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1BXL
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BU of 1bxl by Molmil
STRUCTURE OF BCL-XL/BAK PEPTIDE COMPLEX, NMR, MINIMIZED AVERAGE STRUCTURE
Descriptor: BAK PEPTIDE, BCL-XL
Authors:Sattler, M, Liang, H, Nettesheim, D, Meadows, R.P, Harlan, J.E, Eberstadt, M, Yoon, H, Shuker, S.B, Chang, B.S, Minn, A.J, Thompson, C.B, Fesik, S.W.
Deposit date:1996-10-16
Release date:1997-10-29
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:Structure of Bcl-xL-Bak peptide complex: recognition between regulators of apoptosis.
Science, 275, 1997
2MJN
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BU of 2mjn by Molmil
Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1
Descriptor: Nucleolysin TIA-1 isoform p40
Authors:Sattler, M, Wang, I.
Deposit date:2014-01-13
Release date:2014-04-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structure, dynamics and RNA binding of the multi-domain splicing factor TIA-1.
Nucleic Acids Res., 42, 2014
4UQT
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BU of 4uqt by Molmil
RRM-peptide structure in RES complex
Descriptor: PRE-MRNA-SPLICING FACTOR CWC26, U2 SNRNP COMPONENT IST3
Authors:Tripsianes, K, Friberg, A, Barrandon, C, Seraphin, B, Sattler, M.
Deposit date:2014-06-25
Release date:2014-09-03
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:A Novel Protein-Protein Interaction in the Res (Retention and Splicing) Complex.
J.Biol.Chem., 289, 2014
8POI
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BU of 8poi by Molmil
Molecular Docking of SPF30 Tudor domain with synthetic inhibitor 4-(pyridin-2-yl)thiazol-2-amine
Descriptor: 4-pyridin-2-yl-1,3-thiazol-2-amine, Survival of motor neuron-related-splicing factor 30
Authors:Borggraefe, J, Gaussmann, S, Sattler, M.
Deposit date:2023-07-04
Release date:2023-08-23
Last modified:2023-08-30
Method:SOLUTION NMR
Cite:Pharmacological perturbation of the phase-separating protein SMNDC1.
Nat Commun, 14, 2023
8P25
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BU of 8p25 by Molmil
Solution structure of a chimeric U2AF2 RRM2 / FUBP1 N-Box
Descriptor: Splicing factor U2AF 65 kDa subunit,Far upstream element-binding protein 1
Authors:Hipp, C, Sattler, M.
Deposit date:2023-05-14
Release date:2023-07-26
Last modified:2023-08-16
Method:SOLUTION NMR
Cite:FUBP1 is a general splicing factor facilitating 3' splice site recognition and splicing of long introns.
Mol.Cell, 83, 2023
8B8S
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BU of 8b8s by Molmil
Solution structure of tandem RRM1 and RRM2 domains of yeast NPL3
Descriptor: Serine/arginine (SR)-type shuttling mRNA binding protein NPL3
Authors:Kachariya, N, Sattler, M, Keil, P, Strasser, K.
Deposit date:2022-10-04
Release date:2022-11-09
Last modified:2023-02-08
Method:SOLUTION NMR, SOLUTION SCATTERING
Cite:Npl3 functions in mRNP assembly by recruitment of mRNP components to the transcription site and their transfer onto the mRNA.
Nucleic Acids Res., 51, 2023
7Z0I
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BU of 7z0i by Molmil
human PEX13 SH3 domain
Descriptor: 1,2-ETHANEDIOL, Peroxisomal membrane protein PEX13, ZINC ION
Authors:Gaussmann, S, Zak, K, Sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
7Z0J
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BU of 7z0j by Molmil
human PEX13 SH3 domain in complex with internal FxxxF motif
Descriptor: 1,2-ETHANEDIOL, Peroxisomal membrane protein PEX13
Authors:Gaussmann, S, Zak, K, Kreisz, N, Sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
7Z0K
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BU of 7z0k by Molmil
human PEX13 SH3 in complex with PEX5 W4 (WxxxF/Y) motif
Descriptor: Peroxisomal membrane protein PEX13,Peroxisomal targeting signal 1 receptor
Authors:Gaussmann, S, Napolitano, V, sattler, M.
