1D9K
 
 | | CRYSTAL STRUCTURE OF COMPLEX BETWEEN D10 TCR AND PMHC I-AK/CA | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CONALBUMIN PEPTIDE, ... | | Authors: | Reinherz, E.L, Tan, K, Tang, L, Kern, P, Liu, J.-H, Xiong, Y, Hussey, R.E, Smolyar, A, Hare, B, Zhang, R, Joachimiak, A, Chang, H.-C, Wagner, G, Wang, J.-H. | | Deposit date: | 1999-10-28 | | Release date: | 1999-12-15 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | The crystal structure of a T cell receptor in complex with peptide and MHC class II.
Science, 286, 1999
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8FXJ
 | | Crystal structure of Fab460 | | Descriptor: | ACETATE ION, CHLORIDE ION, Fab460, ... | | Authors: | Tan, K, Kim, M, Reinherz, E.L. | | Deposit date: | 2023-01-24 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
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8FYM
 | | Crystal structure of Fab235 in complex with MPER peptide | | Descriptor: | ALA-SER-LEU-TRP-ASN-TRP-PHE-ASN-ILE-THR-ASN-TRP-LEU-TRP-TYR-ILE-LYS-LYS-LYS, CHLORIDE ION, Fab235, ... | | Authors: | Tan, K, Kim, M, Reinherz, E.L. | | Deposit date: | 2023-01-26 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
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8FZ2
 | | Crystal structure of Fab460 in complex with MPER peptide | | Descriptor: | Fab460, H chain, L chain, ... | | Authors: | Tan, K, Kim, M, Reinherz, E.L. | | Deposit date: | 2023-01-27 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
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8FWF
 | | Crystal structure of Apo form Fab235 | | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | | Authors: | Tan, K, Kim, M, Reinherz, E.L. | | Deposit date: | 2023-01-21 | | Release date: | 2023-10-11 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Inadequate structural constraint on Fab approach rather than paratope elicitation limits HIV-1 MPER vaccine utility.
Nat Commun, 14, 2023
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7JI2
 | | Crystal Structure of H2-Kb in complex with a OVA mutant peptide | | Descriptor: | Beta-2-microglobulin, GLYCEROL, H-2 class I histocompatibility antigen, ... | | Authors: | Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J. | | Deposit date: | 2020-07-22 | | Release date: | 2020-12-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
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2PV6
 | | HIV-1 gp41 Membrane Proximal Ectodomain Region peptide in DPC micelle | | Descriptor: | Envelope glycoprotein | | Authors: | Sun, Z.-Y.J, Oh, K.J, Kim, M, Reinherz, E.L, Wagner, G. | | Deposit date: | 2007-05-09 | | Release date: | 2008-03-18 | | Last modified: | 2022-03-16 | | Method: | SOLUTION NMR | | Cite: | HIV-1 broadly neutralizing antibody extracts its epitope from a kinked gp41 ectodomain region on the viral membrane
Immunity, 28, 2008
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6MF8
 | | TCR alpha transmembrane domain | | Descriptor: | T-cell receptor alpha chain C region | | Authors: | Brazin, K.N, Reinherz, E.L. | | Deposit date: | 2018-09-10 | | Release date: | 2018-12-12 | | Last modified: | 2019-12-18 | | Method: | SOLUTION NMR | | Cite: | The T Cell Antigen Receptor alpha Transmembrane Domain Coordinates Triggering through Regulation of Bilayer Immersion and CD3 Subunit Associations.
Immunity, 49, 2018
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1CI5
 | | GLYCAN-FREE MUTANT ADHESION DOMAIN OF HUMAN CD58 (LFA-3) | | Descriptor: | PROTEIN (LYMPHOCYTE FUNCTION-ASSOCIATED ANTIGEN 3(CD58)) | | Authors: | Sun, Z.Y.J, Dotsch, V, Kim, M, Li, J, Reinherz, E.L, Wagner, G. | | Deposit date: | 1999-04-07 | | Release date: | 1999-06-22 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Functional glycan-free adhesion domain of human cell surface receptor CD58: design, production and NMR studies.
