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4E94
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BU of 4e94 by Molmil
Crystal structure of MccF-like protein from Streptococcus pneumoniae
Descriptor: GLYCEROL, MccC family protein, SULFATE ION
Authors:Nocek, B, Tikhonov, A, Kwon, K, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2012-03-20
Release date:2012-05-09
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.651 Å)
Cite:Crystal structure of MccF-like protein from Streptococcus pneumoniae
TO BE PUBLISHED
6U48
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BU of 6u48 by Molmil
E. coli 50S with phazolicin (PHZ) bound in exit tunnel
Descriptor: 23S rRNA, 50S ribosomal protein bL17, 50S ribosomal protein bL19, ...
Authors:Watson, Z.L, Cate, J.H.D, Polikanov, Y.S, Severinov, K.
Deposit date:2019-08-23
Release date:2019-09-18
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.87 Å)
Cite:Structure of ribosome-bound azole-modified peptide phazolicin rationalizes its species-specific mode of bacterial translation inhibition.
Nat Commun, 10, 2019
4ZJN
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BU of 4zjn by Molmil
Crystal structure of the bacteriophage G20C portal protein
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, Portal protein
Authors:Williams, L.S, Turkenburg, J.P, Levdikov, V.M, Minakhin, L, Severinov, K, Antson, A.A.
Deposit date:2015-04-29
Release date:2015-05-27
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Crystal structure of the bacteriophage G20C portal protein
To be published
1YNN
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BU of 1ynn by Molmil
Taq RNA polymerase-rifampicin complex
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A, Pavlova, O, Zenkin, N, Leon, F, Irschik, H, Jansen, R, Severinov, K, Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
5W4K
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BU of 5w4k by Molmil
Crystal structure of the Thermus thermophilus 70S ribosome in complex with Klebsazolicin and bound to mRNA and A-, P- and E-site tRNAs at 2.7A resolution
Descriptor: 16S Ribosomal RNA, 23S Ribosomal RNA, 30S ribosomal protein S10, ...
Authors:Metelev, M, Osterman, I.A, Ghilarov, D, Khabibullina, N.F, Yakimov, A, Shabalin, K, Utkina, I, Travin, D.Y, Komarova, E.S, Serebryakova, M, Artamonova, T, Khodorkovskii, M, Konevega, A.L, Sergiev, P.V, Severinov, K, Polikanov, Y.S.
Deposit date:2017-06-12
Release date:2017-08-30
Last modified:2019-12-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel.
Nat. Chem. Biol., 13, 2017
5UI7
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BU of 5ui7 by Molmil
Solution NMR Structure of Lasso Peptide Klebsidin
Descriptor: Klebsidin
Authors:Bushin, L.B, Metelev, M, Severinov, K, Seyedsayamdost, M.R.
Deposit date:2017-01-13
Release date:2017-02-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.
ACS Chem. Biol., 12, 2017
5UI6
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BU of 5ui6 by Molmil
Solution NMR Structure of Lasso Peptide Acinetodin
Descriptor: Acinetodin
Authors:Bushin, L.B, Metelev, M, Severinov, K, Seyedsayamdost, M.R.
Deposit date:2017-01-12
Release date:2017-02-08
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Acinetodin and Klebsidin, RNA Polymerase Targeting Lasso Peptides Produced by Human Isolates of Acinetobacter gyllenbergii and Klebsiella pneumoniae.
ACS Chem. Biol., 12, 2017
1HQM
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BU of 1hqm by Molmil
CRYSTAL STRUCTURE OF THERMUS AQUATICUS CORE RNA POLYMERASE-INCLUDES COMPLETE STRUCTURE WITH SIDE-CHAINS (EXCEPT FOR DISORDERED REGIONS)-FURTHER REFINED FROM ORIGINAL DEPOSITION-CONTAINS ADDITIONAL SEQUENCE INFORMATION
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Minakhin, L, Bhagat, S, Brunning, A, Campbell, E.A, Darst, S.A, Ebright, R.H, Severinov, K.
