Author results

6JFH
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THE ASYMMETRIC-RECONSTRUCTED CRYO-EM STRUCTURE OF ZIKA VIRUS-FABZK2B10 COMPLEX
Descriptor:ZIKV structural E protein, strutural protein M, FabZK2B10 heavy chain, ...
Authors:Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q.
Deposit date:2019-02-08
Release date:2019-04-10
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
6JFI
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THE SYMMETRIC-RECONSTRUCTED CRYO-EM STRUCTURE OF ZIKA VIRUS-FABZK2B10 COMPLEX
Descriptor:ZIKV structural protein E, strutural protein M, FabZK2B10 heavy chain, ...
Authors:Wang, L., Wang, R.K., Wang, L., Ben, H.J., Yu, L., Gao, F., Shi, X.L., Yin, C.B., Zhang, F.C., Xiang, Y., Zhang, L.Q.
Deposit date:2019-02-08
Release date:2019-04-10
Last modified:2019-11-06
Method:ELECTRON MICROSCOPY (11 Å)
Cite:Structural Basis for Neutralization and Protection by a Zika Virus-Specific Human Antibody.
Cell Rep, 26, 2019
1SQB
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CRYSTAL STRUCTURE ANALYSIS OF BOVINE BC1 WITH AZOXYSTROBIN
Descriptor:Ubiquinol-cytochrome C reductase complex core protein I, mitochondrial, Ubiquinol-cytochrome C reductase complex core protein 2, ...
Authors:Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
Deposit date:2004-03-18
Release date:2004-09-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.69 Å)
Cite:Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex
J.Mol.Biol., 341, 2004
1SQP
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CRYSTAL STRUCTURE ANALYSIS OF BOVINE BC1 WITH MYXOTHIAZOL
Descriptor:Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor, Ubiquinol-cytochrome-c reductase complex core protein 2, ...
Authors:Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
Deposit date:2004-03-19
Release date:2005-11-01
Last modified:2014-10-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J.Mol.Biol., 341, 2004
1SQQ
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CRYSTAL STRUCTURE ANALYSIS OF BOVINE BC1 WITH METHOXY ACRYLATE STILBENE (MOAS)
Descriptor:Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor, Ubiquinol-cytochrome-c reductase complex core protein 2, ...
Authors:Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
Deposit date:2004-03-19
Release date:2005-10-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J.Mol.Biol., 341, 2004
1SQV
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CRYSTAL STRUCTURE ANALYSIS OF BOVINE BC1 WITH UHDBT
Descriptor:Ubiquinol-cytochrome c reductase complex core protein I, mitochondrial, Ubiquinol-cytochrome c reductase complex core protein 2, ...
Authors:Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
Deposit date:2004-03-19
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J.Mol.Biol., 341, 2004
1SQX
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CRYSTAL STRUCTURE ANALYSIS OF BOVINE BC1 WITH STIGMATELLIN A
Descriptor:Ubiquinol-cytochrome-c reductase complex core protein I, mitochondrial precursor, Ubiquinol-cytochrome-c reductase complex core protein 2, ...
Authors:Esser, L., Quinn, B., Li, Y.F., Zhang, M., Elberry, M., Yu, L., Yu, C.A., Xia, D.
Deposit date:2004-03-21
Release date:2005-09-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J.Mol.Biol., 341, 2004
3BC5
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X-RAY CRYSTAL STRUCTURE OF HUMAN PPAR GAMMA WITH 2-(5-(3-(2-(5-METHYL-2-PHENYLOXAZOL-4-YL)ETHOXY)BENZYL)-2-PHENYL-2H-1,2,3-TRIAZOL-4-YL)ACETIC ACID
Descriptor:Peroxisome proliferator-activated receptor gamma, (5-{3-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]benzyl}-2-phenyl-2H-1,2,3-triazol-4-yl)acetic acid
Authors:Muckelbauer, J.K.
Deposit date:2007-11-12
Release date:2008-11-18
Last modified:2017-08-23
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Design, synthesis and structure-activity relationships of azole acids as novel, potent dual PPAR alpha/gamma agonists.
