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6TZ9
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BU of 6tz9 by Molmil
CryoEM reconstruction of membrane-bound ESCRT-III filament composed of CHMP1B only
Descriptor: Charged multivesicular body protein 1b
Authors:Nguyen, H.C, Frost, A.
Deposit date:2019-08-11
Release date:2020-04-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (6.2 Å)
Cite:Membrane constriction and thinning by sequential ESCRT-III polymerization.
Nat.Struct.Mol.Biol., 27, 2020
6TZ4
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BU of 6tz4 by Molmil
CryoEM reconstruction of membrane-bound ESCRT-III filament composed of CHMP1B+IST1 (right-handed)
Descriptor: Charged multivesicular body protein 1b, IST1 homolog
Authors:Nguyen, H.C, Frost, A.
Deposit date:2019-08-10
Release date:2020-04-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Membrane constriction and thinning by sequential ESCRT-III polymerization.
Nat.Struct.Mol.Biol., 27, 2020
6TZA
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BU of 6tza by Molmil
CryoEM reconstruction of ESCRT-III filament composed of IST1 NTD R16E K27E double mutant
Descriptor: IST1 homolog
Authors:Nguyen, H.C, Frost, A.
Deposit date:2019-08-11
Release date:2020-04-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (7.2 Å)
Cite:Membrane constriction and thinning by sequential ESCRT-III polymerization.
Nat.Struct.Mol.Biol., 27, 2020
6TZ5
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BU of 6tz5 by Molmil
CryoEM reconstruction of membrane-bound ESCRT-III filament composed of CHMP1B+IST1 (left-handed)
Descriptor: Charged multivesicular body protein 1b, IST1 homolog
Authors:Nguyen, H.C, Frost, A.
Deposit date:2019-08-10
Release date:2020-04-08
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Membrane constriction and thinning by sequential ESCRT-III polymerization.
Nat.Struct.Mol.Biol., 27, 2020
4WQO
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BU of 4wqo by Molmil
Structure of VHL-EloB-EloC-Cul2
Descriptor: Cullin-2, Transcription elongation factor B polypeptide 1, Transcription elongation factor B polypeptide 2, ...
Authors:Nguyen, H.C, Xiong, Y.
Deposit date:2014-10-22
Release date:2015-03-04
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Insights into Cullin-RING E3 Ubiquitin Ligase Recruitment: Structure of the VHL-EloBC-Cul2 Complex.
Structure, 23, 2015
7JK9
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BU of 7jk9 by Molmil
Helical filaments of plant light-dependent protochlorophyllide oxidoreductase (LPOR) bound to NADPH, Pchlide, and membrane
Descriptor: 1,2-DISTEAROYL-MONOGALACTOSYL-DIGLYCERIDE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Protochlorophyllide, ...
Authors:Nguyen, H.C, Gabruk, M, Frost, A.
Deposit date:2020-07-28
Release date:2021-03-17
Last modified:2021-10-06
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
Nat.Plants, 7, 2021
6O85
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BU of 6o85 by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ...
Authors:Nguyen, H.C, Kenner, L.R, Frost, A.S.
Deposit date:2019-03-08
Release date:2019-05-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
6O9Z
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BU of 6o9z by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to eukaryotic translation initiation factor 2 from Homo sapiens
Descriptor: Eukaryotic translation initiation factor 2 subunit 1, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
Authors:Nguyen, H.C, Kenner, L.R, Frost, A.S.
Deposit date:2019-03-15
Release date:2019-05-15
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
4WHJ
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BU of 4whj by Molmil
Myxovirus Resistance Protein 2 (MxB)
Descriptor: Interferon-induced GTP-binding protein Mx2
Authors:Xiong, Y, Fribourgh, J.L, Nguyen, H.C.
Deposit date:2014-09-22
Release date:2014-10-29
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural Insight into HIV-1 Restriction by MxB.
