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6V2J
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BU of 6v2j by Molmil
Crystal structure of ClC-ec1 triple mutant (E113Q, E148Q, E203Q)
Descriptor: CHLORIDE ION, H(+)/Cl(-) exchange transporter ClcA
Authors:Maduke, M, Mathews, I.I, Chavan, T.S.
Deposit date:2019-11-24
Release date:2020-05-20
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.62 Å)
Cite:A CLC-ec1 mutant reveals global conformational change and suggests a unifying mechanism for the CLC Cl - /H + transport cycle.
Elife, 9, 2020
8TA2
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BU of 8ta2 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with bound inhibitor AK-42
Descriptor: 2-[[2,6-bis(chloranyl)-3-phenylmethoxy-phenyl]amino]pyridine-3-carboxylic acid, CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA3
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BU of 8ta3 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain Apo state with resolved N-terminal hairpin
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.46 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA4
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BU of 8ta4 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with symmetric C-terminal
Descriptor: CHLORIDE ION, Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA5
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BU of 8ta5 by Molmil
Title: Cryo-EM structure of the human CLC-2 chloride channel transmembrane domain with asymmetric C-terminal
Descriptor: Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-03-20
Method:ELECTRON MICROSCOPY (2.76 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
8TA6
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BU of 8ta6 by Molmil
Cryo-EM structure of the human CLC-2 chloride channel C-terminal domain
Descriptor: Chloride channel protein 2
Authors:Xu, M, Neelands, T, Powers, A.S, Liu, Y, Miller, S, Pintilie, G, Du Bois, J, Dror, R.O, Chiu, W, Maduke, M.
Deposit date:2023-06-26
Release date:2024-01-31
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (4.03 Å)
Cite:CryoEM structures of the human CLC-2 voltage-gated chloride channel reveal a ball-and-chain gating mechanism.
Elife, 12, 2024
5HD8
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BU of 5hd8 by Molmil
Crystal structure of disulfide cross-linked D417C ClC-ec1
Descriptor: CHLORIDE ION, FAB FRAGMENT (HEAVY CHAIN), FAB FRAGMENT (LIGHT CHAIN), ...
Authors:Mathews, I.I, Khantwal, C.M, Maduke, M.
Deposit date:2016-01-05
Release date:2017-01-18
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (3.15 Å)
Cite:Conformational change in CLC transporters: beyond the rotation of Gluex
To be published

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PDB entries from 2024-03-27

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