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3JSD
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BU of 3jsd by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin A chain, Insulin B chain, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2009-09-10
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
3P2X
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BU of 3p2x by Molmil
Insulin fibrillation is the Janus face of induced fit. A chiaral clamp stabilizes the native state at the expense of activity
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3P33
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BU of 3p33 by Molmil
Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Hua, Q.X, Wan, Z.L, Huang, K, Hu, S.Q, Phillip, N.F, Jia, W.H, Whittingham, J, Dodson, G.G, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2010-10-04
Release date:2011-11-23
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin fibrillation is the Janus face of induced fit. A chiral clamp stabilizes the native state at the expense of activity
To be Published
3ROV
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BU of 3rov by Molmil
Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Weiss, M.A, Wan, Z.L, Dodson, E.J, Liu, M, Xu, B, Hua, Q.X, Turkenburg, M, Whittingham, J, Nakagawa, S.H, Huang, K, Hu, S.Q, Jia, W.H, Wang, S.H, Brange, J, Whittaker, J, Arvan, P, Katsoyannis, P.G, Dodson, G.G.
Deposit date:2011-04-26
Release date:2012-05-02
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Insulin's biosynthesis and activity have opposing structural requirements: a new factor in neonatal diabetes mellitus
To be Published
1J73
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BU of 1j73 by Molmil
Crystal structure of an unstable insulin analog with native activity.
Descriptor: ZINC ION, insulin a, insulin b
Authors:Wan, Z, Zhao, M, Nakagawa, S, Jia, W, Weiss, M.A.
Deposit date:2001-05-15
Release date:2001-05-30
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2 Å)
Cite:Non-standard insulin design: structure-activity relationships at the periphery of the insulin receptor.
J.Mol.Biol., 315, 2002
1SJT
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BU of 1sjt by Molmil
MINI-PROINSULIN, TWO CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP, NMR, 20 STRUCTURES
Descriptor: PROINSULIN
Authors:Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1SJU
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BU of 1sju by Molmil
MINI-PROINSULIN, SINGLE CHAIN INSULIN ANALOG MUTANT: DES B30, HIS(B 10)ASP, PRO(B 28)ASP AND PEPTIDE BOND BETWEEN LYS B 29 AND GLY A 1, NMR, 20 STRUCTURES
Descriptor: PROINSULIN
Authors:Hua, Q.X, Hu, S.Q, Jia, W.H, Chu, Y.C, Burke, G.T, Wang, S.H, Katsoyannis, P.G, Weiss, M.A.
Deposit date:1997-10-09
Release date:1998-03-18
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Mini-proinsulin and mini-IGF-I: homologous protein sequences encoding non-homologous structures.
J.Mol.Biol., 277, 1998
1VKT
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BU of 1vkt by Molmil
HUMAN INSULIN TWO DISULFIDE MODEL, NMR, 10 STRUCTURES
Descriptor: INSULIN
Authors:Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A.
Deposit date:1996-10-14
Release date:1997-04-01
Last modified:2021-11-03
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2JZQ
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BU of 2jzq by Molmil
Design of an Active Ultra-Stable Single-Chain Insulin Analog 20 Structures
Descriptor: Insulin
Authors:Hua, Q.X, Nakarawa, S, Jia, W.H, Huang, K, Philips, N.F, Hu, S.Q, Weiss, M.A.
Deposit date:2008-01-11
Release date:2008-02-26
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Design of an active ultrastable single-chain insulin analog: synthesis, structure, and therapeutic implications.
J.Biol.Chem., 283, 2008
2JMN
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BU of 2jmn by Molmil
NMR structure of human insulin mutant His-B10-Asp, Pro-B28-Lys, Lys-B29-Pro, 20 structures
Descriptor: Insulin A chain, Insulin B chain
Authors:Hua, Q.X, Hu, S.Q, Frank, B.H, Jia, W.H, Chu, Y.C, Wang, S.H, Burke, G.T, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2006-11-21
Release date:2006-12-05
Last modified:2023-12-20
Method:SOLUTION NMR
Cite:Mapping the functional surface of insulin by design: structure and function of a novel A-chain analogue.
J.Mol.Biol., 264, 1996
2K9R
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BU of 2k9r by Molmil
Enhancing the activity of insulin by stereospecific unfolding
Descriptor: Insulin
Authors:Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2008-10-23
Release date:2008-11-11
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2K91
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BU of 2k91 by Molmil
Enhancing the activity of insulin by stereospecific unfolding
Descriptor: Insulin
Authors:Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2008-09-29
Release date:2008-11-18
Last modified:2021-10-20
Method:SOLUTION NMR
Cite:Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS.
J.Biol.Chem., 284, 2009
2KJI
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BU of 2kji by Molmil
A divergent ins protein in c. elegans structurally resemble insulin and activates the human insulin receptor
Descriptor: Probable insulin-like peptide beta-type 5
Authors:Hua, Q.X, Nakarawa, S.H, Wilken, R, Ramos, R.R, Jia, W.H, Bass, J, Weiss, M.A.
Deposit date:2009-05-28
Release date:2009-06-16
Last modified:2019-09-18
Method:SOLUTION NMR
Cite:A divergent INS protein in Caenorhabditis elegans structurally resembles human insulin and activates the human insulin receptor.
Genes Dev., 17, 2003
1RWE
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BU of 1rwe by Molmil
Enhancing the activity of insulin at receptor edge: crystal structure and photo-cross-linking of A8 analogues
Descriptor: CHLORIDE ION, Insulin, PHENOL, ...
Authors:Wan, Z, Xu, B, Chu, Y.C, Li, B, Nakagawa, S.H, Qu, Y, Hu, S.Q, Katsoyannis, P.G, Weiss, M.A.
Deposit date:2003-12-16
Release date:2005-02-15
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Enhancing the activity of insulin at the receptor interface: crystal structure and photo-cross-linking of A8 analogues.
Biochemistry, 43, 2004

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