Author results

3ED0
  • Download 3ed0
  • View 3ed0
Molmil generated image of 3ed0
CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH EMODIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, BENZAMIDINE, CHLORIDE ION, ...
著者Zhang, L., Zhang, H., Liu, W., Guo, Y., Shen, X., Jiang, H.
登録日2008-09-02
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization
BMC MICROBIOL., 9, 2009
3U2Q
  • Download 3u2q
  • View 3u2q
Molmil generated image of 3u2q
EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH NVP-LFF571
分子名称:Elongation factor Tu 1, Thiocillin GE2270 analogue NVP-LFF571, GUANOSINE-5'-DIPHOSPHATE, ...
著者Palestrant, D.J.
登録日2011-10-04
公開日2012-05-02
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of LFF571: an investigational agent for Clostridium difficile infection.
J.Med.Chem., 55, 2012
4L1B
  • Download 4l1b
  • View 4l1b
Molmil generated image of 4l1b
CRYSTAL STRUCTURE OF P110ALPHA COMPLEXED WITH NISH2 OF P85ALPHA
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION
著者Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.
登録日2013-06-03
公開日2014-01-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.586 Å)
主引用文献Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
ACS Med Chem Lett, 5, 2014
4L23
  • Download 4l23
  • View 4l23
Molmil generated image of 4l23
CRYSTAL STRUCTURE OF P110ALPHA COMPLEXED WITH NISH2 OF P85ALPHA AND PI-103
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, ...
著者Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.
登録日2013-06-04
公開日2014-01-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
ACS Med Chem Lett, 5, 2014
4L2Y
  • Download 4l2y
  • View 4l2y
Molmil generated image of 4l2y
CRYSTAL STRUCTURE OF P110ALPHA COMPLEXED WITH NISH2 OF P85ALPHA AND COMPOUND 9D
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-amino-5-[4-(morpholin-4-yl)pyrido[3',2':4,5]furo[3,2-d]pyrimidin-2-yl]phenol, ...
著者Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.
登録日2013-06-05
公開日2014-01-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
ACS Med Chem Lett, 5, 2014
4XHR
  • Download 4xhr
  • View 4xhr
Molmil generated image of 4xhr
STRUCTURE OF A PHOSPHOLIPID TRAFFICKING COMPLEX, NATIVE
分子名称:Protein UPS1, mitochondrial, Mitochondrial distribution and morphology protein 35
著者Yu, F., He, F., Wang, C., Zhang, P.
登録日2015-01-06
公開日2015-07-01
最終更新日2015-08-05
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
4XIZ
  • Download 4xiz
  • View 4xiz
Molmil generated image of 4xiz
STRUCTURE OF A PHOSPHOLIPID TRAFFICKING COMPLEX WITH SUBSTRATE
分子名称:Protein UPS1, mitochondrial, Mitochondrial distribution and morphology protein 35, ...
著者Yu, F., He, F., Wang, C., Zhang, P.
登録日2015-01-08
公開日2015-07-01
最終更新日2015-09-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis of intramitochondrial phosphatidic acid transport mediated by Ups1-Mdm35 complex
Embo Rep., 16, 2015
5JBQ
  • Download 5jbq
  • View 5jbq
Molmil generated image of 5jbq
EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH THIOMURACIN ANALOG
分子名称:Elongation factor Tu 1, THIOMURACIN ANALOG, GUANOSINE-5'-DIPHOSPHATE, ...
著者Palestrant, D., Stams, T.
登録日2016-04-13
公開日2016-07-13
最終更新日2016-08-10
実験手法X-RAY DIFFRACTION (2.006 Å)
主引用文献Antibacterial and Solubility Optimization of Thiomuracin A.
J.Med.Chem., 59, 2016
5JDK
  • Download 5jdk
  • View 5jdk
Molmil generated image of 5jdk
CRYSTAL STRUCTURE OF THE DNA BINDING DOMAIN OF SAP1 IN FISSION YEAST S.POMBE
分子名称:Switch-activating protein 1, GLYCEROL
著者He, P., Wang, T.
登録日2016-04-17
公開日2017-02-22
最終更新日2018-01-24
実験手法X-RAY DIFFRACTION (0.998 Å)
主引用文献Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe.
