINO)PROPYL)PYRIDIN-3-YL)ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:ENDOTHELIAL NITRIC OXIDE SYNTHASE, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.048 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
5FW0
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STRUCTURE OF RAT NEURONAL NITRIC OXIDE SYNTHASE HEME DOMAIN IN COMPLEX WITH 6-(2-(5-((2-METHOXYETHYL)(METHYL)AMINO)PYRIDIN-3-YL) ETHYL)-4-METHYLPYRIDIN-2-AMINE
Descriptor:NITRIC OXIDE SYNTHASE, BRAIN, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Li, H., Poulos, T.L.
Deposit date:2016-02-10
Release date:2016-04-20
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Potent and Selective Human Neuronal Nitric Oxide Synthase Inhibition by Optimization of the 2-Aminopyridine-Based Scaffold with a Pyridine Linker.
J.Med.Chem., 59, 2016
6AVO
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CRYO-EM STRUCTURE OF HUMAN IMMUNOPROTEASOME WITH A NOVEL NONCOMPETITIVE INHIBITOR THAT SELECTIVELY INHIBITS ACTIVATED LYMPHOCYTES
Descriptor:Proteasome subunit beta type-9, Proteasome subunit beta type-10, Proteasome subunit beta type-8, ...
Authors:Li, H., Santos, R., Bai, L.
Deposit date:2017-09-04
Release date:2017-12-06
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structure of human immunoproteasome with a reversible and noncompetitive inhibitor that selectively inhibits activated lymphocytes.
Nat Commun, 8, 2017
1L0X
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TCR BETA CHAIN COMPLEXED WITH STREPTOCOCCAL SUPERANTIGEN SPEA
Descriptor:14.3.d T cell receptor beta chain, Exotoxin type A, GLYCEROL
Authors:Li, H., Sundberg, E.J., Mariuzza, R.A.
Deposit date:2002-02-14
Release date:2002-04-03
Last modified:2013-09-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1L0Y
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T CELL RECEPTOR BETA CHAIN COMPLEXED WITH SUPERANTIGEN SPEA SOAKED WITH ZINC
Descriptor:14.3.d T cell receptor beta chain, Exotoxin type A, ZINC ION, ...
Authors:Li, H., Sundberg, E.J., Mariuzza, R.A.
Deposit date:2002-02-14
Release date:2002-04-03
Last modified:2013-09-25
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes.
Structure, 10, 2002
1R0V
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STRUCTURE DETERMINATION OF THE DIMERIC ENDONUCLEASE IN A PSEUDO-FACE-CENTERD P21212 SPACE GROUP
Descriptor:tRNA-intron endonuclease
Authors:Li, H., Zhang, Y.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space group P2(1)2(1)2.
Acta Crystallogr.,Sect.D, 60, 2004
1R11
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STRUCTURE DETERMINATION OF THE DIMERIC ENDONUCLEASE IN A PSEUDO-FACE-CENTERD P21 SPACE GROUP
Descriptor:tRNA-intron endonuclease
Authors:Li, H., Zhang, Y.
Deposit date:2003-09-23
Release date:2004-03-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure determination of a truncated dimeric splicing endonuclease in pseudo-face-centered space group P2(1)2(1)2.
Acta Crystallogr.,Sect.D, 60, 2004
1R21
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SOLUTION STRUCTURE OF HUMAN KI67 FHA DOMAIN
Descriptor:Antigen Ki-67
Authors:Byeon, I.J., Li, H., Tsai, M.D.
Deposit date:2003-09-25
Release date:2003-12-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of Human Ki67 FHA Domain and its Binding to a Phosphoprotein Fragment from hNIFK Reveal Unique Recognition Sites and New Views to the Structural Basis of FHA Domain Functions
J.Mol.Biol., 335, 2004
2FHH
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CRYSTAL STRUCTURE OF MYCOBACTERIUM TUBERCULOSIS PROTEASOME IN COMPLEX WITH A PEPTIDYL BORONATE INHIBITOR MLN-273
Descriptor:20S proteasome, alpha and beta subunits, proteasome, ...
Authors:Li, H.
Deposit date:2005-12-23
Release date:2006-02-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:Structure of the Mycobacterium tuberculosis proteasome and mechanism of inhibition by a peptidyl boronate.
Mol.Microbiol., 59, 2006
2JTQ
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RHODANESE FROM E.COLI
Descriptor:Phage shock protein E
Authors:Jin, C., Li, H.
Deposit date:2007-08-06
Release date:2008-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures and backbone dynamics of Escherichia coli rhodanese PspE in its sulfur-free and persulfide-intermediate forms: implications for the catalytic mechanism of rhodanese.