Bioorg.Med.Chem.Lett., 19, 2009
4R5Y
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THE COMPLEX STRUCTURE OF BRAF V600E KINASE DOMAIN WITH A NOVEL BRAF INHIBITOR
Descriptor:Serine/threonine-protein kinase B-raf, 5-({(1R,1aS,6bR)-1-[5-(trifluoromethyl)-1H-benzimidazol-2-yl]-1a,6b-dihydro-1H-cyclopropa[b][1]benzofuran-5-yl}oxy)-3,4-dihydro-1,8-naphthyridin-2(1H)-one
Authors:Feng, Y., Peng, H., Zhang, Y., Liu, Y., Wei, M.
Deposit date:2014-08-22
Release date:2016-02-24
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:BGB-283, a Novel RAF Kinase and EGFR Inhibitor, Displays Potent Antitumor Activity in BRAF-Mutated Colorectal Cancers.
Mol.Cancer Ther., 14, 2015
4GEH
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CRYSTAL STRUCTURE OF MST4 DIMERIZATION DOMAIN COMPLEX WITH PDCD10
Descriptor:Programmed cell death protein 10, Serine/threonine-protein kinase MST4
Authors:Zhang, M., Shi, Z.B., Zhou, Z.C.
Deposit date:2012-08-02
Release date:2013-04-17
Last modified:2013-07-17
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural mechanism of CCM3 heterodimerization with GCKIII kinases
Structure, 21, 2013
5XMF
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CRYSTAL STRUCTURE OF FELINE MHC CLASS I FOR 2,1 ANGSTROM
Descriptor:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
Authors:Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
Deposit date:2017-05-15
Release date:2017-12-13
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
5XMM
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FLA-E*01801-167W/S
Descriptor:MHC class I antigen alpha chain, Beta-2-microglobulin, Gag polyprotein
Authors:Liang, R., Sun, Y., Wang, J., Wu, Y., Zhang, N., Xia, C.
Deposit date:2017-05-15
Release date:2017-12-13
Last modified:2019-01-16
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Major Histocompatibility Complex Class I (FLA-E*01801) Molecular Structure in Domestic Cats Demonstrates Species-Specific Characteristics in Presenting Viral Antigen Peptides
J. Virol., 92, 2018
6AJF
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJG
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH SQ109
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, N-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-N'-[(1R,3S,5R,7R)-tricyclo[3.3.1.1~3,7~]dec-2-yl]ethane-1,2-diamine, DODECYL-BETA-D-MALTOSIDE, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.604 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJH
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH AU1235
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 1-(2-adamantyl)-3-[2,3,4-tris(fluoranyl)phenyl]urea, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.818 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJI
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH RIMONABANT
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
6AJJ
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CRYSTAL STRUCTURE OF MYCOLIC ACID TRANSPORTER MMPL3 FROM MYCOBACTERIUM SMEGMATIS COMPLEXED WITH ICA38
Descriptor:Drug exporters of the RND superfamily-like protein,Endolysin, (CARBAMOYLMETHYL-CARBOXYMETHYL-AMINO)-ACETIC ACID, alpha-D-glucopyranosyl 6-O-dodecyl-alpha-D-glucopyranoside, ...
Authors:Zhang, B., Li, J., Yang, X.L., Wu, L.J., Yang, H.T., Rao, Z.H.
Deposit date:2018-08-27
Release date:2018-12-26
Last modified:2019-02-13
Method:X-RAY DIFFRACTION (2.794 Å)
Cite:Crystal Structures of Membrane Transporter MmpL3, an Anti-TB Drug Target.
Cell, 176, 2019
2QN1
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH ASIATIC ACID
Descriptor:Glycogen phosphorylase, muscle form, asiatic acid
Authors:Zographos, S.E., Leonidas, D.D., Alexacou, K.-M., Hayes, J., Oikonomakos, N.G.
Deposit date:2007-07-17
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.401 Å)
Cite:Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
2QN2
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GLYCOGEN PHOSPHORYLASE B IN COMPLEX WITH MASLINIC ACID
Descriptor:Glycogen phosphorylase, muscle form, maslinic acid
Authors:Zographos, S.E., Leonidas, D.D., Alexacou, K.-M., Hayes, J., Oikonomakos, N.G.
