Author results

1F3M
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CRYSTAL STRUCTURE OF HUMAN SERINE/THREONINE KINASE PAK1
Descriptor:SERINE/THREONINE-PROTEIN KINASE PAK-ALPHA, IODIDE ION
Authors:Lei, M., Lu, W., Meng, W., Parrini, M.-C., Eck, M.J., Mayer, B.J., Harrison, S.C.
Deposit date:2000-06-05
Release date:2000-06-29
Last modified:2017-02-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch.
Cell(Cambridge,Mass.), 102, 2000
1QZG
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
Descriptor:telomeric single-stranded DNA, Protection of telomeres protein 1, THYMIDINE-5'-PHOSPHATE
Authors:Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1QZH
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CRYSTAL STRUCTURE OF POT1 (PROTECTION OF TELOMERE)- SSDNA COMPLEX
Descriptor:telomeric single-stranded DNA, Protection of telomeres protein 1
Authors:Lei, M., Podell, E.R., Baumann, P., Cech, T.R.
Deposit date:2003-09-16
Release date:2003-11-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA
Nature, 426, 2003
1XJV
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CRYSTAL STRUCTURE OF HUMAN POT1 BOUND TO TELOMERIC SINGLE-STRANDED DNA (TTAGGGTTAG)
Descriptor:hT10 d(TTAGGGTTAG), Protection of telomeres 1
Authors:Lei, M., Podell, E.R., Cech, T.R.
Deposit date:2004-09-25
Release date:2004-12-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection
Nat.Struct.Mol.Biol., 11, 2004
1YHV
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH TWO POINT MUTATIONS (K299R, T423E)
Descriptor:Serine/threonine-protein kinase PAK 1
Authors:Lei, M., Robinson, M.A., Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
1YHW
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CRYSTAL STRUCTURE OF PAK1 KINASE DOMAIN WITH ONE POINT MUTATIONS (K299R)
Descriptor:Serine/threonine-protein kinase PAK 1
Authors:Lei, M., Robinson, M.A., Harrison, S.C.
Deposit date:2005-01-10
Release date:2005-05-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The Active Conformation of the PAK1 Kinase Domain
Structure, 13, 2005
6OGJ
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), DNA (5'-D(*GP*CP*CP*TP*AP*CP*AP*CP*TP*CP*CP*G)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6OGK
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MECP2 MBD IN COMPLEX WITH DNA
Descriptor:Methyl-CpG-binding protein 2, DNA (5'-D(*GP*CP*CP*TP*AP*(5CM)P*AP*CP*TP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*AP*GP*TP*GP*TP*AP*GP*GP*C)-3'), ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium, Structural Genomics Consortium (SGC)
Deposit date:2019-04-02
Release date:2019-05-01
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:MeCP2 MBD in complex with DNA
To Be Published
6C1T
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MBD2 IN COMPLEX WITH A PARTIALLY METHYLATED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, SULFATE ION, ...
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1U
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MBD2 IN COMPLEX WITH A DEOXY-OLIGONUCLEOTIDE
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
6C1V
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MBD2 IN COMPLEX WITH DOUBLE-STRANDED DNA
Descriptor:Methyl-CpG-binding domain protein 2, 12-mer DNA, UNKNOWN ATOM OR ION
Authors:Lei, M., Tempel, W., Arrowsmith, C.H., Bountra, C., Edwards, A.M., Min, J., Structural Genomics Consortium (SGC)
Deposit date:2018-01-05
Release date:2018-02-14
Last modified:2018-05-23
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural basis for the ability of MBD domains to bind methyl-CG and TG sites in DNA.
J. Biol. Chem., 293, 2018
3BQO
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CRYSTAL STRUCTURE OF TRF1 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 1, TERF1-interacting nuclear factor 2
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2007-12-20
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BU8
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND TIN2 PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 2, TERF1-interacting nuclear factor 2
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2008-01-02
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3BUA
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CRYSTAL STRUCTURE OF TRF2 TRFH DOMAIN AND APOLLO PEPTIDE COMPLEX
Descriptor:Telomeric repeat-binding factor 2, DNA cross-link repair 1B protein
Authors:Chen, Y., Yang, Y., van Overbeek, M., Donigian, J.R., Baciu, P., de Lange, T., Lei, M.
