Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
Search by PDB author
3D4Q
DownloadVisualize
BU of 3d4q by Molmil
Pyrazole-based inhibitors of B-Raf kinase
Descriptor: (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime, B-Raf proto-oncogene serine/threonine-protein kinase
Authors:Morales, T, Vigers, G.P.A, Brandhuber, B.J.
Deposit date:2008-05-14
Release date:2008-08-19
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Potent and selective pyrazole-based inhibitors of B-Raf kinase.
Bioorg.Med.Chem.Lett., 18, 2008
3PSD
DownloadVisualize
BU of 3psd by Molmil
Non-oxime pyrazole based inhibitors of B-Raf kinase
Descriptor: 6-[1-(piperidin-4-yl)-3-(pyridin-4-yl)-1H-pyrazol-4-yl]indeno[1,2-c]pyrazole, B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE
Authors:Morales, T, Vigers, G.P.A, Brandhuber, B.J.
Deposit date:2010-12-01
Release date:2011-05-18
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:Non-oxime pyrazole based inhibitors of B-Raf kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3PSB
DownloadVisualize
BU of 3psb by Molmil
Furo[2,3-c]pyridine-based Indanone Oximes as Potent and Selective B-Raf Inhibitors
Descriptor: B-RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE, ethyl 3-{[1-(hydroxyamino)-2H-inden-5-yl]amino}thieno[2,3-c]pyridine-2-carboxylate
Authors:Morales, T, Vigers, G.P.A, Brandhuber, B.J.
Deposit date:2010-12-01
Release date:2011-01-19
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
4MNE
DownloadVisualize
BU of 4mne by Molmil
Crystal structure of the BRAF:MEK1 complex
Descriptor: 7-fluoro-3-[(2-fluoro-4-iodophenyl)amino]-N-{[(2S)-2-hydroxypropyl]oxy}furo[3,2-c]pyridine-2-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
Deposit date:2013-09-10
Release date:2014-06-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8483 Å)
Cite:Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
4MNF
DownloadVisualize
BU of 4mnf by Molmil
Crystal structure of BRAF-V600E bound to GDC0879
Descriptor: 2-{4-[(1E)-1-(hydroxyimino)-2,3-dihydro-1H-inden-5-yl]-3-(pyridin-4-yl)-1H-pyrazol-1-yl}ethanol, CHLORIDE ION, Serine/threonine-protein kinase B-raf
Authors:Sudhamsu, J, Haling, J.R, Morales, T, Brandhuber, B, Hymowitz, S.G.
Deposit date:2013-09-10
Release date:2014-06-18
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.802 Å)
Cite:Structure of the BRAF-MEK Complex Reveals a Kinase Activity Independent Role for BRAF in MAPK Signaling.
Cancer Cell, 26, 2014
3OMV
DownloadVisualize
BU of 3omv by Molmil
Crystal structure of c-raf (raf-1)
Descriptor: (1E)-5-(1-piperidin-4-yl-3-pyridin-4-yl-1H-pyrazol-4-yl)-2,3-dihydro-1H-inden-1-one oxime, RAF proto-oncogene serine/threonine-protein kinase
Authors:Hatzivassiliou, G, Song, K, Yen, I, Brandhuber, B.J, Anderson, D.J, Alvarado, R, Ludlam, M.J, Stokoe, D, Gloor, S.L, Vigers, G.P.A, Morales, T, Aliagas, I, Liu, B, Sideris, S, Hoeflich, K.P, Jaiswal, B.S, Seshagiri, S, Koeppen, H, Belvin, M, Friedman, L.S, Malek, S.
Deposit date:2010-08-27
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (4 Å)
Cite:RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth.
Nature, 464, 2010
3PRF
DownloadVisualize
BU of 3prf by Molmil
Crystal Structure of Human B-Raf Kinase Domain in Complex with a Non-Oxime Furopyridine Inhibitor
Descriptor: 2-chloro-5-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}phenol, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-29
