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5YFM
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BU of 5yfm by Molmil
Human isocitrate dehydrogenase 1 bound with NADP
Descriptor: Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Nordlund, P, Chen, D, Jansson, A, Larsson, A.
Deposit date:2017-09-21
Release date:2017-10-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Human isocitrate dehydrogenase 1 bound with NADP
To Be Published
5YFN
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BU of 5yfn by Molmil
Human isocitrate dehydrogenase 1 bound with isocitrate
Descriptor: ISOCITRIC ACID, Isocitrate dehydrogenase [NADP] cytoplasmic, MAGNESIUM ION, ...
Authors:Nordlund, P, Chen, D, Jansson, A, Larsson, A.
Deposit date:2017-09-21
Release date:2017-10-25
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Human isocitrate dehydrogenase 1 bound with isocitrate
To Be Published
1BIQ
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BU of 1biq by Molmil
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN MUTANT E238A
Descriptor: FE (II) ION, FE (III) ION, HYDROXIDE ION, ...
Authors:Logan, D.T, Demare, F, Persson, B.O, Slaby, A, Sjoberg, B.M, Nordlund, P.
Deposit date:1998-06-18
Release date:1999-01-13
Last modified:2023-08-02
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.
Biochemistry, 37, 1998
5HS3
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BU of 5hs3 by Molmil
Human thymidylate synthase complexed with dUMP and 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol
Descriptor: 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 3-amino-2-benzoyl-4-methylthieno[2,3-b]pyridin-6-ol, Thymidylate synthase
Authors:Chen, D, Almqvist, H, Axelsson, H, Jafari, R, Mateus, A, Haraldsson, M, Larsson, A, Artursson, P, Molina, D.M, Lundback, T, Nordlund, P.
Deposit date:2016-01-25
Release date:2016-02-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.103 Å)
Cite:CETSA screening identifies known and novel thymidylate synthase inhibitors and slow intracellular activation of 5-fluorouracil
Nat Commun, 7, 2016
4TPJ
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BU of 4tpj by Molmil
Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2
Descriptor: ALA-ALA-ALA, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ...
Authors:Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P.
Deposit date:2014-06-07
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.201 Å)
Cite:Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
4TPH
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BU of 4tph by Molmil
Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2
Descriptor: 3,5 DIBROMOTYROSINE, ALANINE, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Guettou, F, Quistgaard, E, Raba, M, Moberg, P, Low, C, Nordlund, P.
Deposit date:2014-06-07
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.155 Å)
Cite:Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
4TPG
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BU of 4tpg by Molmil
Selectivity mechanism of a bacterial homologue of the human drug peptide transporters PepT1 and PepT2
Descriptor: Ala-L-3-Br-Tyr-Ala, DODECYL-BETA-D-MALTOSIDE, Proton:oligopeptide symporter POT family, ...
Authors:Guettou, F, Quistgaard, E.M, Raba, M, Moberg, P, Low, C, Nordlund, P.
Deposit date:2014-06-07
Release date:2014-07-09
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.91 Å)
Cite:Selectivity mechanism of a bacterial homolog of the human drug-peptide transporters PepT1 and PepT2.
Nat.Struct.Mol.Biol., 21, 2014
1AE7
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BU of 1ae7 by Molmil
NOTEXIN, A PRESYNAPTIC NEUROTOXIC PHOSPHOLIPASE A2
Descriptor: PHOSPHOLIPASE A2, SULFATE ION
Authors:Westerlund, B, Nordlund, P, Uhlin, U, Eaker, D, Eklund, H.
Deposit date:1997-03-06
Release date:1997-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The three-dimensional structure of notexin, a presynaptic neurotoxic phospholipase A2 at 2.0 A resolution.
FEBS Lett., 301, 1992
1ABA
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BU of 1aba by Molmil
THE STRUCTURE OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN (THIOREDOXIN). REFINEMENT OF NATIVE AND MUTANT PROTEINS
Descriptor: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, GLUTAREDOXIN
Authors:Eklund, H, Ingelman, M, Soderberg, B.-O, Uhlin, T, Nordlund, P, Nikkola, M, Sonnerstam, U, Joelson, T, Petratos, K.
Deposit date:1992-04-24
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.
J.Mol.Biol., 228, 1992
1AAZ
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BU of 1aaz by Molmil
THE STRUCTURE OF OXIDIZED BACTERIOPHAGE T4 GLUTAREDOXIN (THIOREDOXIN)
Descriptor: CADMIUM ION, GLUTAREDOXIN
Authors:Eklund, H, Ingelman, M, Soderberg, B.-O, Uhlin, T, Nordlund, P, Nikkola, M, Sonnerstam, U, Joelson, T, Petratos, K.
