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2I5J
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CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH DHBNH, AN RNASE H INHIBITOR
分子名称:Reverse transcriptase/ribonuclease H P66 subunit, Reverse transcriptase/ribonuclease H P51 subunit, ALPHA-D-GLUCOSE, ...
著者Himmel, D.M., Sarafianos, S.G., Knight, J.L., Levy, R.M., Arnold, E.
登録日2006-08-24
公開日2006-12-05
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献HIV-1 reverse transcriptase structure with RNase H inhibitor dihydroxy benzoyl naphthyl hydrazone bound at a novel site.
Acs Chem.Biol., 1, 2006
3SR9
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CRYSTAL STRUCTURE OF MOUSE PTPSIGMA
分子名称:Receptor-type tyrosine-protein phosphatase S
著者Wang, J., Hou, L., Li, J., Ding, J.
登録日2011-07-07
公開日2012-05-30
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma
Acta Biochim.Biophys.Sin., 43, 2011
2EW5
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STRUCTURE OF HELICOBACTER PYLORI PEPTIDE DEFORMYLASE IN COMPLEX WITH INHIBITOR
分子名称:peptide deformylase, COBALT (II) ION, 4-{(1E)-3-OXO-3-[(2-PHENYLETHYL)AMINO]PROP-1-EN-1-YL}-1,2-PHENYLENE DIACETATE
著者Cai, J.
登録日2005-11-02
公開日2006-10-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
Protein Sci., 15, 2006
2EW6
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STRUCTURE OF HELICOBACTER PYLORI PEPTIDE DEFORMYLASE IN COMPLEX WITH INHIBITOR
分子名称:peptide deformylase, COBALT (II) ION, (2E)-3-(3,4-DIHYDROXYPHENYL)-N-[2-(4-HYDROXYPHENYL)ETHYL]ACRYLAMIDE
著者Cai, J.
登録日2005-11-02
公開日2006-10-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
Protein Sci., 15, 2006
2EW7
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CRYSTAL STRUCTURE OF HELICOBACTER PYLORI PEPTIDE DEFORMYLASE
分子名称:peptide deformylase, COBALT (II) ION
著者Cai, J.
登録日2005-11-02
公開日2006-10-24
最終更新日2017-10-18
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Peptide deformylase is a potential target for anti-Helicobacter pylori drugs: reverse docking, enzymatic assay, and X-ray crystallography validation
Protein Sci., 15, 2006
2PVP
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CRYSTAL STRUCTURE OF D-ALANINE-D-ALANINE LIGASE FROM HELICOBACTER PYLORI
分子名称:D-alanine-D-alanine ligase
著者Wu, D., Zhang, L., Jiang, H., Shen, X.
登録日2007-05-10
公開日2008-04-01
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Enzymatic characterization and crystal structure analysis of the D-alanine-D-alanine ligase from Helicobacter pylori.
Proteins, 72, 2008
2PWX
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CRYSTAL STRUCTURE OF G11A MUTANT OF SARS-COV 3C-LIKE PROTEASE
分子名称:3C-like proteinase
著者Chen, S., Hu, T., Jiang, H., Shen, X.
登録日2007-05-14
公開日2007-10-30
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutation of Gly-11 on the dimer interface results in the complete crystallographic dimer dissociation of severe acute respiratory syndrome coronavirus 3C-like protease: crystal structure with molecular dynamics simulations.
J.Biol.Chem., 283, 2008
2RJG
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CRYSTAL STRUCTURE OF BIOSYNTHETIC ALAINE RACEMASE FROM ESCHERICHIA COLI
分子名称:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-10-15
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
2RJH
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CRYSTAL STRUCTURE OF BIOSYNTHETIC ALAINE RACEMASE IN D-CYCLOSERINE-BOUND FORM FROM ESCHERICHIA COLI
分子名称:Alanine racemase, SULFATE ION, D-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YLMETHYL]-N,O-CYCLOSERYLAMIDE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-10-15
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8T
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT P219A
分子名称:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-11-02
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8U
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221A
分子名称:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-11-02
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8V
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221K
分子名称:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-11-02
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3B8W
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CRYSTAL STRUCTURE OF ESCHERICHIA COLI ALAINE RACEMASE MUTANT E221P
分子名称:Alanine racemase, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
著者Wu, D., Hu, T., Zhang, L., Jiang, H., Shen, X.
登録日2007-11-02
公開日2008-07-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Residues Asp164 and Glu165 at the substrate entryway function potently in substrate orientation of alanine racemase from E. coli: Enzymatic characterization with crystal structure analysis
Protein Sci., 17, 2008
3BLE
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH MALONATE
分子名称:Citramalate synthase from Leptospira interrogans, ZINC ION, MALONATE ION
著者Zhang, P., Ma, J.