J. Biol. Chem., 292, 2017
5Z0S
  • Download 5z0s
  • View 5z0s
Molmil generated image of 5z0s
CRYSTAL STRUCTURE OF FGFR1 KINASE DOMAIN IN COMPLEX WITH A NOVEL INHIBITOR
分子名称:Fibroblast growth factor receptor 1, 1-[(6-chloroimidazo[1,2-b]pyridazin-3-yl)sulfonyl]-6-(1-methyl-1H-pyrazol-4-yl)-1H-pyrazolo[4,3-b]pyridine
著者Liu, Q., Xu, Y.
登録日2017-12-20
公開日2018-12-26
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure-Based Discovery of a Series of 5H-Pyrrolo[2,3-b]pyrazine FGFR Kinase Inhibitors
Molecules, 23, 2018
1WWN
  • Download 1wwn
  • View 1wwn
Molmil generated image of 1wwn
NMR SOLUTION STRUCTURE OF BMK-BETAIT, AN EXCITATORY SCORPION TOXIN FROM BUTHUS MARTENSI KARSCH
分子名称:Excitatory insect selective toxin 1
著者Wu, H., Tong, X., Chen, X., Zhang, Q., Zheng, X., Zhang, N., Wu, G.
登録日2005-01-10
公開日2006-01-17
最終更新日2011-07-13
実験手法SOLUTION NMR
主引用文献NMR solution structure of BmK-betaIT, an excitatory scorpion beta-toxin without a 'hot spot' at the relevant position
Biochem.Biophys.Res.Commun., 349, 2006
3F9E
  • Download 3f9e
  • View 3f9e
Molmil generated image of 3f9e
CRYSTAL STRUCTURE OF THE S139A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE
分子名称:3C-like proteinase
著者Hu, T., Li, L., Jiang, H., Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9F
  • Download 3f9f
  • View 3f9f
Molmil generated image of 3f9f
CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 6.0
分子名称:3C-like proteinase
著者Hu, T., Li, L., Jiang, H., Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9G
  • Download 3f9g
  • View 3f9g
Molmil generated image of 3f9g
CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 6.5
分子名称:3C-like proteinase
著者Hu, T., Li, L., Jiang, H., Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
3F9H
  • Download 3f9h
  • View 3f9h
Molmil generated image of 3f9h
CRYSTAL STRUCTURE OF THE F140A MUTANT OF SARS-CORONOVIRUS 3C-LIKE PROTEASE AT PH 7.6
分子名称:3C-like proteinase
著者Hu, T., Li, L., Jiang, H., Shen, X.
登録日2008-11-13
公開日2009-09-29
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Two adjacent mutations on the dimer interface of SARS coronavirus 3C-like protease cause different conformational changes in crystal structure.
Virology, 388, 2009
5HEK
  • Download 5hek
  • View 5hek
Molmil generated image of 5hek
CRYSTAL STRUCTURE OF M1.HPYAVI
分子名称:Adenine specific DNA methyltransferase (DpnA)
著者Ma, B., Zhang, H., Liu, W.
登録日2016-01-06
公開日2016-11-16
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori
Oncotarget, 7, 2016
5HFJ
  • Download 5hfj
  • View 5hfj
Molmil generated image of 5hfj
CRYSTAL STRUCTURE OF M1.HPYAVI-SAM COMPLEX
分子名称:Adenine specific DNA methyltransferase (DpnA), S-ADENOSYLMETHIONINE
著者Ma, B., Liu, W., Zhang, H.
登録日2016-01-07
公開日2016-11-16
最終更新日2016-11-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Biochemical and structural characterization of a DNA N6-adenine methyltransferase from Helicobacter pylori
Oncotarget, 7, 2016
2ZD1
  • Download 2zd1
  • View 2zd1
Molmil generated image of 2zd1
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH TMC278 (RILPIVIRINE), A NON-NUCLEOSIDE RT INHIBITOR
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, SULFATE ION, ...
著者Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.
登録日2007-11-16
公開日2008-02-12
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2ZE2
  • Download 2ze2
  • View 2ze2
Molmil generated image of 2ze2
CRYSTAL STRUCTURE OF L100I/K103N MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH TMC278 (RILPIVIRINE), A NON-NUCLEOSIDE RT INHIBITOR
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile
著者Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.
