Author results

1PWF
  • Download 1pwf
  • View 1pwf
Molmil generated image of 1pwf
ONE SUGAR PUCKER FITS ALL: PAIRING VERSATILITY DESPITE CONFORMATIONAL UNIFORMITY IN TNA
Descriptor:5'-D(*GP*CP*GP*TP*AP*(2MU)P*(FA2)P*CP*GP*C)-3', SPERMINE
Authors:Pallan, P.S., Wilds, C.J., Wawrzak, Z., Krishnamurthy, R., Eschenmoser, A., Egli, M.
Deposit date:2003-07-01
Release date:2004-07-13
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.16 Å)
Cite:Why does TNA cross-pair more strongly with RNA than with DNA? an answer from X-ray analysis.
ANGEW.CHEM.INT.ED.ENGL., 42, 2003
2A43
  • Download 2a43
  • View 2a43
Molmil generated image of 2a43
CRYSTAL STRUCTURE OF A LUTEOVIRAL RNA PSEUDOKNOT AND MODEL FOR A MINIMAL RIBOSOMAL FRAMESHIFTING MOTIF
Descriptor:RNA Pseudoknot, MAGNESIUM ION
Authors:Pallan, P.S., Marshall, W.S., Harp, J., Jewett III, F.C., Wawrzak, Z., Brown II, B.A., Rich, A., Egli, M.
Deposit date:2005-06-27
Release date:2005-09-27
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.34 Å)
Cite:Crystal Structure of a Luteoviral RNA Pseudoknot and Model for a Minimal Ribosomal Frameshifting Motif
Biochemistry, 44, 2005
2GUN
  • Download 2gun
  • View 2gun
Molmil generated image of 2gun
RNA-BINDING AFFINITIES AND CRYSTAL STRUCTURE OF OLIGONUCLEOTIDES CONTAINING FIVE-ATOM AMIDE-BASED BACKBONE STRUCTURES
Descriptor:5'-D(*TP*TP*CP*(T2T)P*(CBR)P*TP*TP*C)-3', 5'-R(*GP*AP*AP*GP*AP*AP*GP*AP*A)-3', COBALT (III) ION, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2006-05-01
Release date:2006-08-01
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:RNA-Binding Affinities and Crystal Structure of Oligonucleotides Containing Five-Atom Amide-Based Backbone Structures.
Biochemistry, 45, 2006
2RF3
  • Download 2rf3
  • View 2rf3
Molmil generated image of 2rf3
CRYSTAL STRUCTURE OF TRICYCLO-DNA: AN UNUSUAL COMPENSATORY CHANGE OF TWO ADJACENT BACKBONE TORSION ANGLES
Descriptor:5'-d(CGCG(TCY)ATTCGCG)-3', ZINC ION, SPERMINE
Authors:Pallan, P.S., Ittig, D., Heroux, A., Wawrzak, Z., Leumann, C.J., Egli, M.
Deposit date:2007-09-27
Release date:2008-02-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.
Chem.Commun.(Camb.), 2008, 2008
3CJZ
  • Download 3cjz
  • View 3cjz
Molmil generated image of 3cjz
EFFECTS OF N2,N2-DIMETHYLGUANOSINE ON RNA STRUCTURE AND STABILITY: CRYSTAL STRUCTURE OF AN RNA DUPLEX WITH TANDEM M22G:A PAIRS
Descriptor:RNA (5'-R(*GP*GP*AP*CP*GP*(M2G)P*AP*CP*GP*UP*CP*CP*U)-3')
Authors:Pallan, P.S., Kreutz, C., Bosio, S., Micura, R., Egli, M.
Deposit date:2008-03-14
Release date:2008-10-14
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Effects of N2,N2-dimethylguanosine on RNA structure and stability: crystal structure of an RNA duplex with tandem m2 2G:A pairs.
Rna, 14, 2008
3D0P
  • Download 3d0p
  • View 3d0p
Molmil generated image of 3d0p
INSIGHTS INTO RNA/DNA HYBRID RECOGNITION AND PROCESSING BY RNASE H FROM THE CRYSTAL STRUCTURE OF A NON-SPECIFIC ENZYME-DSDNA COMPLEX
Descriptor:Ribonuclease H, DNA (5'-D(*DCP*DGP*DCP*DGP*DAP*DAP*DTP*DTP*DCP*DGP*DCP*DG)-3'), SODIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2008-05-02
Release date:2008-10-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Insights into RNA/DNA hybrid recognition and processing by RNase H from the crystal structure of a non-specific enzyme-dsDNA complex.
