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1DIF
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BU of 1dif by Molmil
HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
Descriptor: BETA-MERCAPTOETHANOL, HIV-1 PROTEASE, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE
Authors:Silva, A.M, Cachau, R.E, Sham, H.L, Erickson, J.W.
Deposit date:1995-10-09
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Inhibition and catalytic mechanism of HIV-1 aspartic protease.
J.Mol.Biol., 255, 1996
1SME
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BU of 1sme by Molmil
PLASMEPSIN II, A HEMOGLOBIN-DEGRADING ENZYME FROM PLASMODIUM FALCIPARUM, IN COMPLEX WITH PEPSTATIN A
Descriptor: PLASMEPSIN II, Pepstatin
Authors:Silva, A.M, Lee, A.Y, Gulnik, S.V, Goldberg, D.E, Erickson, J.W.
Deposit date:1996-06-11
Release date:1997-01-11
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structure and inhibition of plasmepsin II, a hemoglobin-degrading enzyme from Plasmodium falciparum.
Proc.Natl.Acad.Sci.USA, 93, 1996
4FE6
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BU of 4fe6 by Molmil
Crystal Structure of HIV-1 Protease in Complex with an enamino-oxindole inhibitor
Descriptor: (3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl {(2S,3R)-3-hydroxy-4-[({(3Z)-3-[1-(methylamino)ethylidene]-2-oxo-2,3-dihydro-1H-indol-5-yl}sulfonyl)(2-methylpropyl)amino]-1-phenylbutan-2-yl}carbamate, HIV protease
Authors:Silva, A.M, Eissenstat, M, Guerassina, T, Gulnik, S, Afonina, E, Yu, B, Erickson, J, Ludke, D, Yokoe, H.
Deposit date:2012-05-29
Release date:2012-07-18
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2 Å)
Cite:Enamino-oxindole HIV protease inhibitors.
Bioorg.Med.Chem.Lett., 22, 2012
5A1Z
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BU of 5a1z by Molmil
Cryo-EM structure of Dengue virus serotype 2 strain PVP94-07 complexed with human antibody 2D22 Fab at 37 degrees C
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, ENVELOPE PROTEIN, ...
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Jr, J.E, Lok, S.M.
Deposit date:2015-05-06
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.9 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
4UIF
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BU of 4uif by Molmil
Cryo-EM structure of Dengue virus serotype 2 in complex with antigen-binding fragments of human antibody 2D22
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, ...
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.-N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Junior, J.E, Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (6.5 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
4UIH
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BU of 4uih by Molmil
Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation.
Descriptor: ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN
Authors:Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe, J.E, Lok, S.-M.
Deposit date:2015-03-30
Release date:2015-07-15
Last modified:2018-02-07
Method:ELECTRON MICROSCOPY (20 Å)
Cite:Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.
Science, 349, 2015
2CW3
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BU of 2cw3 by Molmil
X-ray structure of PmSOD2, superoxide dismutase from Perkinsus marinus
Descriptor: FE (III) ION, iron superoxide dismutase
Authors:Asojo, O.A, Schott, E.J, Vasta, G.R, Silva, A.M.
Deposit date:2005-06-16
Release date:2006-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
1LEE
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BU of 1lee by Molmil
CRYSTAL STRUCTURE OF PLASMEPSIN FROM P. FALCIPARUM IN COMPLEX WITH INHIBITOR RS367
Descriptor: 4-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE, Plasmepsin 2
Authors:Asojo, O.A, Afonina, E, Gulnik, S.V, Yu, B, Erickson, J.W, Randad, R, Mehadjed, D, Silva, A.M.
Deposit date:2002-04-09
Release date:2002-10-09
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
2CW2
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BU of 2cw2 by Molmil
Crystal structure of Superoxide dismutase from P. Marinus
Descriptor: FE (III) ION, superoxide dismutase 1
Authors:Asojo, O.A, Schott, E.J, Vasta, G.R, Silva, A.M.
