Author results

2NYL
  • Download 2nyl
  • View 2nyl
Molmil generated image of 2nyl
CRYSTAL STRUCTURE OF PROTEIN PHOSPHATASE 2A (PP2A) HOLOENZYME WITH THE CATALYTIC SUBUNIT CARBOXYL TERMINUS TRUNCATED
Descriptor:Protein phosphatase 2, regulatory subunit A (PR 65), alpha isoform, ...
Authors:Xing, Y., Xu, Y., Chen, Y., Chao, Y., Lin, Z., Shi, Y.
Deposit date:2006-11-20
Release date:2006-12-12
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (3.8 Å)
Cite:Structure of the Protein Phosphatase 2A Holoenzyme.
Cell(Cambridge,Mass.), 127, 2006
3R1G
  • Download 3r1g
  • View 3r1g
Molmil generated image of 3r1g
STRUCTURE BASIS OF ALLOSTERIC INHIBITION OF BACE1 BY AN EXOSITE-BINDING ANTIBODY
Descriptor:Beta-secretase 1, FAB of YW412.8.31 antibody heavy chain, FAB of YW412.8.31 antibody light chain
Authors:Wang, W., Rouge, L., Wu, P., Chiu, C., Chen, Y., Wu, Y., Watts, R.J.
Deposit date:2011-03-10
Release date:2011-06-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:A Therapeutic Antibody Targeting BACE1 Inhibits Amyloid-{beta} Production in Vivo.
Sci Transl Med, 3, 2011
6BD4
  • Download 6bd4
  • View 6bd4
Molmil generated image of 6bd4
CRYSTAL STRUCTURE OF HUMAN APO-FRIZZLED4 RECEPTOR
Descriptor:Frizzled-4/Rubredoxin chimeric protein, ZINC ION, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ...
Authors:Yang, S., Wu, Y., Pu, M., Chen, Y., Dong, S., Guo, Y., Han, G.Y., Stevens, R.C., Zhao, S., Xu, F.
Deposit date:2017-10-21
Release date:2018-08-22
Last modified:2018-09-12
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the Frizzled 4 receptor in a ligand-free state.
Nature, 560, 2018
1C76
  • Download 1c76
  • View 1c76
Molmil generated image of 1c76
STAPHYLOKINASE (SAK) MONOMER
Descriptor:STAPHYLOKINASE
Authors:Rao, Z., Jiang, F., Liu, Y., Zhang, X., Chen, Y., Bartlam, M., Song, H., Ding, Y.
Deposit date:2000-02-01
Release date:2000-08-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Crystal Structure of Staphylokinase Dimer Offers New Clue to Reduction of Immunogenicity
To be published
1Y7H
  • Download 1y7h
  • View 1y7h
Molmil generated image of 1y7h
STRUCTURAL AND BIOCHEMICAL STUDIES IDENTIFY TOBACCO SABP2 AS A METHYLSALICYLATE ESTERASE AND FURTHER IMPLICATE IT IN PLANT INNATE IMMUNITY, NORTHEAST STRUCTURAL GENOMICS TARGET AR2241
Descriptor:salicylic acid-binding protein 2, THIOCYANATE ION
Authors:Forouhar, F., Yang, Y., Kumar, D., Chen, Y., Fridman, E., Park, S.W., Chiang, Y., Acton, T.B., Montelione, G.T., Pichersky, E., Klessig, D.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-08
Release date:2004-12-28
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.52 Å)
Cite:Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Y7I
  • Download 1y7i
  • View 1y7i
Molmil generated image of 1y7i
STRUCTURAL AND BIOCHEMICAL STUDIES IDENTIFY TOBACCO SABP2 AS A METHYLSALICYLATE ESTERASE AND FURTHER IMPLICATE IT IN PLANT INNATE IMMUNITY, NORTHEAST STRUCTURAL GENOMICS TARGET AR2241
Descriptor:salicylic acid-binding protein 2, 2-HYDROXYBENZOIC ACID
Authors:Forouhar, F., Yang, Y., Kumar, D., Chen, Y., Fridman, E., Park, S.W., Chiang, Y., Acton, T.B., Montelione, G.T., Pichersky, E., Klessig, D.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2004-12-08
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural and biochemical studies identify tobacco SABP2 as a methyl salicylate esterase and implicate it in plant innate immunity
Proc.Natl.Acad.Sci.USA, 102, 2005
2LAS
  • Download 2las
  • View 2las
Molmil generated image of 2las
MOLECULAR DETERMINANTS OF PARALOGUE-SPECIFIC SUMO-SIM RECOGNITION
Descriptor:Small ubiquitin-related modifier 1, M-IR2_peptide
Authors:Namanja, A., Li, Y., Su, Y., Wong, S., Lu, J., Colson, L., Wu, C., Li, S., Chen, Y.