Deposit date:2022-02-23
Release date:2023-03-08
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Intramolecular autoinhibition of human PEX13 modulates peroxisomal import
Biorxiv, 2022
1FHO
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BU of 1fho by Molmil
Solution Structure of the PH Domain from the C. Elegans Muscle Protein UNC-89
Descriptor: UNC-89
Authors:Blomberg, N, Baraldi, E, Sattler, M, Saraste, M, Nilges, M.
Deposit date:2000-08-02
Release date:2000-10-04
Last modified:2022-12-21
Method:SOLUTION NMR
Cite:Structure of a PH domain from the C. elegans muscle protein UNC-89 suggests a novel function.
Structure Fold.Des., 8, 2000
4Q9C
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BU of 4q9c by Molmil
IgNAR antibody domain C3
Descriptor: CHLORIDE ION, Novel antigen receptor, SODIUM ION, ...
Authors:Feige, J.M, Graewert, M.A, Marcinowski, M, Hennig, J, Behnke, J, Auslaender, D, Herold, E.M, Peschek, J, Castro, C.D, Flajnik, M.F, Hendershot, L.M, Sattler, M, Groll, M, Buchner, J.
Deposit date:2014-04-30
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.
Proc.Natl.Acad.Sci.USA, 111, 2014
4Q97
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BU of 4q97 by Molmil
IgNAR antibody domain C1
Descriptor: Novel antigen receptor
Authors:Feige, J.M, Graewert, M.A, Marcinowski, M, Hennig, J, Behnke, J, Auslaender, D, Herold, E.M, Peschek, J, Castro, C.D, Flajnik, M.F, Hendershot, L.M, Sattler, M, Groll, M, Buchner, J.
Deposit date:2014-04-29
Release date:2014-07-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The structural analysis of shark IgNAR antibodies reveals evolutionary principles of immunoglobulins.
Proc.Natl.Acad.Sci.USA, 111, 2014
6Y91
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BU of 6y91 by Molmil
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with NADH
Descriptor: Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M.
Deposit date:2020-03-06
Release date:2021-03-31
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Commun Biol, 4, 2021
3DXB
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BU of 3dxb by Molmil
Structure of the UHM domain of Puf60 fused to thioredoxin
Descriptor: 1,2-ETHANEDIOL, CHLORIDE ION, thioredoxin N-terminally fused to Puf60(UHM)
Authors:Corsini, L, Hothorn, M, Scheffzek, K, Stier, G, Sattler, M.
Deposit date:2008-07-24
Release date:2008-10-28
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Dimerization and Protein Binding Specificity of the U2AF Homology Motif of the Splicing Factor Puf60.
J.Biol.Chem., 284, 2009
5JU7
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BU of 5ju7 by Molmil
DNA BINDING DOMAIN OF E.COLI CADC
Descriptor: Transcriptional activator CadC, ZINC ION
Authors:Janowski, R, Schlundt, A, Sattler, M, Niessing, D.
Deposit date:2016-05-10
Release date:2017-04-26
Last modified:2017-05-03
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Structure-function analysis of the DNA-binding domain of a transmembrane transcriptional activator.
Sci Rep, 7, 2017
1D8B
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BU of 1d8b by Molmil
NMR STRUCTURE OF THE HRDC DOMAIN FROM SACCHAROMYCES CEREVISIAE RECQ HELICASE
Descriptor: SGS1 RECQ HELICASE
Authors:Liu, Z, Macias, M.J, Bottomley, M.J, Stier, G, Linge, J.P, Nilges, M, Bork, P, Sattler, M.
Deposit date:1999-10-21
Release date:2000-01-10
Last modified:2022-02-16
Method:SOLUTION NMR
Cite:The three-dimensional structure of the HRDC domain and implications for the Werner and Bloom syndrome proteins.
Structure Fold.Des., 7, 1999
6SPT
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BU of 6spt by Molmil
High resolution crystal structure of N-terminal domain of PEX14 from Trypanosoma brucei in complex with the fist compound with sub-micromolar trypanocidal activity
Descriptor: 5-[(4-methoxynaphthalen-1-yl)methyl]-1-[2-[(2-methyl-1-oxidanyl-propan-2-yl)amino]ethyl]-~{N}-(naphthalen-1-ylmethyl)-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridine-3-carboxamide, BETA-MERCAPTOETHANOL, CHLORIDE ION, ...
