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1FTK
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BU of 1ftk by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2I) IN COMPLEX WITH KAINATE AT 1.6 A RESOLUTION
Descriptor: 3-(CARBOXYMETHYL)-4-ISOPROPENYLPROLINE, GLUTAMATE RECEPTOR SUBUNIT 2
Authors:Gouaux, E, Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
1FTM
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BU of 1ftm by Molmil
CRYSTAL STRUCTURE OF THE GLUR2 LIGAND BINDING CORE (S1S2J) IN COMPLEX WITH AMPA AT 1.7 RESOLUTION
Descriptor: (S)-ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID, GLUTAMATE RECEPTOR SUBUNIT 2, ZINC ION
Authors:Gouaux, E, Armstrong, N.
Deposit date:2000-09-12
Release date:2000-11-01
Last modified:2017-08-02
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Mechanisms for activation and antagonism of an AMPA-sensitive glutamate receptor: crystal structures of the GluR2 ligand binding core.
Neuron, 28, 2000
6C10
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BU of 6c10 by Molmil
Crystal structure of mouse PCDH15 EC11-EL
Descriptor: Protocadherin-15, alpha-D-mannopyranose
Authors:Gouaux, E, Elferich, J, Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.399 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C13
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BU of 6c13 by Molmil
CryoEM structure of mouse PCDH15-4EC-LHFPL5 complex
Descriptor: Protocadherin-15, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Gouaux, E, Ge, J, Elferich, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (11.33 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
6C14
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BU of 6c14 by Molmil
CryoEM structure of mouse PCDH15-1EC-LHFPL5 complex
Descriptor: LHFPL tetraspan subfamily member 5 protein, Protocadherin-15
Authors:Gouaux, E, Elferich, J, Ge, J.
Deposit date:2018-01-03
Release date:2018-08-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (4.5 Å)
Cite:Structure of mouse protocadherin 15 of the stereocilia tip link in complex with LHFPL5.
Elife, 7, 2018
4XP1
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BU of 4xp1 by Molmil
X-ray structure of Drosophila dopamine transporter bound to neurotransmitter dopamine
Descriptor: 1,2-ETHANEDIOL, 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.89 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
4XP5
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BU of 4xp5 by Molmil
X-ray structure of Drosophila dopamine transporter bound to cocaine analogue-RTI55
Descriptor: 1-ETHOXY-2-(2-ETHOXYETHOXY)ETHANE, Antibody fragment heavy chain-protein, 9D5-heavy chain, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2015-01-16
Release date:2015-05-06
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Neurotransmitter and psychostimulant recognition by the dopamine transporter.
Nature, 521, 2015
2NWW
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BU of 2nww by Molmil
Crystal structure of GltPh in complex with TBOA
Descriptor: (3S)-3-(BENZYLOXY)-L-ASPARTIC ACID, 425aa long hypothetical proton glutamate symport protein
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWL
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BU of 2nwl by Molmil
Crystal structure of GltPh in complex with L-Asp
Descriptor: ASPARTIC ACID, PALMITIC ACID, glutamate symport protein
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-15
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
2NWX
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BU of 2nwx by Molmil
Crystal structure of GltPh in complex with L-aspartate and sodium ions
Descriptor: 425aa long hypothetical proton glutamate symport protein, ASPARTIC ACID, PALMITIC ACID, ...
Authors:Gouaux, E, Boudker, O, Ryan, R, Yernool, D, Shimamoto, K.
Deposit date:2006-11-16
Release date:2007-02-27
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Coupling substrate and ion binding to extracellular gate of a sodium-dependent aspartate transporter.
Nature, 445, 2007
4TLL
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BU of 4tll by Molmil
Crystal structure of GluN1/GluN2B NMDA receptor, structure 1
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ...
Authors:Gouaux, E, Lee, C.-H, Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.59 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
4TLM
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BU of 4tlm by Molmil
Crystal structure of GluN1/GluN2B NMDA receptor, structure 2
Descriptor: 1-AMINOCYCLOPROPANECARBOXYLIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[(1R,2S)-3-(4-benzylpiperidin-1-yl)-1-hydroxy-2-methylpropyl]phenol, ...
Authors:Gouaux, E, Lee, C.-H, Lu, W.
Deposit date:2014-05-30
Release date:2014-07-02
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3.77 Å)
Cite:NMDA receptor structures reveal subunit arrangement and pore architecture.
