Author results

1CYA
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NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING
Descriptor:CYCLOSPORIN A
Authors:Fesik, S.W.
Deposit date:1992-02-24
Release date:1994-01-31
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:NMR Studies of [U-13C]Cyclosporin a Bound to Cyclophilin: Bound Conformation and Portions of Cyclosporin Involved in Binding.
Biochemistry, 30, 1991
1CYB
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NMR STUDIES OF (U-13C)CYCLOSPORIN A BOUND TO CYCLOPHILIN: BOUND CONFORMATION AND PORTIONS OF CYCLOSPORIN INVOLVED IN BINDING
Descriptor:CYCLOSPORIN A
Authors:Fesik, S.W.
Deposit date:1992-02-24
Release date:1994-01-31
Last modified:2012-12-12
Method:SOLUTION NMR
Cite:NMR Studies of [U-13C]Cyclosporin a Bound to Cyclophilin: Bound Conformation and Portions of Cyclosporin Involved in Binding.
Biochemistry, 30, 1991
1URK
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SOLUTION STRUCTURE OF THE AMINO TERMINAL FRAGMENT OF UROKINASE-TYPE PLASMINOGEN ACTIVATOR
Descriptor:PLASMINOGEN ACTIVATOR, ALPHA-L-FUCOSE
Authors:Hansen, A.P., Petros, A.M., Meadows, R.P., Nettesheim, D.G., Mazar, A.P., Olejniczak, E.T., Xu, R.X., Pederson, T.M., Henkin, J., Fesik, S.W.
Deposit date:1994-01-10
Release date:1995-05-08
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of the amino-terminal fragment of urokinase-type plasminogen activator.
Biochemistry, 33, 1994
1PLS
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SOLUTION STRUCTURE OF A PLECKSTRIN HOMOLOGY DOMAIN
Descriptor:PLECKSTRIN HOMOLOGY DOMAIN
Authors:Yoon, H.S., Hajduk, P.J., Petros, A.M., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
Deposit date:1994-05-03
Release date:1995-06-03
Last modified:2017-11-29
Method:SOLUTION NMR
Cite:Solution structure of a pleckstrin-homology domain.
Nature, 369, 1994
1FLI
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DNA-BINDING DOMAIN OF FLI-1
Descriptor:FLI-1
Authors:Liang, H., Mao, X., Olejniczak, E.T., Nettesheim, D.G., Yu, L., Meadows, R.P., Thompson, C.B., Fesik, S.W.
Deposit date:1994-09-15
Release date:1995-09-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the ets domain of Fli-1 when bound to DNA.
Nat.Struct.Biol., 1, 1994
1IRS
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IRS-1 PTB DOMAIN COMPLEXED WITH A IL-4 RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:IRS-1, IL-4 RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Huang, B., Olejniczak, E.T., Meadows, R.P., Shuker, S.B., Miyazaki, M., Trub, T., Shoelson, S.E., Feisk, S.W.
Deposit date:1996-03-22
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for IL-4 receptor phosphopeptide recognition by the IRS-1 PTB domain.
Nat.Struct.Biol., 3, 1996
1SHC
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SHC PTB DOMAIN COMPLEXED WITH A TRKA RECEPTOR PHOSPHOPEPTIDE, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:SHC, TRKA RECEPTOR PHOSPHOPEPTIDE
Authors:Zhou, M.-M., Ravichandran, K.S., Olejniczak, E.T., Petros, A.M., Meadows, R.P., Sattler, M., Harlan, J.E., Wade, W.S., Burakoff, S.J., Fesik, S.W.
Deposit date:1996-03-27
Release date:1997-05-15
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure and ligand recognition of the phosphotyrosine binding domain of Shc.
Nature, 378, 1995
1DDF
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FAS DEATH DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:FAS
Authors:Huang, B., Eberstadt, M., Olejniczak, E., Meadows, R.P., Fesik, S.
Deposit date:1996-11-08
Release date:1997-11-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:NMR structure and mutagenesis of the Fas (APO-1/CD95) death domain.
Nature, 384, 1996
1BC9
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CYTOHESIN-1/B2-1 SEC7 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor:CYTOHESIN-1
Authors:Betz, S.F., Schnuchel, A., Wang, H., Olejniczak, E.T., Meadows, R.P., Fesik, S.W.
Deposit date:1998-05-06
Release date:1999-05-11
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1.