Deposit date:2005-06-16
Release date:2006-07-04
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Structures of PmSOD1 and PmSOD2, two superoxide dismutases from the protozoan parasite Perkinsus marinus
ACTA CRYSTALLOGR.,SECT.F, 62, 2006
1LF2
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BU of 1lf2 by Molmil
CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR RS370
Descriptor: 3-AMINO-N-{4-[2-(2,6-DIMETHYL-PHENOXY)-ACETYLAMINO]-3-HYDROXY-1-ISOBUTYL-5-PHENYL-PENTYL}-BENZAMIDE, Plasmepsin 2
Authors:Asojo, O.A, Afonina, E, Gulnik, S.V, Yu, B, Erickson, J.W, Randad, R, Mehadjed, D, Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of Ser205 mutant plasmepsin II from Plasmodium falciparum at 1.8 A in complex with the inhibitors rs367 and rs370.
Acta Crystallogr.,Sect.D, 58, 2002
3J6T
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BU of 3j6t by Molmil
Cryo-EM structure of Dengue virus serotype 3 at 37 degrees C
Descriptor: envelope protein, membrane protein
Authors:Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M.
Deposit date:2014-03-25
Release date:2015-03-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (7 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6S
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BU of 3j6s by Molmil
Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C
Descriptor: envelope protein, membrane protein
Authors:Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M.
Deposit date:2014-03-24
Release date:2015-03-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (6 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
3J6U
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BU of 3j6u by Molmil
Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab
Descriptor: Fab 5J7 heavy chain, Fab 5J7 light chain, envelope protein, ...
Authors:Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M.
Deposit date:2014-03-26
Release date:2015-03-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (9 Å)
Cite:A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins.
Nat Commun, 6, 2015
1LF3
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BU of 1lf3 by Molmil
CRYSTAL STRUCTURE OF PLASMEPSIN II FROM P FALCIPARUM IN COMPLEX WITH INHIBITOR EH58
Descriptor: N-(1-BENZYL-3-{[3-(1,3-DIOXO-1,3-DIHYDRO-ISOINDOL-2-YL)-PROPIONYL]-[2-(HEXAHYDRO-BENZO[1,3]DIOXOL-5-YL)-ETHYL]-AMINO}-2-HYDROXY-PROPYL)-4-BENZYLOXY-3,5-DIMETHOXY-BENZAMIDE, plasmepsin 2
Authors:Asojo, O.A, Gulnik, S.V, Afonina, E, Yu, B, Ellman, J.A, Haque, T.S, Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1LF4
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BU of 1lf4 by Molmil
STRUCTURE OF PLASMEPSIN II
Descriptor: Plasmepsin 2
Authors:Asojo, O.A, Gulnik, S.V, Afonina, E, Yu, B, Ellman, J.A, Haque, T.S, Silva, A.M.
Deposit date:2002-04-10
Release date:2002-10-10
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1LS5
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BU of 1ls5 by Molmil
Crystal structure of plasmepsin IV from P. falciparum in complex with pepstatin A
Descriptor: Pepstatin, plasmepsin IV
Authors:Asojo, O.A, Gulnik, S.V, Afonina, E, Yu, B, Ellman, J.A, Haque, T.S, Silva, A.M.
Deposit date:2002-05-16
Release date:2002-06-12
Last modified:2013-02-27
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Novel uncomplexed and complexed structures of plasmepsin II, an aspartic protease from Plasmodium falciparum.
J.Mol.Biol., 327, 2003
1M43
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BU of 1m43 by Molmil
Crystal structure of PMII in complex with pepstatin a to 2.4 A
Descriptor: Pepstatin, plasmepsin II
Authors:Asojo, O.A, Silva, A.M, Gulnik, S.