Deposit date:2007-07-17
Release date:2008-06-03
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.698 Å)
Cite:Naturally occurring pentacyclic triterpenes as inhibitors of glycogen phosphorylase: synthesis, structure-activity relationships, and X-ray crystallographic studies
J.Med.Chem., 51, 2008
5HW4
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI 16S RRNA METHYLTRANSFERASE RSMI IN COMPLEX WITH ADOMET
Descriptor:Ribosomal RNA small subunit methyltransferase I, S-ADENOSYLMETHIONINE
Authors:Zhao, M., Zhang, H., Dong, Y., Gong, Y.
Deposit date:2016-01-28
Release date:2016-10-19
Last modified:2017-08-16
Method:X-RAY DIFFRACTION (2.211 Å)
Cite:Structural Insights into the Methylation of C1402 in 16S rRNA by Methyltransferase RsmI
Plos One, 11, 2016
5ZXV
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STRUCTURAL DEFINITION OF A UNIQUE NEUTRALIZATION EPITOPE ON THE RECEPTOR-BINDING DOMAIN OF MERS-COV SPIKE GLYCOPROTEIN
Descriptor:MERS-CoV RBD, heavy chain, light chain
Authors:Zhang, S., Wang, X.
Deposit date:2018-05-21
Release date:2018-07-25
Method:X-RAY DIFFRACTION (4.482 Å)
Cite:Structural Definition of a Unique Neutralization Epitope on the Receptor-Binding Domain of MERS-CoV Spike Glycoprotein
Cell Rep, 24, 2018
6DCG
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DISCOVERY OF MK-8353: AN ORALLY BIOAVAILABLE DUAL MECHANISM ERK INHIBITOR FOR ONCOLOGY
Descriptor:Mitogen-activated protein kinase 1, SULFATE ION, (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide
Authors:Boga, S.B., Deng, Y., Zhu, L., Nan, Y., Cooper, A., Shipps Jr., G.W., Doll, R., Shih, N., Zhu, H., Sun, R., Wang, T., Paliwal, S., Tsui, H., Gao, X., Yao, X., Desai, J., Wang, J., Alhassan, A.B., Kelly, J., Patel, M., Muppalla, K., Gudipati, S., Zhang, L., Buevich, A., Hesk, D., Carr, D., Dayananth, P., Mei, H., Cox, K., Sherborne, B., Hruza, A.W., Xiao, L., Jin, W., Long, B., Liu, G., Taylor, S.A., Kirschmeier, P., Windsor, W.T., Bishop, R., Samatar, A.A.
Deposit date:2018-05-06
Release date:2018-08-08
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology.
ACS Med Chem Lett, 9, 2018
6IEG
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CRYSTAL STRUCTURE OF HUMAN MTR4
Descriptor:Exosome RNA helicase MTR4, ADENOSINE-5'-TRIPHOSPHATE
Authors:Chen, J.Y., Yun, C.H.
Deposit date:2018-09-14
Release date:2019-04-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (3.546 Å)
Cite:NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
6IEH
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CRYSTAL STRUCTURES OF THE HMTR4-NRDE2 COMPLEX
Descriptor:Exosome RNA helicase MTR4, Protein NRDE2 homolog, CHLORIDE ION, ...
Authors:Chen, J.Y., Yun, C.H.
Deposit date:2018-09-14
Release date:2019-04-03
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.892 Å)
Cite:NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
6ILC
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CRYSTAL STRUCTURE OF BAT MHC CLASS I PTAL-N*01:01 FOR 2.2 ANGSTROM
Descriptor:MHC class I antigen, Beta-2-microglobulin, HEV-1
Authors:Qu, Z.H., Zhang, N.Z., Xia, C.
Deposit date:2018-10-17
Release date:2019-07-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure and Peptidome of the Bat MHC Class I Molecule Reveal a Novel Mechanism Leading to High-Affinity Peptide Binding.
J Immunol., 202, 2019