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3J5P
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BU of 3j5p by Molmil
Structure of TRPV1 ion channel determined by single particle electron cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.275 Å)
Cite:Structure of the TRPV1 ion channel determined by electron cryo-microscopy.
Nature, 504, 2013
3J5Q
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BU of 3j5q by Molmil
Structure of TRPV1 ion channel in complex with DkTx and RTX determined by single particle electron cryo-microscopy
Descriptor: Kappa-theraphotoxin-Cg1a 1, Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2022-11-02
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
3J5R
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BU of 3j5r by Molmil
Reconstruction of TRPV1 ion channel in complex with capsaicin by single particle cryo-microscopy
Descriptor: Transient receptor potential cation channel subfamily V member 1
Authors:Liao, M, Cao, E, Julius, D, Cheng, Y.
Deposit date:2013-10-28
Release date:2013-12-04
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:TRPV1 structures in distinct conformations reveal activation mechanisms.
Nature, 504, 2013
7RIT
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BU of 7rit by Molmil
Drug-free A. baumannii MsbA
Descriptor: ATP-dependent lipid A-core flippase
Authors:Thelot, F, Liao, M.
Deposit date:2021-07-20
Release date:2021-10-06
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (5.2 Å)
Cite:Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
7RSL
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BU of 7rsl by Molmil
Seipin forms a flexible cage at lipid droplet formation sites
Descriptor: Seipin
Authors:Arlt, H, Sui, X, Folger, B, Adams, C, Chen, X, Remme, R, Hamprecht, F.A, DiMaio, F, Liao, M, Goodman, J.M, Farese Jr, R.V, Walther, T.C.
Deposit date:2021-08-11
Release date:2022-02-09
Last modified:2022-03-30
Method:ELECTRON MICROSCOPY (3.45 Å)
Cite:Seipin forms a flexible cage at lipid droplet formation sites.
Nat.Struct.Mol.Biol., 29, 2022
7TDT
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BU of 7tdt by Molmil
Cryo-EM structure of nanodisc-embedded human ABCA1
Descriptor: Phospholipid-transporting ATPase ABCA1
Authors:Plummer, A.M, Culbertson, A.T, Morales-Perez, C.L, Liao, M.
Deposit date:2022-01-03
Release date:2023-03-29
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Activity and Structural Dynamics of Human ABCA1 in a Lipid Membrane.
J.Mol.Biol., 435, 2023
8FKJ
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BU of 8fkj by Molmil
Yeast ATP Synthase in conformation-3, at pH 6
Descriptor: ATP synthase protein 8, ATP synthase subunit 4, mitochondrial, ...
Authors:Sharma, S, Patel, H, Luo, M, Mueller, D.M, Liao, M.
Deposit date:2022-12-21
Release date:2024-01-24
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F 1 -F o coupling.
Nat.Struct.Mol.Biol., 2024
8FL8
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BU of 8fl8 by Molmil
Yeast ATP Synthase structure in presence of MgATP
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP synthase protein 8, ...
Authors:Sharma, S, Patel, H, Luo, M, Mueller, D.M, Liao, M.
Deposit date:2022-12-21
Release date:2024-01-17
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F 1 -F o coupling.
Nat.Struct.Mol.Biol., 2024
8F29
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BU of 8f29 by Molmil
Yeast ATP synthase in conformation-1 at pH 6
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP synthase protein 8, ATP synthase subunit 4, ...
Authors:Sharma, S, Patel, H, Luo, M, Mueller, D.M, Liao, M.
Deposit date:2022-11-07
Release date:2024-02-07
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (4 Å)
Cite:Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F 1 -F o coupling.
Nat.Struct.Mol.Biol., 2024
8F39
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BU of 8f39 by Molmil
Yeast ATP synthase in conformation-2, at pH 6
Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP synthase protein 8, ATP synthase subunit 4, ...
Authors:Sharma, S, Patel, H, Luo, M, Mueller, D.M, Liao, M.