Deposit date:1992-04-24
Release date:1993-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of oxidized bacteriophage T4 glutaredoxin (thioredoxin). Refinement of native and mutant proteins.
J.Mol.Biol., 228, 1992
5IPX
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BU of 5ipx by Molmil
Structure of ORF49 from KSHV
Descriptor: ORF49 protein, SULFATE ION
Authors:Hew, K, Nordlund, P.
Deposit date:2016-03-10
Release date:2016-11-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structure of the Open Reading Frame 49 Protein Encoded by Kaposi's Sarcoma-Associated Herpesvirus.
J. Virol., 91, 2017
1H7B
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BU of 1h7b by Molmil
Structural basis for allosteric substrate specificity regulation in class III ribonucleotide reductases, native NRDD
Descriptor: ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, PHOSPHATE ION
Authors:Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T.
Deposit date:2001-07-04
Release date:2002-03-28
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
1H79
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BU of 1h79 by Molmil
STRUCTURAL BASIS FOR ALLOSTERIC SUBSTRATE SPECIFICITY REGULATION IN CLASS III RIBONUCLEOTIDE REDUCTASES: NRDD IN COMPLEX WITH DTTP
Descriptor: ANAEROBIC RIBONUCLEOTIDE-TRIPHOSPHATE REDUCTASE LARGE CHAIN, FE (II) ION, MAGNESIUM ION, ...
Authors:Larsson, K.-M, Andersson, J, Sjoeberg, B.-M, Nordlund, P, Logan, D.T.
Deposit date:2001-07-04
Release date:2002-03-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Allosteric Substrate Specificty Regulation in Anaerobic Ribonucleotide Reductase
Structure, 9, 2001
5BQK
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BU of 5bqk by Molmil
CRYSTAL STRUCTURE OF C-TERMINAL DOMAIN OF ICP27 PROTEIN FROM HSV-1
Descriptor: ICP27, ZINC ION
Authors:Patel, V, Rajakannan, V, Dahlroth, S, Nordlund, P.
Deposit date:2015-05-29
Release date:2015-07-01
Last modified:2015-08-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the C-Terminal Domain of the Multifunctional ICP27 Protein from Herpes Simplex Virus 1.
J.Virol., 89, 2015
5EBB
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BU of 5ebb by Molmil
Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with Zn2+
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Acid sphingomyelinase-like phosphodiesterase 3a, GLYCEROL, ...
Authors:Lim, S.M, Yeung, K, Tresaugues, L, Teo, H.L, Nordlund, P.
Deposit date:2015-10-19
Release date:2016-01-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Febs J., 283, 2016
5EBE
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BU of 5ebe by Molmil
Structure of human sphingomyelinase phosphodiesterase like 3A (SMPDL3A) with 5' CMP
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-O-phosphono-beta-D-ribofuranose, ...
Authors:Lim, S.M, Yeung, K, Tresaugues, L, Teo, H.L, Nordlund, P.
Deposit date:2015-10-19
Release date:2016-01-20
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structure and catalytic mechanism of human sphingomyelin phosphodiesterase like 3a - an acid sphingomyelinase homologue with a novel nucleotide hydrolase activity.
Febs J., 283, 2016
1MRR
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BU of 1mrr by Molmil
SUBSTITUTION OF MANGANESE FOR IRON IN RIBONUCLEOTIDE REDUCTASE FROM ESCHERICHIA COLI. SPECTROSCOPIC AND CRYSTALLOGRAPHIC CHARACTERIZATION
Descriptor: MANGANESE (II) ION, MERCURY (II) ION, RIBONUCLEOTIDE REDUCTASE R1 PROTEIN
Authors:Eklund, H, Nordlund, P.
Deposit date:1992-07-28
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Substitution of manganese for iron in ribonucleotide reductase from Escherichia coli. Spectroscopic and crystallographic characterization.
J.Biol.Chem., 267, 1992
4XAL
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BU of 4xal by Molmil
Crystal structure of the conserved core domain of VP22 from HSV-1
Descriptor: Tegument protein VP22, peptide SSGVDL
Authors:Hew, K, Dahlroth, S.L, Nordlund, P.
Deposit date:2014-12-15
Release date:2015-06-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.869 Å)
Cite:VP22 core domain from Herpes simplex virus 1 reveals a surprising structural conservation in both the Alpha- and Gammaherpesvirinae subfamilies.