Deposit date:2011-03-20
Release date:2011-12-14
Last modified:2016-04-27
Method:SOLUTION NMR
Cite:Insights into High Affinity Small Ubiquitin-like Modifier (SUMO) Recognition by SUMO-interacting Motifs (SIMs) Revealed by a Combination of NMR and Peptide Array Analysis.
J.Biol.Chem., 287, 2012
3C5V
  • Download 3c5v
  • View 3c5v
Molmil generated image of 3c5v
PP2A-SPECIFIC METHYLESTERASE APO FORM (PME)
Descriptor:Protein phosphatase methylesterase 1
Authors:Xing, Y., Li, Z., Chen, Y., Stock, J., Jeffrey, P.D., Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
3C5W
  • Download 3c5w
  • View 3c5w
Molmil generated image of 3c5w
COMPLEX BETWEEN PP2A-SPECIFIC METHYLESTERASE PME-1 AND PP2A CORE ENZYME
Descriptor:PP2A A subunit, PP2A C subunit, PP2A-specific methylesterase PME-1
Authors:Xing, Y., Li, Z., Chen, Y., Stock, J., Jeffrey, P.D., Shi, Y.
Deposit date:2008-02-01
Release date:2008-04-15
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural mechanism of demethylation and inactivation of protein phosphatase 2A.
Cell(Cambridge,Mass.), 133, 2008
3DW8
  • Download 3dw8
  • View 3dw8
Molmil generated image of 3dw8
STRUCTURE OF A PROTEIN PHOSPHATASE 2A HOLOENZYME WITH B55 SUBUNIT
Descriptor:Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform, Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform, Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, ...
Authors:Xu, Y., Chen, Y., Zhang, P., Jeffrey, P.D., Shi, Y.
Deposit date:2008-07-21
Release date:2008-10-07
Last modified:2013-10-16
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure of a protein phosphatase 2A holoenzyme: insights into B55-mediated Tau dephosphorylation.
Mol.Cell, 31, 2008
3FDF
  • Download 3fdf
  • View 3fdf
Molmil generated image of 3fdf
CRYSTAL STRUCTURE OF THE SERINE PHOSPHATASE OF RNA POLYMERASE II CTD (SSU72 SUPERFAMILY) FROM DROSOPHILA MELANOGASTER. ORTHORHOMBIC CRYSTAL FORM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET FR253.
Descriptor:FR253
Authors:Kuzin, A.P., Chen, Y., Seetharaman, J., Forouhar, F., Chinag, Y., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-11-25
Release date:2009-01-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Orthorombic crystal structure of serine phosphatase of rna polymerase ii ctd from fly drosofila melanogaster. northeast structural genomics consortium target fr253.
To be Published
3FMV
  • Download 3fmv
  • View 3fmv
Molmil generated image of 3fmv
CRYSTAL STRUCTURE OF THE SERINE PHOSPHATASE OF RNA POLYMERASE II CTD (SSU72 SUPERFAMILY) FROM DROSOPHILA MELANOGASTER. MONOCLINIC CRYSTAL FORM. NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET FR253.
Descriptor:Serine phosphatase of RNA polymerase II CTD
Authors:Kuzin, A.P., Chen, Y., Seetharaman, J., Forouhar, F., Chinag, Y., Fang, Y., Cunningham, K., Ma, L.-C., Xiao, R., Liu, J., Baran, M.C., Acton, T.B., Rost, B., Montelione, G.T., Hunt, J.F., Tong, L., Northeast Structural Genomics Consortium (NESG)
Deposit date:2008-12-22
Release date:2009-01-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (3.31 Å)
Cite:Crystal structure of the serine phosphatase of RNA polymerase II CTD (SSU72 superfamily) from Drosophila melanogaster. Monoclinic crystal form. Northeast Structural Genomics Consortium target FR253.
