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3NL3
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THE CRYSTAL STRUCTURE OF CANDIDA GLABRATA THI6, A BIFUNCTIONAL ENZYME INVOLVED IN THIAMIN BIOSYHTHESIS OF EUKARYOTES
Descriptor:Thiamine biosynthetic bifunctional enzyme, THIAMIN PHOSPHATE, MAGNESIUM ION
Authors:Paul, D., Chatterjee, A., Begley, T.P., Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (3.007 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
3NL5
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THE CRYSTAL STRUCTURE OF CANDIDA GLABRATA THI6, A BIFUNCTIONAL ENZYME INVOLVED IN THIAMIN BIOSYHTHESIS OF EUKARYOTES
Descriptor:Thiamine biosynthetic bifunctional enzyme, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ...
Authors:Paul, D., Chatterjee, A., Begley, T.P., Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
3NL6
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THE CRYSTAL STRUCTURE OF CANDIDA GLABRATA THI6, A BIFUNCTIONAL ENZYME INVOLVED IN THIAMIN BIOSYHTHESIS OF EUKARYOTES
Descriptor:Thiamine biosynthetic bifunctional enzyme, MAGNESIUM ION, THIAMIN PHOSPHATE, ...
Authors:Paul, D., Chatterjee, A., Begley, T.P., Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (2.612 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
3NM1
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THE CRYSTAL STRUCTURE OF CANDIDA GLABRATA THI6, A BIFUNCTIONAL ENZYME INVOLVED IN THIAMIN BIOSYHTHESIS OF EUKARYOTES
Descriptor:Thiamine biosynthetic bifunctional enzyme, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, ...
Authors:Paul, D., Chatterjee, A., Begley, T.P., Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.211 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
3NM3
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THE CRYSTAL STRUCTURE OF CANDIDA GLABRATA THI6, A BIFUNCTIONAL ENZYME INVOLVED IN THIAMIN BIOSYHTHESIS OF EUKARYOTES
Descriptor:Thiamine biosynthetic bifunctional enzyme, MAGNESIUM ION, THIAMIN PHOSPHATE, ...
Authors:Paul, D., Chatterjee, A., Begley, T.P., Ealick, S.E.
Deposit date:2010-06-21
Release date:2010-11-10
Last modified:2013-05-29
Method:X-RAY DIFFRACTION (3.102 Å)
Cite:Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes .
Biochemistry, 49, 2010
3NNK
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BIOCHEMICAL AND STRUCTURAL CHARACTERIZATION OF A UREIDOGLYCINE AMINOTRANSFERASE IN THE KLEBSIELLA PNEUMONIAE URIC ACID CATABOLIC PATHWAY
Descriptor:Ureidoglycine-glyoxylate aminotransferase
Authors:French, J.B., Ealick, S.E.
Deposit date:2010-06-23
Release date:2010-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.58 Å)
Cite:Biochemical and Structural Characterization of a Ureidoglycine Aminotransferase in the Klebsiella pneumoniae Uric Acid Catabolic Pathway.
Biochemistry, 49, 2010
3O15
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS THIAMIN PHOSPHATE SYNTHASE COMPLEXED WITH A CARBOXYLATED THIAZOLE PHOSPHATE
Descriptor:Thiamine-phosphate pyrophosphorylase, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, 2-TRIFLUOROMETHYL-5-METHYLENE-5H-PYRIMIDIN-4-YLIDENEAMINE, ...
Authors:McCulloch, K.M., Hanes, J.W., Abdelwahed, S., Mahanta, N., Hazra, A., Ishida, K., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-20
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Crystal Structure and Kinetic Characterization of Bacillus subtilis Thiamin Phosphate Synthase with a Carboxylated Thiazole Phosphate
to be published
3O16
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CRYSTAL STRUCTURE OF BACILLUS SUBTILIS THIAMIN PHOSPHATE SYNTHASE K159A
Descriptor:Thiamine-phosphate pyrophosphorylase
Authors:McCulloch, K.M., Hanes, J.W., Abdelwahed, S., Mahanta, N., Hazra, A., Ishida, K., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-20
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure and Kinetic Characterization of Bacillus subtilis Thiamin Phosphate Synthase with a Carboxylated Thiazole Phosphate
to be published
3O63
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CRYSTAL STRUCTURE OF THIAMIN PHOSPHATE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS
Descriptor:Probable thiamine-phosphate pyrophosphorylase, PHOSPHATE ION
Authors:McCulloch, K.M., Ramamoorthy, D., Ishida, K., Guida, W.C., Begley, T.P., Ealick, S.E.
