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1EKG
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BU of 1ekg by Molmil
MATURE HUMAN FRATAXIN
Descriptor: FRATAXIN
Authors:Dhe-Paganon, S, Shigeta, R, Chi, Y.I, Ristow, M, Shoelson, S.E.
Deposit date:2000-03-08
Release date:2000-11-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of human frataxin.
J.Biol.Chem., 275, 2000
1Q2H
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BU of 1q2h by Molmil
Phenylalanine Zipper Mediates APS Dimerization
Descriptor: adaptor protein with pleckstrin homology and src homology 2 domains
Authors:Dhe-Paganon, S, Werner, E.D, Nishi, M, Chi, Y.-I, Shoelson, S.E.
Deposit date:2003-07-24
Release date:2004-08-03
Last modified:2022-12-21
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:A phenylalanine zipper mediates APS dimerization.
Nat.Struct.Mol.Biol., 11, 2004
1QQG
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BU of 1qqg by Molmil
CRYSTAL STRUCTURE OF THE PH-PTB TARGETING REGION OF IRS-1
Descriptor: INSULIN RECEPTOR SUBSTRATE 1
Authors:Dhe-Paganon, S, Shoelson, S.E.
Deposit date:1999-06-04
Release date:1999-08-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of the pleckstrin homology-phosphotyrosine binding (PH-PTB) targeting region of insulin receptor substrate 1.
Proc.Natl.Acad.Sci.USA, 96, 1999
1IFR
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BU of 1ifr by Molmil
Structure of Lamin A/C Globular Domain
Descriptor: GLYCEROL, Lamin A/C
Authors:Dhe-Paganon, S, Werner, E.D, Shoelson, S.E.
Deposit date:2001-04-13
Release date:2002-07-17
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Structure of the globular tail of nuclear lamin.
J.Biol.Chem., 277, 2002
1M7W
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BU of 1m7w by Molmil
HNF4a ligand binding domain with bound fatty acid
Descriptor: Hepatocyte nuclear factor 4-alpha, LAURIC ACID
Authors:Dhe-Paganon, S, Duda, K, Iwamoto, M, Chi, Y.I, Shoelson, S.E.
Deposit date:2002-07-22
Release date:2003-07-01
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the HNF4 alpha ligand binding domain in complex with endogenous fatty acid ligand
J.Biol.Chem., 277, 2002
4WVL
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BU of 4wvl by Molmil
Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement
Descriptor: 1,2-ETHANEDIOL, GLYCEROL, Histone-lysine N-methyltransferase, ...
Authors:Xu, X, Dhe-Paganon, S, Blacklow, S.
Deposit date:2014-11-06
Release date:2014-12-03
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.41 Å)
Cite:Structure-Guided DOT1L Probe Optimization by Label-Free Ligand Displacement.
Acs Chem.Biol., 10, 2015
6DUN
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BU of 6dun by Molmil
Crystal Structure Analysis of PIN1
Descriptor: Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, TRIHYDROXYARSENITE(III)
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2018-06-21
Release date:2019-03-06
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Arsenic targets Pin1 and cooperates with retinoic acid to inhibit cancer-driving pathways and tumor-initiating cells.
Nat Commun, 9, 2018
8ECM
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BU of 8ecm by Molmil
Crystal Structure Analysis of Acetyl-CoA acetyltransferase from Firmicutes bacterium
Descriptor: Acetyl-CoA acetyltransferase
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-09-02
Release date:2023-05-31
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Gut microbial metabolism of 5-ASA diminishes its clinical efficacy in inflammatory bowel disease.
Nat Med, 29, 2023
8CUC
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BU of 8cuc by Molmil
Crystal structure analysis of SALL4 zinc finger domain in complex with DNA
Descriptor: DNA (5'-D(P*CP*GP*AP*AP*AP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(P*GP*CP*TP*AP*AP*TP*AP*TP*TP*TP*CP*G)-3'), Sal-like protein 4, ...
Authors:Seo, H.S, Dhe-Paganon, S.
Deposit date:2022-05-17
Release date:2023-05-24
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Crystal Structure Analysis of SALL4 Zinc Finger domain in complex with DNA
To Be Published
4PYZ
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BU of 4pyz by Molmil
Crystal structure of the first two Ubl domains of Deubiquitylase USP7
Descriptor: UNKNOWN ATOM OR ION, Ubiquitin carboxyl-terminal hydrolase 7
Authors:Walker, J.R, Dong, A, Ong, M.S, Dhe-Paganon, S, Kania, J, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
Deposit date:2014-03-28
Release date:2014-04-16
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.84 Å)
Cite:Crystal structure of the first two Ubl domains of Deubiquitylase USP7
to be published
8EBK
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BU of 8ebk by Molmil
Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
Descriptor: ACE-LEU-THR-PHE-0EH-GLU-TYR-TRP-ALA-GLN-LEU-MK8-SER-ALA-ALA, HDMX
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2022-08-31
Release date:2023-10-04
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Crystal Structure Analysis of xHDMX in complex with the stapled peptide PROTAC analog
To Be Published
5JWM
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BU of 5jwm by Molmil
Bivalent BET Bromodomain Inhibition
Descriptor: 2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]-~{N}-[2-[2-[2-[2-[2-[2-[2-[2-[2-[(9~{S})-7-(4-chlorophenyl)-4,5,13-trimethyl-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]ethanoylamino]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethyl]ethanamide, Bromodomain-containing protein 4
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2016-05-12
Release date:2016-07-06
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Design and characterization of bivalent BET inhibitors.