J.Gen.Virol., 96, 2015
5A7J
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BU of 5a7j by Molmil
Crystal structure of INPP5B in complex with benzene 1,2,4,5- tetrakisphosphate
Descriptor: (2,4,5-triphosphonooxyphenyl) dihydrogen phosphate, GLYCEROL, SULFATE ION, ...
Authors:Tresaugues, L, Mills, S.J, Silvander, C, Cozier, G, Potter, B.V.L, Nordlund, P.
Deposit date:2015-07-06
Release date:2016-04-13
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Type-II Inositol Polyphosphate 5-Phosphatase Inpp5B with Synthetic Inositol Polyphosphate Surrogates Reveal New Mechanistic Insights for the Inositol 5-Phosphatase Family.
Biochemistry, 55, 2016
1MXR
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BU of 1mxr by Molmil
High resolution structure of Ribonucleotide reductase R2 from E. coli in its oxidised (Met) form
Descriptor: FE (III) ION, GLYCEROL, MERCURY (II) ION, ...
Authors:Andersson, M.A, Hogbom, M, Nordlund, P.
Deposit date:2002-10-03
Release date:2003-03-25
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Displacement of the tyrosyl radical cofactor in ribonucleotide reductase obtained by single-crystal high-field EPR and 1.4-A x-ray data.
Proc.Natl.Acad.Sci.Usa, 100, 2003
1MTY
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BU of 1mty by Molmil
METHANE MONOOXYGENASE HYDROXYLASE FROM METHYLOCOCCUS CAPSULATUS (BATH)
Descriptor: FE (III) ION, METHANE MONOOXYGENASE HYDROXYLASE
Authors:Rosenzweig, A.C, Nordlund, P, Lippard, S.J, Frederick, C.A.
Deposit date:1996-07-10
Release date:1997-04-21
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Crystal structures of the methane monooxygenase hydroxylase from Methylococcus capsulatus (Bath): implications for substrate gating and component interactions.
Proteins, 29, 1997
1JPR
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BU of 1jpr by Molmil
Mn substituted Ribonucleotide reductase R2 from E. coli oxidized by nitric oxide
Descriptor: MANGANESE (II) ION, MERCURY (II) ION, Protein R2 of Ribonucleotide reductase
Authors:Hogbom, M, Andersson, M.E, Nordlund, P.
Deposit date:2001-08-03
Release date:2001-08-15
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Crystal structures of oxidized dinuclear manganese centres in Mn-substituted class I ribonucleotide reductase from Escherichia coli: carboxylate shifts with implications for O2 activation and radical generation.
J.Biol.Inorg.Chem., 6, 2001
1JQC
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BU of 1jqc by Molmil
Mn substituted Ribonucleotide reductase R2 from E. Coli oxidized by hydrogen peroxide and hydroxylamine
Descriptor: MANGANESE (II) ION, MERCURY (II) ION, Protein R2 of ribonucleotide reductase
Authors:Hogbom, M, Andersson, M.E, Nordlund, P.
Deposit date:2001-08-06
Release date:2001-08-22
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.61 Å)
Cite:Crystal structures of oxidized dinuclear manganese centres in Mn-substituted class I ribonucleotide reductase from Escherichia coli: carboxylate shifts with implications for O2 activation and radical generation.
J.Biol.Inorg.Chem., 6, 2001
1PFR
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BU of 1pfr by Molmil
RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE 1 BETA CHAIN
Descriptor: FE (III) ION, MERCURY (II) ION, PROTEIN R2 OF RIBONUCLEOTIDE REDUCTASE
Authors:Logan, D.T, Su, X.D, Aberg, A, Regnstrom, K, Hajdu, J, Eklund, H, Nordlund, P.
Deposit date:1996-12-03
Release date:1997-03-12
Last modified:2023-08-09
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure of reduced protein R2 of ribonucleotide reductase: the structural basis for oxygen activation at a dinuclear iron site.
Structure, 4, 1996
1PHR
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BU of 1phr by Molmil
THE CRYSTAL STRUCTURE OF A LOW MOLECULAR PHOSPHOTYROSINE PROTEIN PHOSPHATASE
Descriptor: LOW MOLECULAR WEIGHT PHOSPHOTYROSINE PROTEIN PHOSPHATASE, SULFATE ION
Authors:Su, X.-D, Taddei, N, Stefani, M, Ramponi, G, Nordlund, P.
Deposit date:1994-07-05
Release date:1995-07-31
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase.
Nature, 370, 1994

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