EMBO J., 18, 1999
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2ATP
 | | Crystal structure of a CD8ab heterodimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, T-cell surface glycoprotein CD8 alpha chain, T-cell surface glycoprotein CD8 beta chain, ... | | Authors: | Chang, H.C, Tan, K, Ouyang, J, Parisini, E, Liu, J.H, Le, Y, Wang, X, Reinherz, E.L, Wang, J.H. | | Deposit date: | 2005-08-25 | | Release date: | 2005-12-27 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural and Mutational Analyses of a CD8alphabeta Heterodimer and Comparison with the CD8alphaalpha Homodimer.
Immunity, 23, 2005
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1BQH
 | | MURINE CD8AA ECTODOMAIN FRAGMENT IN COMPLEX WITH H-2KB/VSV8 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (BETA-2-MICROGLOBULIN ), PROTEIN (CD8A OR LYT2 OR LYT-2), ... | | Authors: | Wang, J.H, Reinherz, E.L, Kern, P.S, Chang, H.C. | | Deposit date: | 1998-08-16 | | Release date: | 1998-08-19 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb.
Immunity, 9, 1998
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1BWM
 | | A SINGLE-CHAIN T CELL RECEPTOR | | Descriptor: | PROTEIN (ALPHA-BETA T CELL RECEPTOR (TCR) (D10)) | | Authors: | Hare, B.J, Wyss, D.F, Reinherz, E.L, Wagner, G. | | Deposit date: | 1998-09-23 | | Release date: | 1999-07-22 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor.
Nat.Struct.Biol., 6, 1999
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1QA9
 | | Structure of a Heterophilic Adhesion Complex Between the Human CD2 and CD58(LFA-3) Counter-Receptors | | Descriptor: | HUMAN CD2 PROTEIN, HUMAN CD58 PROTEIN | | Authors: | Wang, J.-H, Smolyar, A, Tan, K, Liu, J.-H, Kim, M, Sun, Z.J, Wagner, G, Reinherz, E.L. | | Deposit date: | 1999-04-13 | | Release date: | 1999-04-29 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structure of a heterophilic adhesion complex between the human CD2 and CD58 (LFA-3) counterreceptors.
Cell(Cambridge,Mass.), 97, 1999
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1GYF
 | | GYF DOMAIN FROM HUMAN CD2BP2 PROTEIN | | Descriptor: | PROTEIN (CYTOPLASMIC DOMAIN BINDING PROTEIN (CD2BP2)) | | Authors: | Freund, C, Doetsch, V, Nishizawa, K, Reinherz, E.L, Wagner, G. | | Deposit date: | 1999-04-30 | | Release date: | 2000-01-05 | | Last modified: | 2023-12-27 | | Method: | SOLUTION NMR | | Cite: | The GYF domain is a novel structural fold that is involved in lymphoid signaling through proline-rich sequences.
Nat.Struct.Biol., 6, 1999
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1JBJ
 | | CD3 Epsilon and gamma Ectodomain Fragment Complex in Single-Chain Construct | | Descriptor: | CD3 Epsilon and gamma Ectodomain Fragment Complex | | Authors: | Sun, Z.-Y.J, Kim, K.S, Wagner, G, Reinherz, E.L. | | Deposit date: | 2001-06-05 | | Release date: | 2001-12-05 | | Last modified: | 2022-02-23 | | Method: | SOLUTION NMR | | Cite: | Mechanisms contributing to T cell receptor signaling and assembly revealed by the solution structure of an ectodomain fragment of the CD3 epsilon gamma heterodimer.
Cell(Cambridge,Mass.), 105, 2001
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1NFD
 | | AN ALPHA-BETA T CELL RECEPTOR (TCR) HETERODIMER IN COMPLEX WITH AN ANTI-TCR FAB FRAGMENT DERIVED FROM A MITOGENIC ANTIBODY | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, H57 FAB, N15 ALPHA-BETA T-CELL RECEPTOR | | Authors: | Wang, J.-H, Lim, K, Smolyar, A, Teng, M.-K, Sacchittini, J, Reinherz, E.L. | | Deposit date: | 1997-08-04 | | Release date: | 1998-01-28 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody.
