Author results

6XKL
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SARS-COV-2 HEXAPRO S ONE RBD UP
Descriptor:Spike glycoprotein, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Wrapp, D., Hsieh, C.-L., Goldsmith, J.A., McLellan, J.S.
Deposit date:2020-06-26
Release date:2020-07-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structure-based Design of Prefusion-stabilized SARS-CoV-2 Spikes.
Biorxiv, 2020
6XE6
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STRUCTURE OF HUMAN DISPATCHED-1 (DISP1)
Descriptor:Protein dispatched homolog 1, CHOLESTEROL HEMISUCCINATE, 2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Chen, H., Liu, Y., Li, X.
Deposit date:2020-06-12
Release date:2020-07-08
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (4.54 Å)
Cite:Structure of Human Dispatched-1 (DISP1)
To Be Published
7BZ5
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STRUCTURE OF COVID-19 VIRUS SPIKE RECEPTOR-BINDING DOMAIN COMPLEXED WITH A NEUTRALIZING ANTIBODY
Descriptor:Spike protein S1, Heavy chain of B38, Light chain of B38, ...
Authors:Wu, Y., Qi, J., Gao, F.
Deposit date:2020-04-26
Release date:2020-05-13
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:A noncompeting pair of human neutralizing antibodies block COVID-19 virus binding to its receptor ACE2.
Science, 368, 2020
7BWN
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CRYSTAL STRUCTURE OF A DESIGNED PROTEIN HETEROCATENANE
Descriptor:Chimera of Green fluorescent protein and p53dim, Cellular tumor antigen p53
Authors:Liu, Y.J., Duan, Z.L., Fang, J., Zhang, F., Xiao, J.Y., Zhang, W.B.
Deposit date:2020-04-15
Release date:2020-06-17
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.396 Å)
Cite:Cellular Synthesis and X-ray Crystal Structure of a Designed Protein Heterocatenane.
Angew.Chem.Int.Ed.Engl., 2020
7BTC
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CRYSTAL STRUCTURE OF RHEB Y35N MUTANT BOUND TO GDP
Descriptor:GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE
Authors:Zhang, C., Zhang, T., Ding, J.
Deposit date:2020-04-01
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
7BTD
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CRYSTAL STRUCTURE OF RHEB Y35N MUTANT BOUND TO GPPNHP
Descriptor:GTP-binding protein Rheb, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER
Authors:Zhang, C., Zhang, T., Ding, J.
Deposit date:2020-04-01
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2 Å)
Cite:Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
7BTA
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CRYSTAL STRUCTURE OF RHEB D60K MUTANT BOUND TO GDP
Descriptor:GTP-binding protein Rheb, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION
Authors:Zhang, C., Zhang, T., Ding, J.
Deposit date:2020-03-31
Release date:2020-06-17
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Molecular basis for the functions of dominantly active Y35N and inactive D60K Rheb mutants in mTORC1 signaling.
J Mol Cell Biol, 2020
6W1G
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE FROM PSEUDOMONAS PUTIDA
Descriptor:Hydroxyglutarate synthase, NICKEL (II) ION
Authors:Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
Deposit date:2020-03-04
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.14 Å)
Cite:An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6W1H
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE IN COMPLEX WITH 2-OXOADIPATE FROM PSEUDOMONAS PUTIDA
Descriptor:Hydroxyglutarate synthase, NICKEL (II) ION, 2-OXOADIPIC ACID
Authors:Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
Deposit date:2020-03-04
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6W1K
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CRYSTAL STRUCTURE OF THE HYDROXYGLUTARATE SYNTHASE IN COMPLEX WITH 2-OXOADIPATE FROM ORYZA SATIVA
Descriptor:Hydroxyglutarate synthase, NICKEL (II) ION, 2-OXOADIPIC ACID, ...
Authors:Pereira, J.H., Thompson, M.G., Blake-Hedges, J.M., Keasling, J.D., Adams, P.D.
Deposit date:2020-03-04
Release date:2020-06-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:An iron (II) dependent oxygenase performs the last missing step of plant lysine catabolism.
Nat Commun, 11, 2020
6XZ8
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STRUCTURE OF ALDOSTERONE SYNTHASE (CYP11B2) IN COMPLEX WITH N-[(1R)-1-[5-(6-CHLORO-1,1-DIMETHYL-3-OXO-ISOINDOLIN-2-YL)-3-PYRIDYL]ETHYL]METHANESULFONAMIDE
Descriptor:Cytochrome P450 11B2, mitochondrial, HEME C, ...
Authors:Kuglstatter, A., Joseph, C., Benz, J.
Deposit date:2020-02-03
Release date:2020-06-24
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J.Med.Chem., 63, 2020
6XZ9
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STRUCTURE OF ALDOSTERONE SYNTHASE (CYP11B2) IN COMPLEX WITH 5-CHLORO-3,3-DIMETHYL-2-[5-[1-(1-METHYLPYRAZOLE-4-CARBONYL)AZETIDIN-3-YL]OXY-3-PYRIDYL]ISOINDOLIN-1-ONE
Descriptor:Cytochrome P450 11B2, mitochondrial, HEME C, ...
Authors:Kuglstatter, A., Joseph, C., Benz, J.
Deposit date:2020-02-03
Release date:2020-06-24
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:Discovery of 3-Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors.
