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4V6V
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BU of 4v6v by Molmil
Tetracycline resistance protein Tet(O) bound to the ribosome
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Li, W, Atkinson, G.C, Thakor, N.S, Allas, U, Lu, C, Chan, K.Y, Tenson, T, Schulten, K, Wilson, K.S, Hauryliuk, V, Frank, J.
Deposit date:2013-02-25
Release date:2014-07-09
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (9.8 Å)
Cite:Mechanism of tetracycline resistance by ribosomal protection protein Tet(O).
Nat Commun, 4, 2013
1LCY
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BU of 1lcy by Molmil
Crystal Structure of the Mitochondrial Serine Protease HtrA2
Descriptor: HtrA2 serine protease
Authors:Li, W, Srinivasula, S.M, Chai, J, Li, P, Wu, J.W, Zhang, Z, Alnemri, E.S, Shi, Y.
Deposit date:2002-04-07
Release date:2002-05-22
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi.
Nat.Struct.Biol., 9, 2002
6XA1
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BU of 6xa1 by Molmil
Structure of a drug-like compound stalled human translation termination complex
Descriptor: 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.
Deposit date:2020-06-03
Release date:2020-10-07
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.8 Å)
Cite:Selective inhibition of human translation termination by a drug-like compound.
Nat Commun, 11, 2020
6OLZ
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BU of 6olz by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like molecule with PP tRNA
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-17
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
6OLG
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BU of 6olg by Molmil
Human ribosome nascent chain complex stalled by a drug-like small molecule (CDH1_RNC with PP tRNA)
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-16
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
7CRQ
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BU of 7crq by Molmil
NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode)
Descriptor: DNA (168-MER), Histone H2A, Histone H2B, ...
Authors:Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z.
Deposit date:2020-08-14
Release date:2020-10-21
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.15 Å)
Cite:Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
7CRP
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BU of 7crp by Molmil
NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (1:1 binding mode)
Descriptor: DNA (168-MER), Histone H2A, Histone H2B, ...
Authors:Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z.
Deposit date:2020-08-14
Release date:2020-10-21
Last modified:2021-03-03
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
2YXR
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BU of 2yxr by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.6 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
2YXQ
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BU of 2yxq by Molmil
The plug domain of the SecY protein stablizes the closed state of the translocation channel and maintains a membrane seal
Descriptor: Preprotein translocase secG subunit, Preprotein translocase subunit secE, Preprotein translocase subunit secY
Authors:Li, W, Schulman, S.
Deposit date:2007-04-27
Release date:2007-08-14
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:The plug domain of the SecY protein stabilizes the closed state of the translocation channel and maintains a membrane seal
Mol.Cell, 26, 2007
8AP0
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BU of 8ap0 by Molmil
ForT Mutant T138V
Descriptor: 1-O-pyrophosphono-5-O-phosphono-alpha-D-ribofuranose, 4-azanyl-1~{H}-pyrazole-3,5-dicarboxylic acid, Beta-ribofuranosylaminobenzene 5'-phosphate synthase, ...
Authors:Li, W, Naismith, J.H.
Deposit date:2022-08-09
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase.
Open Biology, 13, 2023
8AOZ
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BU of 8aoz by Molmil
ForT Mutant L24A
Descriptor: 1,2-ETHANEDIOL, 4-azanyl-3-[(2~{S},3~{R},4~{S},5~{R})-3,4-bis(oxidanyl)-5-(phosphonooxymethyl)oxolan-2-yl]-1~{H}-pyrazole-5-carboxylic acid, Beta-ribofuranosylaminobenzene 5'-phosphate synthase, ...
Authors:Li, W, Naismith, J.H.
Deposit date:2022-08-09
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and computational snapshots of C-C bond formation in a C-nucleoside synthase.
Open Biology, 13, 2023
6OM7
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BU of 6om7 by Molmil
Human ribosome nascent chain complex (PCSK9-RNC) stalled by a drug-like small molecule with AA and PE tRNAs
Descriptor: 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S10, ...
Authors:Li, W, Cate, J.H.D.
Deposit date:2019-04-18
Release date:2019-06-19
Last modified:2019-12-18
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:Structural basis for selective stalling of human ribosome nascent chain complexes by a drug-like molecule.
Nat.Struct.Mol.Biol., 26, 2019
1H3L
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BU of 1h3l by Molmil
N-terminal fragment of SigR from Streptomyces coelicolor
Descriptor: RNA POLYMERASE SIGMA FACTOR
Authors:Li, W, Stevenson, C.E.M, Burton, N, Jakimowicz, P, Paget, M.S.B, Buttner, M.J, Lawson, D.M, Kleanthous, C.