Deposit date:2022-11-09
Release date:2024-02-07
Last modified:2024-02-21
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Conformational ensemble of yeast ATP synthase at low pH reveals unique intermediates and plasticity in F 1 -F o coupling.
Nat.Struct.Mol.Biol., 2024
7MDX
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BU of 7mdx by Molmil
LolCDE nucleotide-free
Descriptor: Lipo-releasing system transmembrane protein lolC, Lipoprotein-releasing system ATP-binding protein LolD, Lipoprotein-releasing system transmembrane protein, ...
Authors:Sharma, S, Liao, M.
Deposit date:2021-04-06
Release date:2021-08-11
Last modified:2022-02-16
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins
Nat Commun, 12, 2021
7R6L
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BU of 7r6l by Molmil
5 prime exon-free pre-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct
Descriptor: Group I intron, 3 prime fragment plus 3 prime exon, 5 prime fragment, ...
Authors:Thelot, F, Liu, D, Liao, M, Yin, P.
Deposit date:2021-06-22
Release date:2022-05-04
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (2.85 Å)
Cite:Sub-3- angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
Nat.Methods, 19, 2022
7R6N
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BU of 7r6n by Molmil
Exon-free state of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic trimeric construct
Descriptor: Group I intron, MAGNESIUM ION
Authors:Thelot, F, Liu, D, Liao, M, Yin, P.
Deposit date:2021-06-22
Release date:2022-05-04
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Sub-3- angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
Nat.Methods, 19, 2022
7R6M
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BU of 7r6m by Molmil
Post-2S intermediate of the Tetrahymena group I intron, symmetry-expanded monomer from a synthetic dimeric construct
Descriptor: Group I intron, Ligated exon mimic of the Group I intron, MAGNESIUM ION
Authors:Thelot, F, Liu, D, Liao, M, Yin, P.
Deposit date:2021-06-22
Release date:2022-05-04
Last modified:2022-06-01
Method:ELECTRON MICROSCOPY (3.68 Å)
Cite:Sub-3- angstrom cryo-EM structure of RNA enabled by engineered homomeric self-assembly.
Nat.Methods, 19, 2022
8ESM
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BU of 8esm by Molmil
Human triacylglycerol synthesizing enzyme DGAT1 in complex with T863 inhibitor
Descriptor: Diacylglycerol O-acyltransferase 1, {(1r,4r)-4-[4-(4-amino-7,7-dimethyl-7H-pyrimido[4,5-b][1,4]oxazin-6-yl)phenyl]cyclohexyl}acetic acid
Authors:Sui, X, Kun, W, Walther, T, Farese, R, Liao, M.
Deposit date:2022-10-14
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
Nat Commun, 14, 2023
8ETM
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BU of 8etm by Molmil
Human triacylglycerol synthesizing enzyme DGAT1 in complex with DGAT1IN1 inhibitor
Descriptor: Diacylglycerol O-acyltransferase 1, [(1S,4r)-4-{4-[(4S)-2-({[4-(trifluoromethoxy)phenyl]methyl}carbamoyl)imidazo[1,2-a]pyridin-6-yl]phenyl}cyclohexyl]acetic acid
Authors:Sui, X, Kun, W, Walther, T, Farese, R, Liao, M.
Deposit date:2022-10-17
Release date:2023-06-07
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Mechanism of action for small-molecule inhibitors of triacylglycerol synthesis.
Nat Commun, 14, 2023
7MDY
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BU of 7mdy by Molmil
LolCDE nucleotide-bound
Descriptor: ADP ORTHOVANADATE, Lipo-releasing system transmembrane protein lolC, Lipoprotein transporter subunit LolE, ...
Authors:Sharma, S, Liao, M.