EMBO J., 17, 1998
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1OSZ
 | | MHC CLASS I H-2KB HEAVY CHAIN COMPLEXED WITH BETA-2 MICROGLOBULIN AND AN (L4V) MUTANT OF THE VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN | | Descriptor: | BETA-2 MICROGLOBULIN, MHC CLASS I H-2KB HEAVY CHAIN, VESICULAR STOMATITIS VIRUS NUCLEOPROTEIN | | Authors: | Ghendler, Y, Teng, M.-K, Liu, J.-H, Witte, T, Liu, J, Kim, K.S, Kern, P, Chang, H.-C, Wang, J.-H, Reinherz, E.L. | | Deposit date: | 1998-06-18 | | Release date: | 1999-01-13 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Differential thymic selection outcomes stimulated by focal structural alteration in peptide/major histocompatibility complex ligands.
Proc.Natl.Acad.Sci.USA, 95, 1998
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6WL3
 | | preTCRbeta-pMHC complex crystal structure | | Descriptor: | ARG-GLY-TYR-LEU-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J. | | Deposit date: | 2020-04-18 | | Release date: | 2020-12-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
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6WL4
 | | preTCRbeta-pMHC complex crystal structure | | Descriptor: | ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J. | | Deposit date: | 2020-04-18 | | Release date: | 2020-12-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
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6WL2
 | | preTCRbeta-pMHC complex crystal structure | | Descriptor: | ARG-GLY-TYR-VAL-TYR-GLN-GLY-LEU, H-2 class I histocompatibility antigen, K-B alpha chain, ... | | Authors: | Li, X, Mallis, R.J, Mizsei, R, Tan, K, Reinherz, E.L, Wang, J. | | Deposit date: | 2020-04-18 | | Release date: | 2020-12-23 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Pre-T cell receptors topologically sample self-ligands during thymocyte beta-selection.
Science, 371, 2021
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1WBZ
 | | CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | | Descriptor: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, K-B ALPHA CHAIN PRECURSOR, ... | | Authors: | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | | Deposit date: | 2004-11-05 | | Release date: | 2005-01-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005
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1WBX
 | | CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | | Descriptor: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | | Authors: | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | | Deposit date: | 2004-11-05 | | Release date: | 2005-01-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005
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1WBY
 | | CRYSTAL STRUCTURES OF MURINE MHC CLASS I H-2 Db AND Kb MOLECULES IN COMPLEX WITH CTL EPITOPES FROM INFLUENZA A VIRUS: IMPLICATIONS FOR TCR REPERTOIRE SELECTION AND IMMUNODOMINANCE | | Descriptor: | BETA-2MICROGLOBULIN, H-2 CLASS I HISTOCOMPATIBILITY ANTIGEN, D-B ALPHA CHAIN, ... | | Authors: | Meijers, R, Lai, C, Yang, Y, Liu, J, Zhong, W, Wang, J, Reinherz, E.L. | | Deposit date: | 2004-11-05 | | Release date: | 2005-01-19 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Crystal Structures of Murine Mhc Class I H-2 D(B) and K(B) Molecules in Complex with Ctl Epitopes from Influenza a Virus: Implications for Tcr Repertoire Selection and Immunodominance
J.Mol.Biol., 345, 2005
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1XMW
 | | CD3 EPSILON AND DELTA ECTODOMAIN FRAGMENT COMPLEX IN SINGLE-CHAIN CONSTRUCT | | Descriptor: | Chimeric CD3 mouse Epsilon and sheep Delta Ectodomain Fragment Complex | | Authors: | Sun, Z.-Y.J, Kim, S.T, Kim, I.C, Fahmy, A, Reinherz, E.L, Wagner, G. | | Deposit date: | 2004-10-04 | | Release date: | 2004-11-30 | | Last modified: | 2022-03-02 | | Method: | SOLUTION NMR | | Cite: | Solution structure of the CD3epsilondelta ectodomain and comparison with CD3epsilongamma as a basis for modeling T cell receptor topology and signaling.
Proc.Natl.Acad.Sci.Usa, 101, 2004
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1JL4
 | | CRYSTAL STRUCTURE OF THE HUMAN CD4 N-TERMINAL TWO DOMAIN FRAGMENT COMPLEXED TO A CLASS II MHC MOLECULE | | Descriptor: | H-2 CLASS II HISTOCOMPATIBILITY ANTIGEN, A-K ALPHA CHAIN, A-K BETA CHAIN, ... | | Authors: | Wang, J.-H, Meijers, R, Reinherz, E.L. | | Deposit date: | 2001-07-15 | | Release date: | 2001-09-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (4.3 Å) | | Cite: | Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule.
Proc.Natl.Acad.Sci.USA, 98, 2001
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