Cell Cycle, 7, 2008
3P4B
  • Download 3p4b
  • View 3p4b
Molmil generated image of 3p4b
ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-P3
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', BARIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4C
  • Download 3p4c
  • View 3p4c
Molmil generated image of 3p4c
ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RA2U2-R32
Descriptor:5'-R(*(CFZ)P*GP*(AF2)P*AP*(UFT)P*UP*(CFZ)P*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.15 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3P4D
  • Download 3p4d
  • View 3p4d
Molmil generated image of 3p4d
ALTERNATINGLY MODIFIED 2'FLUORO RNA OCTAMER F/RC4G4
Descriptor:5'-R(*(CFZ)P*CP*(CFZ)P*CP*(GF2)P*GP*(GF2)P*G)-3'
Authors:Pallan, P.S., Greene, E.M., Jicman, P.A., Pandey, R.K., Manoharan, M., Rozners, E., Egli, M.
Deposit date:2010-10-06
Release date:2011-01-05
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Unexpected origins of the enhanced pairing affinity of 2'-fluoro-modified RNA.
Nucleic Acids Res., 39, 2011
3UKB
  • Download 3ukb
  • View 3ukb
Molmil generated image of 3ukb
(R)-CET-BNA DECAMER STRUCTURE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(RCE)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3UKC
  • Download 3ukc
  • View 3ukc
Molmil generated image of 3ukc
(S)-CET-BNA DECAMER STRUCTURE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(1TL)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (1.54 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3UKE
  • Download 3uke
  • View 3uke
Molmil generated image of 3uke
(S)-CMOE-BNA DECAMER STRUCTURE
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(CSM)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2011-11-09
Release date:2012-06-20
Last modified:2012-08-08
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Structure and nuclease resistance of 2',4'-constrained 2'-O-methoxyethyl (cMOE) and 2'-O-ethyl (cEt) modified DNAs.
Chem.Commun.(Camb.), 48, 2012
3V06
  • Download 3v06
  • View 3v06
Molmil generated image of 3v06
CRYSTAL STRUCTURE OF S-6'-ME-3'-FLUORO HEXITOL NUCLEIC ACID
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(F5H)P*AP*CP*GP*C)-3'), STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2011-12-07
Release date:2012-02-08
Method:X-RAY DIFFRACTION (1.53 Å)
Cite:Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012
3V07
  • Download 3v07
  • View 3v07
Molmil generated image of 3v07
CRYSTAL STRUCTURE OF R-6'-ME-3'-FLUORO HEXITOL NUCLEIC ACID
Descriptor:DNA (5'-D(*GP*CP*GP*TP*AP*(F6H)P*AP*CP*GP*C)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2011-12-07
Release date:2012-02-08
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Insights from crystal structures into the opposite effects on RNA affinity caused by the s- and R-6'-methyl backbone modifications of 3'-fluoro hexitol nucleic Acid.
Biochemistry, 51, 2012
4R1Z
  • Download 4r1z
  • View 4r1z
Molmil generated image of 4r1z
ZEBRA FISH CYTOCHROME P450 17A1 WITH ABIRATERONE
Descriptor:Cyp17a1 protein, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R20
  • Download 4r20
  • View 4r20
Molmil generated image of 4r20
ZEBRA FISH CYTOCHROME P450 17A2 WITH ABIRATERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, Abiraterone, ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.86 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4R21
  • Download 4r21
  • View 4r21
Molmil generated image of 4r21
ZEBRA FISH CYTOCHROME P450 17A2 WITH PROGESTERONE
Descriptor:Cytochrome P450 family 17 polypeptide 2, PROTOPORPHYRIN IX CONTAINING FE, PROGESTERONE
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-08-08
Release date:2014-12-31
Last modified:2015-03-04
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Structural and Kinetic Basis of Steroid 17 alpha, 20-Lyase Activity in Teleost Fish Cytochrome P450 17A1 and Its Absence in Cytochrome P450 17A2.