Deposit date:2010-07-28
Release date:2011-07-27
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystal Structure and Identification of Potential Inhibitor Compounds for Mycobacterium tuberculosis Thiamin Phosphate Synthase
to be published
3O7H
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CRYSTAL STRUCTURE OF 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:OHCU decarboxylase
Authors:French, J.B., Ealick, S.E.
Deposit date:2010-07-30
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase.
J.Biol.Chem., 285, 2010
3O7I
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CRYSTAL STRUCTURE OF 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:OHCU decarboxylase
Authors:French, J.B., Ealick, S.E.
Deposit date:2010-07-30
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase.
J.Biol.Chem., 285, 2010
3O7J
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CRYSTAL STRUCTURE OF 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:OHCU decarboxylase, 1-(2,5-DIOXO-2,5-DIHYDRO-1H-IMIDAZOL-4-YL)UREA
Authors:French, J.B., Ealick, S.E.
Deposit date:2010-07-30
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase.
J.Biol.Chem., 285, 2010
3O7K
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CRYSTAL STRUCTURE OF 2-OXO-4-HYDROXY-4-CARBOXY-5-UREIDOIMIDAZOLINE DECARBOXYLASE FROM KLEBSIELLA PNEUMONIAE
Descriptor:OHCU decarboxylase
Authors:French, J.B., Ealick, S.E.
Deposit date:2010-07-30
Release date:2010-09-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase.
J.Biol.Chem., 285, 2010
3O90
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HIGH RESOLUTION CRYSTAL STRUCTURES OF STREPTOCOCCUS PNEUMONIAE NICOTINAMIDASE WITH TRAPPED INTERMEDIATES PROVIDE INSIGHTS INTO CATALYTIC MECHANISM AND INHIBITION BY ALDEHYDES
Descriptor:nicotinamidase, ZINC ION
Authors:French, J.B., Cen, Y., Sauve, A.A., Ealick, S.E.
Deposit date:2010-08-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
3O91
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HIGH RESOLUTION CRYSTAL STRUCTURES OF STREPTOCOCCUS PNEUMONIAE NICOTINAMIDASE WITH TRAPPED INTERMEDIATES PROVIDE INSIGHTS INTO CATALYTIC MECHANISM AND INHIBITION BY ALDEHYDES
Descriptor:nicotinamidase, ZINC ION
Authors:French, J.B., Cen, Y., Sauve, A.A., Ealick, S.E.
Deposit date:2010-08-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
3O92
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HIGH RESOLUTION CRYSTAL STRUCTURES OF STREPTOCOCCUS PNEUMONIAE NICOTINAMIDASE WITH TRAPPED INTERMEDIATES PROVIDE INSIGHTS INTO CATALYTIC MECHANISM AND INHIBITION BY ALDEHYDES
Descriptor:nicotinamidase, ZINC ION
Authors:French, J.B., Cen, Y., Sauve, A.A., Ealick, S.E.
Deposit date:2010-08-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
3O93
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HIGH RESOLUTION CRYSTAL STRUCTURES OF STREPTOCOCCUS PNEUMONIAE NICOTINAMIDASE WITH TRAPPED INTERMEDIATES PROVIDE INSIGHTS INTO CATALYTIC MECHANISM AND INHIBITION BY ALDEHYDES
Descriptor:nicotinamidase, ZINC ION
Authors:French, J.B., Cen, Y., Sauve, A.A., Ealick, S.E.
Deposit date:2010-08-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
3O94
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HIGH RESOLUTION CRYSTAL STRUCTURES OF STREPTOCOCCUS PNEUMONIAE NICOTINAMIDASE WITH TRAPPED INTERMEDIATES PROVIDE INSIGHTS INTO CATALYTIC MECHANISM AND INHIBITION BY ALDEHYDES
Descriptor:nicotinamidase, NICOTINAMIDE, ZINC ION
Authors:French, J.B., Cen, Y., Sauve, A.A., Ealick, S.E.