Authors:Napolitano, V, Dawidowski, M, Kalel, V.C, Fino, R, Emmanouilidis, L, Lenhart, D, Ostertag, M, Kaiser, M, Kolonko, M, Schilebs, W, Maser, P, Tetko, I, Hadian, K, Plettenburg, O, Erdmann, R, Sattler, M, Popowicz, G.M, Dubin, G.
Deposit date:2019-09-02
Release date:2020-01-01
Last modified:2020-02-05
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity.
J.Med.Chem., 63, 2020
4QQB
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BU of 4qqb by Molmil
Structural basis for the assembly of the SXL-UNR translation regulatory complex
Descriptor: Protein sex-lethal, Upstream of N-ras, isoform A, ...
Authors:Hennig, J, Popowicz, G.M, Sattler, M.
Deposit date:2014-06-27
Release date:2014-09-03
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structural basis for the assembly of the Sxl-Unr translation regulatory complex.
Nature, 515, 2014
6DCL
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BU of 6dcl by Molmil
Crystal structure of UP1 bound to pri-miRNA-18a terminal loop
Descriptor: 1,2-ETHANEDIOL, Heterogeneous nuclear ribonucleoprotein A1, RNA (5'-R(*AP*GP*UP*AP*GP*AP*UP*UP*AP*GP*C)-3')
Authors:Kooshapur, H, Sattler, M.
Deposit date:2018-05-07
Release date:2018-06-27
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (2.497 Å)
Cite:Structural basis for terminal loop recognition and stimulation of pri-miRNA-18a processing by hnRNP A1.
Nat Commun, 9, 2018
4JA7
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BU of 4ja7 by Molmil
Rat PP5 co-crystallized with P5SA-2
Descriptor: MAGNESIUM ION, Serine/threonine-protein phosphatase 5
Authors:Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K.
Deposit date:2013-02-18
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
4JA9
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BU of 4ja9 by Molmil
Rat PP5 apo
Descriptor: MAGNESIUM ION, Serine/threonine-protein phosphatase 5
Authors:Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K.
Deposit date:2013-02-18
Release date:2014-02-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism.
Biosci.Rep., 35, 2015
6R8G
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BU of 6r8g by Molmil
Crystal structure of malate dehydrogenase from Plasmodium Falciparum in complex with 4-(3,4-difluorophenyl)thiazol-2-amine
Descriptor: 4-[3,4-bis(fluoranyl)phenyl]-1,3-thiazol-2-amine, Malate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, ...
Authors:Romero, A.R, Calderone, V, Gentili, M, Lunev, S, Groves, M, Popowicz, G, Domling, A, Sattler, M.
Deposit date:2019-04-01
Release date:2020-04-15
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Fragment-Based Approach Identifies an Allosteric Pocket that Impacts Malate Dehydrogenase Activity
Commun Biol, 2021
6STF
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BU of 6stf by Molmil
Human Rab8a phosphorylated at Ser111 in complex with GDP
Descriptor: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Ras-related protein Rab-8A
Authors:Vieweg, S, Mulholland, K, Braeuning, B, Kachariya, N, Lai, Y, Toth, R, Sattler, M, Groll, M, Itzen, A, Muqit, M.M.K.
Deposit date:2019-09-10
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Biochem.J., 477, 2020
6STG
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BU of 6stg by Molmil
Human Rab8a phosphorylated at Ser111 in complex with GPPNP
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ...
Authors:Vieweg, S, Mulholland, K, Braeuning, B, Kachariya, N, Lai, Y, Toth, R, Sattler, M, Groll, M, Itzen, A, Muqit, M.M.K.
Deposit date:2019-09-10
Release date:2020-04-22
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2-mediated phosphorylation at Threonine72.
Biochem.J., 477, 2020
2JW6
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BU of 2jw6 by Molmil
Solution structure of the DEAF1 MYND domain
Descriptor: Deformed epidermal autoregulatory factor 1 homolog, ZINC ION
Authors:Spadaccini, R, Perrin, H, Bottomley, M, Ansieu, S, Sattler, M.
Deposit date:2007-10-08
Release date:2007-12-25
Last modified:2013-04-10
Method:SOLUTION NMR
Cite:Retraction notice to "Structure and functional analysis of the MYND domain" [J. Mol. Biol. (2006) 358, 498-508].
J.Mol.Biol., 376, 2008

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