Author results

5GVB
  • Download 5gvb
  • View 5gvb
Molmil generated image of 5gvb
SEPB DOMAIN OF HUMAN AND-1
分子名称:WD repeat and HMG-box DNA-binding protein 1
著者Guan, C.C., Li, J.
登録日2016-09-05
公開日2017-04-19
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome.
J. Biol. Chem., 292, 2017
5GVA
  • Download 5gva
  • View 5gva
Molmil generated image of 5gva
WD40 DOMAIN OF HUMAN AND-1
分子名称:WD repeat and HMG-box DNA-binding protein 1
著者Guan, C.C., Li, J.
登録日2016-09-04
公開日2017-04-19
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (1.851 Å)
主引用文献The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome
J. Biol. Chem., 292, 2017
5LSI
  • Download 5lsi
  • View 5lsi
Molmil generated image of 5lsi
CRYSTAL STRUCTURE OF THE KINETOCHORE MIS12 COMPLEX HEAD2 SUBDOMAIN CONTAINING DSN1 AND NSL1 FRAGMENTS
分子名称:Kinetochore-associated protein DSN1 homolog, Kinetochore-associated protein NSL1 homolog, SULFATE ION
著者Vetter, I.R., Petrovic, A., Keller, J., Liu, Y.
登録日2016-09-02
公開日2016-11-16
最終更新日2016-12-07
実験手法X-RAY DIFFRACTION (2.002 Å)
主引用文献Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell, 167, 2016
5LSJ
  • Download 5lsj
  • View 5lsj
Molmil generated image of 5lsj
CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C DELTA-HEAD2 COMPLEX
分子名称:Protein MIS12 homolog, Polyamine-modulated factor 1, Kinetochore-associated protein DSN1 homolog, ...
著者Vetter, I.R., Petrovic, A., Keller, J., Liu, Y.
登録日2016-09-02
公開日2016-11-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.25 Å)
主引用文献Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell, 167, 2016
5LSK
  • Download 5lsk
  • View 5lsk
Molmil generated image of 5lsk
CRYSTAL STRUCTURE OF THE HUMAN KINETOCHORE MIS12-CENP-C COMPLEX
分子名称:Protein MIS12 homolog, Polyamine-modulated factor 1, Kinetochore-associated protein DSN1 homolog, ...
著者Vetter, I.R., Petrovic, A., Keller, J., Liu, Y.
登録日2016-09-02
公開日2016-11-16
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (3.502 Å)
主引用文献Structure of the MIS12 Complex and Molecular Basis of Its Interaction with CENP-C at Human Kinetochores.
Cell, 167, 2016
5GUT
  • Download 5gut
  • View 5gut
Molmil generated image of 5gut
THE CRYSTAL STRUCTURE OF MOUSE DNMT1 (731-1602) MUTANT - N1248A
分子名称:DNA (cytosine-5)-methyltransferase 1, S-ADENOSYL-L-HOMOCYSTEINE, ZINC ION, ...
著者Chen, S.J., Ye, F.
登録日2016-08-31
公開日2017-09-06
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (2.099 Å)
主引用文献Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS Chem. Biol., 13, 2018
5GUV
  • Download 5guv
  • View 5guv
Molmil generated image of 5guv
THE CRYSTAL STRUCTURE OF MOUSE DNMT1 (731-1602) MUTANT - R1279D
分子名称:DNA (cytosine-5)-methyltransferase 1, ZINC ION
著者Ye, F., Chen, S.J.
登録日2016-08-31
公開日2017-08-30
最終更新日2019-03-13
実験手法X-RAY DIFFRACTION (3.078 Å)
主引用文献Biochemical Studies and Molecular Dynamic Simulations Reveal the Molecular Basis of Conformational Changes in DNA Methyltransferase-1.
ACS Chem. Biol., 13, 2018
5T5A
  • Download 5t5a
  • View 5t5a
Molmil generated image of 5t5a
CRYSTAL STRUCTURE OF THE TWISTER SISTER (TS) RIBOZYME AT 2.0 ANGSTROM
分子名称:DNA/RNA (71-MER), MAGNESIUM ION
著者Lilley, D.M.J., Liu, Y., Wilson, T.J.