Deposit date:2021-04-06
Release date:2021-08-11
Last modified:2021-08-18
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Mechanism of LolCDE as a molecular extruder of bacterial triacylated lipoproteins
Nat Commun, 12, 2021
7MET
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BU of 7met by Molmil
A. baumannii MsbA in complex with TBT1 decoupler
Descriptor: 2-(4-chlorobenzamido)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid, ATP-dependent lipid A-core flippase
Authors:Thelot, F, Liao, M.
Deposit date:2021-04-07
Release date:2021-10-06
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3.97 Å)
Cite:Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
7MEW
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BU of 7mew by Molmil
E. coli MsbA in complex with G247
Descriptor: (2E)-3-{1-cyclopropyl-7-[(1S)-1-(3,6-dichloro-2-fluorophenyl)ethoxy]naphthalen-2-yl}prop-2-enoic acid, ATP-dependent lipid A-core flippase
Authors:Thelot, F, Liao, M.
Deposit date:2021-04-08
Release date:2021-10-06
Last modified:2021-11-10
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:Distinct allosteric mechanisms of first-generation MsbA inhibitors.
Science, 374, 2021
6C66
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BU of 6c66 by Molmil
CRISPR RNA-guided surveillance complex, pre-nicking
Descriptor: CRISPR-associated helicase, Cas3 family, CRISPR-associated protein, ...
Authors:Xiao, Y, Luo, M, Liao, M, Ke, A.
Deposit date:2018-01-17
Release date:2018-06-27
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.66 Å)
Cite:Structure basis for RNA-guided DNA degradation by Cascade and Cas3.
Science, 361, 2018
8ERC
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BU of 8erc by Molmil
Human Membrane-bound O-acyltransferase 7
Descriptor: Lysophospholipid acyltransferase 7
Authors:Wang, K, Liao, M, Farese, R.V, Walther, T.C.
Deposit date:2022-10-11
Release date:2023-09-27
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:The structure of phosphatidylinositol remodeling MBOAT7 reveals its catalytic mechanism and enables inhibitor identification.
Nat Commun, 14, 2023
6VYI
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BU of 6vyi by Molmil
Cryo-EM structure of human diacylglycerol O-acyltransferase 1
Descriptor: Diacylglycerol O-acyltransferase 1, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate
Authors:Sui, X, Wang, K, Gluchowski, N, Liao, M, Walther, C.T, Farese, V.R.
Deposit date:2020-02-26
Release date:2020-05-13
Last modified:2024-03-06
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structure and catalytic mechanism of a human triacylglycerol-synthesis enzyme.
Nature, 581, 2020
6VXJ
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BU of 6vxj by Molmil
Structure of ABCG2 bound to SN38
Descriptor: 7-ethyl-10-hydroxycamptothecin, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
Authors:Orlando, B.J, Liao, M.
Deposit date:2020-02-22
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
6VXH
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BU of 6vxh by Molmil
Structure of ABCG2 bound to imatinib
Descriptor: 4-(4-METHYL-PIPERAZIN-1-YLMETHYL)-N-[4-METHYL-3-(4-PYRIDIN-3-YL-PYRIMIDIN-2-YLAMINO)-PHENYL]-BENZAMIDE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
Authors:Orlando, B.J, Liao, M.
Deposit date:2020-02-21
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (4 Å)
Cite:ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020
6VXI
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BU of 6vxi by Molmil
Structure of ABCG2 bound to mitoxantrone
Descriptor: 1,4-DIHYDROXY-5,8-BIS({2-[(2-HYDROXYETHYL)AMINO]ETHYL}AMINO)-9,10-ANTHRACENEDIONE, Broad substrate specificity ATP-binding cassette transporter ABCG2, CHOLESTEROL
Authors:Orlando, B.J, Liao, M.
Deposit date:2020-02-21
Release date:2020-05-13
Last modified:2020-05-20
Method:ELECTRON MICROSCOPY (3.7 Å)
Cite:ABCG2 transports anticancer drugs via a closed-to-open switch.
Nat Commun, 11, 2020

 

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