Deposit date:2002-09-10
Release date:2002-10-03
Last modified:2015-09-23
Method:X-RAY DIFFRACTION (2.375 Å)
Cite:Identification and Structure of the Anti-Sigma Factor-Binding Domain of the Disulfide-Stress Regulated Sigma Factor Sigma(R) from Streptomyces Coelicolor
J.Mol.Biol., 323, 2002
4HKF
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BU of 4hkf by Molmil
Crystal structure of Danio rerio MEC-17 catalytic domain in complex with acetyl-CoA
Descriptor: ACETYL COENZYME *A, Alpha-tubulin N-acetyltransferase, SULFATE ION
Authors:Li, W, Zhong, C, Sun, B, Xu, S, Zhang, T, Ding, J.
Deposit date:2012-10-15
Release date:2012-12-12
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Molecular basis of the acetyltransferase activity of MEC-17 towards alpha- tubulin
Cell Res., 22, 2012
1TB6
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BU of 1tb6 by Molmil
2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-sulfonato-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-alpha-D-glucopyranose-(1-4)-2,3,6-tri-O-methyl-beta-D-glucopyranose-(1-4)-2,3-di-O-methyl-6-O-sulfonato-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-alpha-L-idopyranuronic acid-(1-4)-methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Li, W, Johnson, D.J, Esmon, C.T, Huntington, J.A.
Deposit date:2004-05-19
Release date:2004-08-17
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the antithrombin-thrombin-heparin ternary complex reveals the antithrombotic mechanism of heparin.
Nat.Struct.Mol.Biol., 11, 2004
1ZR4
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BU of 1zr4 by Molmil
Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently linked to two Cleaved DNAs
Descriptor: AAA, TCAGTGTCCGATAATTTAT, TTATCGGACACTG, ...
Authors:Li, W, Kamtekar, S, Xiong, Y, Sarkis, G.J, Grindley, N.D, Steitz, T.A.
Deposit date:2005-05-19
Release date:2005-08-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
1ZR2
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BU of 1zr2 by Molmil
Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently Linked to two Cleaved DNAs
Descriptor: AAA, TCAGTGTCCGATAATTTAT, TTATCGGACACTG, ...
Authors:Li, W, Kamtekar, S, Xiong, Y, Sarkis, G.J, Grindley, N.D, Steitz, T.A.
Deposit date:2005-05-18
Release date:2005-08-30
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs.
Science, 309, 2005
3B9F
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BU of 3b9f by Molmil
1.6 A structure of the PCI-thrombin-heparin complex
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, GLYCEROL, Plasma serine protease inhibitor, ...
Authors:Li, W, Adams, T.E, Huntington, J.A.
Deposit date:2007-11-05
Release date:2008-04-22
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Molecular basis of thrombin recognition by protein C inhibitor revealed by the 1.6-A structure of the heparin-bridged complex.
Proc.Natl.Acad.Sci.Usa, 105, 2008
2OL2
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BU of 2ol2 by Molmil
High Resolution Structure of Native PCI in Space Group P21
Descriptor: GLYCEROL, Plasma serine protease inhibitor
Authors:Li, W, Huntington, J.A.
Deposit date:2007-01-18
Release date:2007-03-13
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
3DY0
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BU of 3dy0 by Molmil
Crystal Structure of Cleaved PCI Bound to Heparin
Descriptor: 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, C-terminus Plasma serine protease inhibitor, GLYCEROL, ...
Authors:Li, W, Huntington, J.A.
Deposit date:2008-07-25
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:The heparin binding site of protein C inhibitor is protease-dependent.
J.Biol.Chem., 283, 2008
4D3Z
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BU of 4d3z by Molmil
The structure of inactive prolegumain from chinese hamster, trigonal space group.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, PROLEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
4D3X
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BU of 4d3x by Molmil
The structure of mature legumain from chinese hamster.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, LEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
4D3Y
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BU of 4d3y by Molmil
The structure of inactive prolegumain from chinese hamster.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, LEGUMAIN
Authors:Li, W, Heinz, D.W, Krausze, J.
Deposit date:2014-10-24
Release date:2016-01-20
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Detailed Look Into Chinese Hamster Legumain Active Site Structure and Exploration of its Function
To be Published
2HI9
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BU of 2hi9 by Molmil
Crystal Structure of human native protein C inhibitor
Descriptor: CITRIC ACID, GLYCEROL, Plasma serine protease inhibitor
Authors:Li, W, Adams, T.E, Huntington, J.A.
Deposit date:2006-06-29
Release date:2007-03-13
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of native protein C inhibitor provides insight into its multiple functions.
J.Biol.Chem., 282, 2007
3J9Z
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BU of 3j9z by Molmil
Activation of GTP Hydrolysis in mRNA-tRNA Translocation by Elongation Factor G
Descriptor: 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Li, W, Liu, Z, Koripella, R.K, Langlois, R, Sanyal, S, Frank, J.
Deposit date:2015-03-27
Release date:2015-07-01
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.
Sci Adv, 1, 2015

217705

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