Proc.Natl.Acad.Sci.USA, 95, 1998
1G3F
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NMR STRUCTURE OF A 9 RESIDUE PEPTIDE FROM SMAC/DIABLO COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:INHIBITOR OF APOPTOSIS PROTEIN 3, SMAC, ZINC ION
Authors:Liu, Z., Sun, C., Olejniczak, E.T., Meadows, R.P., Betz, S.F., Oost, T., Herrmann, J., Wu, J.C., Fesik, S.W.
Deposit date:2000-10-24
Release date:2001-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural basis for binding of Smac/DIABLO to the XIAP BIR3 domain.
Nature, 408, 2000
1G5J
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COMPLEX OF BCL-XL WITH PEPTIDE FROM BAD
Descriptor:APOPTOSIS REGULATOR BCL-X, BAD PROTEIN
Authors:Petros, A.M., Nettesheim, D.G., Wang, Y., Olejniczak, E.T., Meadows, R.P., Mack, J., Swift, K., Matayoshi, E.D., Zhang, H., Thompson, C.B., Fesik, S.W.
Deposit date:2000-11-01
Release date:2001-02-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studies.
Protein Sci., 9, 2000
1IB8
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SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE
Descriptor:CONSERVED PROTEIN SP14.3
Authors:Yu, L., Gunasekera, A.H., Mack, J., Olejniczak, E.T., Chovan, L.E., Ruan, X., Towne, D.L., Lerner, C.G., Fesik, S.W.
Deposit date:2001-03-27
Release date:2002-03-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:SOLUTION STRUCTURE AND FUNCTION OF A CONSERVED PROTEIN SP14.3 ENCODED BY AN ESSENTIAL STREPTOCOCCUS PNEUMONIAE GENE
J.Mol.Biol., 311, 2001
1K3K
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SOLUTION STRUCTURE OF A BCL-2 HOMOLOG FROM KAPOSI'S SARCOMA VIRUS
Descriptor:functional anti-apoptotic factor vBCL-2 homolog
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2001-10-03
Release date:2002-04-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a Bcl-2 homolog from Kaposi sarcoma virus.
Proc.Natl.Acad.Sci.USA, 99, 2002
1P0R
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SOLUTION STRUCTURE OF UBL5 A HUMAN UBIQUITIN-LIKE PROTEIN
Descriptor:ubiquitin-like 5
Authors:McNally, T., Huang, Q., Janis, R.S., Liu, Z., Olejniczak, E.T., Reilly, R.M.
Deposit date:2003-04-10
Release date:2003-10-28
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structural analysis of UBL5, a novel ubiquitin-like modifier
Protein Sci., 12, 2003
1Q3T
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SOLUTION STRUCTURE AND FUNCTION OF AN ESSENTIAL CMP KINASE OF STREPTOCOCCUS PNEUMONIAE
Descriptor:Cytidylate kinase
Authors:Yu, L., Mack, J., Hajduk, P.J., Kakavas, S.J., Saiki, A.Y., Lerner, C.G., Olejniczak, E.T.
Deposit date:2003-07-31
Release date:2004-08-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure and function of an essential CMP kinase of Streptococcus pneumoniae
Protein Sci., 12, 2003
1Q59
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SOLUTION STRUCTURE OF THE BHRF1 PROTEIN FROM EPSTEIN-BARR VIRUS, A HOMOLOG OF HUMAN BCL-2
Descriptor:Early antigen protein R
Authors:Huang, Q., Petros, A.M., Virgin, H.W., Fesik, S.W., Olejniczak, E.T.
Deposit date:2003-08-06
Release date:2003-09-23
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of the BHRF1 Protein From Epstein-Barr Virus, a Homolog of Human Bcl-2
J.Mol.Biol., 332, 2003
1SSK
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STRUCTURE OF THE N-TERMINAL RNA-BINDING DOMAIN OF THE SARS COV NUCLEOCAPSID PROTEIN
Descriptor:Nucleocapsid protein
Authors:Huang, Q., Yu, L., Petros, A.M., Gunasekera, A., Liu, Z., Xu, N., Hajduk, P., Mack, J., Fesik, S.W., Olejniczak, E.T.
Deposit date:2004-03-24
Release date:2004-06-08
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the N-Terminal RNA-Binding Domain of the SARS CoV Nucleocapsid Protein.
Biochemistry, 43, 2004
1TFQ
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, N-METHYLALANYL-3-METHYLVALYL-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2004-09-07
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of Potent Antagonists of the Antiapoptotic Protein XIAP for the Treatment of Cancer.
