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4RS1
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BU of 4rs1 by Molmil
Crystal structure of receptor-cytokine complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Broughton, S.E, Parker, M.W, Dhagat, U.
Deposit date:2014-11-06
Release date:2015-11-11
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.68 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
5UWC
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BU of 5uwc by Molmil
Cytokine-receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CITRIC ACID, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2017-02-21
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
5UV8
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BU of 5uv8 by Molmil
Interleukin-3 Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Interleukin-3, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2017-02-19
Release date:2018-02-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:A dual role for the N-terminal domain of the IL-3 receptor in cell signalling.
Nat Commun, 9, 2018
4GG6
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BU of 4gg6 by Molmil
Protein complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, HLA class II histocompatibility antigen, DQ alpha 1 chain, ...
Authors:Broughton, S.E, Theodossis, A, Petersen, J, Reid, H.H, Rossjohn, J.
Deposit date:2012-08-06
Release date:2012-10-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.
Immunity, 37, 2012
4GG8
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BU of 4gg8 by Molmil
Immune Receptor
Descriptor: T-CELL RECEPTOR, SP3.4 ALPHA CHAIN, SP3.4 BETA CHAIN, ...
Authors:Broughton, S.E, Theodossis, A, Petersen, J, Reid, H.H, Rossjohn, J.
Deposit date:2012-08-06
Release date:2012-10-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Biased T cell receptor usage directed against human leukocyte antigen DQ8-restricted gliadin peptides is associated with celiac disease.
Immunity, 37, 2012
4JZJ
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BU of 4jzj by Molmil
Crystal Structure of Receptor-Fab Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy Chain, Fab Light Chain, ...
Authors:Broughton, S.E, Parker, M.W.
Deposit date:2013-04-03
Release date:2014-04-09
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.801 Å)
Cite:Dual mechanism of interleukin-3 receptor blockade by an anti-cancer antibody
Cell Rep, 8, 2014
4NKQ
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BU of 4nkq by Molmil
Structure of a Cytokine Receptor Complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, Granulocyte-macrophage colony-stimulating factor, ...
Authors:Parker, M.W, Broughton, S.E.
Deposit date:2013-11-13
Release date:2015-09-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Conformational Changes in the GM-CSF Receptor Suggest a Molecular Mechanism for Affinity Conversion and Receptor Signaling.
Structure, 24, 2016
2B7A
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BU of 2b7a by Molmil
The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor
Descriptor: 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE, Tyrosine-protein kinase JAK2
Authors:Lucet, I.S, Fantino, E, Styles, M, Bamert, R, Patel, O, Broughton, S.E, Walter, M, Burns, C.J, Treutlein, H, Wilks, A.F, Rossjohn, J.
Deposit date:2005-10-04
Release date:2006-01-10
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2 Å)
Cite:The structural basis of Janus kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor.
Blood, 107, 2006
6BFQ
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BU of 6bfq by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Descriptor: Fab Heavy chain, Fab Light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
2OGV
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BU of 2ogv by Molmil
Crystal Structure of the Autoinhibited Human c-Fms Kinase Domain
Descriptor: Macrophage colony-stimulating factor 1 receptor precursor
Authors:Walter, M, Lucet, I.S, Patel, O, Broughton, S.E, Bamert, R, Williams, N.K, Fantino, E, Wilks, A.F, Rossjohn, J.
Deposit date:2007-01-09
Release date:2007-02-06
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The 2.7 A crystal structure of the autoinhibited human c-Fms kinase domain.
J.Mol.Biol., 367, 2007
6BFS
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BU of 6bfs by Molmil
The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies
Descriptor: Fab Heavy Chain, Fab light Chain, Granulocyte-macrophage colony-stimulating factor
Authors:Dhagat, U, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2017-10-26
Release date:2018-09-12
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:The mechanism of GM-CSF inhibition by human GM-CSF auto-antibodies suggests novel therapeutic opportunities.
MAbs, 10, 2018
6NMY
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BU of 6nmy by Molmil
A Cytokine-receptor complex
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cytokine receptor common subunit beta, ...
Authors:Dhagat, U, Kan, W.L, Hercus, T.R, Broughton, S.E, Nero, T.L, Lopez, A.F, Parker, M.W.
Deposit date:2019-01-13
Release date:2020-01-22
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.301 Å)
Cite:Signalling conformation of cell surface receptor
To Be Published

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PDB entries from 2024-03-27

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