登録日2007-12-11
公開日2008-11-11
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3BLF
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH PYRUVATE
分子名称:Citramalate synthase from Leptospira interrogans, ZINC ION, PYRUVIC ACID
著者Zhang, P., Ma, J.
登録日2007-12-11
公開日2008-11-11
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3BLI
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CRYSTAL STRUCTURE OF THE CATALYTIC DOMAIN OF LICMS IN COMPLEXED WITH PYRUVATE AND ACETYL-COA
分子名称:Citramalate synthase from Leptospira interrogans, ZINC ION, ACETYL COENZYME *A, ...
著者Zhang, P., Ma, J.
登録日2007-12-11
公開日2008-11-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Molecular basis of the substrate specificity and the catalytic mechanism of citramalate synthase from Leptospira interrogans
Biochem.J., 415, 2008
3CF8
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH QUERCETIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Wu, D., Liu, W., Shen, X., Jiang, H.
登録日2008-03-03
公開日2008-12-09
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
3CF9
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH APIGENIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, 5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, ...
著者Zhang, L., Wu, D., Liu, W., Shen, X., Jiang, H.
登録日2008-03-03
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
3D04
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH SAKURANETIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, CHLORIDE ION, BENZAMIDINE, ...
著者Zhang, L., Kong, Y., Wu, D., Shen, X., Jiang, H.
登録日2008-05-01
公開日2008-12-09
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Three flavonoids targeting the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: crystal structure characterization with enzymatic inhibition assay
Protein Sci., 17, 2008
3DON
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CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE FROM STAPHYLOCOCCUS EPIDERMIDIS
分子名称:Shikimate dehydrogenase, GLYCEROL
著者Han, C., Hu, T., Wu, D., Zhou, J., Shen, X., Qu, D., Jiang, H.
登録日2008-07-05
公開日2009-05-05
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis
Febs J., 276, 2009
3DOO
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CRYSTAL STRUCTURE OF SHIKIMATE DEHYDROGENASE FROM STAPHYLOCOCCUS EPIDERMIDIS COMPLEXED WITH SHIKIMATE
分子名称:Shikimate dehydrogenase, (3R,4S,5R)-3,4,5-TRIHYDROXYCYCLOHEX-1-ENE-1-CARBOXYLIC ACID
著者Han, C., Hu, T., Wu, D., Zhou, J., Shen, X., Qu, D., Jiang, H.
登録日2008-07-05
公開日2009-05-05
最終更新日2014-11-12
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis
Febs J., 276, 2009
3ED0
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CRYSTAL STRUCTURE OF (3R)-HYDROXYACYL-ACYL CARRIER PROTEIN DEHYDRATASE (FABZ) FROM HELICOBACTER PYLORI IN COMPLEX WITH EMODIN
分子名称:(3R)-hydroxymyristoyl-acyl carrier protein dehydratase, BENZAMIDINE, CHLORIDE ION, ...
著者Zhang, L., Zhang, H., Liu, W., Guo, Y., Shen, X., Jiang, H.
登録日2008-09-02
公開日2009-07-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Emodin targets the beta-hydroxyacyl-acyl carrier protein dehydratase from Helicobacter pylori: enzymatic inhibition assay with crystal structural and thermodynamic characterization
BMC MICROBIOL., 9, 2009
3U2Q
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EF-TU (ESCHERICHIA COLI) IN COMPLEX WITH NVP-LFF571
分子名称:Elongation factor Tu 1, Thiocillin GE2270 analogue NVP-LFF571, GUANOSINE-5'-DIPHOSPHATE, ...
著者Palestrant, D.J.
登録日2011-10-04
公開日2012-05-02
最終更新日2012-12-12
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Discovery of LFF571: an investigational agent for Clostridium difficile infection.
J.Med.Chem., 55, 2012
4L1B
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CRYSTAL STRUCTURE OF P110ALPHA COMPLEXED WITH NISH2 OF P85ALPHA
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, SULFATE ION
著者Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.
登録日2013-06-03
公開日2014-01-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.586 Å)
主引用文献Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
ACS Med Chem Lett, 5, 2014
4L23
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CRYSTAL STRUCTURE OF P110ALPHA COMPLEXED WITH NISH2 OF P85ALPHA AND PI-103
分子名称:Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform, Phosphatidylinositol 3-kinase regulatory subunit alpha, 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, ...
著者Zhang, J., Zhao, Y.L., Chen, Y.Y., Huang, M., Jiang, F.
登録日2013-06-04
公開日2014-01-01
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.501 Å)
主引用文献Crystal Structures of PI3K alpha Complexed with PI103 and Its Derivatives: New Directions for Inhibitors Design.
ACS Med Chem Lett, 5, 2014