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4Y8W
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BU of 4y8w by Molmil
Crystal Structure of Human Cytochrome P450 21A2 Progesterone Complex
Descriptor: Cytochrome P450 21-hydroxylase, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Pallan, P.S, Lei, L, Egli, M.
Deposit date:2015-02-16
Release date:2015-04-15
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
J.Biol.Chem., 290, 2015
1PWF
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BU of 1pwf by Molmil
One Sugar Pucker Fits All: Pairing Versatility Despite Conformational Uniformity in TNA
Descriptor: 5'-D(*GP*CP*GP*TP*AP*(2MU)P*(FA2)P*CP*GP*C)-3', SPERMINE
Authors:Pallan, P.S, Wilds, C.J, Wawrzak, Z, Krishnamurthy, R, Eschenmoser, A, Egli, M.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
ANGEW.CHEM.INT.ED.ENGL., 42, 2003
2GUN
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BU of 2gun by Molmil
RNA-Binding Affinities and Crystal Structure of Oligonucleotides containing Five-Atom Amide-Based Backbone Structures
Descriptor: 5'-D(*TP*TP*CP*(T2T)P*(CBR)P*TP*TP*C)-3', 5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3', COBALT (III) ION, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2006-05-01
Release date:2006-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RNA-Binding Affinities and Crystal Structure of Oligonucleotides Containing Five-Atom Amide-Based Backbone Structures.
Biochemistry, 45, 2006
8SV4
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BU of 8sv4 by Molmil
7-Deazapurines and 5-Halogenpyrimidine DNA duplex
Descriptor: 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, ACETATE ION, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2023-05-15
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
8SV3
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BU of 8sv3 by Molmil
7-Deazapurines and 5-Halogenpyrimidine DNA duplex
Descriptor: GLYCEROL, MAGNESIUM ION, Modified DNA, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2023-05-15
Release date:2023-10-04
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Conformational Morphing by a DNA Analogue Featuring 7-Deazapurines and 5-Halogenpyrimidines and the Origins of Adenine-Tract Geometry.
Biochemistry, 62, 2023
2A43
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BU of 2a43 by Molmil
Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif
Descriptor: MAGNESIUM ION, RNA Pseudoknot
Authors:Pallan, P.S, Marshall, W.S, Harp, J, Jewett III, F.C, Wawrzak, Z, Brown II, B.A, Rich, A, Egli, M.
Deposit date:2005-06-27
Release date:2005-09-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif
Biochemistry, 44, 2005
7JJE
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BU of 7jje by Molmil
Sarcin-ricin loop with guanosine dithiophosphate residue.
Descriptor: RNA (27-MER)
Authors:Pallan, P.S, Egli, M, Harp, J.M.
Deposit date:2020-07-25
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
7JJD
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BU of 7jjd by Molmil
Sarcin-ricin loop with guanosine monothiophosphate residue.
Descriptor: RNA (27-MER)
Authors:Pallan, P.S, Egli, M, Harp, J.M.
Deposit date:2020-07-25
Release date:2020-12-23
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.21 Å)
Cite:Incorporating a Thiophosphate Modification into a Common RNA Tetraloop Motif Causes an Unanticipated Stability Boost.
Biochemistry, 59, 2020
5DO5
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BU of 5do5 by Molmil
Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate
Descriptor: RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(AF2)P*(2SG)P*CP*G)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2015-09-10
Release date:2016-09-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate
To Be Published
2RF3
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BU of 2rf3 by Molmil
Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles
Descriptor: 5'-d(CGCG(TCY)ATTCGCG)-3', SPERMINE, ZINC ION
Authors:Pallan, P.S, Ittig, D, Heroux, A, Wawrzak, Z, Leumann, C.J, Egli, M.
Deposit date:2007-09-27
Release date:2008-02-12
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
Chem.Commun.(Camb.), 2008, 2008
3D0P
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BU of 3d0p by Molmil
Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex
Descriptor: DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*DTP*DCP*DGP*DCP*DG)-3'), Ribonuclease H, SODIUM ION
Authors:Pallan, P.S, Egli, M.
Deposit date:2008-05-02
Release date:2008-10-07
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.
Cell Cycle, 7, 2008
3CJZ
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BU of 3cjz by Molmil
Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m22G:A pairs
Descriptor: RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3')
Authors:Pallan, P.S, Kreutz, C, Bosio, S, Micura, R, Egli, M.
Deposit date:2008-03-14
Release date:2008-10-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.
Rna, 14, 2008
4R20
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BU of 4r20 by Molmil
Zebra fish cytochrome P450 17A2 with Abiraterone
Descriptor: Abiraterone, Cytochrome P450 family 17 polypeptide 2, MERCURY (II) ION, ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4RBY
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BU of 4rby by Molmil
First X-ray structure of RNA containing guanosine phosphorodithioate
Descriptor: 5'-R(*CP*GP*CP*(2SG)P*AP*AP*UP*UP*AP*GP*CP*G)-3', STRONTIUM ION
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RC0
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BU of 4rc0 by Molmil
X-ray structure of RNA containing guanosine phosphorodithioate
Descriptor: 5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(A2M)P*(2SG)P*CP*G)-3'
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4R21
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BU of 4r21 by Molmil
Zebra fish cytochrome P450 17A2 with Progesterone
Descriptor: Cytochrome P450 family 17 polypeptide 2, PROGESTERONE, PROTOPORPHYRIN IX CONTAINING FE
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4RBZ
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BU of 4rbz by Molmil
X-ray structure of RNA containing adenosine phosphorodithioate
Descriptor: 5'-R(*CP*GP*CP*GP*(A2M)P*(ADS)P*UP*UP*AP*GP*CP*G)-3'
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4R1Z
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BU of 4r1z by Molmil
Zebra fish cytochrome P450 17A1 with Abiraterone
Descriptor: Abiraterone, Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE
Authors:Pallan, P.S, Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
5SWM
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BU of 5swm by Molmil
BACILLUS HALODURANS RNASE H MUTANT D132N IN COMPLEX WITH 12-MER FRNA/DNA HYBRID
Descriptor: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, DNA (12-MER), ...
Authors:Pallan, P.S, Egli, M.
Deposit date:2016-08-08
Release date:2016-09-21
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'-FRNA:DNA Hybrid.
Biochemistry, 55, 2016
3UKC
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BU of 3ukc by Molmil
(S)-cEt-BNA decamer structure
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(1TL)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3UKE
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BU of 3uke by Molmil
(S)-cMOE-BNA decamer structure
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(CSM)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3P4C
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BU of 3p4c by Molmil
Alternatingly modified 2'Fluoro RNA octamer f/rA2U2-R32
Descriptor: 5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', STRONTIUM ION
Authors:Pallan, P.S, Greene, E.M, Jicman, P.A, Pandey, R.K, Manoharan, M, Rozners, E, Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3V06
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BU of 3v06 by Molmil
Crystal structure of S-6'-Me-3'-fluoro hexitol nucleic acid
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(F5H)P*AP*CP*GP*C)-3'), STRONTIUM ION
Authors:Pallan, P.S, Egli, M.
Deposit date:2011-12-07
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012
3UKB
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BU of 3ukb by Molmil
(R)-cEt-BNA decamer structure
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(RCE)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3V07
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BU of 3v07 by Molmil
Crystal structure of R-6'-Me-3'-fluoro hexitol nucleic acid
Descriptor: DNA (5'-D(*GP*CP*GP*TP*AP*(F6H)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S, Egli, M.
Deposit date:2011-12-07
Release date:2012-02-08
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012

 

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