Author results

6F27
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NMR SOLUTION STRUCTURE OF NON-BOUND [DES-ARG10]-KALLIDIN (DAKD)
Descriptor:DAKD
Authors:Richter, C., Jonker, H.R.A., Schwalbe, H., Joedicke, L., Mao, J., Kuenze, G., Reinhart, C., Kalavacherla, T., Meiler, J., Preu, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-23
Release date:2018-01-10
Last modified:2019-05-08
Method:SOLUTION NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
2NDJ
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STRUCTURAL BASIS FOR KCNE3 AND ESTROGEN MODULATION OF THE KCNQ1 CHANNEL
Descriptor:Potassium voltage-gated channel subfamily E member 3
Authors:Sanders, C.R., Van Horn, W.D., Kroncke, B.M., Sisco, N.J., Meiler, J., Vanoye, C.G., Song, Y., Nannemann, D.P., Welch, R.C., Kang, C., Smith, J., George, A.L.
Deposit date:2016-06-09
Release date:2016-09-21
Last modified:2017-12-20
Method:SOLUTION NMR
Cite:Structural basis for KCNE3 modulation of potassium recycling in epithelia.
Sci Adv, 2, 2016
3TDN
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COMPUTATIONALLY DESIGNED TWO-FOLD SYMMETRIC TIM-BARREL PROTEIN, FLR
Descriptor:FLR SYMMETRIC ALPHA-BETA TIM BARREL
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L., Meiler, J.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
4PAM
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.101 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAN
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFITE ION, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAO
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.003 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
4PAQ
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A CONSERVED PHENYLALANINE AS RELAY BETWEEN THE 5 HELIX AND THE GDP BINDING REGION OF HETEROTRIMERIC G PROTEIN
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, MAGNESIUM ION
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2014-04-09
Release date:2014-07-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:A Conserved Phenylalanine as a Relay between the alpha 5 Helix and the GDP Binding Region of Heterotrimeric Gi Protein alpha Subunit.
J.Biol.Chem., 289, 2014
5KDL
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CRYSTAL STRUCTURE OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT BOUND TO GTPGAMMAS
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
5KDO
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HETEROTRIMERIC COMPLEX OF THE 4 ALANINE INSERTION VARIANT OF THE GI ALPHA1 SUBUNIT AND THE GBETA1-GGAMMA1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(T) subunit gamma-T1, ...
Authors:Kaya, A.I., Lokits, A.D., Gilbert, J., Iverson, T.M., Meiler, J., Hamm, H.E.
Deposit date:2016-06-08
Release date:2016-08-03
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A Conserved Hydrophobic Core in G alpha i1 Regulates G Protein Activation and Release from Activated Receptor.
J.Biol.Chem., 291, 2016
6F3V
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BACKBONE STRUCTURE OF BRADYKININ (BK) PEPTIDE BOUND TO HUMAN BRADYKININ 2 RECEPTOR (B2R) DETERMINED BY MAS SSNMR
Descriptor:Bradykinin (BK)
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2019-08-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3W
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BACKBONE STRUCTURE OF FREE BRADYKININ (BK) IN DDM/CHS DETERGENT MICELLE DETERMINED BY MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Lopez, J.J., Shukla, A.K., Kuenze, G., Meiler, J., Schwalbe, H., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2019-08-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3X
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BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE IN FROZEN DDM/CHS DETERGENT MICELLE SOLUTION DETERMINED BY DNP-ENHANCED MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2019-08-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
6F3Y
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BACKBONE STRUCTURE OF DES-ARG10-KALLIDIN (DAKD) PEPTIDE BOUND TO HUMAN BRADYKININ 1 RECEPTOR (B1R) DETERMINED BY DNP-ENHANCED MAS SSNMR
Descriptor:Kininogen-1
Authors:Mao, J., Kuenze, G., Joedicke, L., Meiler, J., Michel, H., Glaubitz, C.
Deposit date:2017-11-29
Release date:2018-01-10
Last modified:2019-08-21
Method:SOLID-STATE NMR
Cite:The molecular basis of subtype selectivity of human kinin G-protein-coupled receptors.
Nat. Chem. Biol., 14, 2018
2K21
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NMR STRUCTURE OF HUMAN KCNE1 IN LMPG MICELLES AT PH 6.0 AND 40 DEGREE C
Descriptor:Potassium voltage-gated channel subfamily E member
Authors:Kang, C., Tian, C., Sonnichsen, F.D., Smith, J.A., Meiler, J., George, A.L., Vanoye, C.G., Sanders, C.R., Kim, H.
Deposit date:2008-03-19
Release date:2008-12-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of KCNE1 and implications for how it modulates the KCNQ1 potassium channel.