Deposit date:2010-08-03
Release date:2011-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:High-resolution crystal structures of Streptococcus pneumoniae nicotinamidase with trapped intermediates provide insights into the catalytic mechanism and inhibition by aldehydes .
Biochemistry, 49, 2010
3PKV
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CRYSTAL STRUCTURE OF TOXOFLAVIN LYASE (TFLA)
Descriptor:Toxoflavin lyase (TflA)
Authors:Fenwick, M.K., Philmus, B., Begley, T.P., Ealick, S.E.
Deposit date:2010-11-12
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
3PKW
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CRYSTAL STRUCTURE OF TOXOFLAVIN LYASE (TFLA) BOUND TO MN(II)
Descriptor:Toxoflavin lyase (TflA), MANGANESE (II) ION
Authors:Fenwick, M.K., Philmus, B., Begley, T.P., Ealick, S.E.
Deposit date:2010-11-12
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
3PKX
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CRYSTAL STRUCTURE OF TOXOFLAVIN LYASE (TFLA) BOUND TO MN(II) AND TOXOFLAVIN
Descriptor:Toxoflavin lyase (TflA), MANGANESE (II) ION, 1,6-dimethylpyrimido[5,4-e][1,2,4]triazine-5,7(1H,6H)-dione
Authors:Fenwick, M.K., Philmus, B., Begley, T.P., Ealick, S.E.
Deposit date:2010-11-12
Release date:2011-01-12
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Toxoflavin lyase requires a novel 1-his-2-carboxylate facial triad .
Biochemistry, 50, 2011
3PNP
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THE HIGH RESOLUTION CRYSTAL STRUCTURE OF BOVINE SPLEEN PURINE NUCLEOSIDE PHOSPHORYLASE IN COMPLEX FORMS WITH PHOSPHATE AND 9-DEAZAINOSINE
Descriptor:PURINE NUCLEOSIDE PHOSPHORYLASE, MAGNESIUM ION, PHOSPHATE ION
Authors:Pugmire, M.J., Mao, C., Ealick, S.E.
Deposit date:1998-03-27
Release date:1999-03-30
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The High Resolution Crystal Structure of Bovine Spleen Purine Nucleoside Phosphorylase in Complex Forms with Phosphate and 9-Deazainosine
To be Published
3QH2
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CRYSTAL STRUCTURE OF TENI FROM BACILLUS SUBTILIS COMPLEXED WITH PRODUCT CTHZ-P
Descriptor:Regulatory protein tenI, 4-methyl-5-[2-(phosphonooxy)ethyl]-1,3-thiazole-2-carboxylic acid, SULFATE ION
Authors:Han, Y., Zhang, Y., Hazra, A., Chatterjee, A., Lai, R., Begley, T.P., Ealick, S.E.
Deposit date:2011-01-25
Release date:2011-05-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.231 Å)
Cite:A Missing Enzyme in Thiamin Thiazole Biosynthesis: Identification of TenI as a Thiazole Tautomerase.
J.Am.Chem.Soc., 133, 2011
3QPB
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CRYSTAL STRUCTURE OF STREPTOCOCCUS PYOGENES URIDINE PHOSPHORYLASE REVEALS A SUBCLASS OF THE NP-I SUPERFAMILY
Descriptor:Uridine phosphorylase, RIBOSE-1-PHOSPHATE, URACIL
Authors:Tran, T.H., Christoffersen, S., Parker, W.B., Piskur, J., Serra, I., Terreni, M., Ealick, S.E.
Deposit date:2011-02-11
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:The Crystal Structure of Streptococcus pyogenes Uridine Phosphorylase Reveals a Distinct Subfamily of Nucleoside Phosphorylases.
Biochemistry, 50, 2011
3QVA
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STRUCTURE OF KLEBSIELLA PNEUMONIAE 5-HYDROXYISOURATE HYDROLASE
Descriptor:Transthyretin-like protein, PHOSPHATE ION
Authors:French, J.B., Ealick, S.E.
Deposit date:2011-02-25
Release date:2011-08-24
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.755 Å)
Cite:Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae.
Acta Crystallogr.,Sect.D, 67, 2011