登録日2007-12-05
公開日2008-02-12
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
Proc.Natl.Acad.Sci.Usa, 105, 2008
3BGR
  • Download 3bgr
  • View 3bgr
Molmil generated image of 3bgr
CRYSTAL STRUCTURE OF K103N/Y181C MUTANT HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH TMC278 (RILPIVIRINE), A NON-NUCLEOSIDE RT INHIBITOR
分子名称:Reverse transcriptase/ribonuclease H, p51 RT, 4-{[4-({4-[(E)-2-cyanoethenyl]-2,6-dimethylphenyl}amino)pyrimidin-2-yl]amino}benzonitrile, ...
著者Das, K., Bauman, J.D., Clark Jr., A.D., Shatkin, A.J., Arnold, E.
登録日2007-11-27
公開日2008-02-12
最終更新日2015-06-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献High-resolution structures of HIV-1 reverse transcriptase/TMC278 complexes: Strategic flexibility explains potency against resistance mutations.
Proc.Natl.Acad.Sci.Usa, 105, 2008
4EKF
  • Download 4ekf
  • View 4ekf
Molmil generated image of 4ekf
STRUCTURE OF THE INACTIVE ADENOVIRUS PROTEINASE AT 0.98 ANGSTROM RESOLUTION
分子名称:Adenain, SODIUM ION
著者Baniecki, M.L., McGrath, W.J., Mangel, W.F.
登録日2012-04-09
公開日2012-10-10
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (0.98 Å)
主引用文献Regulation of a Viral Proteinase by a Peptide and DNA in One-dimensional Space: III. ATOMIC RESOLUTION STRUCTURE OF THE NASCENT FORM OF THE ADENOVIRUS PROTEINASE.
J.Biol.Chem., 288, 2013
1R0A
  • Download 1r0a
  • View 1r0a
Molmil generated image of 1r0a
CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE COVALENTLY TETHERED TO DNA TEMPLATE-PRIMER SOLVED TO 2.8 ANGSTROMS
分子名称:5'-D(*A*TP*GP*CP*AP*TP*CP*GP*GP*CP*GP*CP*TP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*GP*GP*T)-3', 5'-D(*C*CP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*AP*GP*CP*GP*CP*CP*GP*(2DA))-3', Reverse transcriptase, ...
著者Tuske, S., Ding, J., Arnold, E.
登録日2003-09-19
公開日2004-08-03
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nonnucleoside inhibitor binding affects the interactions of the fingers subdomain of human immunodeficiency virus type 1 reverse transcriptase with DNA.
J.Virol., 78, 2004
1XD5
  • Download 1xd5
  • View 1xd5
Molmil generated image of 1xd5
CRYSTAL STRUCTURES OF NOVEL MONOMERIC MONOCOT MANNOSE-BINDING LECTINS FROM GASTRODIA ELATA
分子名称:antifungal protein GAFP-1, SULFATE ION
著者Liu, W., Yang, N., Wang, M., Huang, R.H., Hu, Z., Wang, D.C.
登録日2004-09-04
公開日2005-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Mechanism Governing the Quaternary Organization of Monocot Mannose-binding Lectin Revealed by the Novel Monomeric Structure of an Orchid Lectin
J.Biol.Chem., 280, 2005
1XD6
  • Download 1xd6
  • View 1xd6
Molmil generated image of 1xd6
CRYSTAL STRUCTURES OF NOVEL MONOMERIC MONOCOT MANNOSE-BINDING LECTINS FROM GASTRODIA ELATA
分子名称:gastrodianin-4, SULFATE ION
著者Liu, W., Yang, N., Wang, M., Huang, R.H., Hu, Z., Wang, D.C.
登録日2004-09-04
公開日2005-01-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Mechanism Governing the Quaternary Organization of Monocot Mannose-binding Lectin Revealed by the Novel Monomeric Structure of an Orchid Lectin
J.Biol.Chem., 280, 2005
3C5Q
  • Download 3c5q
  • View 3c5q
Molmil generated image of 3c5q
CRYSTAL STRUCTURE OF DIAMINOPIMELATE DECARBOXYLASE (I148L MUTANT) FROM HELICOBACTER PYLORI COMPLEXED WITH L-LYSINE
分子名称:Diaminopimelate decarboxylase, PYRIDOXAL-5'-PHOSPHATE, LYSINE, ...
著者Hu, T., Wu, D., Jiang, H., Shen, X.
登録日2008-02-01
公開日2008-05-27
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Crystal structure of diaminopimelate decarboxylase from Helicobacter pylori
To be Published