Deposit date:2002-07-02
Release date:2002-07-24
Last modified:2021-10-27
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Novel uncomplexed and complex structures of PM II, an aspartic protease from P. falciparum
To be Published
4AGS
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BU of 4ags by Molmil
Leishmania TDR1 - a unique trimeric glutathione transferase
Descriptor: 1,2-ETHANEDIOL, GLUTATHIONE, THIOL-DEPENDENT REDUCTASE 1
Authors:Fyfe, P.K, Westrop, G.D, Silva, A.M, Coombs, G.H, Hunter, W.N.
Deposit date:2012-01-31
Release date:2012-07-04
Last modified:2012-08-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Leishmania Tdr1 Structure, a Unique Trimeric Glutathione Transferase Capable of Deglutathionylation and Antimonial Prodrug Activation.
Proc.Natl.Acad.Sci.USA, 109, 2012
4SBV
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BU of 4sbv by Molmil
The REFINEMENT OF SOUTHERN BEAN MOSAIC VIRUS IN RECIPROCAL SPACE
Descriptor: CALCIUM ION, SOUTHERN BEAN MOSAIC VIRUS COAT PROTEIN
Authors:Rossmann, M.G.
Deposit date:1985-04-01
Release date:1985-07-17
Last modified:2023-06-28
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Refined structure of southern bean mosaic virus at 2.9 A resolution.
J.Mol.Biol., 197, 1987
6WY1
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BU of 6wy1 by Molmil
Crystal structure of an engineered thermostable dengue virus 2 envelope protein dimer
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Dengue 2 soluble recombinant envelope
Authors:Kudlacek, S.T, Lakshmanane, P, Kuhlman, B.
Deposit date:2020-05-12
Release date:2021-11-10
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.42 Å)
Cite:Designed, highly expressing, thermostable dengue virus 2 envelope protein dimers elicit quaternary epitope antibodies.
Sci Adv, 7, 2021
8DV6
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BU of 8dv6 by Molmil
Zika virus envelope protein structure in complex with a potent Human mAb
Descriptor: Envelope protein E, mAb Fab Heavy Chain, mAb Fab Light Chain
Authors:Cameron, A, Puhl, A.C, deSilva, A.M, Premkumar, L.
Deposit date:2022-07-28
Release date:2023-01-04
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (3.38 Å)
Cite:Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.
Plos Pathog., 19, 2023
7YAR
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BU of 7yar by Molmil
ZIKV_Fab_G9E
Descriptor: E protein, M protein, heavy chain, ...
Authors:Shu, B, Thiam-Seng, N, Lok, S.
Deposit date:2022-06-28
Release date:2023-01-04
Last modified:2023-08-02
Method:ELECTRON MICROSCOPY (5.9 Å)
Cite:Structure and neutralization mechanism of a human antibody targeting a complex Epitope on Zika virus.
Plos Pathog., 19, 2023
3DSL
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BU of 3dsl by Molmil
The Three-dimensional Structure of Bothropasin, the Main Hemorrhagic Factor from Bothrops jararaca venom.
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, FUROYL-LEUCINE, ...
Authors:Muniz, J.R.C, Ambrosio, A, Selistre-de-Araujo, H.S, Oliva, G, Garratt, R.C, Souza, D.H.F.
Deposit date:2008-07-13
Release date:2008-10-21
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:The three-dimensional structure of bothropasin, the main hemorrhagic factor from Bothrops jararaca venom: Insights for a new classification of snake venom metalloprotease subgroups.
Toxicon, 52, 2008
1LYB
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BU of 1lyb by Molmil
CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, PEPSTATIN, ...
Authors:Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993
1LYA
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BU of 1lya by Molmil
CRYSTAL STRUCTURES OF NATIVE AND INHIBITED FORMS OF HUMAN CATHEPSIN D: IMPLICATIONS FOR LYSOSOMAL TARGETING AND DRUG DESIGN
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CATHEPSIN D, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Baldwin, E.T, Bhat, T.N, Gulnik, S, Erickson, J.W.
Deposit date:1993-04-22
Release date:1994-01-31
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design.
Proc.Natl.Acad.Sci.USA, 90, 1993

 

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