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3PRI
DownloadVisualize
BU of 3pri by Molmil
Crystal Structure of Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor
Descriptor: 3-(4-{[2-(pyrimidin-2-yl)furo[2,3-c]pyridin-3-yl]amino}-1H-indazol-3-yl)propan-1-ol, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-29
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3PPK
DownloadVisualize
BU of 3ppk by Molmil
Human B-Raf Kinase in Complex with a Non-Oxime Furopyridine Inhibitor
Descriptor: 3-[(5-hydroxynaphthalen-2-yl)amino]-N-(pyrimidin-4-yl)furo[2,3-c]pyridine-2-carboxamide, Serine/threonine-protein kinase B-raf
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-24
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3PPJ
DownloadVisualize
BU of 3ppj by Molmil
Human B-Raf Kinase in Complex with a Furopyridine Inhibitor
Descriptor: Serine/threonine-protein kinase B-raf, methyl 3-{[(5S)-1-(hydroxyamino)-5H-inden-5-yl]amino}furo[2,3-c]pyridine-2-carboxylate
Authors:Voegtli, W.C, Vigers, G.P.A, Morales, T, Brandhuber, B.J.
Deposit date:2010-11-24
Release date:2011-02-02
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (3.7 Å)
Cite:Non-oxime inhibitors of B-Raf(V600E) kinase.
Bioorg.Med.Chem.Lett., 21, 2011
3QKL
DownloadVisualize
BU of 3qkl by Molmil
Spirochromane Akt Inhibitors
Descriptor: GSK-3 beta peptide, N-{(2S)-3-[(3S)-8',9'-dihydro-1H,3'H-spiro[piperidine-3,7'-pyrano[3,2-e]indazol]-1-yl]-2-hydroxypropyl}-N-(2-ethoxyethyl)-2,6-dimethylbenzenesulfonamide, RAC-alpha serine/threonine-protein kinase
Authors:Kallan, N.C, Spencer, K.L, Blake, J.F, Xu, R, Heizer, J, Bencsik, J.R, Mitchell, I.S, Gloor, S.L, Martinson, M, Risom, T, Gross, S.D, Morales, T, Vigers, G.P.A, Brandhuber, B.J, Skelton, N.J.
Deposit date:2011-02-01
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Discovery and SAR of spirochromane Akt inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3QKK
DownloadVisualize
BU of 3qkk by Molmil
Spirochromane Akt Inhibitors
Descriptor: GSK-3 beta peptide, N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(2R)-6-hydroxy-4-oxo-3,4-dihydro-1'H-spiro[chromene-2,3'-piperidin]-1'-yl]propyl}-2,6-dimethylbenzenesulfonamide, RAC-alpha serine/threonine-protein kinase
Authors:Kallan, N.C, Spencer, K.L, Blake, J.F, Xu, R, Heizer, J, Bencsik, J.R, Mitchell, I.S, Gloor, S.L, Martinson, M, Risom, T, Gross, S.D, Morales, T, Vigers, G.P.A, Brandhuber, B.J, Skelton, N.J.
Deposit date:2011-02-01
Release date:2011-03-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and SAR of spirochromane Akt inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3QKM
DownloadVisualize
BU of 3qkm by Molmil
Spirocyclic sulfonamides as AKT inhibitors
Descriptor: N-(2-ethoxyethyl)-N-{(2S)-2-hydroxy-3-[(5R)-2-(quinazolin-4-yl)-2,7-diazaspiro[4.5]dec-7-yl]propyl}-2,6-dimethylbenzenesulfonamide, RAC-alpha serine/threonine-protein kinase
Authors:Xu, R, Banka, A, Blake, J.F, Mitchell, I.S, Wallace, E.M, Gloor, S.L, Martinson, M, Risom, T, Gross, S.D, Morales, T, Vigers, G.P.A, Brandhuber, B.J, Skelton, N.J.
Deposit date:2011-02-01
Release date:2011-04-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA.
Bioorg.Med.Chem.Lett., 21, 2011

217705

PDB entries from 2024-03-27

PDB statisticsPDBj update infoContact PDBjnumon