Deposit date:2000-12-18
Release date:2001-02-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Bacterial RNA polymerase subunit omega and eukaryotic RNA polymerase subunit RPB6 are sequence, structural, and functional homologs and promote RNA polymerase assembly.
Proc.Natl.Acad.Sci.USA, 98, 2001
5XJ0
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BU of 5xj0 by Molmil
T. thermophilus RNA polymerase holoenzyme bound with gp39 and gp76
Descriptor: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
Authors:Ooi, W.Y, Murayama, Y, Mekler, V, Minakhin, L, Severinov, K, Yokoyama, S, Sekine, S.
Deposit date:2017-04-28
Release date:2017-12-20
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (4.004 Å)
Cite:A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation
Nucleic Acids Res., 46, 2018
4MI1
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BU of 4mi1 by Molmil
Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with aspartyl sulfamoyl adenylates
Descriptor: 5'-O-(L-alpha-aspartylsulfamoyl)adenosine, Microcin immunity protein MccF, SULFATE ION
Authors:Nocek, B, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-08-30
Release date:2014-04-23
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with aspartyl sulfamoyl adenylates
TO BE PUBLISHED
2MC5
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BU of 2mc5 by Molmil
A bacteriophage transcription regulator inhibits bacterial transcription initiation by -factor displacement
Descriptor: 45L
Authors:Liu, B, Shadrin, A, Sheppard, C, Xu, Y, Severinov, K, Matthews, S, Wigneshweraraj, S.
Deposit date:2013-08-14
Release date:2014-03-26
Last modified:2014-04-30
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MC6
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BU of 2mc6 by Molmil
A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement
Descriptor: DNA-directed RNA polymerase subunit beta', RNA polymerase inhibitor p7
Authors:Liu, B, Shadrin, A, Sheppard, C, Xu, Y, Severinov, K, Matthews, S, Wigneshweraraj, S.
Deposit date:2013-08-15
Release date:2014-04-02
Last modified:2014-05-07
Method:SOLUTION NMR
Cite:A bacteriophage transcription regulator inhibits bacterial transcription initiation by sigma-factor displacement.
Nucleic Acids Res., 42, 2014
2MW3
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BU of 2mw3 by Molmil
Solution NMR structure of the lasso peptide streptomonomicin
Descriptor: Lasso peptide
Authors:Tietz, J.I, Zhu, L, Mitchell, D.A, Metelev, M, Melby, J.O, Blair, P.M, Livnat, I, Severinov, K.
Deposit date:2014-10-24
Release date:2015-01-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure, bioactivity, and resistance mechanism of streptomonomicin, an unusual lasso Peptide from an understudied halophilic actinomycete.
Chem.Biol., 22, 2015
1YNJ
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BU of 1ynj by Molmil
Taq RNA polymerase-Sorangicin complex
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Campbell, E.A, Pavlova, O, Zenkin, N, Leon, F, Irschik, H, Jansen, R, Severinov, K, Darst, S.A.
Deposit date:2005-01-24
Release date:2005-03-15
Last modified:2024-02-14
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structural, functional, and genetic analysis of sorangicin inhibition of bacterial RNA polymerase
Embo J., 24, 2005
2A6H
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BU of 2a6h by Molmil
Crystal structure of the T. thermophilus RNA polymerase holoenzyme in complex with antibiotic sterptolydigin
Descriptor: DNA-directed RNA polymerase alpha chain, DNA-directed RNA polymerase beta chain, DNA-directed RNA polymerase beta' chain, ...
Authors:Temiakov, D, Zenkin, N, Vassylyeva, M.N, Perederina, A, Tahirov, T.H, Savkina, M, Zorov, S, Nikiforov, V, Igarashi, N, Matsugaki, N, Wakatsuki, S, Severinov, K, Vassylyev, D.G, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:2005-07-02
Release date:2005-09-20
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural basis of transcription inhibition by antibiotic streptolydigin.