J.Biol.Chem., 290, 2015
4RBY
  • Download 4rby
  • View 4rby
Molmil generated image of 4rby
FIRST X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*(2SG)P*AP*AP*UP*UP*AP*GP*CP*G)-3', STRONTIUM ION
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.19 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RBZ
  • Download 4rbz
  • View 4rbz
Molmil generated image of 4rbz
X-RAY STRUCTURE OF RNA CONTAINING ADENOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*(A2M)P*(ADS)P*UP*UP*AP*GP*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4RC0
  • Download 4rc0
  • View 4rc0
Molmil generated image of 4rc0
X-RAY STRUCTURE OF RNA CONTAINING GUANOSINE PHOSPHORODITHIOATE
Descriptor:5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(A2M)P*(2SG)P*CP*G)-3'
Authors:Pallan, P.S., Egli, M.
Deposit date:2014-09-13
Release date:2015-09-16
Last modified:2017-07-12
Method:X-RAY DIFFRACTION (1.13 Å)
Cite:Crystal Structure, Stability and siRNA Activity of Phosphorodithioate-Modified RNAs
To be Published
4Y8W
  • Download 4y8w
  • View 4y8w
Molmil generated image of 4y8w
CRYSTAL STRUCTURE OF HUMAN CYTOCHROME P450 21A2 PROGESTERONE COMPLEX
Descriptor:Cytochrome P450 21-hydroxylase, SULFATE ION, PROTOPORPHYRIN IX CONTAINING FE, ...
Authors:Pallan, P.S., Lei, L., Egli, M.
Deposit date:2015-02-16
Release date:2015-04-15
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.64 Å)
Cite:Human Cytochrome P450 21A2, the Major Steroid 21-Hydroxylase: STRUCTURE OF THE ENZYMEPROGESTERONE SUBSTRATE COMPLEX AND RATE-LIMITING C-H BOND CLEAVAGE.
J.Biol.Chem., 290, 2015
5DO5
  • Download 5do5
  • View 5do5
Molmil generated image of 5do5
CRYSTAL STRUCTURE OF 2'-FLUORO-RNA BEARING A PHOSPHORODITHIOATE
Descriptor:RNA (5'-R(*CP*GP*CP*GP*AP*AP*UP*UP*(AF2)P*(2SG)P*CP*G)-3')
Authors:Pallan, P.S., Egli, M.
Deposit date:2015-09-10
Release date:2016-09-21
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:Crystal Structure of 2'-Fluoro-RNA bearing a phosphorodithioate
To Be Published
5SWM
  • Download 5swm
  • View 5swm
Molmil generated image of 5swm
BACILLUS HALODURANS RNASE H MUTANT D132N IN COMPLEX WITH 12-MER FRNA/DNA HYBRID
Descriptor:Ribonuclease H, RNA (12-MER), DNA (12-MER), ...
Authors:Pallan, P.S., Egli, M.
Deposit date:2016-08-08
Release date:2016-09-21
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Limits of RNA 2'-OH Mimicry by Fluorine: Crystal Structure of Bacillus halodurans RNase H Bound to a 2'-FRNA:DNA Hybrid.
Biochemistry, 55, 2016
3EY1
  • Download 3ey1
  • View 3ey1
Molmil generated image of 3ey1
A CONFORMATIONAL TRANSITION IN THE STRUCTURE OF A 2'-THIOMETHYL-MODIFIED DNA VISUALIZED AT HIGH RESOLUTION
Descriptor:Ribonuclease H, 5'-D(*CP*GP*CP*GP*AP*AP*(USM)P*(USM)P*CP*GP*CP*G)-3', GLYCEROL
Authors:Egli, M., Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009
3EY2
  • Download 3ey2
  • View 3ey2
Molmil generated image of 3ey2
A CONFORMATIONAL TRANSITION IN THE STRUCTURE OF A 2'-THIOMETHYL-MODIFIED DNA VISUALIZED AT HIGH RESOLUTION
Descriptor:5'-D(*GP*CP*GP*TP*AP*(USM)P*AP*CP*GP*C)-3', N-methylpropane-1,3-diamine
Authors:Egli, M., Pallan, P.S.
Deposit date:2008-10-17
Release date:2009-04-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:A conformational transition in the structure of a 2'-thiomethyl-modified DNA visualized at high resolution.
Chem.Commun.(Camb.), 15, 2009