Nature, 511, 2014
6NJM
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BU of 6njm by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 15F1 Fab heavy chain, 15F1 Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
6NJL
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BU of 6njl by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.7 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
6NJN
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BU of 6njn by Molmil
Architecture and subunit arrangement of native AMPA receptors
Descriptor: 11B8 scFv, 15F1 Fab heavy chain, 15F1 Fab light chain, ...
Authors:Gouaux, E, Zhao, Y.
Deposit date:2019-01-03
Release date:2019-04-24
Last modified:2021-05-05
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Architecture and subunit arrangement of native AMPA receptors elucidated by cryo-EM.
Science, 364, 2019
4M48
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BU of 4m48 by Molmil
X-ray structure of dopamine transporter elucidates antidepressant mechanism
Descriptor: 9D5 antibody, heavy chain, light chain, ...
Authors:Gouaux, E, Penmatsa, A, Wang, K.
Deposit date:2013-08-06
Release date:2013-09-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.955 Å)
Cite:X-ray structure of dopamine transporter elucidates antidepressant mechanism.
Nature, 503, 2013
8TKP
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BU of 8tkp by Molmil
Structure of the C. elegans TMC-2 complex
Descriptor: 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Clark, S, Jeong, H, Goehring, A, Posert, R, Gouaux, E.
Deposit date:2023-07-25
Release date:2024-03-27
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The structure of the Caenorhabditis elegans TMC-2 complex suggests roles of lipid-mediated subunit contacts in mechanosensory transduction.
Proc.Natl.Acad.Sci.USA, 121, 2024
7USX
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BU of 7usx by Molmil
Structure of Contracted C. elegans TMC-1 complex
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.09 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USW
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BU of 7usw by Molmil
Structure of Expanded C. elegans TMC-1 complex
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
7USY
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BU of 7usy by Molmil
Structure of C. elegans TMC-1 complex with ARRD-6
Descriptor: 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Jeong, H, Clark, S, Gouaux, E.
Deposit date:2022-04-26
Release date:2022-10-19
Last modified:2023-08-09
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structures of the TMC-1 complex illuminate mechanosensory transduction.
Nature, 610, 2022
5KK2
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BU of 5kk2 by Molmil
Architecture of fully occupied GluA2 AMPA receptor - TARP complex elucidated by single particle cryo-electron microscopy
Descriptor: Glutamate receptor 2, Voltage-dependent calcium channel gamma-2 subunit
Authors:Zhao, Y, Chen, S, Yoshioka, C, Baconguis, I, Gouaux, E.
Deposit date:2016-06-20
Release date:2016-07-06
Last modified:2018-07-18
Method:ELECTRON MICROSCOPY (7.3 Å)
Cite:Architecture of fully occupied GluA2 AMPA receptor-TARP complex elucidated by cryo-EM.
Nature, 536, 2016
7U2O
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BU of 7u2o by Molmil
A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-Expanded-open state
Descriptor: Glycine receptor subunit alphaZ1, aminomethanesulfonic acid, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Zhu, H, Gouaux, E.
Deposit date:2022-02-24
Release date:2023-03-01
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:A novel compound mimics the structural and functional effects of the full agonist glycine on glycine channels-Expanded-open state
To Be Published
6VTK
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BU of 6vtk by Molmil
Structure of an acid-sensing ion channel solubilized by styrene maleic acid and in a desensitized state at low pH
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid-sensing ion channel 1
Authors:Yoder, N, Gouaux, E.
Deposit date:2020-02-12
Release date:2020-03-11
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:The His-Gly motif of acid-sensing ion channels resides in a reentrant 'loop' implicated in gating and ion selectivity.
Elife, 9, 2020
8DE3
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BU of 8de3 by Molmil
Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
Descriptor: 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab antibody in the presence of cocaine
To Be Published
8DE4
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BU of 8de4 by Molmil
Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
Descriptor: (2S)-N-methyl-1-phenylpropan-2-amine, 15B8 Fab heavy chain variable domain, 15B8 Fab light chain variable domain, ...
Authors:Yang, D, Gouaux, E.
Deposit date:2022-06-19
Release date:2023-07-05
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Native serotonin transporter in complex with 15B8 Fab in the presence of methamphetamine
To be published

217705

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