Mol.Cell, 19, 2005
5F5X
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BU of 5f5x by Molmil
Crystal structure of S116A Ba3275 with AMP bound
Descriptor: ADENOSINE MONOPHOSPHATE, MccC family protein Ba3275
Authors:Nocek, B, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-04
Release date:2015-12-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.006 Å)
Cite:Crystal structure of Ba3275-AMP complex from Bacillus cereus ATCC 10987
To Be Published
5F9M
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BU of 5f9m by Molmil
Crystal structure of native B3275, member of MccF family of enzymes
Descriptor: MccC family protein
Authors:Nocek, B, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-09
Release date:2015-12-30
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.402 Å)
Cite:Crystal structure of native B3275, member of MccF family of enzymes.
To Be Published
5FCD
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BU of 5fcd by Molmil
Crystal structure of MccD protein
Descriptor: CHLORIDE ION, MccD, UNK-UNK-UNK-MSE-UNK, ...
Authors:Nocek, B, Jedrzejczak, R, Anderson, W.F, Severinov, K, Dubiley, S, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-15
Release date:2015-12-30
Last modified:2017-02-08
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of MccD protein.
To Be Published
5FD8
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BU of 5fd8 by Molmil
Crystal Structure of MccF-like Protein (BA_5613) in complex with ASA (alanyl sulfamoyl adenylates)
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, LD-carboxypeptidase family protein
Authors:Nocek, B, Severinov, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2015-12-15
Release date:2015-12-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystal Structure of MccF-like Protein (BA_5613) in complex with ASA ( (alanyl sulfamoyl adenylates)
To Be Published
4INJ
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BU of 4inj by Molmil
Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product
Descriptor: DI(HYDROXYETHYL)ETHER, GLYCEROL, Lmo1638 protein, ...
Authors:Nocek, B, Tikhonov, A, Severinov, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-01-04
Release date:2013-02-20
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of the S111A mutant of member of MccF clade from Listeria monocytogenes EGD-e with product
To be Published
4JVO
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BU of 4jvo by Molmil
Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with alanyl sulfamoyl adenylates
Descriptor: '5'-O-(N-(L-ALANYL)-SULFAMOYL)ADENOSINE, GLYCEROL, Microcin immunity protein MccF
Authors:Nocek, B, Tikhonov, A, Severinov, K, Anderson, W.F, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2013-03-25
Release date:2013-06-12
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the double mutant (S112A, H303A) of B.anthracis mycrocine immunity protein (MccF) with alanyl sulfamoyl adenylates
TO BE PUBLISHED
5K99
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BU of 5k99 by Molmil
Crystal structure of microcin immunity protein MccF from Bacillus anthracis in complex with McC
Descriptor: Microcin C, Microcin C7 self-immunity protein mccF
Authors:Nocek, B, Kulikovsky, A, Severinov, K, Dubiley, S, Joachimiak, A, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID)
Deposit date:2016-05-31
Release date:2017-03-22
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of microcin immunity protein MccF from Bacillus anthracis in complex with McC
To Be Published
5NJB
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BU of 5njb by Molmil
E. coli Microcin-processing metalloprotease TldD/E with actinonin bound
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ACTINONIN, ...
Authors:Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJF
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BU of 5njf by Molmil
E. coli Microcin-processing metalloprotease TldD/E (TldD H262A mutant) with pentapeptide bound
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ALA-ALA-ALA-ALA-ALA, ...
Authors:Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017
5NJC
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BU of 5njc by Molmil
E. coli Microcin-processing metalloprotease TldD/E (TldD E263A mutant) with hexapeptide bound
Descriptor: 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Metalloprotease PmbA, ...
Authors:Ghilarov, D, Serebryakova, M, Stevenson, C.E.M, Hearnshaw, S.J, Volkov, D, Maxwell, A, Lawson, D.M, Severinov, K.
Deposit date:2017-03-28
Release date:2017-10-04
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:The Origins of Specificity in the Microcin-Processing Protease TldD/E.
Structure, 25, 2017

 

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