Deposit date:2008-01-02
Release date:2008-02-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A shared docking motif in TRF1 and TRF2 used for differential recruitment of telomeric proteins.
Science, 319, 2008
3CRT
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
Deposit date:2008-04-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
3CRU
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STRUCTURAL CHARACTERIZATION OF AN ENGINEERED ALLOSTERIC PROTEIN
Descriptor:Glutathione S-transferase class-mu 26 kDa isozyme, GLUTATHIONE
Authors:Sagermann, M., Chapleau, R., DeLorimier, E., Lei, M.
Deposit date:2008-04-07
Release date:2009-02-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Using affinity chromatography to engineer and characterize pH-dependent protein switches.
Protein Sci., 18, 2009
6AGB
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CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P
Descriptor:Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ...
Authors:Lan, P., Tan, M., Wu, J., Lei, M.
Deposit date:2018-08-10
Release date:2018-10-17
Last modified:2019-02-20
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AH3
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CRYO-EM STRUCTURE OF YEAST RIBONUCLEASE P WITH PRE-TRNA SUBSTRATE
Descriptor:Ribonuclease P RNA, Ribonucleases P/MRP protein subunit POP1, Ribonucleases P/MRP protein subunit POP3, ...
Authors:Lan, P., Tan, M., Wu, J., Lei, M.
Deposit date:2018-08-16
Release date:2018-10-17
Last modified:2018-12-26
Method:ELECTRON MICROSCOPY (3.48 Å)
Cite:Structural insight into precursor tRNA processing by yeast ribonuclease P.
Science, 362, 2018
6AHR
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P
Descriptor:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHU
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CRYO-EM STRUCTURE OF HUMAN RIBONUCLEASE P WITH MATURE TRNA
Descriptor:H1 RNA, Ribonucleases P/MRP protein subunit POP1, Ribonuclease P protein subunit p38, ...
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
6AHV
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CRYSTAL STRUCTURE OF HUMAN RPP40
Descriptor:Ribonuclease P protein subunit p40
Authors:Wu, J., Niu, S., Tan, M., Lan, P., Lei, M.
Deposit date:2018-08-20
Release date:2018-12-05
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Cryo-EM Structure of the Human Ribonuclease P Holoenzyme.
Cell, 175, 2018
5H65
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CRYSTAL STRUCTURE OF HUMAN POT1 AND TPP1
Descriptor:Protection of telomeres protein 1, Adrenocortical dysplasia protein homolog, ZINC ION
Authors:Chen, C., Wu, J., Lei, M.
Deposit date:2016-11-10
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural insights into POT1-TPP1 interaction and POT1 C-terminal mutations in human cancer.
Nat Commun, 8, 2017
5XXE
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CRYSTAL STRUCTURE OF POZ1 AND TPZ1
Descriptor:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, SULFATE ION, ...
Authors:Xue, J., Chen, H., Wu, J., Lei, M.
Deposit date:2017-07-03
Release date:2017-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
5XXF
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CRYSTAL STRUCTURE OF POZ1, TPZ1 AND RAP1
Descriptor:Protection of telomeres protein poz1, Protection of telomeres protein tpz1, Rap1, ...
Authors:Xue, J., Chen, H., Wu, J., Lei, M.
Deposit date:2017-07-03
Release date:2017-12-20
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the fission yeast S. pombe telomeric Tpz1-Poz1-Rap1 complex.
Cell Res., 27, 2017
6K0A
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CRYO-EM STRUCTURE OF AN ARCHAEAL RIBONUCLEASE P
Descriptor:Ribonuclease P protein component 2, Ribonuclease P protein component 3, Ribonuclease P protein component 1, ...
Authors:Wan, F., Lan, P., Wu, J., Lei, M.
Deposit date:2019-05-05
Release date:2019-06-19
Last modified:2019-07-03
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019