Nat.Chem.Biol., 12, 2016
5K5F
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BU of 5k5f by Molmil
NMR structure of the HLTF HIRAN domain
Descriptor: Helicase-like transcription factor
Authors:Bezsonova, I, Neculai, D, Korzhnev, D, Weigelt, J, Bountra, C, Edwards, A, Arrowsmith, C, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2016-05-23
Release date:2016-06-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure of the HLTF HIRAN domain
To Be Published
4WJL
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BU of 4wjl by Molmil
Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Inactive dipeptidyl peptidase 10, ...
Authors:Bezerra, G.A, Dobrovetsky, E, Seitova, A, Fedosyuk, S, Dhe-Paganon, S, Gruber, K.
Deposit date:2014-09-30
Release date:2015-03-18
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Structure of human dipeptidyl peptidase 10 (DPPY): a modulator of neuronal Kv4 channels.
Sci Rep, 5, 2015
5BNH
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BU of 5bnh by Molmil
Crystal structure of the HLTF HIRAN domain with a ssDNA fragment
Descriptor: ACETATE ION, DNA (5'-D(*(GD)P*GP*TP*G)-3'), DNA (5'-D(*(TD)P*TP*G)-3'), ...
Authors:Neculai, D, Walker, J.R, Weigelt, J, Bountra, C, Edwards, A.M, Arrowsmith, C.H, Dhe-Paganon, S.
Deposit date:2015-05-26
Release date:2016-05-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Co-crystal structure of the HLTF HIRAN domain with a ssDNA fragment
To Be Published
2Z5D
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BU of 2z5d by Molmil
Human ubiquitin-conjugating enzyme E2 H
Descriptor: SODIUM ION, Ubiquitin-conjugating enzyme E2 H
Authors:Bochkarev, A, Cui, H, Walker, J.R, Newman, E.M, Mackenzie, F, Battaile, K.P, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2007-07-06
Release date:2007-10-09
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
MOL.CELL PROTEOMICS, 11, 2012
6MBZ
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BU of 6mbz by Molmil
Structure of Transcription Factor
Descriptor: Signal transducer and activator of transcription 5B
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2018-08-30
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.21 Å)
Cite:Structural and functional consequences of the STAT5BN642Hdriver mutation.
Nat Commun, 10, 2019
6MBW
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BU of 6mbw by Molmil
Structure of Transcription Factor
Descriptor: Signal transducer and activator of transcription 5B
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2018-08-30
Release date:2019-06-19
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.29 Å)
Cite:Structural and functional consequences of the STAT5BN642H driver mutation.
Nat Commun, 10, 2019
6VQM
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BU of 6vqm by Molmil
Crystal Structure Analysis of human ACK1
Descriptor: 2-({4-[(3R,5S)-3,5-dimethylpiperazin-1-yl]-2-methoxyphenyl}amino)-9-methyl-5,7-dihydro-6H-pyrimido[5,4-d][1,3]benzodiazepin-6-one, Activated CDC42 kinase 1, SULFATE ION
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2020-02-05
Release date:2021-02-10
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.87 Å)
Cite:Crystal Structure Analysis of human ACK1
To Be Published
5WHH
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BU of 5whh by Molmil
Crystal Structure of Bcl-2-related protein A1 in complex with stapled peptide (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2)
Descriptor: (AQ7)T(0EH)LRRFGD(MK8)INFRQ(NH2), Bcl-2-related protein A1, CHLORIDE ION
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-07-17
Release date:2018-01-17
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.38 Å)
Cite:Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure, 26, 2018
7KMR
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BU of 7kmr by Molmil
Crystal structure analysis of human KRAS mutant
Descriptor: GUANOSINE-5'-DIPHOSPHATE, Isoform 2B of GTPase KRas
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2020-11-03
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Regulation of GTPase function by autophosphorylation.
Mol.Cell, 82, 2022
5WHI
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BU of 5whi by Molmil
Crystal Structure of Bcl-2-related protein A1
Descriptor: Bcl-2-related protein A1, CACODYLIC ACID
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2017-07-17
Release date:2018-01-17
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
Structure, 26, 2018
7LI5
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BU of 7li5 by Molmil
Crystal Structure Analysis of human TEAD1
Descriptor: 1-[(3R,4R)-3-[4-(pyridin-3-yl)-1H-1,2,3-triazol-1-yl]-4-{[4-(trifluoromethyl)phenyl]methoxy}pyrrolidin-1-yl]prop-2-en-1-one, SULFATE ION, Transcriptional enhancer factor TEF-1
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-01-26
Release date:2022-02-02
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Crystal Structure Analysis of human TEAD1
To Be Published
7MKX
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BU of 7mkx by Molmil
Crystal Structure Analysis of human CDK2 and CCNA2 complex
Descriptor: 2-[(5-bromo-2-{4-[(cyanomethyl)sulfamoyl]anilino}pyrimidin-4-yl)amino]-6-fluorobenzamide, Cyclin-A2, Cyclin-dependent kinase 2
Authors:Seo, H.-S, Dhe-Paganon, S.
Deposit date:2021-04-27
Release date:2022-11-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.08 Å)
Cite:Crystal Structure Analysis of human CDK2 and CCNA2 complex
To Be Published
1Y6L
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BU of 1y6l by Molmil
Human ubiquitin conjugating enzyme E2E2
Descriptor: Ubiquitin-conjugating enzyme E2E2
Authors:Walker, J.R, Avvakumov, G.V, Newman, E.M, Mackenzie, F, Kozieradzki, I, Bochkarev, A, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC)
Deposit date:2004-12-06
Release date:2005-01-11
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
Mol Cell Proteomics, 11, 2012

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