J.Med.Chem., 63, 2020
6LON
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CRYSTAL STRUCTURE OF HPSG
Descriptor:PFL2/glycerol dehydratase family glycyl radical enzyme, (2~{S})-2,3-bis(oxidanyl)propane-1-sulfonic acid, GLYCEROL, ...
Authors:Liu, J., Zhang, Y., Yuchi, Z.
Deposit date:2020-01-06
Release date:2020-06-24
Last modified:2020-07-22
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Two radical-dependent mechanisms for anaerobic degradation of the globally abundant organosulfur compound dihydroxypropanesulfonate.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VBN
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CRYSTAL STRUCTURE OF HTDO2 BOUND TO INHIBITOR GNE1
Descriptor:Tryptophan 2,3-dioxygenase, PROTOPORPHYRIN IX CONTAINING FE, 1,5-anhydro-2,3-dideoxy-3-[(5S)-5H-imidazo[5,1-a]isoindol-5-yl]-D-threo-pentitol
Authors:Harris, S.F., Oh, A.
Deposit date:2019-12-19
Release date:2020-05-06
Method:X-RAY DIFFRACTION (3.18 Å)
Cite:Implementation of the CYP Index for the Design of Selective Tryptophan-2,3-dioxygenase Inhibitors.
Acs Med.Chem.Lett., 11, 2020
6V8W
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CDYL2 CHROMODOMAIN IN COMPLEX WITH A SYNTHETIC PEPTIDE
Descriptor:Chromodomain Y-like protein 2, IVA-PHE-ALA-PHE-5T3-SER-NH2, UNKNOWN ATOM OR ION
Authors:Dong, C., Tempel, W., James, L.I., Lamb, K.N., Bountra, C., Edwards, A.M., Arrowsmith, C.H., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-12-12
Release date:2020-01-15
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V41
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CRYSTAL STRUCTURE OF CDY1 CHROMODOMAIN BOUND TO H3K9ME3
Descriptor:Testis-specific chromodomain protein Y 1, Histone H3.1 Peptide, UNKNOWN ATOM OR ION
Authors:Qin, S., Tempel, W., Walker, J.R., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-27
Release date:2019-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.603 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V3N
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CRYSTAL STRUCTURE OF CDYL2 IN COMPLEX WITH H3K27ME3
Descriptor:Chromodomain Y-like protein 2, ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, UNKNOWN ATOM OR ION
Authors:Qin, S., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-11-26
Release date:2020-04-01
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2R
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CBX7 MUTANT V13A IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:Chromobox protein homolog 7, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Walker, J.R., Stuckey, J.I., Dickson, B.M., James, L.I., Frye, S.V., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2S
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF MPP8 IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:M-phase phosphoprotein 8, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-11-25
Release date:2019-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2D
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CRYSTAL STRUCTURE OF CHROMODOMAIN OF CDYL2 IN COMPLEX WITH INHIBITOR UNC3866
Descriptor:Chromodomain Y-like protein 2, UNC3866, UNKNOWN ATOM OR ION
Authors:Liu, Y., Tempel, W., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6V2H
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CRYSTAL STRUCTURE OF CDYL2 IN COMPLEX WITH H3TK27ME3
Descriptor:Chromodomain Y-like protein 2, H3tK27me3, NICKEL (II) ION, ...
Authors:Dong, C., Tempel, W., Walker, J.R., Bountra, C., Arrowsmith, C.H., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-11-22
Release date:2019-12-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
6L8U
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CRYSTAL STRUCTURE OF HUMAN BCDIN3D IN COMPLEX WITH SAH
Descriptor:RNA 5'-monophosphate methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Liu, Y., Martinez, A., Yamashita, S., Tomita, K.
Deposit date:2019-11-07
Release date:2019-12-25
Last modified:2020-03-25
Method:X-RAY DIFFRACTION (2.925 Å)
Cite:Crystal structure of human cytoplasmic tRNAHis-specific 5'-monomethylphosphate capping enzyme.
Nucleic Acids Res., 48, 2020
6L8K
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STRUCTURE OF URT1 IN COMPLEX WITH UTP
Descriptor:UTP:RNA uridylyltransferase 1, URIDINE 5'-TRIPHOSPHATE
Authors:Lingru, Z.
Deposit date:2019-11-06
Release date:2020-01-29
Last modified:2020-04-01
Method:X-RAY DIFFRACTION (2.999 Å)
Cite:Crystal structure of Arabidopsis terminal uridylyl transferase URT1.
Biochem.Biophys.Res.Commun., 524, 2020
6UPK
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STRUCTURE OF FACT_SUBNUCLEOSOME COMPLEX 1
Descriptor:Histone H3.1, Histone H4, Histone H2A, ...
Authors:Zhou, K., Tan, Y.Z., Wei, H., Liu, Y., Carragher, B., Potter, C., Luger, K.
Deposit date:2019-10-17
Release date:2019-12-11
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
6UPL
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STRUCTURE OF FACT_SUBNUCLEOSOME COMPLEX 2
Descriptor:Histone H3.1, Histone H4, Histone H2A, ...
Authors:Zhou, K., Tan, Y.Z., Wei, H., Liu, Y., Carragher, B., Potter, C., Luger, K.
Deposit date:2019-10-17
Release date:2019-12-11
Last modified:2020-01-29
Method:ELECTRON MICROSCOPY (7.4 Å)
Cite:FACT caught in the act of manipulating the nucleosome.
Nature, 577, 2020
167327
數據於2020-08-05公開中