Cell Host Microbe, 16, 2014
6CAJ
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BU of 6caj by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
Authors:Tsai, J.C, Miller-Vedam, L.E, Anand, A.A, Jaishankar, P, Nguyen, H.C, Renslo, A.R, Frost, A, Walter, P.
Deposit date:2018-01-31
Release date:2018-04-11
Last modified:2019-11-20
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Structure of the nucleotide exchange factor eIF2B reveals mechanism of memory-enhancing molecule.
Science, 359, 2018
7L7G
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BU of 7l7g by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B from Homo sapiens (updated model of PDB ID: 6CAJ)
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Translation initiation factor eIF-2B subunit alpha, Translation initiation factor eIF-2B subunit beta, ...
Authors:Tsai, J.C, Miller-Vedam, L.E, Anand, A, Jaishankar, P, Nguyen, H.C, Wang, L, Renslo, A.R, Frost, A, Walter, P.
Deposit date:2020-12-28
Release date:2021-03-24
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:eIF2B conformation and assembly state regulates the integrated stress response.
Elife, 10, 2021
7KKJ
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BU of 7kkj by Molmil
Structure of anti-SARS-CoV-2 Spike nanobody mNb6
Descriptor: CHLORIDE ION, SULFATE ION, Synthetic nanobody mNb6
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-25
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKK
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BU of 7kkk by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody Nb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (3.03 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
7KKL
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BU of 7kkl by Molmil
SARS-CoV-2 Spike in complex with neutralizing nanobody mNb6
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Schoof, M.S, Faust, B.F, Saunders, R.A, Sangwan, S, Rezelj, V, Hoppe, N, Boone, M, Billesboelle, C.B, Puchades, C, Azumaya, C.M, Kratochvil, H.T, Zimanyi, M, Desphande, I, Liang, J, Dickinson, S, Nguyen, H.C, Chio, C.M, Merz, G.E, Thompson, M.C, Diwanji, D, Schaefer, K, Anand, A.A, Dobzinski, N, Zha, B.S, Simoneau, C.R, Leon, K, White, K.M, Chio, U.S, Gupta, M, Jin, M, Li, F, Liu, Y, Zhang, K, Bulkley, D, Sun, M, Smith, A.M, Rizo, A.N, Moss, F, Brilot, A.F, Pourmal, S, Trenker, R, Pospiech, T, Gupta, S, Barsi-Rhyne, B, Belyy, V, Barile-Hill, A.W, Nock, S, Liu, Y, Krogan, N.J, Ralston, C.Y, Swaney, D.L, Garcia-Sastre, A, Ott, M, Vignuzzi, M, Walter, P, Manglik, A, QCRG Structural Biology Consortium
Deposit date:2020-10-27
Release date:2020-11-11
Last modified:2021-04-21
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
Science, 370, 2020
8HNI
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BU of 8hni by Molmil
hnRNP A2/B1 RRMs in complex with telomeric DNA
Descriptor: DNA (5'-D(P*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*T)-3'), Heterogeneous nuclear ribonucleoproteins A2/B1
Authors:Liu, Y, Abula, A, Xiao, H, Guo, H, Li, T, Zheng, L, Chen, B, Nguyen, H, Ji, X.
Deposit date:2022-12-07
Release date:2023-11-29
Method:X-RAY DIFFRACTION (2.644 Å)
Cite:Structural Insight Into hnRNP A2/B1 Homodimerization and DNA Recognition.
J.Mol.Biol., 435, 2023
8GZZ
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BU of 8gzz by Molmil
Local refinement of SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab
Descriptor: Spike protein S1, rabbit monoclonal antibody 1H1 Fab heavy chain, rabbit monoclonal antibody 1H1 Fab light chain
Authors:Guo, H, Gao, Y, Lu, Y, Yang, H, Ji, X.