Biochemistry, 47, 2008
2JTR
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RHODANESE PERSULFIDE FROM E. COLI
Descriptor:Phage shock protein E
Authors:Jin, C., Li, H.
Deposit date:2007-08-06
Release date:2008-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures and backbone dynamics of Escherichia coli rhodanese PspE in its sulfur-free and persulfide-intermediate forms: implications for the catalytic mechanism of rhodanese.
Biochemistry, 47, 2008
2JTS
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RHODANESE WITH ANIONS FROM E. COLI
Descriptor:Phage shock protein E
Authors:Jin, C., Li, H.
Deposit date:2007-08-06
Release date:2008-06-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structures and backbone dynamics of Escherichia coli rhodanese PspE in its sulfur-free and persulfide-intermediate forms: implications for the catalytic mechanism of rhodanese.
Biochemistry, 47, 2008
2KUP
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SOLUTION STRUCTURE OF THE COMPLEX OF THE PTB DOMAIN OF SNT-2 AND 19-RESIDUE PEPTIDE (AA 1571-1589) OF HALK
Descriptor:Fibroblast growth factor receptor substrate 3, 19-residue peptide from ALK tyrosine kinase receptor
Authors:Li, H., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-02-24
Release date:2010-05-26
Last modified:2014-02-12
Method:SOLUTION NMR
Cite:Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
J.Struct.Funct.Genom., 11, 2010
2KUQ
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SOLUTION STRUCTURE OF THE CHIMERA OF THE PTB DOMAIN OF SNT-2 AND 19-RESIDUE PEPTIDE (AA 1571-1589) OF HALK
Descriptor:Fibroblast growth factor receptor substrate 3, LINKER, 19-residue peptide from ALK tyrosine kinase receptor
Authors:Li, H., Koshiba, S., Tomizawa, T., Watanabe, S., Harada, T., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2010-02-24
Release date:2010-05-26
Last modified:2014-02-12
Method:SOLUTION NMR
Cite:Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
J.Struct.Funct.Genom., 11, 2010
2LC2
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SOLUTION STRUCTURE OF THE RXLR EFFECTOR P. CAPSICI AVR3A4
Descriptor:AVR3a4
Authors:Li, H., Koshiba, S., Yaeno, T., Sato, M., Watanabe, S., Harada, T., Shirasu, K., Kigawa, T.
Deposit date:2011-04-12
Release date:2011-08-03
Method:SOLUTION NMR
Cite:A PIP-binding interface in the oomycete RXLR effector AVR3A is required for its accumulation in host cells to modulate plant immunity
To be Published
2QYG
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CRYSTAL STRUCTURE OF A RUBISCO-LIKE PROTEIN RLP2 FROM RHODOPSEUDOMONAS PALUSTRIS
Descriptor:Ribulose bisphosphate carboxylase-like protein 2
Authors:Li, H., Chan, S., Tabita, F.R., Eisenberg, D.
Deposit date:2007-08-14
Release date:2007-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Function, structure, and evolution of the RubisCO-like proteins and their RubisCO homologs.
Microbiol.Mol.Biol.Rev., 71, 2007
2YS5
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SOLUTION STRUCTURE OF THE COMPLEX OF THE PTB DOMAIN OF SNT-2 AND 19-RESIDUE PEPTIDE (AA 1571-1589) OF HALK
Descriptor:Fibroblast growth factor receptor substrate 3, ALK tyrosine kinase receptor
Authors:Li, H., Koshiba, S., Inoue, M., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-03
Release date:2008-04-08
Last modified:2014-02-12
Method:SOLUTION NMR
Cite:Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
J.Struct.Funct.Genom., 11, 2010
2YT2
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SOLUTION STRUCTURE OF THE CHIMERA OF THE PTB DOMAIN OF SNT-2 AND 19-RESIDUE PEPTIDE (AA 1571-1589) OF HALK
Descriptor:Fibroblast growth factor receptor substrate 3 and ALK tyrosine kinase receptor
Authors:Li, H., Koshiba, S., Tomizawa, T., Watanabe, S., Harada, T., Kigawa, T., Yokoyama, S., RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2007-04-05
Release date:2008-04-08
Last modified:2014-02-12
Method:SOLUTION NMR
Cite:Structural basis for the recognition of nucleophosmin-anaplastic lymphoma kinase oncoprotein by the phosphotyrosine binding domain of Suc1-associated neurotrophic factor-induced tyrosine-phosphorylated target-2
J.Struct.Funct.Genom., 11, 2010