To be Published
3GX8
  • Download 3gx8
  • View 3gx8
Molmil generated image of 3gx8
STRUCTURAL AND BIOCHEMICAL CHARACTERIZATION OF YEAST MONOTHIOL GLUTAREDOXIN GRX5
Descriptor:Monothiol glutaredoxin-5, mitochondrial, SULFATE ION
Authors:Wang, Y., He, Y.X., Yu, J., Xiong, Y., Chen, Y., Zhou, C.Z.
Deposit date:2009-04-01
Release date:2010-04-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.673 Å)
Cite:Structural and biochemical characterization of yeast monothiol glutaredoxin Grx5
To be Published
3V35
  • Download 3v35
  • View 3v35
Molmil generated image of 3v35
ALDOSE REDUCTASE COMPLEXED WITH A NITRO COMPOUND
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-[(5-nitro-1,3-thiazol-2-yl)carbamoyl]phenyl acetate, ...
Authors:Zheng, X., Zhang, L., Chen, Y., Luo, H., Hu, X.
Deposit date:2011-12-13
Release date:2012-08-29
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
3V36
  • Download 3v36
  • View 3v36
Molmil generated image of 3v36
ALDOSE REDUCTASE COMPLEXED WITH GLCERALDEHYDE
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, GLYCERALDEHYDE, ...
Authors:Zheng, X., Zhang, L., Chen, Y., Luo, H., Hu, X.
Deposit date:2011-12-13
Release date:2012-08-29
Last modified:2014-07-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:Partial inhibition of aldose reductase by nitazoxanide and its molecular basis.
Chemmedchem, 7, 2012
4GMB
  • Download 4gmb
  • View 4gmb
Molmil generated image of 4gmb
CRYSTAL STRUCTURE OF HUMAN WD REPEAT DOMAIN 5 WITH COMPOUND MM-402
Descriptor:WD repeat-containing protein 5, MM-402
Authors:Karatas, H., Townsend, E.C., Chen, Y., Bernard, D., Cao, F., Liu, L., Lei, M., Dou, Y., Wang, S.
Deposit date:2012-08-15
Release date:2014-02-19
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (2.781 Å)
Cite:Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction.
J. Med. Chem., 2017
4XSQ
  • Download 4xsq
  • View 4xsq
Molmil generated image of 4xsq
STRUCTURE OF A VARIABLE LYMPHOCYTE RECEPTOR-LIKE PROTEIN BF66946 FROM BRANCHIOSTOMA FLORIDAE
Descriptor:variable lymphocyte receptor-like protein Bf66946, 1,2-ETHANEDIOL, GLYCEROL
Authors:Cao, D.D., Cheng, W., Jiang, Y.L., Wang, W.J., Li, Q., Chen, Y., Zhou, C.Z.
Deposit date:2015-01-22
Release date:2016-03-23
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae.
Sci Rep, 6, 2016
4Y1L
  • Download 4y1l
  • View 4y1l
Molmil generated image of 4y1l
UBC9 HOMODIMER THE MISSING LINK IN POLY-SUMO CHAIN FORMATION
Descriptor:SUMO-conjugating enzyme UBC9, RWD domain-containing protein 3
Authors:Aileen, Y.A., Ambaye, N.D., Li, Y.J., Vega, R., Bzymek, K., Williams, J.C., Hu, W., Chen, Y.
Deposit date:2015-02-08
Release date:2015-05-06
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:RWD Domain as an E2 (Ubc9)-Interaction Module.
J.Biol.Chem., 290, 2015
5XU0
  • Download 5xu0
  • View 5xu0
Molmil generated image of 5xu0
STRUCTURE OF THE MEMBRANE FUSION PROTEIN SPR0693 FROM STREPTOCOCCUS PNEUMONIAE R6
Descriptor:Membrane-fusion protein
Authors:Yang, H.B., Jiang, Y.L., Hou, W.T., Chen, M.T., Chen, Y., Zhou, C.Z.
