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9PAI
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BU of 9pai by Molmil
CLEAVED SUBSTRATE VARIANT OF PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor: PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 19-364, PROTEIN (PLASMINOGEN ACTIVATOR INHIBITOR-1) residues 365-397
Authors:Aertgeerts, K, De Bondt, H.L, De Ranter, C.J, Declerck, P.J.
Deposit date:1999-03-11
Release date:1999-03-19
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Mechanisms contributing to the conformational and functional flexibility of plasminogen activator inhibitor-1.
Nat.Struct.Biol., 2, 1995
3EOX
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BU of 3eox by Molmil
High quality structure of cleaved PAI-1-stab
Descriptor: Plasminogen activator inhibitor 1
Authors:Dewilde, M, Declerck, P.J, Rabijns, A, Strelkov, S.V.
Deposit date:2008-09-29
Release date:2009-02-17
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.61 Å)
Cite:High quality structure of cleaved PAI-1-stab.
J.Struct.Biol., 165, 2009
3LW2
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BU of 3lw2 by Molmil
Mouse Plasminogen Activator Inhibitor-1 (PAI-1)
Descriptor: Plasminogen activator inhibitor 1
Authors:Dewilde, M, Van De Craen, B, Compernolle, G, Madsen, J.B, Strelkov, S.V, Gils, A, Declerck, P.J.
Deposit date:2010-02-23
Release date:2010-04-07
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Subtle structural differences between human and mouse PAI-1 reveal the basis for biochemical differences.
J.Struct.Biol., 171, 2010
6GWQ
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BU of 6gwq by Molmil
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with an Inhibitory Nanobody (VHH-2g-42)
Descriptor: Plasminogen Activator Inhibitor-1, VHH-2g-42
Authors:Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWP
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BU of 6gwp by Molmil
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Descriptor: Plasminogen Activator Inhibitor-1, VHH-2g-42, VHH-2w-64
Authors:Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.28 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6GWN
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BU of 6gwn by Molmil
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with Two Inhibitory Nanobodies (VHH-2g-42, VHH-2w-64)
Descriptor: Plasminogen activator inhibitor 1, VHH-2g-42, VHH-2w-64
Authors:Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2018-06-25
Release date:2020-01-01
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Molecular mechanism of two nanobodies that inhibit PAI-1 activity reveals a modulation at distinct stages of the PAI-1/plasminogen activator interaction.
J.Thromb.Haemost., 18, 2020
6ZRV
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BU of 6zrv by Molmil
Crystal Structure of Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F) in Complex with an Inhibitory Nanobody (VHH-s-a93, Nb93)
Descriptor: Plasminogen activator inhibitor 1, VHH-s-a93 (Nb93)
Authors:Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2020-07-15
Release date:2020-08-26
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural Insights into the Mechanism of a Nanobody That Stabilizes PAI-1 and Modulates Its Activity.
Int J Mol Sci, 21, 2020
7AQF
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BU of 7aqf by Molmil
Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-stab)
Descriptor: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1
Authors:Sillen, M, Strelkov, S.V, Declerck, P.J.
Deposit date:2020-10-21
Release date:2021-02-17
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.77 Å)
Cite:Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22, 2021
7AQG
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BU of 7aqg by Molmil
Crystal Structure of Small Molecule Inhibitor TM5484 Bound to Stabilized Active Plasminogen Activator Inhibitor-1 (PAI-1-W175F)
Descriptor: 5-Chloro-2-[[2-[3-(furan-3-yl)anilino]-2-oxoacetyl]amino]benzoic acid, Plasminogen activator inhibitor 1, VHH-2g-42 (Nb42), ...
Authors:Sillen, M, Strelkov, S.V, Declerck, P.J.
Deposit date:2020-10-21
Release date:2021-02-24
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Structural Insight into the Two-Step Mechanism of PAI-1 Inhibition by Small Molecule TM5484.