登録日2016-08-30
公開日2017-03-08
最終更新日2017-04-26
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of a nucleolytic ribozyme that employs a catalytic metal ion.
Nat. Chem. Biol., 13, 2017
5GTM
  • Download 5gtm
  • View 5gtm
Molmil generated image of 5gtm
MODIFIED HUMAN MXA, NUCLEOTIDE-FREE FORM
分子名称:Interferon-induced GTP-binding protein Mx1
著者Chen, Y., Gao, S.
登録日2016-08-22
公開日2017-05-31
最終更新日2017-06-21
実験手法X-RAY DIFFRACTION (2.896 Å)
主引用文献Conformational dynamics of dynamin-like MxA revealed by single-molecule FRET
Nat Commun, 8, 2017
5T1G
  • Download 5t1g
  • View 5t1g
Molmil generated image of 5t1g
CHROMO SHADOW DOMAIN OF CBX1 IN COMPLEX WITH A HISTONE PEPTIDE
分子名称:Chromobox protein homolog 1, Histone H3.1, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-08-19
公開日2016-09-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献chromo shadow domain of CBX1 in complex with a histone peptide
To Be Published
5T1I
  • Download 5t1i
  • View 5t1i
Molmil generated image of 5t1i
CBX3 CHROMO SHADOW DOMAIN IN COMPLEX WITH HISTONE H3 PEPTIDE
分子名称:Chromobox protein homolog 3, Histone H3.1, UNKNOWN ATOM OR ION
著者Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
登録日2016-08-19
公開日2016-09-14
最終更新日2017-04-19
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Peptide recognition by heterochromatin protein 1 (HP1) chromoshadow domains revisited: Plasticity in the pseudosymmetric histone binding site of human HP1.
J. Biol. Chem., 292, 2017
5GT5
  • Download 5gt5
  • View 5gt5
Molmil generated image of 5gt5
STRUCTURAL BASIS OF THE SPECIFIC ACTIVITY AND THERMOSTABILITY OF PECTATE LYASE (PELN) FROM PAENIBACILLUS SP. 0602
分子名称:Pectate lyase
著者Zhou, Z.P., Liu, Y., Song, J.N.
登録日2016-08-18
公開日2017-10-25
実験手法X-RAY DIFFRACTION (1.449 Å)
主引用文献Structure-based engineering of a pectate lyase with improved specific activity for ramie degumming.
Appl. Microbiol. Biotechnol., 101, 2017
5GSA
  • Download 5gsa
  • View 5gsa
Molmil generated image of 5gsa
EED IN COMPLEX WITH AN ALLOSTERIC PRC2 INHIBITOR
分子名称:Polycomb protein EED, Histone-lysine N-methyltransferase EZH2, N-(furan-2-ylmethyl)-8-(4-methylsulfonylphenyl)-[1,2,4]triazolo[4,3-c]pyrimidin-5-amine
著者Zhao, K., Zhao, M., Luo, X., Zhang, H.
登録日2016-08-15
公開日2017-02-01
最終更新日2017-04-05
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献An allosteric PRC2 inhibitor targeting the H3K27me3 binding pocket of
Nat. Chem. Biol., 13, 2017
5GS6
  • Download 5gs6
  • View 5gs6
Molmil generated image of 5gs6
FULL-LENGTH NS1 STRUCTURE OF ZIKA VIRUS FROM 2015 BRAZIL STRAIN
分子名称:NS1 of Zika virus from 2015 Brazil strain, N-ACETYL-D-GLUCOSAMINE
著者Xu, X.Y., Song, H., Qi, J.X., Shi, Y., Gao, G.F.
登録日2016-08-14
公開日2016-10-05
最終更新日2016-11-16
実験手法X-RAY DIFFRACTION (2.852 Å)
主引用文献Contribution of intertwined loop to membrane association revealed by Zika virus full-length NS1 structure
Embo J., 35, 2016
5SWD
  • Download 5swd
  • View 5swd
Molmil generated image of 5swd
STRUCTURE OF THE ADENINE RIBOSWITCH APTAMER DOMAIN IN AN INTERMEDIATE-BOUND STATE
分子名称:Vibrio vulnificus strain 93U204 chromosome II, adenine riboswitch aptamer domain, ADENINE, ...