J.Med.Chem., 47, 2004
1TFT
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NMR STRUCTURE OF AN ANTAGONISTS OF THE XIAP-CASPASE-9 INTERACTION COMPLEXED TO THE BIR3 DOMAIN OF XIAP
Descriptor:Baculoviral IAP repeat-containing protein 4, ZINC ION, 1-[3,3-DIMETHYL-2-(2-METHYLAMINO-PROPIONYLAMINO)-BUTYRYL]-4-PHENOXY-PYRROLIDINE-2-CARBOXYLIC ACID(1,2,3,4-TETRAHYDRO-NAPHTHALEN-1-YL)-AMIDE
Authors:Oost, T.K., Sun, C., Armstrong, R.C., Al-Assaad, A.S., Betz, S.F., Deckwerth, T.L., Elmore, S.W., Meadows, R.P., Olejniczak, E.T., Oleksijew, A.K., Oltersdorf, T., Rosenberg, S.H., Shoemaker, A.R., Zou, H., Fesik, S.W.
Deposit date:2004-05-27
Release date:2005-05-03
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer.
J.Med.Chem., 47, 2004
1XOX
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SOLUTION STRUCTURE OF HUMAN SURVIVIN
Descriptor:Apoptosis inhibitor survivin, ZINC ION
Authors:Sun, C., Nettesheim, D., Liu, Z., Olejniczak, E.T.
Deposit date:2004-10-07
Release date:2005-01-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of human survivin and its binding interface with smac/diablo
Biochemistry, 44, 2005
1ZP5
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CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN MMP-8 AND A N-HYDROXYUREA INHIBITOR
Descriptor:Neutrophil collagenase, CALCIUM ION, ZINC ION, ...
Authors:Campestre, C., Agamennone, M., Tortorella, P., Preziuso, S., Biasone, A., Gavuzzo, E., Pochetti, G., Mazza, F., Tschesche, H., Gallina, C.
Deposit date:2005-05-16
Release date:2005-12-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:N-Hydroxyurea as zinc binding group in matrix metalloproteinase inhibition: Mode of binding in a complex with MMP-8.
Bioorg.Med.Chem.Lett., 16, 2006
2A9H
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NMR STRUCTURAL STUDIES OF A POTASSIUM CHANNEL / CHARYBDOTOXIN COMPLEX
Descriptor:Voltage-gated potassium channel, charybdotoxin
Authors:Yu, L., Sun, C., Song, D., Shen, J., Xu, N., Gunasekera, A., Hajduk, P.J., Olejniczak, E.T.
Deposit date:2005-07-11
Release date:2006-01-10
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex.
Biochemistry, 44, 2005
2ABO
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NMR STRUCTURE OF GAMMA HERPESVIRUS 68 A VIRAL BCL-2 HOMOLOG
Descriptor:bcl-2 homolog
Authors:Loh, J., Huang, Q., Petros, A.M., Nettesheim, D., van Dyk, L.F., Labrada, L., Speck, S.H., Levine, B., Olejniczak, E.T., Virgin, H.W.
Deposit date:2005-07-15
Release date:2006-05-16
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A surface groove essential for viral Bcl-2 function during chronic infection in vivo.
Plos Pathog., 1, 2005
2GMX
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SELECTIVE AMINOPYRIDINE-BASED C-JUN N-TERMINAL KINASE INHIBITORS WITH CELLULAR ACTIVITY
Descriptor:Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ...
Authors:Abad-Zapatero, C.
Deposit date:2006-04-07
Release date:2006-06-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Aminopyridine-Based c-Jun N-Terminal Kinase Inhibitors with Cellular Activity and Minimal Cross-Kinase Activity.
J.Med.Chem., 49, 2006
2H96
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DISCOVERY OF POTENT, HIGHLY SELECTIVE, AND ORALLY BIOAVAILABLE PYRIDINE CARBOXAMIDE C-JUN NH2-TERMINAL KINASE INHIBITORS
Descriptor:Mitogen-activated protein kinase 8, C-jun-amino-terminal kinase-interacting protein 1, SULFATE ION, ...
Authors:Abad-Zapatero, C.
Deposit date:2006-06-09
Release date:2006-07-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of potent, highly selective, and orally bioavailable pyridine carboxamide c-Jun NH2-terminal kinase inhibitors.
J.Med.Chem., 49, 2006