Biochemistry, 47, 2008
2K39
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RECOGNITION DYNAMICS UP TO MICROSECONDS REVEALED FROM RDC DERIVED UBIQUITIN ENSEMBLE IN SOLUTION
Descriptor:Ubiquitin
Authors:Lange, O.F., Lakomek, N.A., Fares, C., Schroder, G., Walter, K., Becker, S., Meiler, J., Grubmuller, H., Griesinger, C., de Groot, B.L.
Deposit date:2008-04-25
Release date:2008-06-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Recognition dynamics up to microseconds revealed from an RDC-derived ubiquitin ensemble in solution.
Science, 320, 2008
2LLE
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COMPUTATIONAL DESIGN OF AN EIGHT-STRANDED (BETA/ALPHA)-BARREL FROM FRAGMENTS OF DIFFERENT FOLDS
Descriptor:Chemotaxis protein CheY, Imidazole glycerol phosphate synthase subunit HisF chimera
Authors:Coles, M., Truffault, V., Eisenbeis, S., Proffitt, W., Meiler, J., Hocker, B.
Deposit date:2011-11-07
Release date:2012-03-21
Method:SOLUTION NMR
Cite:Potential of fragment recombination for rational design of proteins.
J.Am.Chem.Soc., 134, 2012
5TQL
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CRYSTAL STRUCTURE OF TIM-BARREL PROTEIN HISF-C9S
Descriptor:Imidazole glycerol phosphate synthase subunit HisF, PHOSPHATE ION
Authors:Bender, B.J., Meiler, J.
Deposit date:2016-10-24
Release date:2016-11-16
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Experimental and Computational Identification of Naive Binders to a TIM-Barrel Protein Scaffold
To Be Published
6BP2
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THERAPEUTIC HUMAN MONOCLONAL ANTIBODY MR191 BOUND TO A MARBURGVIRUS GLYCOPROTEIN
Descriptor:Envelope glycoprotein, Envelope glycoprotein GP2, MR191 Fab Heavy Chain, ...
Authors:King, L.B., Fusco, M.L., Flyak, A.I., Ilinykh, P.A., Huang, K., Gunn, B., Kirchdoerfer, R.N., Hastie, K.M., Sangha, A.K., Meiler, J., Alter, G., Bukreyev, A., Crowe, J.E.J., Saphire, E.O.
Deposit date:2017-11-21
Release date:2018-01-17
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (3.172 Å)
Cite:The Marburgvirus-Neutralizing Human Monoclonal Antibody MR191 Targets a Conserved Site to Block Virus Receptor Binding.
Cell Host Microbe, 23, 2018
4ZV6
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CRYSTAL STRUCTURE OF THE ARTIFICIAL ALPHAREP-7 OCTARELLINV.1 COMPLEX
Descriptor:AlphaRep-7, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Urvoas, A., Valerio-Lepiniec, M., Minard, P., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-18
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
5BOP
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CRYSTAL STRUCTURE OF THE ARTIFICIAL NANOBODY OCTARELLINV.1 COMPLEX
Descriptor:Nanobody, Octarellin V.1
Authors:Figueroa, M., Sleutel, M., Pardon, E., Steyaert, J., Martial, J.A., van de Weerdt, C.
Deposit date:2015-05-27
Release date:2016-05-25
Last modified:2016-06-08
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:The unexpected structure of the designed protein Octarellin V.1 forms a challenge for protein structure prediction tools.
J.Struct.Biol., 195, 2016
5JRP
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CRYSTAL STRUCTURE OF MONOCLONAL ANTIBODY MR78 FAB
Descriptor:marberg virus monoclonal antibody MR78 Fab light chain, marberg virus monoclonal antibody MR78 Fab heavy chain, SODIUM ION
Authors:Dong, J., Crowe, J.
Deposit date:2016-05-06
Release date:2017-11-08
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
5WEQ
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THE CRYSTAL STRUCTURE OF A MR78 MUTANT
Descriptor:MR78 mutant light chain, MR78 mutant Fab heavy chain
Authors:Dong, J., Williamson, L.E., Crowe, J.E.
Deposit date:2017-07-10
Release date:2018-04-25
Method:X-RAY DIFFRACTION (2 Å)
Cite:Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein.
Structure, 25, 2017
3TDM
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COMPUTATIONALLY DESIGNED TIM-BARREL PROTEIN, HALFFLR
Descriptor:Computationally designed two-fold symmetric TIM-barrel protein, FLR (half molecule), PHOSPHATE ION
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
2KN5
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A CORRESPONDENCE BETWEEN SOLUTION-STATE DYNAMICS OF AN INDIVIDUAL PROTEIN AND THE SEQUENCE AND CONFORMATIONAL DIVERSITY OF ITS FAMILY
Descriptor:Ubiquitin
Authors:Friedland, G.D.
Deposit date:2009-08-14
Release date:2009-11-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A correspondence between solution-state dynamics of an individual protein and the sequence and conformational diversity of its family.
PLOS COMPUT.BIOL., 5, 2009
3MF6
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
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