著者Stagno, J.R., Wang, Y.-X., Liu, Y., Bhandari, Y.R., Conrad, C.E., Nelson, G., Li, C., Wendel, D.R., White, T.A., Barty, A., Tuckey, R.A., Zatsepin, N.A., Grant, T.D., Fromme, P., Tan, K., Ji, X., Spence, J.C.H.
登録日2016-08-08
公開日2016-11-23
最終更新日2018-02-14
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography.
Nature, 541, 2017
5SWE
  • Download 5swe
  • View 5swe
Molmil generated image of 5swe
LIGAND-BOUND STRUCTURE OF ADENINE RIBOSWITCH APTAMER DOMAIN CONVERTED IN CRYSTAL FROM ITS LIGAND-FREE STATE USING LIGAND MIXING SERIAL FEMTOSECOND CRYSTALLOGRAPHY
分子名称:Vibrio vulnificus strain 93U204 chromosome II, adenine riboswitch aptamer domain, ADENINE
著者Stagno, J.R., Wang, Y.-X., Liu, Y., Bhandari, Y.R., Conrad, C.E., Nelson, G., Li, C., Wendel, D.R., White, T.A., Barty, A., Tuckey, R.A., Zatsepin, N.A., Grant, T.D., Fromme, P., Tan, K., Ji, X., Spence, J.C.H.
登録日2016-08-08
公開日2016-11-23
最終更新日2018-02-14
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Structures of riboswitch RNA reaction states by mix-and-inject XFEL serial crystallography.
Nature, 541, 2017
5GON
  • Download 5gon
  • View 5gon
Molmil generated image of 5gon
STRUCTURES OF A BETA-LACTAM BRIDGED ANALOGUE IN COMPLEX WITH TUBULIN
分子名称:Tubulin alpha-1B chain, Tubulin beta-2B chain, Stathmin-4, ...
著者Zhou, L., Liu, Y., Cheng, L., Wang, Y.
登録日2016-07-28
公開日2017-03-22
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Potent Antitumor Activities and Structure Basis of the Chiral beta-Lactam Bridged Analogue of Combretastatin A-4 Binding to Tubulin.
J. Med. Chem., 59, 2016
5GMZ
  • Download 5gmz
  • View 5gmz
Molmil generated image of 5gmz
HEPATITIS B VIRUS CORE PROTEIN Y132A MUTANT IN COMPLEX WITH 4-METHYL HETEROARYLDIHYDROPYRIMIDINE
分子名称:Core protein, ISOPROPYL ALCOHOL, (2S)-4,4-difluoro-1-[[(4S)-4-(4-fluorophenyl)-5-methoxycarbonyl-4-methyl-2-(1,3-thiazol-2-yl)-1H-pyrimidin-6-yl]methyl]pyrrolidine-2-carboxylic acid, ...
著者Xu, Z.H., Zhou, Z.
登録日2016-07-18
公開日2016-08-10
最終更新日2016-09-07
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design and Synthesis of Orally Bioavailable 4-Methyl Heteroaryldihydropyrimidine Based Hepatitis B Virus (HBV) Capsid Inhibitors
J.Med.Chem., 59, 2016
5KR7
  • Download 5kr7
  • View 5kr7
Molmil generated image of 5kr7
KDM4C BOUND TO PYRAZOLO-PYRIMIDINE SCAFFOLD
分子名称:Lysine-specific demethylase 4C, FE (II) ION, ZINC ION, ...
著者Bellon, S.F., Poy, F., Setser, J.W.
登録日2016-07-07
公開日2016-08-17
最終更新日2016-08-31
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Identification of potent, selective KDM5 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5KEK
  • Download 5kek
  • View 5kek
Molmil generated image of 5kek
STRUCTURE DETERMINATION OF A SELF-ASSEMBLING DNA CRYSTAL
分子名称:DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*CP*TP*CP*A)-3'), DNA (5'-D(P*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*GP*T)-3'), ...
