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3J4J
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BU of 3j4j by Molmil
Model of full-length T. thermophilus Translation Initiation Factor 2 refined against its cryo-EM density from a 30S Initiation Complex map
Descriptor: Translation initiation factor IF-2
Authors:Simonetti, A, Marzi, S, Billas, I.M.L, Tsai, A, Fabbretti, A, Myasnikov, A, Roblin, P, Vaiana, A.C, Hazemann, I, Eiler, D, Steitz, T.A, Puglisi, J.D, Gualerzi, C.O, Klaholz, B.P.
Deposit date:2013-08-26
Release date:2013-09-25
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (11.5 Å)
Cite:Involvement of protein IF2 N domain in ribosomal subunit joining revealed from architecture and function of the full-length initiation factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
4V9S
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BU of 4v9s by Molmil
Crystal structure of antibiotic GE82832 bound to 70S ribosome
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2018-06-27
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
4V9R
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BU of 4v9r by Molmil
Crystal structure of antibiotic DITYROMYCIN bound to 70S ribosome
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ...
Authors:Bulkley, D.P, Brandi, L, Polikanov, Y.S, Fabbretti, A, O'Connor, M, Gualerzi, C.O, Steitz, T.A.
Deposit date:2013-12-05
Release date:2014-07-09
Last modified:2014-12-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:The antibiotics dityromycin and GE82832 bind protein S12 and block EF-G-catalyzed translocation.
Cell Rep, 6, 2014
5ME0
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BU of 5me0 by Molmil
Structure of the 30S Pre-Initiation Complex 1 (30S IC-1) Stalled by GE81112
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S.
Deposit date:2016-11-14
Release date:2017-01-11
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (13.5 Å)
Cite:Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
5ME1
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BU of 5me1 by Molmil
Structure of the 30S Pre-Initiation Complex 2 (30S IC-2) Stalled by GE81112
Descriptor: 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ...
Authors:Lopez-Alonso, J.P, Fabbretti, A, Kaminishi, T, Iturrioz, I, Brandi, L, Gil Carton, D, Gualerzi, C, Fucini, P, Connell, S.
Deposit date:2016-11-14
Release date:2017-01-11
Last modified:2019-11-13
Method:ELECTRON MICROSCOPY (13.5 Å)
Cite:Structure of a 30S pre-initiation complex stalled by GE81112 reveals structural parallels in bacterial and eukaryotic protein synthesis initiation pathways.
Nucleic Acids Res., 45, 2017
5IWA
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BU of 5iwa by Molmil
Crystal structure of the 30S ribosomal subunit from Thermus thermophilus in complex with the GE81112 peptide antibiotic
Descriptor: (2S,3S)-2-{[(2S)-3-(2-amino-1H-imidazol-5-yl)-2-{[(2S,4S)-5-(carbamoyloxy)-4-hydroxy-2-({[(2S,3S)-3-hydroxypiperidin-2-yl]carbonyl}amino)pentanoyl]amino}propanoyl]amino}-3-(2-chloro-1H-imidazol-5-yl)-3-hydroxypropanoic acid, 16S ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Schedlbauer, A, Kaminishi, T, Ochoa-Lizarralde, B, Chieko, N, Masahito, K, Takemoto, C, Yokoyama, S, Connell, S.R, Fucini, P.
Deposit date:2016-03-22
Release date:2016-04-27
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of translation initiation complex formation by GE81112 unravels a 16S rRNA structural switch involved in P-site decoding.
Proc.Natl.Acad.Sci.USA, 113, 2016
5DM6
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BU of 5dm6 by Molmil
Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ...
Authors:Kaminishi, T, Schedlbauer, A, Ochoa-Lizarralde, B, Connell, S.R, Fucini, P.
Deposit date:2015-09-08
Release date:2015-11-11
Last modified:2016-02-03
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
5DM7
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BU of 5dm7 by Molmil
Crystal structure of the 50S ribosomal subunit from Deinococcus radiodurans in complex with hygromycin A
Descriptor: 23S ribosomal RNA, 50S ribosomal protein L1, 50S ribosomal protein L11, ...
Authors:Kaminishi, T, Schedlbauer, A, Ochoa-Lizarralde, B, Connell, S.R, Fucini, P.
Deposit date:2015-09-08
Release date:2015-11-11
Last modified:2015-11-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A.
Nucleic Acids Res., 43, 2015
4B3X
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BU of 4b3x by Molmil
Bacterial translation initiation factor IF2 (1-363), apo form
Descriptor: GLYCEROL, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-26
Release date:2013-05-29
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B43
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BU of 4b43 by Molmil
Bacterial translation initiation factor IF2 (1-363), apo form, double mutant K86L H130A
Descriptor: GLYCEROL, IODIDE ION, MAGNESIUM ION, ...
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.937 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B44
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BU of 4b44 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH8.0
Descriptor: GUANOSINE-5'-DIPHOSPHATE, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-09-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Molecular Basis of GTP Hydrolysis by Bacterial Translation Initiation Factor If2
To be Published
4B47
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BU of 4b47 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GDP at pH6.5
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.301 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013
4B48
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BU of 4b48 by Molmil
Bacterial translation initiation factor IF2 (1-363), complex with GTP
Descriptor: GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, TRANSLATION INITIATION FACTOR IF-2
Authors:Simonetti, A, Urzhumtsev, A, Klaholz, B.P.
Deposit date:2012-07-27
Release date:2013-05-29
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of the Protein Core of Translation Initiation Factor 2 in Apo, GTP-Bound and Gdp-Bound Forms
Acta Crystallogr.,Sect.D, 69, 2013

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