Int J Mol Sci, 22, 2021
7AQL
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BU of 7aql by Molmil
Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7)
Descriptor: SULFATE ION, scFv-33H1F7
Authors:Sillen, M, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2020-10-22
Release date:2021-11-03
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal Structure of an Anti-Plasminogen Activator Inhibitor-1 (PAI-1) scFv antibody fragment (scFv-33H1F7)
To Be Published
5LHR
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BU of 5lhr by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the active site binding inhibitory nanobody Nb22
Descriptor: Camelid-Derived Antibody Fragment Nb22, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHP
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BU of 5lhp by Molmil
The p-aminobenzamidine active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment, P-AMINO BENZAMIDINE, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.63 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHQ
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BU of 5lhq by Molmil
The EGR-cmk active site inhibited catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, L-alpha-glutamyl-N-{(1S)-4-{[amino(iminio)methyl]amino}-1-[(1S)-2-chloro-1-hydroxyethyl]butyl}glycinamide, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5LHS
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BU of 5lhs by Molmil
The ligand free catalytic domain of murine urokinase-type plasminogen activator
Descriptor: NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.047 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5HVF
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BU of 5hvf by Molmil
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-i83)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Carboxypeptidase B2, ...
Authors:Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVH
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BU of 5hvh by Molmil
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with two Inhibitory Nanobodies
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Carboxypeptidase B2, ...
Authors:Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
5HVG
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BU of 5hvg by Molmil
Crystal Structure of Thrombin-activatable Fibrinolysis Inhibitor in Complex with an Inhibitory Nanobody (VHH-a204)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, ...
Authors:Zhou, X, Weeks, S.D, Strelkov, S.V, Declerck, P.J.
Deposit date:2016-01-28
Release date:2016-06-22
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (3.05 Å)
Cite:Elucidation of the molecular mechanisms of two nanobodies that inhibit thrombin-activatable fibrinolysis inhibitor activation and activated thrombin-activatable fibrinolysis inhibitor activity.
J.Thromb.Haemost., 14, 2016
1DB2
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BU of 1db2 by Molmil
CRYSTAL STRUCTURE OF NATIVE PLASMINOGEN ACTIVATOR INHIBITOR-1
Descriptor: PLASMINOGEN ACTIVATOR INHIBITOR-1
Authors:Nar, H, Bauer, M, Stassen, J.M, Lang, D, Gils, A, Declerck, P.
Deposit date:1999-11-02
Release date:1999-11-10
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Plasminogen activator inhibitor 1. Structure of the native serpin, comparison to its other conformers and implications for serpin inactivation.
J.Mol.Biol., 297, 2000
5LHN
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BU of 5lhn by Molmil
The catalytic domain of murine urokinase-type plasminogen activator in complex with the allosteric inhibitory nanobody Nb7
Descriptor: 1,2-ETHANEDIOL, Camelid-Derived Antibody Fragment Nb7, SULFATE ION, ...
Authors:Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P, Andreasen, P.A.
Deposit date:2016-07-12
Release date:2017-06-28
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator.
Sci Rep, 7, 2017
5HGG
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BU of 5hgg by Molmil
Crystal structure of uPA in complex with a camelid-derived antibody fragment
Descriptor: (3S)-3-[(2S,3S,4R)-3,4-DIMETHYLTETRAHYDROFURAN-2-YL]BUTYL LAURATE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Camelid Derived Antibody Fragment, ...
Authors:Yung, K.W.Y, Kromann-Hansen, T, Andreasen, P.A, Ngo, J.C.K.
Deposit date:2016-01-08
Release date:2016-06-01
Last modified:2016-08-10
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior
J.Biol.Chem., 291, 2016
5HDO
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BU of 5hdo by Molmil
Crystal structure of a nanobody raised against urokinase-type plasminogen activator
Descriptor: Anti-HCV NS3/4A serine protease immoglobulin heavy chain, CHLORIDE ION, SULFATE ION
Authors:Kromann-Hansen, T.
Deposit date:2016-01-05
Release date:2016-06-01
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:A Camelid-derived Antibody Fragment Targeting the Active Site of a Serine Protease Balances between Inhibitor and Substrate Behavior.
J.Biol.Chem., 291, 2016

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