著者Simmons, C.R., Birktoft, J.J., Seeman, N.C., Yan, H.
登録日2016-06-09
公開日2016-08-10
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (3.098 Å)
主引用文献Construction and Structure Determination of a Three-Dimensional DNA Crystal.
J.Am.Chem.Soc., 138, 2016
5KEO
  • Download 5keo
  • View 5keo
Molmil generated image of 5keo
STRUCTURE DETERMINATION OF A SELF-ASSEMBLING DNA CRYSTAL
分子名称:DNA (5'-D(*GP*AP*GP*CP*AP*GP*AP*CP*CP*TP*GP*AP*CP*GP*AP*CP*AP*CP*TP*CP*A)-3'), DNA (5'-D(P*CP*GP*TP*CP*A)-3'), DNA (5'-D(*TP*CP*TP*GP*AP*GP*TP*GP*T)-3'), ...
著者Simmons, C.R., Birktoft, J.J., Seeman, N.C., Yan, H.
登録日2016-06-09
公開日2016-08-10
最終更新日2016-08-24
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Construction and Structure Determination of a Three-Dimensional DNA Crystal.
J.Am.Chem.Soc., 138, 2016
5KDT
  • Download 5kdt
  • View 5kdt
Molmil generated image of 5kdt
STRUCTURE OF THE HUMAN GLUN1/GLUN2A LBD IN COMPLEX WITH GNE0723
分子名称:Glutamate receptor ionotropic, NMDA 2A, NMDA 1, ...
著者Wallweber, H.J.A., Lupardus, P.J.
登録日2016-06-08
公開日2016-07-13
実験手法X-RAY DIFFRACTION (2.44 Å)
主引用文献Discovery of GluN2A-Selective NMDA Receptor Positive Allosteric Modulators (PAMs): Tuning Deactivation Kinetics via Structure-Based Design.
J. Med. Chem., 59, 2016
5KCV
  • Download 5kcv
  • View 5kcv
Molmil generated image of 5kcv
CRYSTAL STRUCTURE OF ALLOSTERIC INHIBITOR, ARQ 092, IN COMPLEX WITH AUTOINHIBITED FORM OF AKT1
分子名称:RAC-alpha serine/threonine-protein kinase, 3-[3-[4-(1-azanylcyclobutyl)phenyl]-5-phenyl-imidazo[4,5-b]pyridin-2-yl]pyridin-2-amine
著者Eathiraj, S.
登録日2016-06-07
公開日2016-06-29
最終更新日2016-07-27
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of 3-(3-(4-(1-Aminocyclobutyl)phenyl)-5-phenyl-3H-imidazo[4,5-b]pyridin-2-yl)pyridin-2-amine (ARQ 092): An Orally Bioavailable, Selective, and Potent Allosteric AKT Inhibitor.
J.Med.Chem., 59, 2016
5K4L
  • Download 5k4l
  • View 5k4l
Molmil generated image of 5k4l
CRYSTAL STRUCTURE OF KDM5A IN COMPLEX WITH A NAPHTHYRIDONE INHIBITOR
分子名称:Lysine-specific demethylase 5A, Unknown Peptide, NICKEL (II) ION, ...
著者Kiefer, J.R., Vinogradova, M.V.
登録日2016-05-20
公開日2016-08-10
最終更新日2016-09-07
実験手法X-RAY DIFFRACTION (3.179 Å)
主引用文献Design and evaluation of 1,7-naphthyridones as novel KDM5 inhibitors.
Bioorg.Med.Chem.Lett., 26, 2016
5JZV
  • Download 5jzv
  • View 5jzv
Molmil generated image of 5jzv
THE STRUCTURE OF D77G HCINAP-ADP
分子名称:Adenylate kinase isoenzyme 6, ADENOSINE-5'-DIPHOSPHATE
著者Liu, Y., Yang, Z., Yang, Y., Cai, X., Zheng, X.
登録日2016-05-17
公開日2016-08-10
最終更新日2017-12-06
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
Nat Commun, 7, 2016