Deposit date:2017-06-22
Release date:2018-01-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.95 Å)
Cite:Structure of a MacAB-like efflux pump from Streptococcus pneumoniae.
Nat Commun, 9, 2018
5XU1
  • Download 5xu1
  • View 5xu1
Molmil generated image of 5xu1
STRUCTURE OF A NON-CANONICAL ABC TRANSPORTER FROM STREPTOCOCCUS PNEUMONIAE R6
Descriptor:ABC transporter ATP-binding protein, ABC transporter permeae, MAGNESIUM ION
Authors:Yang, H.B., Jiang, Y.L., Hou, W.T., Chen, M.T., Chen, Y., Zhou, C.Z.
Deposit date:2017-06-22
Release date:2018-01-24
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of a MacAB-like efflux pump from Streptococcus pneumoniae.
Nat Commun, 9, 2018
5YBX
  • Download 5ybx
  • View 5ybx
Molmil generated image of 5ybx
CRYSTAL STRUCTURE OF THE N-TERMINAL DOMAIN OF BQT4 IN S.POMBE
Descriptor:Bouquet formation protein 4
Authors:Hu, C., Chen, Y.
Deposit date:2017-09-05
Release date:2018-09-19
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:The Inner Nuclear Membrane Protein Bqt4 in Fission Yeast Contains a DNA-Binding Domain Essential for Telomere Association with the Nuclear Envelope.
Structure, 27, 2019
6KM7
  • Download 6km7
  • View 6km7
Molmil generated image of 6km7
THE STRUCTURAL BASIS FOR THE INTERNAL INTERACTION IN RBBP5
Descriptor:Retinoblastoma-binding protein 5, SULFATE ION, NONAETHYLENE GLYCOL, ...
Authors:Han, J., Li, T., Chen, Y.
Deposit date:2019-07-31
Release date:2019-10-02
Last modified:2019-11-13
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:The internal interaction in RBBP5 regulates assembly and activity of MLL1 methyltransferase complex.
Nucleic Acids Res., 47, 2019
1EV7
  • Download 1ev7
  • View 1ev7
Molmil generated image of 1ev7
CRYSTAL STRUCTURE OF DNA RESTRICTION ENDONUCLEASE NAEI
Descriptor:TYPE IIE RESTRICTION ENDONUCLEASE NAEI
Authors:Huai, Q., Colandene, J.D., Chen, Y., Luo, F., Zhao, Y.
Deposit date:2000-04-19
Release date:2000-10-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal structure of NaeI-an evolutionary bridge between DNA endonuclease and topoisomerase.
EMBO J., 19, 2000
1FGL
  • Download 1fgl
  • View 1fgl
Molmil generated image of 1fgl
CYCLOPHILIN A COMPLEXED WITH A FRAGMENT OF HIV-1 GAG PROTEIN
Descriptor:CYCLOPHILIN A, HIV-1 GAG PROTEIN
Authors:Zhao, Y., Chen, Y., Schutkowski, M., Fischer, G., Ke, H.
Deposit date:1996-11-18
Release date:1997-04-01
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Cyclophilin A complexed with a fragment of HIV-1 gag protein: insights into HIV-1 infectious activity.
Structure, 5, 1997
1IAX
  • Download 1iax
  • View 1iax
Molmil generated image of 1iax
CRYSTAL STRUCTURE OF ACC SYNTHASE COMPLEXED WITH PLP
Descriptor:1-AMINOCYCLOPROPANE-1-CARBOXYLATE SYNTHASE 2, SULFATE ION, PYRIDOXAL-5'-PHOSPHATE
Authors:Huai, Q., Xia, Y., Chen, Y., Callahan, B., Li, N., Ke, H.
Deposit date:2001-03-24
Release date:2001-04-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structures of 1-aminocyclopropane-1-carboxylate (ACC) synthase in complex with aminoethoxyvinylglycine and pyridoxal-5'-phosphate provide new insight into catalytic mechanisms
J.Biol.Chem., 276, 2001