Deposit date:2022-09-27
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.52 Å)
Cite:Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
Commun Biol, 6, 2023
8GZ4
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BU of 8gz4 by Molmil
Crystal structure of MPXV phosphatase
Descriptor: Dual specificity protein phosphatase H1, PHOSPHATE ION
Authors:Yang, H.T, Wang, W, Huang, H.J, Ji, X.Y.
Deposit date:2022-09-25
Release date:2023-05-17
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.802 Å)
Cite:Crystal structure of monkeypox H1 phosphatase, an antiviral drug target.
Protein Cell, 14, 2023
8ITU
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BU of 8itu by Molmil
SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 IgG.
Descriptor: 1H1 heavy chain, 1H1 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Guo, H, Gao, Y, Lu, Y, Yang, H, Ji, X.
Deposit date:2023-03-23
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
Commun Biol, 6, 2023
6E8G
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BU of 6e8g by Molmil
CryoEM reconstruction of IST1-CHMP1B copolymer filament bound to ssDNA at 2.9 Angstrom resolution
Descriptor: Charged multivesicular body protein 1b, IST1 homolog
Authors:Talledge, N, Frost, A, McCullough, J.
Deposit date:2018-07-29
Release date:2018-08-15
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:The ESCRT-III proteins IST1 and CHMP1B assemble around nucleic acids
Biorxiv, 2018
6O81
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BU of 6o81 by Molmil
Electron cryo-microscopy of the eukaryotic translation initiation factor 2B bound to translation initiation factor 2 from Homo sapiens
Descriptor: 2-(4-chloranylphenoxy)-~{N}-[4-[2-(4-chloranylphenoxy)ethanoylamino]cyclohexyl]ethanamide, Eukaryotic translation initiation factor 2 subunit 1, Eukaryotic translation initiation factor 2 subunit 3, ...
Authors:Nguyen, H, Kenner, L, Frost, A.
Deposit date:2019-03-08
Release date:2019-05-15
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:eIF2B-catalyzed nucleotide exchange and phosphoregulation by the integrated stress response.
Science, 364, 2019
6NIL
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BU of 6nil by Molmil
cryoEM structure of the truncated HIV-1 Vif/CBFbeta/A3F complex
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3F, Virion infectivity factor, ...
Authors:Hu, Y, Xiong, Y.
Deposit date:2018-12-29
Release date:2019-12-11
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis of antagonism of human APOBEC3F by HIV-1 Vif.
Nat.Struct.Mol.Biol., 26, 2019
8H00
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BU of 8h00 by Molmil
SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in the class 1 conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Guo, H, Gao, Y, Lu, Y, Yang, H, Ji, X.
Deposit date:2022-09-27
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.41 Å)
Cite:Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
Commun Biol, 6, 2023
8H01
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BU of 8h01 by Molmil
SARS-CoV-2 Omicron BA.1 Spike glycoprotein in complex with rabbit monoclonal antibody 1H1 Fab in class 2 conformation
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein, ...
Authors:Guo, H, Gao, Y, Lu, Y, Yang, H, Ji, X.
Deposit date:2022-09-27
Release date:2023-04-12
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Mechanism of a rabbit monoclonal antibody broadly neutralizing SARS-CoV-2 variants
Commun Biol, 6, 2023
7WS2
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BU of 7ws2 by Molmil
Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development
Descriptor: 510A5 heavy chain, 510A5 light chain, Spike protein S1
Authors:Guo, H, Gao, Y, Ji, X, Yang, H.
Deposit date:2022-01-28
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022
7WS6
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BU of 7ws6 by Molmil
Structures of Omicron Spike complexes illuminate broad-spectrum neutralizing antibody development
Descriptor: 510A5 heavy chain, 510A5 light chain, Spike protein S1
Authors:Guo, H, Gao, Y, Ji, X, Yang, H.
Deposit date:2022-01-28
Release date:2022-06-01
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structures of Omicron spike complexes and implications for neutralizing antibody development.
Cell Rep, 39, 2022

 

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